Details of the Target

General Information of Target

Target ID LDTP10156
Target Name Armadillo repeat-containing protein 5 (ARMC5)
Gene Name ARMC5
Gene ID 79798
Synonyms
Armadillo repeat-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWA
ACCVVTKKVVQGIDLNQIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAV
SQVNRINETKHSVLQYVGGVMSVEMQAPKLLWLKENLREICWDKAGHFFDLPDFLSWKAT
GVTARSLCSLVCKWTYSAEKGWDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTP
EAARDLGLLPGIAVAASLIDAHAGGLGVIGADVRGHGLICEGQPVTSRLAVICGTSSCHM
GISKDPIFVPGVWGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQ
SIYAYLNSHLDLIKKAQPVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLKLSQDLDDL
AILYLATVQAIALGTRFIIEAMEAAGHSISTLFLCGGLSKNPLFVQMHADITGMPVVLSQ
EVESVLVGAAVLGACASGDFASVQEAMAKMSKVGKVVFPRLQDKKYYDKKYQVFLKLVEH
QKEYLAIMNDD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production.
Uniprot ID
Q96C12
Ensemble ID
ENST00000268314.9
HGNC ID
HGNC:25781

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.S107L .
CAOV3 SNV: p.C707F .
DU145 SNV: p.L875M .
HCT15 SNV: p.D438E .
HEC1 SNV: p.A799T .
HEC1B SNV: p.A799T .
HG3 SNV: p.R764Ter .
HSC4 SNV: p.S713F .
LS180 SNV: p.L614I .
MCC13 SNV: p.P105L .
MEWO SNV: p.P478S .
MFE319 SNV: p.A800T .
MOLT4 SNV: p.P845S .
NCIH661 SNV: p.G829C .
SUPT1 SNV: p.E30G .
U118MG SNV: p.C273S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C894(7.72)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
NAIA_5
 Probe Info  		C273(0.00); C164(0.00); C15(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C894(1.06); C353(1.40); C575(0.94); C579(0.94)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C894(1.19); C353(1.43); C575(1.08); C579(1.08)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C894(0.92); C353(1.63); C356(1.15); C575(0.69)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C894(1.01); C353(0.90); C356(1.19); C575(0.88)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C894(1.03); C353(0.99); C356(1.14); C575(0.83)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C894(1.13); C353(1.51); C356(1.11); C575(0.78)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C894(1.05); C353(1.10); C356(1.12); C575(0.86)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C894(1.12); C353(1.34); C356(1.05); C575(0.90)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C894(1.08); C353(1.74); C356(1.35); C575(0.86)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C894(1.09); C353(1.04); C356(1.06); C575(0.87)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C894(1.07); C353(1.06); C356(1.16); C575(0.90)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C894(1.03); C353(0.92); C356(1.12); C575(0.69)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C894(1.25); C353(1.44); C575(1.00); C579(1.00)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C894(0.90); C353(1.13); C356(1.26); C575(0.91)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C894(0.98); C353(0.89); C356(1.23); C575(0.86)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C894(1.11); C353(1.09); C356(1.15); C575(0.87)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C894(1.01); C353(0.89); C356(0.89); C575(0.77)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C894(1.10); C353(0.98); C356(0.91); C575(0.80)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C894(1.30); C353(1.10); C356(1.07); C575(0.93)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C894(1.41); C353(1.18); C356(1.03); C575(0.83)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C894(1.28); C353(1.22); C356(1.06); C575(0.88)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C894(1.23); C353(1.14); C356(1.13); C575(0.96)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C894(1.21); C353(1.09); C356(0.90); C575(0.97)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C894(1.08); C353(1.40); C575(1.02); C579(1.02)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C894(1.11); C353(1.26); C356(1.19); C575(0.75)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C894(1.36); C353(1.30); C356(1.12); C575(0.76)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C894(1.12); C353(1.04); C356(1.02); C575(0.87)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C894(1.34); C353(1.35); C356(1.13); C575(0.63)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C894(1.17); C353(1.65); C356(1.38); C575(0.95)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C894(1.25); C353(1.15); C356(0.96); C575(0.78)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C894(1.38); C353(1.14); C356(1.28); C575(0.82)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C894(1.26); C353(1.26); C356(1.32); C575(0.96)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C894(1.07); C353(0.94); C356(1.00); C575(1.15)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C894(0.75); C353(1.12); C356(0.86); C575(0.84)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C894(1.12); C353(0.99); C356(0.86); C575(1.06)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C894(0.73); C353(0.87); C356(0.97); C575(0.98)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C894(1.22); C353(1.19); C356(0.94); C575(0.93)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C894(0.94); C353(1.14); C356(0.89); C575(1.08)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C894(0.90); C353(1.06); C356(0.95); C575(1.19)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C894(1.42); C353(1.06); C356(0.87); C575(1.05)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C894(1.69); C353(1.19); C356(0.93); C575(0.98)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C894(0.97); C353(1.05); C356(0.95); C575(0.97)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C894(1.01); C353(1.14); C356(1.14); C575(1.18)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C894(1.00); C353(1.18); C356(1.04); C575(0.89)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C894(0.93); C353(0.84); C575(1.06); C579(1.06)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C894(1.46); C353(1.21); C356(1.10); C575(1.01)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C894(1.36); C353(1.19); C356(1.21); C575(1.07)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C894(0.98); C353(1.04); C356(0.99); C575(1.21)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C894(0.98); C353(1.12); C356(1.12); C575(1.06)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C884(0.91); C353(1.03); C356(1.03); C657(1.04)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C884(0.88); C657(1.01); C665(1.01); C894(1.19)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C884(0.97); C657(0.97); C665(0.97); C353(1.08)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C657(1.08); C665(1.08); C884(1.10); C353(1.13)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C353(1.04); C356(1.04); C575(1.31); C579(1.31)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C575(1.02); C579(1.02); C884(1.05); C894(1.11)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C353(0.86); C884(0.90); C894(0.98); C657(1.12)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C884(0.88); C894(0.95); C657(0.96); C665(0.96)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C884(0.98); C575(1.02); C579(1.02); C657(1.09)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C353(1.08); C356(1.08); C894(1.09); C884(1.20)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C353(1.10); C356(1.10); C575(1.15); C579(1.15)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C894(1.06); C353(1.23); C356(1.23); C575(1.26)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C894(1.24); C353(1.16); C356(1.16); C575(1.05)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C894(1.31); C353(1.16); C356(1.16); C575(1.18)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C894(0.77); C353(1.10); C356(1.10); C575(1.32)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C657(0.82); C665(0.82); C575(0.92); C579(0.92)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C353(1.00); C356(1.00); C657(1.10); C665(1.10)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C657(0.87); C665(0.87); C353(0.90); C356(0.90)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C894(0.93); C575(1.01); C579(1.01); C657(1.03)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C657(0.91); C665(0.91); C894(1.00); C353(1.36)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C657(0.81); C665(0.81); C894(1.02); C353(1.03)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C894(0.84); C657(0.92); C665(0.92); C353(0.99)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C657(0.86); C665(0.86); C894(1.03); C353(1.09)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C657(0.82); C665(0.82); C894(0.97); C353(1.15)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C575(0.61); C579(0.61); C356(0.85); C884(0.90)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C575(0.70); C579(0.70); C884(0.88); C356(0.99)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C884(0.94); C575(1.04); C579(1.04); C356(1.16)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C575(0.62); C579(0.62); C884(0.90); C894(1.16)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C575(0.80); C579(0.80); C884(0.98); C353(1.18)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C657(0.89); C665(0.89); C575(1.03); C579(1.03)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C575(0.74); C579(0.74); C884(0.92); C356(1.21)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C575(0.68); C579(0.68); C884(0.96); C356(1.10)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C575(0.63); C579(0.63); C884(1.01); C356(1.27)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C575(0.80); C579(0.80); C894(0.97); C356(0.97)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C575(0.67); C579(0.67); C356(0.81); C353(0.93)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C356(0.85); C894(0.87); C353(0.94); C575(1.01)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C356(0.86); C353(0.90); C894(1.02); C575(1.10)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C894(0.86); C353(0.89); C356(0.90); C575(1.11)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C575(0.91); C579(0.91); C356(1.03); C894(1.08)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C575(0.81); C579(0.81); C894(0.99); C353(1.18)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C575(0.95); C579(0.95); C657(1.00); C665(1.00)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C894(0.92); C356(1.06); C353(1.11); C575(1.12)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C575(0.79); C579(0.79); C356(0.89); C353(0.99)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C575(0.92); C579(0.92); C356(0.96); C894(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C575(1.08); C579(1.08); C894(1.08); C356(1.26)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C575(0.79); C579(0.79); C356(0.91); C894(0.93)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C356(0.92); C894(0.93); C575(0.96); C579(0.96)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C575(0.99); C579(0.99); C353(1.08); C894(1.12)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C894(1.02); C575(1.03); C579(1.03); C353(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C575(1.01); C579(1.01); C894(1.03); C353(1.30)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C353(0.86); C894(1.00); C575(1.08); C579(1.08)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C575(0.84); C579(0.84); C657(1.03); C665(1.03)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C353(0.74); C575(1.06); C579(1.06); C894(1.17)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C575(0.92); C579(0.92); C353(0.92); C894(1.04)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C353(0.98); C575(1.02); C579(1.02); C894(1.08)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C353(0.71); C894(1.03); C575(1.07); C579(1.07)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C353(0.83); C894(0.96); C575(1.25); C579(1.25)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C894(1.09); C575(1.14); C579(1.14); C353(1.39)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C894(1.06); C353(1.20); C575(1.33); C579(1.33)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C575(0.92); C579(0.92); C353(1.10); C356(1.18)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C575(0.77); C579(0.77); C353(1.01); C356(1.03)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C575(0.97); C579(0.97); C356(1.18); C353(1.24)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C884(0.84); C353(0.90); C575(1.00); C579(1.00)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C575(0.80); C579(0.80); C356(1.15); C894(1.26)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C575(0.70); C579(0.70); C356(0.96); C894(1.06)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C575(0.89); C579(0.89); C356(1.18); C353(1.20)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C575(0.68); C579(0.68); C356(0.94); C894(1.37)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C575(0.89); C579(0.89); C356(1.17); C894(1.30)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C575(1.00); C579(1.00); C356(1.30); C353(1.30)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C575(0.88); C579(0.88); C356(1.23); C353(1.25)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C575(1.07); C579(1.07); C356(1.39); C894(1.41)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C894(0.93); C884(0.98); C575(1.08); C579(1.08)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C894(0.97); C575(1.02); C579(1.02); C884(1.10)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C884(0.83); C657(0.94); C665(0.94); C575(0.96)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C353(0.95); C356(0.95); C575(1.02); C579(1.02)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C353(0.94); C356(0.94); C657(1.05); C665(1.05)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C575(0.99); C579(0.99); C884(1.03); C353(1.08)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C575(1.27); C579(1.27); C884(1.54); C353(1.62)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C575(1.23); C579(1.23); C353(1.60); C356(1.60)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C575(1.29); C579(1.29); C894(1.70); C884(1.73)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C575(0.99); C579(0.99); C884(1.19); C353(1.22)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C575(1.08); C579(1.08); C884(1.09); C353(1.19)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C575(0.96); C579(0.96); C353(0.98); C356(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C575(1.05); C579(1.05); C353(1.06); C356(1.06)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C884(0.95); C575(1.01); C579(1.01); C657(1.04)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C575(1.08); C579(1.08); C894(1.11); C657(1.17)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C353(1.02); C356(1.02); C894(1.04); C884(1.23)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C575(1.22); C579(1.22); C353(1.82); C356(1.82)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C353(0.89); C356(0.89); C575(1.00); C579(1.00)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C353(0.83); C356(0.83); C575(1.04); C579(1.04)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C353(0.86); C356(0.86); C575(0.93); C579(0.93)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C575(0.90); C579(0.90); C353(1.02); C356(1.02)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C353(0.96); C356(0.96); C575(1.11); C579(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C353(0.77); C356(0.77); C657(0.88); C665(0.88)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C575(0.92); C579(0.92); C353(0.95); C356(0.95)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C657(0.89); C665(0.89); C575(0.98); C579(0.98)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C353(0.88); C356(0.88); C575(0.99); C579(0.99)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C353(0.85); C356(0.85); C575(1.10); C579(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C575(0.92); C579(0.92); C353(0.99); C356(0.99)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C657(0.89); C665(0.89); C353(0.90); C356(0.90)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C657(0.78); C665(0.78); C575(0.81); C579(0.81)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C353(0.92); C356(0.92); C575(0.98); C579(0.98)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C353(0.85); C356(0.85); C575(0.96); C579(0.96)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C575(0.97); C579(0.97); C353(1.06); C356(1.14)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C575(0.77); C579(0.77); C894(0.92); C356(1.07)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C894(1.00); C353(0.92); C575(1.01); C579(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C657(0.85); C665(0.85); C884(0.86); C353(0.98)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C884(1.00); C353(1.14); C894(1.14); C575(1.26)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C575(1.07); C579(1.07); C356(1.10); C657(1.14)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C894(0.99); C575(1.35); C579(1.35); C353(1.44)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C657(0.94); C665(0.94); C575(1.08); C579(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C884(0.88); C353(1.09); C657(1.10); C665(1.10)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C884(0.90); C657(0.98); C665(0.98); C575(1.16)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C884(0.77); C657(0.97); C665(0.97); C575(1.08)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C657(0.76); C665(0.76); C884(0.86); C894(0.98)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C353(0.96); C356(0.96); C657(1.08); C665(1.08)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C353(1.01); C356(1.01); C657(1.04); C665(1.04)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C657(0.89); C665(0.89); C353(1.07); C356(1.07)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C657(1.03); C665(1.03); C353(1.08); C356(1.08)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C657(0.86); C665(0.86); C353(0.93); C356(0.93)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C894(0.98); C353(1.23); C575(1.33); C579(1.33)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C657(0.84); C665(0.84); C575(1.02); C579(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C657(0.98); C665(0.98); C575(1.07); C579(1.07)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C575(0.68); C579(0.68); C884(0.95); C356(0.98)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C884(0.83); C575(0.84); C579(0.84); C356(0.93)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C884(0.83); C575(0.94); C579(0.94); C356(1.06)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C575(0.76); C579(0.76); C356(0.94); C884(1.02)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C575(0.65); C579(0.65); C884(0.95); C894(1.11)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C575(1.09); C579(1.09); C894(1.15); C353(1.29)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C353(1.03); C356(1.05); C575(1.15); C579(1.15)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C894(1.04); C356(1.04); C575(1.11); C579(1.11)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C894(1.08); C575(1.19); C579(1.19); C353(1.33)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C356(0.86); C353(0.96); C575(1.04); C579(1.04)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C353(1.14); C894(1.25); C575(1.44); C579(1.44)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C353(0.90); C894(1.13); C575(1.16); C579(1.16)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C353(1.08); C894(1.63); C575(1.81); C579(1.81)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C894(1.14); C353(1.16); C575(1.40); C579(1.40)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C575(0.70); C579(0.70); C356(0.97); C353(1.24)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C575(0.68); C579(0.68); C353(0.89); C356(0.93)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C575(0.77); C579(0.77); C356(0.89); C353(1.13)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C575(0.80); C579(0.80); C356(1.13); C353(1.24)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C575(0.99); C579(0.99); C353(1.23); C657(1.26)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C575(0.98); C579(0.98); C894(1.00); C353(1.25)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C575(1.08); C579(1.08); C353(1.29); C657(1.39)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C894(0.85); C657(0.96); C665(0.96); C575(1.05)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C356(0.86); C353(0.89); C657(1.09); C665(1.09)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C657(0.86); C665(0.86); C356(0.94); C575(0.99)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C657(0.93); C665(0.93); C575(0.98); C579(0.98)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C575(0.93); C579(0.93); C657(0.94); C665(0.94)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C657(0.99); C665(0.99); C356(1.00); C575(1.02)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C356(1.01); C353(1.12); C575(1.19); C579(1.19)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C356(0.96); C353(1.10); C575(1.21); C579(1.21)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C575(0.90); C579(0.90); C356(0.97); C657(0.99)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C356(0.92); C353(1.09); C657(1.13); C665(1.13)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C353(1.03); C356(0.88); C575(1.14); C579(1.14)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C353(1.20); C356(1.06); C575(0.94); C579(0.94)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C353(1.09); C356(0.98); C575(1.01); C579(1.01)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C353(1.21); C356(1.17); C575(0.98); C579(0.98)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C353(1.14); C356(1.06); C575(1.02); C579(1.02)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C894(1.45); C353(1.16); C356(1.13); C575(1.07)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C353(1.16); C356(1.07); C575(0.97); C579(0.97)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C894(2.10); C575(1.15); C579(1.15); C657(1.03)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C894(1.26); C353(0.98); C356(0.98); C575(1.15)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C894(1.44); C353(0.99); C356(0.99); C575(1.27)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C894(1.25); C353(0.87); C356(0.87); C575(1.32)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C894(0.98); C353(1.03); C356(1.03); C575(1.16)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C894(1.21); C353(0.91); C356(0.91); C575(1.19)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C894(0.95); C353(0.82); C356(0.82); C575(1.22)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C894(1.01); C353(1.03); C356(1.03); C575(1.43)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C894(15.01); C353(1.23); C356(1.23); C575(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C894(1.71); C353(1.18); C356(1.18); C575(1.41)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C894(0.88); C353(0.89); C356(0.89); C575(1.13)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C894(0.71); C353(0.77); C356(0.77); C575(1.66)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C894(0.97); C353(0.89); C356(0.89); C575(1.28)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C894(1.17); C353(1.04); C356(1.04); C575(1.37)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C894(1.95); C353(0.96); C356(0.96); C575(1.45)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C894(1.34); C353(1.04); C356(1.04); C575(0.90)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C894(1.23); C353(0.98); C356(0.98); C575(0.86)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C894(0.98); C353(1.05); C356(1.05); C575(0.85)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C894(1.14); C353(0.97); C356(0.97); C575(0.98)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C894(1.06); C353(1.13); C356(1.13); C575(0.91)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C894(1.24); C353(0.92); C356(0.92); C575(0.87)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C894(1.14); C353(1.05); C356(1.05); C575(0.81)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C894(1.10); C353(1.01); C356(1.01); C575(0.87)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C894(1.15); C353(1.11); C356(1.11); C575(0.97)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C894(1.21); C353(1.00); C356(1.00); C575(0.89)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C894(0.81); C353(1.01); C356(1.01); C575(0.87)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C894(1.21); C353(1.04); C356(1.04); C575(0.85)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C894(2.68); C353(1.15); C356(1.15); C575(0.89)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C894(1.17); C353(1.01); C356(1.01); C575(0.87)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C894(1.03); C353(1.07); C356(1.07); C575(0.90)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C894(1.32); C353(1.23); C356(1.16); C575(1.15)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C894(1.28); C353(0.95); C356(0.95); C575(0.84)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C894(1.24); C575(0.94); C579(0.94); C657(0.96)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C894(1.38); C575(0.96); C579(0.96); C657(1.00)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C894(1.78); C575(1.14); C579(1.14); C657(0.98)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C894(1.97); C575(1.12); C579(1.12); C657(1.05)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C894(1.31); C575(1.12); C579(1.12); C657(1.05)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C894(2.36); C575(1.25); C579(1.25); C657(1.30)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C894(1.49); C575(1.02); C579(1.02); C657(1.25)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C894(1.61); C575(1.17); C579(1.17); C657(1.07)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C894(1.86); C575(0.96); C579(0.96); C657(1.03)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C894(1.09); C353(1.15); C356(1.24); C575(1.10)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C894(1.12); C575(1.02); C579(1.02); C657(1.03)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C894(1.56); C575(1.35); C579(1.35); C657(1.12)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C894(1.44); C575(1.19); C579(1.19); C657(1.11)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C894(1.76); C575(1.29); C579(1.29); C657(1.15)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C894(1.48); C575(1.09); C579(1.09); C657(1.23)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C894(0.99); C353(0.97); C356(1.31); C575(0.94)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C894(1.41); C353(0.84); C356(0.94); C575(1.03)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C894(0.94); C353(0.92); C356(1.03); C575(1.04)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C894(1.11); C353(0.91); C356(1.02); C575(0.97)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C894(1.18); C353(1.29); C356(1.42); C575(2.00)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C894(1.00); C353(0.85); C356(0.97); C575(1.03)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C894(1.17); C353(1.05); C356(0.96); C575(0.94)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C894(0.87); C353(0.82); C356(0.90); C575(1.07)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C894(1.52); C353(0.88); C356(1.02); C575(0.95)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C894(1.42); C353(0.93); C356(1.03); C575(1.03)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C894(0.94); C353(1.07); C356(1.03); C575(0.95)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C894(1.02); C353(0.85); C356(0.96); C575(1.05)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C894(1.22); C353(0.95); C356(1.03); C575(0.98)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C894(0.93); C353(0.71); C356(0.85); C575(0.95)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C894(0.93); C353(0.86); C356(1.02); C575(1.02)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C894(2.01); C353(1.33); C356(1.14); C575(1.04)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C894(3.61); C353(0.73); C356(1.08); C575(1.30)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C894(1.20); C353(1.01); C575(0.94); C579(0.94)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C894(1.24); C353(1.03); C575(1.10); C579(1.10)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C894(1.05); C353(0.88); C575(1.05); C579(1.05)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C894(1.37); C353(1.18); C575(1.01); C579(1.01)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C894(1.52); C353(1.04); C575(0.97); C579(0.97)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C894(1.03); C353(1.23); C575(0.88); C579(0.88)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C894(1.09); C353(1.24); C575(0.95); C579(0.95)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C894(1.25); C353(0.85); C575(1.08); C579(1.08)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C894(1.21); C353(0.88); C575(0.98); C579(0.98)  LDD0811  [5]
 LDCM0468  Fragment33 HCT 116 C894(1.75); C575(1.06); C579(1.06); C657(1.11)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C894(2.85); C353(0.90); C356(0.90); C575(1.60)  LDD0744  [5]
 LDCM0023  KB03 Jurkat C894(7.72)  LDD0209  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 2 (CNOT2) CNOT2/3/5 family Q9NZN8
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Proline-rich protein 35 (PRR35) . P0CG20

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.