Details of the Target

General Information of Target

Target ID LDTP09960
Target Name Segment polarity protein dishevelled homolog DVL-3 (DVL3)
Gene Name DVL3
Gene ID 1857
Synonyms
KIAA0208; Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEG
GLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNSKIFLDL
DTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPD
TWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSG
GNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHG
TENGLQDNDIKLRVSEWEVIQESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEF
QRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQ
QNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEER
IQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIP
FSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFD
VSIDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQ
LAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYGGAASAGASVFG
ASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEM
ENNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDH
KVCASERPPKDLGYMYFYRRIPS
Target Bioclass
Other
Family
DSH family
Subcellular location
Cytoplasm
Function Involved in the signal transduction pathway mediated by multiple Wnt genes.
Uniprot ID
Q92997
Ensemble ID
ENST00000313143.9
HGNC ID
HGNC:3087
ChEMBL ID
CHEMBL6028

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.M666CfsTer2 .
COLO792 SNV: p.P439L .
HEC1 SNV: p.P627L .
Ishikawa (Heraklio) 02 ER SNV: p.R292C .
JURKAT SNV: p.V416I Compound 10    Probe Info 
LS180 SNV: p.D130Y; p.N707T .
MFE319 SNV: p.G663D .
MOLT4 SNV: p.A696T .
RH30 SNV: p.Y540S .
SW1783 SNV: p.G561S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C336(1.11)  LDD0078  [1]
m-APA
 Probe Info  		N.A.  LDD2232  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C336(1.05); C344(0.80); C69(1.19)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C336(1.41); C69(1.23)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C344(0.79)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C344(0.66)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C344(0.77)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C344(1.11)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C344(1.15)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C344(1.18)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C344(1.00)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C344(0.80)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C344(0.91)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C344(0.93)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C336(1.13); C69(0.87)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C344(0.74)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C344(0.78)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C344(0.93)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C336(0.99); C344(0.79); C69(1.09)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C336(1.21); C344(0.89); C69(1.03)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C336(1.44); C344(1.01); C69(0.97)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C336(1.36); C344(0.87); C69(0.96)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C336(1.29); C344(1.14); C69(0.92)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C336(1.20); C344(0.94); C69(0.96)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C336(1.22); C344(0.91); C69(1.08)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C336(1.04); C69(0.88)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C336(0.97); C344(0.77); C69(1.07)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C336(1.12); C344(1.30); C69(0.91)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C336(1.26); C344(0.77); C69(0.99)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C336(1.08); C344(1.11); C69(1.05)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C336(1.12); C344(0.91); C69(1.07)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C336(1.30); C344(0.82); C69(1.21)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C336(1.32); C344(0.93); C69(1.07)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C336(1.36); C344(1.02); C69(0.99)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C336(1.66); C344(1.09); C69(0.87)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C336(1.40); C344(1.05); C69(0.85)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C336(1.58); C344(1.04); C69(0.96)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C336(1.23); C344(1.30); C69(0.91)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C336(1.19); C344(1.16); C69(0.85)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C336(1.35); C344(0.98); C69(0.92)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C336(1.61); C344(1.24); C69(0.92)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C336(1.69); C344(1.16); C69(0.91)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C336(1.05); C344(1.18); C69(0.92)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C336(1.12); C344(1.02); C69(0.86)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C336(1.51); C344(1.49); C69(0.91)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C336(1.42); C344(1.30); C69(0.87)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C336(1.17); C69(0.89)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C336(1.52); C344(1.46); C69(0.93)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C336(1.39); C344(1.24); C69(0.87)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C336(1.18); C344(1.10); C69(0.95)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C336(1.10); C344(0.82)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C344(0.87); C336(1.33)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C344(0.72); C336(1.19)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C344(0.58); C336(1.29)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C344(0.72); C336(1.32)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C344(0.51); C336(1.52)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C344(0.49); C336(1.42)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C69(0.98); C336(1.11)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C344(0.68); C336(1.06)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C344(0.66); C336(1.12)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C344(0.62); C336(1.13)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C344(0.77); C336(1.67)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C336(1.19); C344(0.68)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C336(1.18); C344(0.92)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C336(1.06); C344(0.64)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C336(1.04); C344(0.64)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C344(0.93); C69(1.00); C336(1.11)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C344(0.88); C69(0.94); C336(1.13)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C69(0.97); C344(1.07); C336(1.09)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C344(0.75); C336(1.16); C69(1.20)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C69(0.97); C344(1.05); C336(1.06)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C69(0.92); C344(0.99); C336(1.11)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C69(0.95); C344(1.04); C336(1.13)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C69(0.81); C336(0.99); C344(1.11)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C336(0.99); C69(1.03); C344(1.09)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C69(0.87); C336(1.06); C344(1.40)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C69(0.96); C336(1.20); C344(1.27)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C69(0.99); C336(1.19); C344(1.36)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C69(0.87); C336(1.18); C344(1.32)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C69(0.98); C336(1.23); C344(1.43)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C344(0.76); C336(1.11); C69(1.20)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C69(1.02); C336(1.16); C344(1.49)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C69(1.09); C344(1.19); C336(1.19)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C69(1.04); C344(1.33); C336(1.36)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C69(1.03); C336(1.26); C344(1.47)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C69(1.06); C336(1.20); C344(1.38)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C336(0.94); C344(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C336(1.00); C344(1.17)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C336(1.00); C344(1.12)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C336(1.02); C344(1.27)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C336(1.06); C344(1.31)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C344(0.95); C336(1.18); C69(1.35)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C336(0.94); C344(1.44)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C336(1.06); C344(1.18)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C336(1.04); C344(1.41)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C336(1.07); C344(1.27)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C336(0.97); C344(1.29)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C336(1.01); C344(1.40)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C344(0.73); C336(1.13)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C344(1.07); C336(1.19)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C344(0.87); C336(1.20)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C344(0.99); C336(1.23)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C344(0.93); C336(1.25); C69(1.25)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C336(1.36); C344(1.42)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C344(0.98); C336(1.05)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C336(1.08); C344(1.24)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C344(0.88); C336(1.08)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C344(0.91); C336(1.12)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C336(1.28); C344(1.62)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C344(1.25); C336(1.43)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C344(1.13); C336(1.25)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C344(1.20); C336(1.21)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C344(1.21); C336(1.36)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C69(1.05); C336(1.25)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C344(1.15); C336(1.38)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C344(0.84); C336(1.31)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C344(0.98); C336(1.53)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C344(0.98); C336(1.33)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C344(0.99); C336(1.49)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C344(1.02); C336(1.50)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C344(1.01); C336(1.33)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C344(0.95); C336(1.62)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C336(0.84); C344(1.17); C69(1.42)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C336(0.78); C69(1.07); C344(1.29)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C69(1.05); C336(1.17)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C336(0.92); C69(1.20); C344(1.30)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C336(0.86); C69(1.17); C344(1.23)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C336(0.85); C69(1.21); C344(1.27)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C336(0.94); C69(1.05); C344(1.75)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C336(0.89); C69(1.13); C344(1.47)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C336(0.95); C69(1.15); C344(1.56)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C336(1.01); C69(1.24); C344(1.34)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C336(0.97); C344(1.20); C69(1.38)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C336(0.87); C344(1.19); C69(1.27)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C336(0.90); C344(1.22); C69(1.41)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C69(1.11); C336(1.23)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C336(1.01); C69(1.13); C344(1.22)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C336(0.88); C344(1.15); C69(1.20)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C336(0.92); C69(1.17); C344(1.58)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C69(0.92); C336(1.42); C344(1.65)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C69(1.06); C336(1.28); C344(1.54)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C69(0.99); C344(1.23); C336(1.36)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C69(0.99); C344(1.17); C336(1.38)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C69(0.91); C336(1.05); C344(1.31)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C69(0.98); C336(1.14); C344(1.30)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C69(0.91); C336(1.45); C344(1.46)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C69(1.08); C336(1.14); C344(1.14)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C69(1.04); C336(1.54); C344(1.64)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C69(0.98); C336(1.44); C344(1.54)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C69(0.95); C336(1.23); C344(1.34)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C69(1.04); C336(1.13); C344(1.43)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C69(0.99); C344(1.21); C336(1.31)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C69(1.00); C344(1.30); C336(1.38)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C69(1.07); C336(1.32); C344(1.68)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C344(0.61)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C344(0.53)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C336(1.10); C69(0.97)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C69(1.00); C336(1.14)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C69(1.04); C336(1.51)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C336(1.11)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C336(1.25)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C336(1.68)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C344(0.82); C69(1.17); C336(1.18)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C69(1.06); C336(1.35)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C69(0.89); C336(1.38)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C69(0.84); C336(1.01)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C69(0.96); C336(1.07)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C344(0.91); C336(0.99); C69(1.06)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C69(0.90); C336(0.98); C344(1.01)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C69(0.90); C344(1.01); C336(1.14)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C69(1.02); C344(1.02); C336(1.10)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C69(0.92); C344(1.19); C336(1.24)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C336(1.57)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C69(0.96); C344(1.12); C336(1.14)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C69(1.01); C344(1.11); C336(1.24)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C69(0.87); C336(0.88); C344(1.36)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C69(0.98); C336(1.21); C344(1.49)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C69(1.07); C336(1.11); C344(1.86)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C69(1.08); C336(1.24); C344(1.77)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C69(1.05); C336(1.16); C344(1.41)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C336(1.20); C344(2.06)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C336(1.10); C344(1.12)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C344(1.10); C336(1.10)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C336(1.52)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C336(1.13); C344(1.14)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C344(0.90); C336(1.13)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C336(1.20); C344(1.64)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C344(1.41); C336(1.41)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C336(1.27); C344(1.45)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C344(1.07); C336(1.10)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C336(1.42); C344(1.95)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C336(1.35); C344(1.42)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C344(0.99); C336(1.37)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C336(1.65)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C336(1.24)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C336(1.43)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C336(1.27)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C336(1.06)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C336(1.16)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C336(1.10)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C336(1.38)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C336(1.17)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C336(1.03)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C336(1.21)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C336(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C336(1.25)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C336(1.18)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C336(1.14)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C336(1.24)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C336(1.33)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C336(1.23)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C336(1.13)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C336(1.07)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C336(1.09)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C336(1.24)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C336(1.26)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C336(1.20)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C336(1.08)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C336(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C336(1.10)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C336(1.15)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C336(1.13)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C336(1.37)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C336(0.97)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C336(0.98)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C336(1.26)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C336(1.28)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C336(1.04)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C336(1.22); C69(1.39)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C336(1.21); C69(1.05)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C336(1.18); C69(1.34)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C336(0.98); C69(1.49)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C336(1.13)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C336(0.94); C69(1.33)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C336(0.98); C69(1.31)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C336(1.09); C69(1.41)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C336(0.91); C69(0.80)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C336(1.09); C69(1.24)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C336(1.05); C69(1.12)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C336(1.16); C69(0.93)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C336(1.29); C69(1.02)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C336(1.28); C69(1.08)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C336(1.00); C69(1.08)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C336(1.06)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C336(1.06); C69(1.65)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C336(1.04); C344(1.01)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C336(1.02); C344(1.52)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C336(1.00); C344(1.24)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C336(1.02); C344(1.74)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C336(0.99); C344(1.07)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C336(1.14); C344(2.16)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C336(1.09); C344(1.03)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C336(1.00); C344(1.41)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C336(1.27); C344(1.68)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C336(1.27)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C336(1.12); C344(1.10)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C336(1.02); C344(1.21)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C336(1.04); C344(1.20)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C336(0.99); C344(1.48)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C336(1.00); C344(1.35)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C336(1.29); C344(1.19); C69(1.20)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C336(1.06); C344(1.39); C69(1.28)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C336(1.29); C344(1.14); C69(1.16)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C336(1.42); C344(1.00); C69(1.17)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C336(1.55)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C336(1.06); C344(1.20); C69(1.19)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C336(1.22); C344(1.07); C69(1.12)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C336(1.55); C344(1.01); C69(1.14)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C336(1.48); C344(1.31); C69(1.25)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C336(1.68); C344(1.26); C69(1.21)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C336(1.26); C344(1.05); C69(0.93)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C336(1.25); C344(1.27); C69(1.47)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C336(1.66); C344(1.39); C69(1.38)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C336(1.37); C344(1.17); C69(1.29)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C336(1.77); C344(1.32); C69(1.30)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C336(1.39)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C336(1.15); C344(1.60); C69(1.18)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C336(1.22); C344(0.98); C69(1.15)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C336(1.31); C344(1.05); C69(0.99)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C336(1.52); C344(1.11); C69(0.89)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C336(1.47); C344(1.72); C69(0.80)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C336(1.25); C344(1.58); C69(0.98)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C336(1.10); C344(0.88); C69(1.06)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C336(1.09); C344(0.82); C69(1.19)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C336(1.38); C344(0.89); C69(1.23)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C336(1.62); C344(1.23); C69(1.36)  LDD0811  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C344(5.12); C69(1.55)  LDD1702  [8]
 LDCM0468  Fragment33 HCT 116 C336(1.03); C344(1.57)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C336(1.13)  LDD0744  [1]
 LDCM0021  THZ1 HCT 116 C336(1.14)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Ribosomal RNA-processing protein 8 (RRP8) RRP8 family O43159
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Casein kinase I isoform delta (CSNK1D) CK1 Ser/Thr protein kinase family P48730
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Translin (TSN) Translin family Q15631
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
RWD domain-containing protein 2B (RWDD2B) . P57060
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Stomatin (STOM) Band 7/mec-2 family P27105
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 41 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A5 (HOXA5) Antp homeobox family P20719
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Wilms tumor protein (WT1) EGR C2H2-type zinc-finger protein family P19544
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Krueppel-like factor 4 (KLF4) Krueppel C2H2-type zinc-finger protein family O43474
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and BTB domain-containing protein 47 (ZBTB47) Krueppel C2H2-type zinc-finger protein family Q9UFB7
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Zinc finger protein 2 (ZNF2) Krueppel C2H2-type zinc-finger protein family Q9BSG1
Zinc finger protein 264 (ZNF264) Krueppel C2H2-type zinc-finger protein family O43296
Zinc finger protein 319 (ZNF319) Krueppel C2H2-type zinc-finger protein family Q9P2F9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 441 (ZNF441) Krueppel C2H2-type zinc-finger protein family Q8N8Z8
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 699 (ZNF699) Krueppel C2H2-type zinc-finger protein family Q32M78
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 775 (ZNF775) Krueppel C2H2-type zinc-finger protein family Q96BV0
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) LRRFIP family Q9Y608
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
TATA box-binding protein-like 1 (TBPL1) TBP family P62380
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger protein 408 (ZNF408) . Q9H9D4
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-3 complex subunit mu-1 (AP3M1) Adaptor complexes medium subunit family Q9Y2T2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) BACURD family Q9H3F6
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Cancer/testis antigen family 45 member A10 (CT45A10) CT45 family P0DMU9
Cancer/testis antigen family 45 member A3 (CT45A3) CT45 family Q8NHU0
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-1 (DVL1) DSH family O14640
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Activator of basal transcription 1 (ABT1) ESF2/ABP1 family Q9ULW3
Protein FAM13C (FAM13C) FAM13 family Q8NE31
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Fibroblast growth factor 16 (FGF16) Heparin-binding growth factors family O43320
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Protein naked cuticle homolog 1 (NKD1) NKD family Q969G9
Spermatid nuclear transition protein 1 (TNP1) Nuclear transition protein 1 family P09430
Testis-specific Y-encoded-like protein 6 (TSPYL6) Nucleosome assembly protein (NAP) family Q8N831
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Prickle-like protein 1 (PRICKLE1) Prickle / espinas / testin family Q96MT3
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Pre-mRNA-splicing factor 38A (PRPF38A) PRP38 family Q8NAV1
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Nucleolar protein 12 (NOL12) RRP17 family Q9UGY1
Histone deacetylase complex subunit SAP30L (SAP30L) SAP30 family Q9HAJ7
Something about silencing protein 10 (UTP3) SAS10 family Q9NQZ2
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Eukaryotic translation initiation factor 1b (EIF1B) SUI1 family O60739
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1) TNFAIP8 family Q8WVP5
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
A-kinase anchor protein 17A (AKAP17A) . Q02040
Arf-GAP with dual PH domain-containing protein 1 (ADAP1) . O75689
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Centrosomal protein of 164 kDa (CEP164) . Q9UPV0
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Chromobox protein homolog 8 (CBX8) . Q9HC52
Chromodomain Y-like protein 2 (CDYL2) . Q8N8U2
INO80 complex subunit B (INO80B) . Q9C086
Kelch-like protein 12 (KLHL12) . Q53G59
Leucine zipper protein 4 (LUZP4) . Q9P127
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Melanoma-associated antigen B4 (MAGEB4) . O15481
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Proline-rich protein 13 (PRR13) . Q9NZ81
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Protein TFG (TFG) . Q92734
RING finger protein 151 (RNF151) . Q2KHN1
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) . Q15696
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Vinexin (SORBS3) . O60504
YTH domain-containing protein 1 (YTHDC1) . Q96MU7

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761