Details of the Target

General Information of Target

Target ID LDTP10721
Target Name Alsin (ALS2)
Gene Name ALS2
Gene ID 57679
Synonyms
ALS2CR6; KIAA1563; Alsin; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGL
QAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKG
ISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEY
MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKL
ADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLF
PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEA
EDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLA
SYQKGHHPAQFSKCW
Target Bioclass
Other
Function May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
Uniprot ID
Q96Q42
Ensemble ID
ENST00000264276.11
HGNC ID
HGNC:443

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.G901E DBIA    Probe Info 
AN3CA SNV: p.M1176V DBIA    Probe Info 
AU565 SNV: p.E1557Q DBIA    Probe Info 
COLO829 SNV: p.Q1303Ter DBIA    Probe Info 
DU145 Deletion: p.L625Ter .
HCT116 SNV: p.S694N DBIA    Probe Info 
HCT15 SNV: p.S710I .
HEC1 SNV: p.S449N DBIA    Probe Info 
HEC1B SNV: p.S449N .
KMCH1 SNV: p.H1381Y .
MFE319 Deletion: p.N1091del
SNV: p.I30T		 .
NCIH1703 SNV: p.Q866L DBIA    Probe Info 
NCIH196 SNV: p.G260V DBIA    Probe Info 
OCILY3 SNV: p.G461Ter .
SNGM SNV: p.A310T; p.G414S .
SW1116 SNV: p.Q1355Ter .
SW403 SNV: p.E1414Ter DBIA    Probe Info 
SW756 SNV: p.E1348D .
UACC257 Deletion: p.H761MfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C1454(226.94); C916(15.68)  LDD0209  [2]
IA-alkyne
 Probe Info  		C1454(5.21)  LDD1705  [3]
IPM
 Probe Info  		C664(0.91)  LDD1701  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1300(0.82); C874(1.44); C877(1.44); C916(0.88)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C232(1.23); C235(1.23); C664(0.88); C874(0.94)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1300(0.49); C232(1.61); C235(1.61); C874(0.88)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1300(0.58); C232(1.42); C235(1.42); C874(0.80)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1300(0.53); C232(1.17); C235(1.17); C874(0.69)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1300(0.58); C232(1.61); C235(1.61); C874(0.90)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1300(0.59); C232(1.14); C235(1.14); C874(0.97)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1300(0.53); C232(1.38); C235(1.38); C874(0.82)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1300(0.54); C232(1.70); C235(1.70); C874(0.71)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1300(0.44); C232(1.74); C235(1.74); C874(0.74)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1300(0.61); C232(1.77); C235(1.77); C874(0.64)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1300(0.66); C232(1.27); C235(1.27); C874(0.70)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C232(1.31); C235(1.31); C664(0.87); C874(1.17)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1300(0.69); C232(1.61); C235(1.61); C874(0.68)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1300(0.69); C232(2.11); C235(2.11); C874(0.75)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1300(0.51); C232(2.06); C235(2.06); C874(0.79)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1300(0.92); C232(0.83); C235(0.83); C874(0.79)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1300(0.89); C232(0.87); C235(0.92); C874(0.67)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1300(0.91); C232(0.92); C235(1.01); C874(0.81)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1300(0.91); C232(0.88); C235(1.02); C874(0.99)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1300(0.97); C232(0.85); C235(1.06); C874(1.43)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1300(0.97); C232(0.98); C235(0.95); C874(0.94)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1300(1.01); C232(0.87); C235(1.00); C874(1.25)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C232(1.05); C235(1.05); C664(0.96); C874(1.52)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1300(0.91); C232(0.84); C235(0.92); C874(0.50)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1300(1.09); C232(0.88); C235(1.00); C874(0.79)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1300(1.09); C232(0.91); C235(0.91); C874(1.13)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1300(0.93); C232(0.83); C235(0.91); C874(0.59)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1300(0.87); C232(0.84); C235(0.93); C874(1.08)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1300(0.99); C232(0.90); C235(0.87); C874(0.79)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1300(0.91); C232(0.91); C235(0.89); C874(0.95)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1300(0.86); C232(0.86); C235(0.86); C874(1.18)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1300(1.38)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1300(1.16)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1300(0.98)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1300(1.04)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1300(1.30)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1300(1.49)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1300(1.20)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1300(1.25)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1300(1.40)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1300(1.51)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1300(1.66)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1300(1.28)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C232(1.40); C235(1.40); C664(0.85); C874(1.28)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1300(1.59)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1300(1.59)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1300(1.45)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C1110(1.29); C1126(1.29); C1300(1.10); C232(0.86)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C1110(0.63); C1126(0.63); C1300(0.87); C874(0.88)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C1110(0.66); C1126(0.66); C874(0.80); C877(0.80)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1110(0.71); C1126(0.71); C232(0.83); C874(0.86)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C232(0.79); C235(0.87); C874(0.90); C877(0.90)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C1110(0.74); C1126(0.74); C664(0.87); C232(0.99)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C1110(0.81); C1126(0.81); C1300(0.90); C232(0.90)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C916(0.83); C664(0.89); C874(1.18); C877(1.18)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C232(0.72); C1300(0.89); C1110(0.92); C1126(0.92)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C1110(0.83); C1126(0.83); C664(0.96); C1300(1.00)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1110(0.73); C1126(0.73); C232(0.79); C235(0.89)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C232(0.69); C874(0.87); C877(0.87); C1110(0.90)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1110(0.66); C1126(0.66); C1300(0.94); C232(0.83)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1110(0.84); C1126(0.84); C1300(0.76); C232(0.92)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1110(0.82); C1126(0.82); C1300(1.02); C232(0.89)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1110(0.98); C1126(0.98); C1300(1.01); C232(0.83)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C916(0.85); C232(0.87); C235(0.87); C874(1.34)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C916(0.96); C232(1.29); C235(1.29); C874(1.60)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C916(0.89); C232(1.16); C235(1.16); C1110(1.16)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C916(0.70); C1300(0.77); C874(1.14); C877(1.14)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C916(0.82); C874(1.10); C877(1.10); C1110(1.14)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C916(0.89); C874(0.99); C877(0.99); C232(1.37)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C1110(0.87); C1126(0.87); C916(0.87); C232(0.97)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C916(0.76); C1110(0.94); C1126(0.94); C232(0.98)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C916(0.88); C232(1.05); C235(1.05); C874(1.21)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1300(0.82); C1110(0.89); C1126(0.89); C232(1.05)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1110(0.76); C1126(0.76); C1300(0.84); C232(1.25)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1300(0.83); C1110(0.92); C1126(0.92); C874(1.28)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1110(0.73); C1126(0.73); C1300(0.89); C232(1.27)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1300(0.87); C1110(1.13); C1126(1.13); C232(1.21)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C916(0.79); C1300(1.00); C874(1.23); C877(1.23)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1110(0.77); C1126(0.77); C1300(0.87); C874(1.37)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1110(0.70); C1126(0.70); C1300(0.90); C232(1.24)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1300(0.86); C1110(0.89); C1126(0.89); C232(1.43)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1300(0.88); C1110(0.92); C1126(0.92); C232(1.21)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1300(0.75); C1110(0.92); C1126(0.92); C232(1.21)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C664(0.80); C1300(0.97); C232(1.47); C235(1.47)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C1110(0.95); C1126(0.95); C1300(0.97); C664(0.98)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C664(0.84); C1110(1.08); C1126(1.08); C1300(1.12)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C664(1.01); C1300(1.15); C232(1.25); C235(1.25)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C1110(1.00); C1126(1.00); C664(1.04); C1300(1.15)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C1300(0.81); C916(0.85); C874(1.45); C877(1.45)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C1110(0.90); C1126(0.90); C664(0.94); C1300(1.16)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C1300(0.93); C1110(1.02); C1126(1.02); C664(1.08)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C664(1.05); C1110(1.07); C1126(1.07); C232(1.09)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1110(1.01); C1126(1.01); C1300(1.04); C664(1.07)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C664(0.81); C1300(1.11); C1110(1.17); C1126(1.17)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C664(0.78); C1110(0.89); C1126(0.89); C1300(0.89)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C1110(0.59); C1126(0.59); C232(1.10); C235(1.10)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C1110(0.51); C1126(0.51); C232(0.83); C235(0.83)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C1110(0.40); C1126(0.40); C232(0.88); C235(0.88)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C1110(0.66); C1126(0.66); C1300(1.10); C232(1.11)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C916(0.68); C1300(0.87); C874(1.22); C877(1.22)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C1110(0.52); C1126(0.52); C232(1.01); C235(1.01)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C232(0.94); C235(0.94); C1110(0.97); C1126(0.97)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C1110(0.52); C1126(0.52); C232(0.88); C235(0.88)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C1110(0.65); C1126(0.65); C232(0.87); C235(0.87)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C1110(0.54); C1126(0.54); C232(0.84); C235(0.84)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C1110(0.59); C1126(0.59); C874(0.94); C877(0.94)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C1110(0.77); C1126(0.77); C232(0.86); C235(0.86)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C874(1.02); C877(1.02); C916(1.09); C1300(1.16)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C874(1.02); C877(1.02); C664(1.20); C1300(1.24)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C874(1.07); C877(1.07); C1300(1.27); C232(1.35)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C664(0.92); C916(1.20); C874(1.26); C877(1.26)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C916(1.02); C1300(1.02); C874(1.10); C877(1.10)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C916(0.67); C664(1.18); C874(1.18); C877(1.18)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C916(0.81); C1300(1.15); C874(1.21); C877(1.21)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C916(0.87); C874(1.00); C877(1.00); C1300(1.13)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C874(1.08); C877(1.08); C1300(1.13); C916(1.15)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C916(1.25); C874(1.25); C877(1.25); C664(1.38)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C874(1.08); C877(1.08); C1300(1.25); C916(1.28)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1300(1.13); C874(1.19); C877(1.19); C664(1.50)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C874(0.99); C877(0.99); C916(1.03); C1300(1.12)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C874(0.92); C877(0.92); C1300(1.06); C916(1.24)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C664(0.88); C874(1.05); C877(1.05); C232(1.37)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C874(0.84); C877(0.84); C1300(0.96); C916(1.19)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C874(0.94); C877(0.94); C1300(0.96); C916(1.03)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C874(0.95); C877(0.95); C1300(0.99); C916(1.42)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C874(1.00); C877(1.00); C1300(1.06); C916(1.17)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C874(0.95); C877(0.95); C1300(1.14); C916(1.42)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C874(0.96); C877(0.96); C1300(1.03); C916(1.17)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C874(0.92); C877(0.92); C1300(1.15); C916(1.38)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C874(0.92); C877(0.92); C1300(1.00); C916(1.05)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C1300(0.95); C874(0.98); C877(0.98); C916(1.09)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C874(0.93); C877(0.93); C1300(0.99); C916(1.36)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C664(0.95); C232(1.23); C235(1.23); C916(1.27)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C874(1.03); C877(1.03); C1300(1.10); C916(1.46)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C874(0.93); C877(0.93); C1300(1.23); C916(1.37)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C874(0.87); C877(0.87); C1300(1.18); C916(1.39)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C1300(1.00); C232(1.03); C235(1.03); C874(1.27)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C1300(0.96); C232(1.00); C235(1.00); C874(1.38)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C1300(0.98); C232(1.08); C235(1.08); C664(1.24)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C1300(1.09); C874(1.15); C877(1.15); C232(1.22)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C874(0.89); C877(0.89); C664(0.98); C1300(0.98)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C1300(0.93); C664(1.03); C874(1.13); C877(1.13)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1300(1.07); C232(1.23); C235(1.23); C874(1.24)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C664(1.01); C874(1.07); C877(1.07); C1300(1.14)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C1300(0.98); C232(1.09); C235(1.09); C664(1.41)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C1300(1.01); C232(1.17); C235(1.17); C874(1.38)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1300(1.03); C664(1.09); C232(1.14); C235(1.14)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C232(1.01); C235(1.01); C1300(1.05); C664(1.13)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C1300(0.96); C874(1.08); C877(1.08); C664(1.11)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C1300(0.99); C232(1.06); C235(1.06); C664(1.30)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C1300(1.07); C664(1.25); C232(1.31); C235(1.31)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C1300(0.47); C874(0.78); C877(0.78); C232(1.60)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1300(0.58); C874(0.63); C877(0.63); C232(1.41)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C232(1.05); C235(1.05); C664(0.90); C874(1.27)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C664(0.85); C874(1.22); C877(1.22); C232(1.24)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C664(1.03); C874(1.21); C877(1.21); C916(1.58)  LDD0592  [6]
 LDCM0367  CL1 HCT 116 C1300(1.02); C874(1.18); C877(1.18); C1110(1.27)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C1110(0.84); C1126(0.84); C1300(1.06); C874(1.13)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C916(0.71); C1300(0.84); C874(1.44); C877(1.44)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C664(0.90); C916(1.01); C874(1.09); C877(1.09)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C232(1.03); C235(1.03); C664(1.27); C916(1.31)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C916(0.75); C664(0.94); C232(1.18); C235(1.18)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C664(0.88); C232(1.13); C235(1.13); C916(1.17)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C916(1.02); C874(1.04); C877(1.04); C232(1.26)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1110(0.90); C1126(0.90); C916(1.14); C874(1.26)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C916(1.11); C1110(1.13); C1126(1.13); C232(1.41)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1110(1.02); C1126(1.02); C916(1.02); C874(1.06)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C916(0.84); C1110(0.88); C1126(0.88); C874(1.12)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1110(1.07); C1126(1.07); C1300(1.12); C874(1.54)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1110(1.04); C1126(1.04); C916(1.22); C874(1.41)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1110(0.69); C1126(0.69); C916(0.94); C232(1.08)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1300(0.88); C232(1.11); C235(1.11); C1110(1.26)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1300(0.86); C1110(0.91); C1126(0.91); C232(1.31)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1300(0.78); C1110(0.78); C1126(0.78); C232(1.19)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1300(0.78); C1110(0.90); C1126(0.90); C232(1.08)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1110(0.75); C1126(0.75); C1300(0.77); C874(1.18)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C1110(0.90); C1126(0.90); C232(0.96); C235(0.96)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C664(0.98); C1300(1.01); C232(1.45); C235(1.45)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C1110(0.91); C1126(0.91); C664(1.05); C1300(1.20)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C1110(0.78); C1126(0.78); C1300(0.98); C874(1.26)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C1110(0.92); C1126(0.92); C1300(1.04); C664(1.05)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C1110(0.64); C1126(0.64); C232(0.97); C235(0.97)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C1110(0.59); C1126(0.59); C232(0.80); C235(0.80)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C232(0.67); C235(0.67); C874(0.97); C877(0.97)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C1110(0.59); C1126(0.59); C232(0.82); C235(0.82)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C916(0.85); C232(0.96); C235(0.96); C1300(1.13)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C916(1.04); C664(1.04); C232(1.05); C235(1.05)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C232(0.92); C235(0.92); C916(1.06); C664(1.13)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C916(0.97); C1300(1.10); C874(1.13); C877(1.13)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C1110(0.85); C1126(0.85); C1300(1.10); C874(1.34)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C1110(0.99); C1126(0.99); C1300(1.05); C874(1.20)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C1110(1.01); C1126(1.01); C1300(1.02); C874(1.89)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C1300(0.93); C232(1.02); C235(1.02); C916(1.13)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C1300(0.92); C916(1.04); C232(1.19); C235(1.19)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C916(0.71); C1300(0.81); C664(1.10); C232(1.16)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C1300(0.90); C664(1.10); C232(1.10); C235(1.10)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C874(0.77); C877(0.77); C1300(1.00); C1110(1.06)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C1300(0.95); C916(0.95); C664(1.25); C232(1.37)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C1300(0.99); C664(1.09); C916(1.12); C232(1.35)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C664(0.94); C1300(1.38); C232(1.67); C235(1.67)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1300(0.90); C916(1.03); C232(1.10); C235(1.10)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1300(1.04); C664(1.10); C916(1.31); C232(1.34)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1300(1.04); C232(1.27); C235(1.27); C664(1.09)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1300(0.93); C232(1.18); C235(1.18); C664(1.15)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1300(1.05); C232(1.14); C235(1.14); C664(1.03)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1300(1.03); C232(1.36); C235(1.36); C664(1.10)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1300(1.09); C232(1.23); C235(1.23); C664(1.13)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1110(0.75); C1126(0.75); C1300(0.98); C874(1.07)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1300(0.93); C232(1.04); C235(1.04); C664(1.19)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1300(0.81); C232(0.86); C235(0.86); C664(1.05)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1300(0.54); C664(1.02); C874(1.08); C877(1.08)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1300(0.58); C664(1.10); C874(1.06); C877(1.06)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1300(0.71); C664(1.12); C874(1.41); C877(1.41)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1300(0.76); C664(1.01); C874(2.08); C877(2.08)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1300(0.75); C664(1.04); C874(1.32); C877(1.32)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1300(0.56); C664(1.01); C874(1.50); C877(1.50)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1300(0.72); C664(1.00); C874(1.60); C877(1.60)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1110(0.79); C1126(0.79); C1300(0.98); C874(1.06)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1300(0.75); C664(1.03); C874(1.51); C877(1.51)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1300(0.59); C664(0.98); C874(1.30); C877(1.30)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1300(0.77); C664(1.15); C874(1.63); C877(1.63)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1300(0.81); C664(1.13); C874(1.51); C877(1.51)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1300(0.70); C664(1.09); C874(1.46); C877(1.46)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1300(0.77); C664(1.19); C874(1.86); C877(1.86)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1300(1.10); C232(1.16); C235(1.16); C874(0.97)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1300(0.92); C232(1.06); C235(1.06); C874(1.05)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1300(1.00); C232(1.21); C235(1.21); C874(0.91)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1300(0.89); C232(1.13); C235(1.13); C874(0.80)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1110(1.24); C1126(1.24); C1300(0.95); C874(1.18)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1300(0.95); C232(1.45); C235(1.45); C874(0.82)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1300(1.13); C232(1.40); C235(1.40); C874(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1300(0.94); C232(1.10); C235(1.10); C874(0.90)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1300(1.00); C232(1.09); C235(1.09); C874(0.86)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1300(0.93); C232(0.91); C235(0.91); C874(0.96)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1300(1.06); C232(1.15); C235(1.15); C874(0.85)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1300(1.13); C232(1.15); C235(1.15); C874(1.06)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1300(0.84); C232(1.47); C235(1.47); C874(0.81)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1300(1.15); C232(1.19); C235(1.19); C874(0.88)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1300(0.96); C232(0.93); C235(0.93); C874(0.78)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1110(0.76); C1126(0.76); C1300(0.96); C874(1.01)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1300(0.93); C232(1.02); C235(1.02); C874(0.96)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1110(0.27); C1126(0.27); C1300(1.15); C874(1.16)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1110(0.31); C1126(0.31); C1300(1.07); C874(1.17)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1110(0.36); C1126(0.36); C1300(0.97); C874(1.57)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1110(0.23); C1126(0.23); C1300(0.76); C874(1.37)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1110(0.31); C1126(0.31); C1300(1.01); C874(0.99)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1110(0.27); C1126(0.27); C1300(1.13); C874(1.20)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1110(0.28); C1126(0.28); C1300(0.87); C874(1.40)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1110(0.29); C1126(0.29); C1300(0.94); C874(1.58)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1110(0.31); C1126(0.31); C1300(0.82); C874(1.30)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1110(0.92); C1126(0.92); C1300(0.92); C874(1.16)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1110(0.27); C1126(0.27); C1300(0.81); C874(1.39)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1110(0.32); C1126(0.32); C1300(1.03); C874(1.30)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1110(0.30); C1126(0.30); C1300(1.12); C874(1.25)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1110(0.29); C1126(0.29); C1300(0.86); C874(1.84)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1110(0.42); C1126(0.42); C1300(0.89); C874(1.11)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1300(0.88); C232(1.10); C235(1.10); C664(0.98)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1300(0.96); C232(0.92); C235(0.92); C664(1.13)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1300(1.06); C232(1.06); C235(1.06); C664(1.04)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1300(1.11); C232(1.15); C235(1.15); C664(0.98)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1110(1.39); C1126(1.39); C1300(0.95); C874(1.66)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1300(0.90); C232(1.05); C235(1.05); C664(0.95)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1300(1.07); C232(1.01); C235(1.01); C664(0.95)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1300(1.23); C232(1.51); C235(1.51); C664(0.95)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1300(1.05); C232(1.30); C235(1.30); C664(1.11)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1300(1.36); C232(1.55); C235(1.55); C664(1.07)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1300(1.07); C232(1.04); C235(1.04); C664(1.01)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1300(1.08); C232(0.95); C235(0.95); C664(0.91)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1300(1.18); C232(1.14); C235(1.14); C664(0.94)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1300(1.14); C232(1.33); C235(1.33); C664(0.88)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1300(1.53); C232(1.81); C235(1.81); C664(1.08)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1110(1.14); C1126(1.14); C1300(0.96); C874(1.05)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1300(1.05); C232(0.88); C235(0.88); C664(1.18)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1300(0.73); C874(1.22); C877(1.22); C916(0.99)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1300(0.86); C874(1.25); C877(1.25); C916(0.68)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1300(0.81); C874(0.93); C877(0.93); C916(0.67)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1300(0.70); C874(1.29); C877(1.29); C916(0.66)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1300(0.82); C874(1.44); C877(1.44); C916(0.74)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1300(0.83); C874(1.17); C877(1.17); C916(0.82)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1300(0.77); C874(1.26); C877(1.26); C916(0.79)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1300(0.90); C874(1.40); C877(1.40); C916(0.83)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1300(0.91); C874(1.30); C877(1.30); C916(0.82)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C916(1.12); C664(1.05); C178(1.06)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C664(1.43)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C1110(0.23); C1126(0.23); C1300(0.88); C874(1.25)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C1300(0.83); C664(1.28); C874(1.77); C877(1.77)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C916(0.91); C664(0.93); C430(1.03); C552(0.97)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C1454(226.94); C916(15.68)  LDD0209  [2]
 LDCM0024  KB05 MEL167 C664(1.45)  LDD3316  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-5A (RAB5A) Rab family P20339

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840