Details of the Target

General Information of Target

Target ID LDTP10336
Target Name OTU domain-containing protein 5 (OTUD5)
Gene Name OTUD5
Gene ID 55593
Synonyms
OTU domain-containing protein 5; EC 3.4.19.12; Deubiquitinating enzyme A; DUBA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGG
AAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVYVLTVTELLEDWEDSVSIGRKREWF
KVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP
Target Bioclass
Enzyme
Family
Peptidase C85 family
Subcellular location
Nucleus
Function
Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability.
Uniprot ID
Q96G74
Ensemble ID
ENST00000156084.8
HGNC ID
HGNC:25402

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.90  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C519(2.19)  LDD0169  [2]
DBIA
 Probe Info  		C519(1.06)  LDD0078  [3]
IA-alkyne
 Probe Info  		C224(0.00); C434(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C224(0.00); C434(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		N.A.  LDD0147  [6]
AOyne
 Probe Info  		14.80  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C519(2.19)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C224(1.38)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C224(1.37)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C224(0.95)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C224(1.02)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C224(1.03)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C224(1.06)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C224(0.86)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C224(0.97)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C224(1.02)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C224(1.13)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C224(1.21)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C224(1.05)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C224(1.11)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C224(1.23)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C224(1.07)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C224(0.98)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C224(1.40)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C224(0.96)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C224(1.06)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C224(1.07)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C224(0.93)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C224(0.86)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C224(1.05)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C224(1.07)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C224(1.36)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C224(0.95)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C224(0.93)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C224(0.74)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C224(0.92)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C224(1.19)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C224(1.10)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C224(0.91)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C224(0.97); C519(1.14)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C224(1.09); C519(1.02)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C224(0.86); C519(1.06)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C224(1.06); C519(1.40)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C224(1.14); C519(1.36)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C224(0.87); C519(0.95)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C224(0.81); C519(0.94)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C224(0.94); C519(1.13)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C224(1.15); C519(1.00)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C224(0.96); C519(0.99)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C224(0.90); C519(1.13)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C224(1.06); C519(1.25)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C224(1.19)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C224(0.83); C519(0.87)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C224(1.03); C519(1.13)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C224(1.12); C519(1.31)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C224(0.88)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C224(1.00)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C224(0.96)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C224(0.88)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C224(1.01)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C224(0.88)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C224(0.89)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C224(1.32)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C224(0.94)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C224(1.07)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C224(0.91)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C224(0.99)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C224(0.95)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C224(1.13)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C224(1.11)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C224(0.89)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C224(1.20)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C224(1.19)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C224(1.14)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C224(0.93)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C224(1.01)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C224(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C224(1.08)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C224(1.07)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C224(0.98)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C224(0.81)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C224(0.89)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C224(0.88)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C224(1.04)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C224(0.98)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C224(1.08)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C224(0.88)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C224(0.93)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C224(1.08)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C224(0.87)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C224(0.89)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C224(1.35)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C224(0.95)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C224(1.02)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C224(1.34)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C224(1.15)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C224(1.07)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C224(0.97)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C224(0.94)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C224(1.20)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C224(1.56)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C224(1.12)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C224(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C224(0.96)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C224(1.03)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C224(1.08)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C224(1.40)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C224(0.97)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C224(1.13)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C224(0.89)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C224(1.10)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C224(1.11)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C224(1.41)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C224(1.20)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C224(1.67)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C224(1.05); C519(0.97)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C224(0.87); C519(0.85)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C224(0.98); C519(1.07)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C224(1.20)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C224(0.99); C519(0.73)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C224(0.99); C519(0.84)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C224(0.92); C519(0.78)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C224(0.86); C519(0.79)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C224(0.98); C519(0.73)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C224(0.98); C519(0.75)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C224(0.85); C519(0.79)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C224(0.82); C519(0.78)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C224(0.70)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C224(0.91)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C224(1.24)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C224(0.82)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C224(0.78)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C224(0.78)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C224(0.97)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C224(0.78)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C224(0.70)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C224(0.72)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C224(0.74)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C224(0.94)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C224(0.81)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C224(1.12)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C224(0.77)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C224(0.75)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C224(0.78)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C224(1.02)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C224(1.04)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C224(1.06)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C224(1.12)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C224(1.35)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C224(1.26)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C224(1.15)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C224(0.92)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C224(1.24)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C224(0.99)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C224(1.13)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C224(1.29)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C224(1.20)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C224(1.19)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C224(1.12)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C224(1.14)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C224(1.15)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C224(1.12)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C224(1.18)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C224(1.49)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 13.17  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C519(1.06)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C224(0.63)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C224(0.90)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C224(0.93)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C224(1.23)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C224(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C224(1.00)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C224(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C224(0.98)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C224(1.03)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C224(0.87)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C224(0.99)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C224(1.04)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C224(1.12)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C224(0.81)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C224(1.01)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C224(0.82)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C224(0.97)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C224(0.76)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C224(0.98)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C224(1.17)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C224(1.08)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C224(1.32)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C224(1.61)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C224(1.26)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C224(1.10)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C224(0.92)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C224(1.11)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C224(1.31)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C224(1.15)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C224(0.95); C519(0.91)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C224(0.92); C519(0.78)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C224(1.01); C519(0.91)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C224(0.88); C519(0.85)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C224(0.86)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C224(0.82)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C224(0.97)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C224(0.92)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C224(0.54)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C224(0.69)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C224(0.77)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C224(0.66)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C224(0.82)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C224(0.68)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C224(1.00)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C224(0.87)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C224(0.67)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C224(0.83)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C224(0.91)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C224(0.73)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C224(0.80)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C224(0.75)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C224(0.78)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C224(1.48)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C224(0.90)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C224(0.88)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C224(1.06)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C224(1.24)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C224(1.08)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C224(0.89)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C224(1.02)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C224(1.06)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C224(0.67)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C224(1.12)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C224(0.97)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C224(1.44)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C224(1.10)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C224(1.05)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C224(1.28)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C224(0.98)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C224(1.35)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C224(1.31)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C224(1.17)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C224(0.79)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C224(1.04)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C224(1.18)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C224(1.04)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C224(0.84)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C224(1.03)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C224(0.96)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C224(0.95)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C224(0.98)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C224(1.17)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C224(0.97)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C224(0.77)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C224(1.16)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C224(1.30); C519(1.24)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C224(1.32); C519(1.27)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C224(1.52); C519(1.53)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C224(1.47); C519(1.55)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C224(1.29); C519(1.19)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C224(1.30); C519(1.23)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C224(1.10); C519(1.07)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C224(1.62); C519(1.44)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C224(1.29); C519(1.29)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C224(0.99)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C224(1.36); C519(1.06)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C224(1.17); C519(1.06)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C224(1.25); C519(1.13)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C224(1.29); C519(1.25)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C224(1.17); C519(1.14)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C224(0.97)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C224(1.15)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C224(0.95)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C224(0.91)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C224(1.65)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C224(1.07)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C224(0.93)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C224(0.73)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C224(1.22)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C224(0.93)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C224(0.75)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C224(0.91)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C224(0.98)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C224(0.92)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C224(0.94)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C224(0.76)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C224(1.03)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C224(1.02)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C224(1.38)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C224(1.03)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C224(1.67)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C224(1.18)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C224(0.74)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C224(0.76)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C224(1.28)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C224(1.34)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C224(1.03); C519(0.70); C434(1.14)  LDD1698  [9]
 LDCM0575  Fragment13 Ramos C434(1.36)  LDD2192  [10]
 LDCM0580  Fragment21 Ramos C434(0.71)  LDD2195  [10]
 LDCM0586  Fragment28 Ramos C434(3.18)  LDD2198  [10]
 LDCM0589  Fragment31 Ramos C434(0.80)  LDD2200  [10]
 LDCM0468  Fragment33 HEK-293T C224(1.21); C519(1.19)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C224(1.30)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C519(1.76); C224(1.26)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C519(1.34); C224(1.23)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C519(2.98); C224(1.09)  LDD0082  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578