Details of the Target

General Information of Target

Target ID LDTP09818
Target Name Protein Jade-3 (JADE3)
Gene Name JADE3
Gene ID 9767
Synonyms
KIAA0215; PHF16; Protein Jade-3; Jade family PHD finger protein 3; PHD finger protein 16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPV
GRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSG
AFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLG
NYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRI
ITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNE
TCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVG
KQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLY
VNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQL
QAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDK
STEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFS
EEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
Target Bioclass
Transcription factor
Family
JADE family
Function Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity.
Uniprot ID
Q92613
Ensemble ID
ENST00000611250.4
HGNC ID
HGNC:22982

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C732(0.98)  LDD2228  [1]
AHL-Pu-1
 Probe Info  		C290(2.03)  LDD0168  [2]
DBIA
 Probe Info  		C223(1.68); C231(1.68); C226(1.68)  LDD0080  [3]
IA-alkyne
 Probe Info  		C244(0.00); C247(0.00); C279(0.00)  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		C290(0.00); C768(0.00); C732(0.00)  LDD0018  [8]
AOyne
 Probe Info  		14.60  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C290(2.03)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C688(2.70)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C247(1.12); C258(1.12)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C226(1.01); C231(1.01); C325(1.13)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C315(0.82); C322(0.79); C325(0.79)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C315(0.69); C322(0.88); C325(0.88)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C315(0.80); C322(0.70); C325(0.70)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C315(0.71); C322(0.66); C325(0.66)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C315(0.71); C322(0.72); C325(0.72)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C315(0.75); C322(0.72); C325(0.72)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C315(0.73); C322(0.59); C325(0.59)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C315(0.86); C322(0.74); C325(0.75)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C315(0.67); C322(0.80); C325(0.92)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C315(0.76); C322(0.75); C325(0.84)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C226(0.69); C231(0.69); C325(1.11)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C315(0.70); C322(0.66); C325(0.73)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C315(0.61); C322(0.69); C325(0.80)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C315(0.73); C322(0.62); C325(0.62)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C322(1.08); C325(1.08)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C322(0.98); C325(0.98)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C322(0.96); C325(0.96)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C322(1.02); C325(1.02)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C322(1.00); C325(1.00)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C322(1.05); C325(1.05)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C322(1.04); C325(1.04)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C226(0.80); C231(0.80); C325(1.07)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C322(1.01); C325(1.01)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C322(1.08); C325(1.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C322(0.99); C325(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C322(1.04); C325(1.04)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C322(0.93); C325(0.93)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C322(0.96); C325(0.96)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C322(1.07); C325(1.07)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C322(0.98); C325(0.98)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C322(0.90); C325(0.90)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C322(0.88); C325(0.88)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C322(0.86); C325(0.86)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C322(0.90); C325(0.90)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C322(1.03); C325(1.03)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C322(1.00); C325(1.00)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C322(0.86); C325(0.86)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C322(0.89); C325(0.89)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C322(0.89); C325(0.89)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C322(0.83); C325(0.83)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C322(0.78); C325(0.78)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C322(0.90); C325(0.90)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C226(1.08); C231(1.08); C325(1.09)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C322(0.84); C325(0.84)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C322(0.87); C325(0.87)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C322(1.02); C325(1.02)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C223(1.26); C231(1.26)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C223(1.11); C231(1.11)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C223(0.91); C231(0.91)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C223(0.95); C231(0.95)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C223(1.08); C231(1.08)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C223(1.04); C231(1.04)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C223(1.00); C231(1.00)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C226(1.37); C231(1.37); C325(1.48)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C223(1.04); C231(1.04)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C223(1.33); C231(1.33)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C223(1.23); C231(1.23)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C223(1.06); C231(1.06)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C223(1.12); C231(1.12)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C223(1.26); C231(1.26)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C223(1.43); C231(1.43)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C223(1.96); C231(1.96)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C226(2.29); C231(2.29); C322(0.93); C325(0.93)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C226(1.47); C231(1.47); C322(1.06); C325(1.06)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C226(1.26); C231(1.26); C322(1.00); C325(1.00)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C247(1.10); C258(1.10)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C226(1.79); C231(1.79); C322(1.11); C325(1.11)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C226(1.40); C231(1.40); C322(1.31); C325(1.31)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C226(1.80); C231(1.80); C322(1.18); C325(1.18)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C226(2.23); C231(2.23); C322(0.96); C325(0.96)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C226(1.36); C231(1.36); C322(0.99); C325(0.99)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C226(1.26); C231(1.26)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C226(1.52); C231(1.52)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C226(1.03); C231(1.03)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C226(1.21); C231(1.21)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C226(1.71); C231(1.71)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C247(0.95); C258(0.95)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C226(1.06); C231(1.06)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C226(1.11); C231(1.11)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C226(1.19); C231(1.19)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C226(1.61); C231(1.61)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C226(0.93); C231(0.93)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C226(1.23); C231(1.23)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C226(1.00); C231(1.00)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C226(0.89); C231(0.89)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C226(1.02); C231(1.02)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C226(1.04); C231(1.04)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C247(0.86); C258(0.86)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C226(1.07); C231(1.07)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C226(1.10); C231(1.10)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C226(1.77); C231(1.77)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C226(1.00); C231(1.00)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C226(1.46); C231(1.46)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C226(1.08); C231(1.08)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C226(0.93); C231(0.93)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C226(1.00); C231(1.00)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C226(1.48); C231(1.48)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C226(1.05); C231(1.05)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C247(0.86); C258(0.86)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C226(1.78); C231(1.78)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C226(1.32); C231(1.32)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C226(0.96); C231(0.96)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C226(1.68); C231(1.68)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C226(1.48); C231(1.48)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C226(1.24); C231(1.24)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C226(1.12); C231(1.12)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C315(0.91)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C315(0.93)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C315(1.03)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C226(0.80); C231(0.80); C325(1.01)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C315(1.11)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C315(1.42)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C315(0.89)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C315(1.12)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C315(1.01)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C315(1.09)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C315(1.11)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C315(0.76)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C258(0.55); C223(0.77); C231(0.77)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C258(0.66); C223(0.78); C231(0.78)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C226(0.71); C231(0.71); C325(1.12)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C223(0.65); C231(0.65); C258(0.92)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C223(0.61); C231(0.61); C258(0.61)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C223(0.79); C231(0.79); C258(0.88)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C223(0.70); C231(0.70); C258(0.77)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C258(0.59); C223(0.82); C231(0.82)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C223(0.76); C231(0.76); C258(0.80)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C258(0.59); C223(0.68); C231(0.68)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C258(0.53); C223(0.69); C231(0.69)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C258(0.62); C223(0.65); C231(0.65)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C223(0.65); C231(0.65); C258(0.76)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C226(0.82); C231(0.82); C325(1.07)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C258(0.44); C223(0.74); C231(0.74)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C258(0.56); C223(0.66); C231(0.66)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C258(0.50); C223(0.53); C231(0.53)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C322(0.76); C325(0.76)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C322(0.88); C325(0.88)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C322(0.79); C325(0.79)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C322(0.77); C325(0.77)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C322(0.98); C325(0.98)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C322(0.81); C325(0.81)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C322(0.79); C325(0.79)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C322(0.93); C325(0.93)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C322(0.80); C325(0.80)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C322(0.76); C325(0.76)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C322(0.83); C325(0.83)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C322(0.85); C325(0.85)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C322(1.13); C325(1.13)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C322(0.75); C325(0.75)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C322(0.73); C325(0.73)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C315(0.43); C322(0.66); C325(0.66)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C315(0.69); C322(0.70); C325(0.70)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C226(1.03); C231(1.03); C325(1.09)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C226(1.18); C231(1.18); C325(1.55)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C226(1.04); C231(1.04); C325(1.23)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C322(1.21); C325(1.21); C247(1.19); C255(1.19)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C223(0.76); C231(0.76); C247(0.98); C258(0.98)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C247(1.03); C258(1.03); C223(1.15); C231(1.15)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C247(0.86); C258(0.86)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C226(1.11); C231(1.11); C325(1.38)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C226(1.79); C231(1.79); C325(1.34)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C226(1.05); C231(1.05); C325(1.13)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C226(1.16); C231(1.16); C325(1.12)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C226(1.11); C231(1.11); C322(0.99); C325(0.99)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C226(1.14); C231(1.14); C322(1.03); C325(1.03)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C226(1.00); C231(1.00); C322(1.18); C325(1.18)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C226(1.52); C231(1.52); C322(0.95); C325(0.95)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C226(1.14); C231(1.14); C322(1.00); C325(1.00)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C223(1.13); C231(1.13); C247(1.23); C258(1.23)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C226(1.25); C231(1.25); C322(0.75); C325(0.75)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C226(1.28); C231(1.28); C322(0.86); C325(0.86)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C226(1.18); C231(1.18)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C226(1.35); C231(1.35)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C226(1.77); C231(1.77)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C226(1.32); C231(1.32)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C226(1.37); C231(1.37)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C226(1.15); C231(1.15)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C226(1.16); C231(1.16)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C226(1.13); C231(1.13)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C223(1.23); C231(1.23); C247(1.27); C258(1.27)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C226(1.09); C231(1.09)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C226(0.97); C231(0.97)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C226(1.04); C231(1.04)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C226(1.60); C231(1.60)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C226(1.25); C231(1.25)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C315(1.05)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C315(1.02)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C315(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C315(0.94)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C247(1.21); C258(1.21); C223(1.65); C231(1.65)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C223(0.89); C231(0.89); C247(0.99); C258(0.99)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C223(1.03); C231(1.03); C247(1.19); C258(1.19)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C247(0.97); C258(0.97); C223(1.01); C231(1.01)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C247(0.80); C258(0.80); C223(1.04); C231(1.04)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C247(1.32); C258(1.32); C223(1.57); C231(1.57)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C247(1.04); C258(1.04); C223(1.24); C231(1.24)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C247(0.88); C258(0.88); C223(1.23); C231(1.23)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C247(0.87); C258(0.87); C223(1.17); C231(1.17)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C247(1.00); C258(1.00); C223(1.05); C231(1.05)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C223(1.13); C231(1.13); C247(1.14); C258(1.14)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C247(0.98); C258(0.98); C223(1.35); C231(1.35)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C247(1.15); C258(1.15); C223(1.22); C231(1.22)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C223(0.88); C231(0.88); C247(0.86); C258(0.86)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C223(1.21); C231(1.21); C247(0.95); C258(0.95)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C223(0.81); C231(0.81); C247(0.84); C258(0.84)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C223(1.21); C231(1.21); C247(0.93); C258(0.93)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C223(1.05); C231(1.05); C247(0.93); C258(0.93)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C223(1.20); C231(1.20); C247(0.91); C258(0.91)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C223(1.14); C231(1.14); C247(1.02); C258(1.02)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C223(1.13); C231(1.13); C315(0.92)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C223(1.32); C231(1.32); C315(1.07)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C223(1.57); C231(1.57); C315(0.94)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C223(1.50); C231(1.50); C315(0.95)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C223(2.26); C231(2.26); C315(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C223(1.72); C231(1.72); C315(0.86)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C223(1.48); C231(1.48); C315(0.99)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C223(1.29); C231(1.29); C315(1.16)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C223(1.03); C231(1.03); C247(0.98); C258(0.98)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C223(1.59); C231(1.59); C315(0.88)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C223(1.43); C231(1.43); C315(1.03)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C223(1.41); C231(1.41); C315(1.04)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C223(2.12); C231(2.12); C315(1.09)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C223(1.49); C231(1.49); C315(1.00)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C223(1.76); C231(1.76); C315(0.93)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C315(0.89)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C315(0.83)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C315(1.02)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C315(0.88)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C223(1.08); C231(1.08); C247(1.14); C258(1.14)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C315(0.91)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C315(0.92)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C315(0.99)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C315(0.94)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C315(1.00)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C315(0.93)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C315(0.87)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C315(0.82)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C315(0.92)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C315(0.96)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C223(0.92); C231(0.92); C247(0.98); C258(0.98)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C315(0.84)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C226(0.89); C231(0.89); C255(0.80); C258(0.80)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C226(1.10); C231(1.10); C255(0.56); C258(0.56)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C226(0.92); C231(0.92); C255(0.36); C258(0.36)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C226(0.89); C231(0.89); C255(0.71); C258(0.71)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C226(1.00); C231(1.00); C255(0.45); C258(0.45)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C226(1.28); C231(1.28); C255(0.55); C258(0.55)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C226(1.07); C231(1.07); C255(0.65); C258(0.65)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C226(1.40); C231(1.40); C255(0.34); C258(0.34)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C226(1.05); C231(1.05); C255(0.55); C258(0.55)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C223(0.94); C231(0.94); C247(0.99); C258(0.99)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C226(1.10); C231(1.10); C255(0.55); C258(0.55)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C226(1.27); C231(1.27); C255(0.44); C258(0.44)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C226(1.01); C231(1.01); C255(0.55); C258(0.55)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C226(1.55); C231(1.55); C255(0.67); C258(0.67)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C226(1.74); C231(1.74); C255(0.19); C258(0.19)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C247(1.16); C258(1.16); C322(1.05); C325(1.05)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C247(0.99); C258(0.99); C322(0.75); C325(0.75)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C247(1.08); C258(1.08); C322(1.08); C325(1.08)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C247(1.18); C258(1.18); C322(0.95); C325(0.95)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C223(1.13); C231(1.13); C247(1.14); C258(1.14)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C247(1.34); C258(1.34); C322(1.19); C325(1.19)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C247(0.85); C258(0.85); C322(0.99); C325(0.99)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C247(1.08); C258(1.08); C322(0.98); C325(0.98)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C247(1.05); C258(1.05); C322(0.91); C325(0.91)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C247(1.20); C258(1.20); C322(0.97); C325(0.97)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C247(0.96); C258(0.96); C322(0.87); C325(0.87)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C247(1.07); C258(1.07); C322(1.10); C325(1.10)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C247(1.10); C258(1.10); C322(1.01); C325(1.01)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C247(1.22); C258(1.22); C322(1.00); C325(1.00)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C247(1.20); C258(1.20); C322(1.14); C325(1.14)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C223(1.03); C231(1.03); C247(1.06); C258(1.06)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C247(0.79); C258(0.79); C322(0.70); C325(0.70)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C247(0.99); C258(0.99)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C247(0.82); C258(0.82)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C247(0.86); C258(0.86)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C247(0.85); C258(0.85)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C247(0.84); C258(0.84)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C247(0.97); C258(0.97)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C247(0.94); C258(0.94)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C247(0.84); C258(0.84)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C247(0.98); C258(0.98)  LDD0811  [3]
 LDCM0634  CY-0357 Hep-G2 C732(0.98)  LDD2228  [1]
 LDCM0468  Fragment33 HEK-293T C226(1.40); C231(1.40); C255(0.35); C258(0.35)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C223(2.33); C231(2.33); C315(0.90)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C223(1.68); C231(1.68); C226(1.68)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C223(2.85); C231(2.85); C226(2.85)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C223(2.08); C231(2.08); C226(2.08)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C322(1.21); C325(1.21); C247(1.19); C255(1.19)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Caspase-6 (CASP6) Peptidase C14A family P55212
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Melanoma-associated antigen 11 (MAGEA11) . P43364
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.