Details of the Target

General Information of Target

Target ID LDTP10493
Target Name Abscission/NoCut checkpoint regulator (ZFYVE19)
Gene Name ZFYVE19
Gene ID 84936
Synonyms
ANCHR; MPFYVE; Abscission/NoCut checkpoint regulator; ANCHR; MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKYQGEVQSLKLDDDSVIEGVSDQVLVAVVVSFALIATLVYALFRNVHQNIHPENQELV
RVLREQLQTEQDAPAATRQQFYTDMYCPICLHQASFPVETNCGHLFCGACIIAYWRYGSW
LGAISCPICRQTVTLLLTVFGEDDQSQDVLRLHQDINDYNRRFSGQPRSIMERIMDLPTL
LRHAFREMFSVGGLFWMFRIRIILCLMGAFFYLISPLDFVPEALFGILGFLDDFFVIFLL
LIYISIMYREVITQRLTR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Uniprot ID
Q96K21
Ensemble ID
ENST00000299173.14
HGNC ID
HGNC:20758

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K331(10.00); K91(10.00)  LDD0277  [1]
IPM
 Probe Info  		C128(0.00); C80(0.00); C83(0.00)  LDD0241  [2]
BTD
 Probe Info  		C128(0.98)  LDD2152  [3]
Acrolein
 Probe Info  		N.A.  LDD0232  [4]
DBIA
 Probe Info  		C435(1.14); C441(1.14); C83(0.98); C104(0.89)  LDD0078  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C128(0.98)  LDD2152  [3]
 LDCM0214  AC1 HEK-293T C80(0.91); C83(0.91)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C104(1.15); C107(1.15); C80(0.86); C83(0.86)  LDD0813  [5]
 LDCM0216  AC100 HCT 116 C104(0.73); C107(0.73)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C104(0.84); C107(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C104(0.92); C107(0.92)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C104(1.08); C107(1.08)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C104(1.06); C107(1.06)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C104(0.77); C107(0.77)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C104(0.74); C107(0.74)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C104(0.94); C107(0.91)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C104(0.66); C107(0.71)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C104(0.71); C107(0.64)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C104(0.99); C107(0.99); C80(0.77); C83(0.77)  LDD0824  [5]
 LDCM0227  AC110 HCT 116 C104(0.73); C107(0.71)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C104(0.82); C107(0.87)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C104(0.94); C107(1.06)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C80(1.01); C83(1.01)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C80(1.61); C83(1.61)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C80(1.07); C83(1.08)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C80(1.35); C83(1.42)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C80(1.01); C83(0.92)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C80(0.90); C83(0.93)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C80(1.05); C83(0.98)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C104(1.20); C107(1.20); C80(0.85); C83(0.85)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C80(1.09); C83(1.09)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C80(1.16); C83(0.93)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C80(1.00); C83(0.90)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C80(1.01); C83(0.98)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C80(1.06); C83(1.00)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C80(1.24); C83(1.20)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C80(1.35); C83(1.30)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C80(1.22); C83(1.22)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C104(1.08); C107(1.08); C80(0.75); C83(0.75)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C104(1.30); C107(1.30); C80(0.52); C83(0.52)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C104(1.17); C107(1.17); C80(0.57); C83(0.57)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C104(1.54); C107(1.54); C80(0.66); C83(0.66)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C104(0.65); C107(0.65); C80(0.75); C83(0.75)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C104(0.96); C107(0.96); C80(0.65); C83(0.65)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C104(1.41); C107(1.41); C80(0.75); C83(0.75)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C104(1.08); C107(1.08); C80(0.68); C83(0.68)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C104(0.89); C107(0.89); C80(0.73); C83(0.73)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C104(0.76); C107(0.76); C80(0.71); C83(0.71)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C104(0.90); C107(0.90); C80(0.72); C83(0.72)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C104(0.88); C107(0.88); C80(0.73); C83(0.73)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C104(1.52); C107(1.52); C80(1.04); C83(1.04)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C104(0.77); C107(0.77); C80(0.76); C83(0.76)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C104(0.89); C107(0.89); C80(0.86); C83(0.86)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C104(0.79); C107(0.79); C80(0.59); C83(0.59)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C80(0.91); C83(0.91); C104(1.29); C107(1.29)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C80(0.81); C83(0.81); C104(0.82); C107(0.96)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C104(0.62); C80(0.75); C83(0.75); C107(0.88)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C80(0.82); C83(0.82); C107(0.98); C104(1.12)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C104(0.75); C80(0.77); C83(0.77); C107(0.95)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C104(0.89); C107(0.91); C80(0.92); C83(0.92)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C80(0.94); C83(0.94); C107(0.99); C104(1.01)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C104(0.97); C107(0.97); C80(0.90); C83(0.90)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C80(0.56); C83(0.56); C107(0.71); C104(0.79)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C80(0.56); C83(0.56); C104(0.81); C107(0.81)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C80(0.59); C83(0.59); C104(0.79); C107(0.89)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C80(0.63); C83(0.63); C104(0.88); C107(0.92)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C104(0.79); C107(0.81); C80(0.58); C83(0.58)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C104(1.03); C107(0.77); C80(0.55); C83(0.55)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C104(1.02); C107(0.96); C80(0.66); C83(0.66)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C104(0.72); C107(0.86); C80(0.61); C83(0.61)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C80(0.59); C83(0.59); C104(1.05); C107(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C80(0.55); C83(0.55); C104(0.79); C107(0.79)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C80(0.56); C83(0.56); C104(1.02); C107(1.02)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C80(1.14); C83(1.14)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C80(0.48); C83(0.48); C104(0.95); C107(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C80(0.53); C83(0.53); C104(0.95); C107(0.95)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C80(0.48); C83(0.48); C104(0.93); C107(0.93)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C80(0.36); C83(0.36); C104(0.82); C107(0.82)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C80(0.41); C83(0.41); C104(1.05); C107(1.05)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C80(0.72); C83(0.72)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C80(0.71); C83(0.71)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C80(0.64); C83(0.64)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C80(0.72); C83(0.72)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C80(0.64); C83(0.64)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C80(0.80); C83(0.80)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C80(0.90); C83(0.90)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C80(0.83); C83(0.83)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C80(0.93); C83(0.93)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C80(0.75); C83(0.75)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C80(0.96); C83(0.96)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C80(1.09); C83(1.09)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C80(1.00); C83(1.00)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C80(1.02); C83(1.02)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C80(1.20); C83(1.20)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C80(1.29); C83(1.29)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C80(0.98); C83(0.98)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C80(0.92); C83(0.92)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C80(1.28); C83(1.28)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C80(1.18); C83(1.18)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C80(1.58); C83(1.58)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C80(1.22); C83(1.22)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C80(1.16); C83(1.16)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C104(2.16); C107(2.16); C80(1.11); C83(1.11)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C104(1.58); C107(1.58); C80(1.12); C83(1.12)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C104(1.35); C107(1.35); C80(1.10); C83(1.10)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C104(1.75); C107(1.75); C80(0.95); C83(0.95)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C80(0.87); C83(0.87)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C104(1.17); C107(1.17); C80(1.04); C83(1.04)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C104(1.36); C107(1.36); C80(0.86); C83(0.86)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C104(1.48); C107(1.48); C80(0.80); C83(0.80)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C104(1.13); C107(1.13); C80(0.90); C83(0.90)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C104(2.19); C107(2.19); C80(1.09); C83(1.09)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C104(2.70); C107(2.70); C80(1.04); C83(1.04)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C104(1.42); C107(1.42); C80(1.24); C83(1.24)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C104(1.27); C107(1.27)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C104(1.17); C107(1.17)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C104(1.12); C107(1.12)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C104(1.23); C107(1.23); C80(1.00); C83(1.00)  LDD0921  [5]
 LDCM0324  AC60 HCT 116 C104(1.03); C107(1.03)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C104(0.96); C107(0.96)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C104(1.14); C107(1.14)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C104(1.09); C107(1.09)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C104(0.93); C107(0.93)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C104(0.37); C107(0.37)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C104(0.42); C107(0.42)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C104(0.52); C107(0.52)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C104(0.87); C107(0.87)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C104(1.27); C107(1.27)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C104(0.90); C107(0.90); C80(0.83); C83(0.83)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C104(1.03); C107(1.03)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C104(0.87); C107(0.87)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C104(1.37); C107(1.37)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C104(1.46); C107(1.46)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C104(1.29); C107(1.29)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C104(1.67); C107(1.67)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C104(1.13); C107(1.13)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C104(1.12); C107(1.12)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C104(1.09); C107(1.09)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C104(1.04); C107(1.04)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C104(0.93); C107(0.93); C80(0.96); C83(0.96)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C104(1.36); C107(1.36)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C104(0.93); C107(0.93)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C104(1.53); C107(1.53)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C104(1.71); C107(1.71)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C104(1.31); C107(1.31)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C104(1.23); C107(1.23)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C104(1.20); C107(1.20)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C104(1.47); C107(1.47)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C104(2.04); C107(2.04)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C104(2.20); C107(2.20)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C104(0.55); C107(0.55)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C104(1.74); C107(1.74)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C104(1.53); C107(1.53)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C104(1.28); C107(1.28)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C104(1.54); C107(1.54)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C104(1.30); C107(1.30)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C104(1.43); C107(1.43)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C104(1.62); C107(1.62)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C104(1.89); C107(1.89)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C104(0.64); C107(0.64)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C104(1.05); C107(1.05); C80(1.07); C83(1.07)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C104(1.11); C107(1.11); C80(0.87); C83(0.87)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C104(1.75); C107(1.75); C80(1.04); C83(1.04)  LDD0873  [5]
 LDCM0020  ARS-1620 HCC44 C435(1.14); C441(1.14); C83(0.98); C104(0.89)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C104(1.05); C107(1.05); C80(1.09); C83(1.09)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C104(0.55); C107(0.55); C80(0.75); C83(0.75)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C80(0.80); C83(0.80)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C104(0.93); C107(0.93); C80(0.89); C83(0.89)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C104(1.31); C107(1.31); C80(0.99); C83(0.99)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C104(1.23); C107(1.23); C80(0.82); C83(0.82)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C104(0.87); C107(0.87); C80(0.79); C83(0.79)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C80(0.38); C83(0.38); C104(0.84); C107(0.84)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C80(0.35); C83(0.35); C104(1.15); C107(1.15)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C80(0.46); C83(0.46); C104(0.90); C107(0.90)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C80(0.39); C83(0.39); C104(0.92); C107(0.92)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C80(0.57); C83(0.57); C104(1.01); C107(1.01)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C104(0.46); C107(0.46); C80(0.56); C83(0.56)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C80(0.27); C83(0.27); C104(0.88); C107(0.88)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C80(0.37); C83(0.37); C104(0.97); C107(0.97)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C80(0.79); C83(0.79)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C80(0.94); C83(0.94)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C80(0.94); C83(0.94)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C80(0.86); C83(0.86)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C80(0.79); C83(0.79)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C80(1.10); C83(1.10)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C80(1.10); C83(1.10)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C80(1.18); C83(1.18)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C104(0.48); C107(0.48); C80(0.68); C83(0.68)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C80(1.34); C83(1.34)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C104(1.66); C107(1.66); C80(1.04); C83(1.04)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C104(1.57); C107(1.57); C80(0.91); C83(0.91)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C104(2.10); C107(2.10); C80(0.95); C83(0.95)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C104(1.76); C107(1.76); C80(1.12); C83(1.12)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C104(0.71); C107(0.71)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C104(1.32); C107(1.32)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C104(0.90); C107(0.90)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C104(1.38); C107(1.38)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C80(0.56); C83(0.56); C104(0.81); C107(0.81)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C80(0.75); C83(0.75); C104(0.82); C107(0.82)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C80(0.71); C83(0.71); C104(1.08); C107(1.08)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C104(0.81); C107(0.81); C80(0.92); C83(0.92)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C80(0.82); C83(0.82); C104(0.95); C107(0.95)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C104(0.76); C107(0.76); C80(0.97); C83(0.97)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C104(0.79); C107(0.79); C80(0.84); C83(0.84)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C80(0.97); C83(0.97); C104(1.32); C107(1.32)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C80(0.94); C83(0.94); C104(0.96); C107(0.96)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C80(0.74); C83(0.74); C104(0.79); C107(0.79)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C80(1.00); C83(1.00); C104(1.02); C107(1.02)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C80(0.81); C83(0.81); C104(0.99); C107(0.99)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C104(0.54); C107(0.54); C80(0.80); C83(0.80)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C104(0.65); C107(0.65); C80(0.88); C83(0.88)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C104(1.03); C107(1.03); C80(0.98); C83(0.98)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C104(0.59); C107(0.59); C80(0.77); C83(0.77)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C104(0.77); C107(0.77); C80(1.10); C83(1.10)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C104(0.64); C107(0.64); C80(1.09); C83(1.09)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C104(1.12); C107(1.12); C80(1.10); C83(1.10)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C104(0.62); C107(0.62); C80(0.87); C83(0.87)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C104(0.94); C107(0.94)  LDD1018  [5]
 LDCM0421  CL32 HCT 116 C80(0.90); C83(0.90)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C80(0.76); C83(0.76)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C80(0.70); C83(0.70)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C80(0.84); C83(0.84)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C80(0.76); C83(0.76)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C80(0.65); C83(0.65)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C80(0.85); C83(0.85)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C104(1.33); C107(1.33); C80(1.09); C83(1.09)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C80(0.94); C83(0.94)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C80(0.77); C83(0.77)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C80(0.59); C83(0.59)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C80(0.84); C83(0.84)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C80(0.88); C83(0.88)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C80(0.81); C83(0.81)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C104(0.83); C107(0.83)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C104(0.76); C107(0.76)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C104(1.05); C107(1.05)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C104(0.79); C107(0.79)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C104(0.98); C107(0.98); C80(0.96); C83(0.96)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C104(0.97); C107(0.97)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C104(0.65); C107(0.65)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C104(1.16); C107(1.16)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C104(1.38); C107(1.38)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C104(1.09); C107(1.09)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C104(0.96); C107(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C104(1.00); C107(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C104(0.82); C107(0.82)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C104(0.78); C107(0.78)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C104(0.89); C107(0.89)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C104(1.03); C107(1.03); C80(1.11); C83(1.11)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C104(0.95); C107(0.95)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C80(1.03); C83(1.03)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C80(1.18); C83(1.18)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C80(0.94); C83(0.94)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C80(1.21); C83(1.21)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C80(0.92); C83(0.92)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C80(1.08); C83(1.08)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C80(0.75); C83(0.75)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C80(0.59); C83(0.59)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C80(0.62); C83(0.62)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C104(0.55); C107(0.55); C80(0.59); C83(0.59)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C80(0.77); C83(0.77)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C80(0.81); C83(0.81)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C80(0.68); C83(0.68)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C80(0.69); C83(0.69)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C80(0.70); C83(0.70)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C104(1.17); C107(1.17); C80(0.87); C83(0.87)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C104(0.97); C107(0.97); C80(0.60); C83(0.60)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C104(0.96); C107(0.96); C80(0.67); C83(0.67)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C104(0.87); C107(0.87); C80(0.68); C83(0.68)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C104(1.16); C107(1.16); C80(0.78); C83(0.78)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C104(0.88); C107(0.88); C80(0.77); C83(0.77)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C104(0.88); C107(0.88); C80(0.82); C83(0.82)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C104(0.80); C107(0.80); C80(0.61); C83(0.61)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C104(0.98); C107(0.98); C80(0.65); C83(0.65)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C104(0.99); C107(0.99); C80(0.76); C83(0.76)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C104(1.07); C107(1.07); C80(0.85); C83(0.85)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C104(0.91); C107(0.91); C80(0.79); C83(0.79)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C104(0.89); C107(0.89); C80(0.79); C83(0.79)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C104(0.97); C107(0.97); C80(0.80); C83(0.80)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C104(0.96); C107(0.96); C80(0.74); C83(0.74)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C104(0.84); C107(0.84); C80(0.75); C83(0.75)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C104(0.95); C107(0.95); C80(0.56); C83(0.56)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C80(0.92); C83(0.92)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C80(0.75); C83(0.75)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C80(0.81); C83(0.81)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C80(0.90); C83(0.90)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C80(0.90); C83(0.90)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C80(0.67); C83(0.67)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C80(0.78); C83(0.78)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C80(0.82); C83(0.82)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C80(1.03); C83(1.03)  LDD1092  [5]
 LDCM0576  Fragment14 Ramos 1.12  LDD2193  [8]
 LDCM0588  Fragment30 Ramos 0.88  LDD2199  [8]
 LDCM0590  Fragment32 Ramos 1.42  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C80(0.91); C83(0.91)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos 0.84  LDD2203  [8]
 LDCM0427  Fragment51 HCT 116 C80(0.81); C83(0.81)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C435(1.29); C432(2.05); C441(1.37); C80(1.63)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C435(1.40); C432(1.85); C441(1.58); C80(1.39)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C435(1.54); C432(1.50); C441(1.38); C80(1.26)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0232  [4]
 LDCM0021  THZ1 HCT 116 C432(1.21); C435(1.21); C441(1.21)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 4A (VPS4A) AAA ATPase family Q9UN37
Vacuolar protein sorting-associated protein 4B (VPS4B) AAA ATPase family O75351
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein dpy-30 homolog (DPY30) Dpy-30 family Q9C005
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Axin-1 (AXIN1) . O15169
MIT domain-containing protein 1 (MITD1) . Q8WV92

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578