Details of the Target

General Information of Target

Target ID LDTP10183
Target Name Solute carrier family 25 member 36 (SLC25A36)
Gene Name SLC25A36
Gene ID 55186
Synonyms
Solute carrier family 25 member 36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRLLHPALPLLLGATLTFRALRRALCRLPLPVHVRADPLRTWRWHNLLVSFAHSIVSGI
WALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVM
AMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMKISNAQDHLLYRVNKYVNLVMYF
LFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLMLDVMIIIYFSRLLRSDFCPEHVPKKQH
KDKFLTE
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.
Uniprot ID
Q96CQ1
Ensemble ID
ENST00000324194.12
HGNC ID
HGNC:25554

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE296 SNV: p.A234T DBIA    Probe Info 
RD SNV: p.V89G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C67(2.38)  LDD1700  [1]
DBIA
 Probe Info  		C15(0.60); C25(0.60)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
TFBX
 Probe Info  		C67(0.00); C105(0.00); C239(0.00)  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
NAIA_5
 Probe Info  		C163(0.00); C239(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C67(0.97)  LDD2152  [1]
 LDCM0214  AC1 HCT 116 C15(0.60); C25(0.60)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C15(0.75); C163(1.12); C25(0.75)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C25(1.15)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C25(1.03)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C25(1.09)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C25(1.07)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C25(0.96)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C25(1.11)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C25(0.89)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C25(1.06)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C25(1.18)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C25(1.15)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C15(0.75); C163(0.88); C25(0.75)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C25(0.89)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C25(0.56)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C25(0.83)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C15(0.98); C25(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C15(0.87); C25(0.87)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C15(0.76); C25(0.76)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C15(0.77); C25(0.77)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C15(0.98); C25(0.98)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C15(0.93); C25(0.93)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C15(0.89); C25(0.89)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C15(0.90); C163(1.12); C25(0.90)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C15(0.94); C25(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C15(1.00); C25(1.00)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C15(0.81); C25(0.81)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C15(0.97); C25(0.97)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C15(1.14); C25(1.14)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C15(1.02); C25(1.02)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C15(0.71); C25(0.71)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C15(0.79); C25(0.79)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C15(0.81); C25(0.81)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C15(0.90); C25(0.90)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C15(0.69); C25(0.69)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C15(0.90); C25(0.90)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C15(0.91); C25(0.91)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C15(0.90); C25(0.90)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C15(0.90); C25(0.90)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C15(0.81); C25(0.81)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C15(0.81); C25(0.81)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C15(0.83); C25(0.83)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C15(0.84); C25(0.84)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C15(0.92); C25(0.92)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C15(0.86); C163(0.81); C25(0.86)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C15(0.85); C25(0.85)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C15(0.85); C25(0.85)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C15(0.91); C25(0.91)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C163(0.58)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C163(0.80)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C163(0.95)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C163(0.64)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C163(0.91)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C163(0.91)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C163(0.88)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C15(0.86); C25(0.86); C163(1.10)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C163(0.73)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C163(0.73)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C163(0.76)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C163(0.58)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C163(0.69)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C163(0.58)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C163(0.62)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C163(0.54)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C15(0.85); C25(0.96)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C15(0.75); C25(0.89)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C15(0.74); C25(1.25)  LDD0876  [2]
 LDCM0279  AC2 HCT 116 C15(0.74); C25(0.74)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C15(0.66); C25(0.83)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C15(0.70); C25(0.70)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C15(1.07); C25(1.10)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C15(0.92); C25(0.86)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C15(0.74); C25(1.00)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C163(0.61)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C163(0.69)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C163(0.79)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C163(0.63)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C163(0.89)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C15(0.85); C25(0.85)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C163(0.67)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C163(0.63)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C163(0.71)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C163(0.67)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C163(0.50)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C15(0.84); C25(0.84)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C15(0.63); C25(0.63)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C15(0.49); C25(0.49)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C15(0.52); C25(0.52)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C15(0.50); C25(0.50)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C15(0.68); C25(0.68)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C15(0.46); C25(0.46)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C15(0.55); C25(0.55)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C15(0.45); C25(0.45)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C15(0.55); C25(0.55)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C15(0.44); C25(0.44)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C15(0.41); C25(0.41)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C15(1.26); C25(0.83)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C15(1.23); C25(0.86)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C15(1.06); C25(0.80)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C15(0.90); C25(0.86)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C15(0.69); C25(0.69)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C15(0.99); C25(0.75)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C15(1.21); C25(0.66)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C15(1.35); C25(0.77)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C15(1.03); C25(0.78)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C15(1.39); C25(0.81)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C15(1.23); C25(0.79)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C15(1.39); C25(0.77)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C15(0.88); C25(1.07)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C15(0.81); C25(1.12)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C15(0.74); C25(1.15)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C15(0.82); C25(0.82); C163(1.03)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C15(0.80); C25(0.88)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C15(0.90); C25(0.86)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C15(0.78); C25(0.88)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C15(0.68); C25(0.95)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C15(0.70); C25(0.94)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C15(0.77); C25(0.86)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C15(0.77); C25(1.01)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C15(0.66); C25(1.03)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C25(1.10)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C25(1.10)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C15(1.03); C25(1.03); C163(1.12)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C25(1.12)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C25(1.10)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C25(1.06)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C25(0.93)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C25(1.18)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C25(1.22)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C25(1.24)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C25(1.14)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C25(1.11)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C25(1.16)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C15(0.85); C25(0.85); C163(0.96)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C25(1.19)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C25(1.22)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C25(1.12)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C163(0.78); C15(0.78); C25(0.78)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C15(0.64); C25(0.64); C163(0.85)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C15(0.60); C25(0.60); C163(0.76)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C15(0.69); C25(0.69); C163(1.05)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C15(0.59); C25(0.59); C163(1.17)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C15(0.70); C25(0.70); C163(1.15)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C163(0.71); C15(0.78); C25(0.78)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C15(0.97); C25(0.97); C163(1.39)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C15(0.71); C25(0.71); C163(0.97)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C15(0.87); C25(0.87); C163(0.88)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C15(0.72); C25(0.72); C163(0.98)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C163(0.66); C15(0.75); C25(0.75)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C15(0.66); C25(0.66); C163(0.79)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C15(0.79); C25(0.79); C163(0.88)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C15(0.74); C25(0.74); C163(0.82)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C25(1.02)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C25(1.12)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C15(1.01); C163(1.30); C25(1.01)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C15(0.98); C25(0.98); C163(1.00)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C15(0.78); C25(0.78); C163(1.14)  LDD0592  [2]
 LDCM0367  CL1 PaTu 8988t C15(0.85); C25(0.85)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C15(0.69); C25(0.69)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C15(0.66); C25(0.66)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C15(0.66); C25(0.66); C163(0.82)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C163(0.71); C15(0.86); C25(0.86)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C163(0.88); C15(1.28); C25(1.28)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C163(0.98); C15(1.01); C25(1.01)  LDD0690  [2]
 LDCM0374  CL105 HEK-293T C15(0.68); C25(0.89)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C15(0.69); C25(0.90)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C15(0.64); C25(1.00)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C15(0.74); C25(1.07)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C15(0.73); C25(0.88)  LDD0976  [2]
 LDCM0379  CL11 PaTu 8988t C15(0.81); C25(0.81)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C15(0.74); C25(0.90)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C15(0.68); C25(0.98)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C163(0.73)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C163(0.60)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C163(0.62)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C163(0.51)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C163(0.56)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C15(0.58); C25(0.58)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C15(0.37); C25(0.37)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C15(0.53); C25(0.53)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C15(0.71); C25(0.71)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C15(0.63); C25(0.63)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C15(1.35); C25(0.86)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C15(1.21); C25(0.84)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C15(0.81); C25(0.77)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C15(1.11); C25(0.95)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C15(0.80); C25(1.08)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C15(0.70); C25(0.94)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C15(0.76); C25(1.13)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C15(0.74); C25(1.01)  LDD0997  [2]
 LDCM0400  CL13 PaTu 8988t C15(0.77); C25(0.77)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C15(0.74); C25(0.74)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C15(0.69); C25(0.69)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C163(0.57)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C163(0.52)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C163(0.51)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C163(0.56)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C15(0.67); C25(0.67)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C163(0.56)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C163(0.57)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C163(0.78)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C163(0.70)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C163(0.67)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C163(0.75)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C163(0.58)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C163(0.73)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C163(0.58)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C163(0.65)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C15(0.51); C25(0.51)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C163(0.59)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C15(0.66); C25(0.66)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C15(0.50); C25(0.50)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C15(0.57); C25(0.57)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C15(0.60); C25(0.60)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C15(0.60); C25(0.60)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C15(0.57); C25(0.57)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C15(0.56); C25(0.56)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C15(0.67); C25(0.67)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C15(0.52); C25(0.52)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C15(0.58); C25(0.58)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C15(0.68); C25(0.68)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C15(0.66); C25(0.66)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C15(0.59); C25(0.59)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C15(0.49); C25(0.49)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C15(0.52); C25(0.52)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C25(1.07)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C25(1.03)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C25(0.99)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C25(1.01)  LDD1037  [2]
 LDCM0440  CL5 PaTu 8988t C15(0.75); C25(0.75)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C25(0.87)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C25(0.92)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C25(1.06)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C25(0.91)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C25(0.89)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C25(1.07)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C25(0.91)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C25(0.95)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C25(0.98)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C25(0.95)  LDD1048  [2]
 LDCM0451  CL6 PaTu 8988t C15(0.65); C25(0.65)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C25(0.86)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C15(0.85); C25(0.85)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C15(1.05); C25(1.05)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C15(0.80); C25(0.80)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C15(0.88); C25(0.88)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C15(0.97); C25(0.97)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C15(0.78); C25(0.78)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C15(0.81); C25(0.81)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C15(0.70); C25(0.70)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C15(0.66); C25(0.66)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C15(0.77); C25(0.77)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C15(0.73); C25(0.73)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C15(0.80); C25(0.80)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C15(0.85); C25(0.85)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C15(0.83); C25(0.83)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C15(0.82); C25(0.82)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C15(0.59); C25(0.59)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C15(0.82); C25(0.82)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C15(0.77); C25(0.77)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C15(0.76); C25(0.76)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C15(0.59); C25(0.59)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C15(0.67); C25(0.67)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C15(0.80); C25(0.80)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C15(0.63); C25(0.63)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C15(0.71); C25(0.71)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C15(0.93); C25(0.93)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C15(0.79); C25(0.79)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C15(0.84); C25(0.84)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C15(0.80); C25(0.80)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C15(0.76); C25(0.76)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C15(0.92); C25(0.92)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C15(0.67); C25(0.67)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C15(1.04); C25(1.04)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C15(0.75); C25(0.75)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C15(0.79); C25(0.79)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C15(0.83); C25(0.83)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C15(0.66); C25(0.66)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C15(0.62); C25(0.62)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C15(0.69); C25(0.69)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C15(0.72); C25(0.72)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C15(0.71); C25(0.71)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C15(0.70); C25(0.70)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C239(1.36); C163(1.04); C67(1.05); C105(1.03)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C15(0.83); C25(0.83)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C15(0.62); C25(0.62)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C239(1.10); C163(1.01); C67(0.94); C105(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C239(1.14); C163(0.94); C67(0.98); C105(0.96)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C82(2.31)  LDD3310  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C67(1.12)  LDD2093  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C67(2.14)  LDD2119  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C67(0.85)  LDD2125  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C67(2.38)  LDD1700  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C239(1.11)  LDD2150  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840