Details of the Target

General Information of Target

Target ID LDTP09330
Target Name Pumilio homolog 2 (PUM2)
Gene Name PUM2
Gene ID 23369
Synonyms
KIAA0235; PUMH2; Pumilio homolog 2; Pumilio-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQP
IMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRD
AETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYP
GNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSA
GLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLA
FGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAA
AAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSS
SLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSG
RYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFP
NLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVI
QKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAE
QTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASN
VVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKII
MHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level.
Uniprot ID
Q8TB72
Ensemble ID
ENST00000338086.9
HGNC ID
HGNC:14958

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y662(8.50)  LDD0259  [1]
ONAyne
 Probe Info  		K747(0.41)  LDD0274  [2]
STPyne
 Probe Info  		K747(0.68)  LDD0277  [2]
m-APA
 Probe Info  		11.75  LDD0403  [3]
AHL-Pu-1
 Probe Info  		C169(2.28)  LDD0169  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
DBIA
 Probe Info  		C813(0.45)  LDD0533  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C813(0.00); C169(0.00); C887(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C813(0.00); C169(0.00); C887(0.00); C982(0.00)  LDD0037  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		C169(0.00); C813(0.00)  LDD2156  [10]
NHS
 Probe Info  		N.A.  LDD0010  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
W1
 Probe Info  		N.A.  LDD0236  [11]
NAIA_5
 Probe Info  		C813(0.00); C887(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C169(2.28)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C887(0.98); C813(1.02); C983(1.06)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C813(1.35)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C813(0.45)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C813(0.53)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C813(0.65)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C813(0.56)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C813(0.57)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C813(0.52)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C813(0.46)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C813(0.46)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C813(0.48)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C813(0.67)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C813(1.15)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C813(0.50)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C813(0.56)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C813(0.48)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C813(0.75)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C813(1.07)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C813(1.05)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C813(0.81)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C813(0.70)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C813(0.85)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C813(0.82)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C813(1.46)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C813(0.78)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C813(0.88)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C813(0.90)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C813(0.67)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C813(0.74)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C813(0.86)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C813(1.05)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C813(1.03)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C813(2.89)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C813(1.17)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C813(1.00)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C813(1.50)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C813(0.93)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C813(1.13)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C813(1.44)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C813(0.97)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C813(1.11)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C813(1.24)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C813(5.76)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C813(0.88)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C813(1.52)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C813(1.05)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C813(1.71)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C813(0.88)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C813(1.08)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C813(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C813(1.35)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C813(1.15)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C813(1.20)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C813(1.16)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C813(1.12)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C813(1.36)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C813(1.10)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C813(0.89)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C813(1.32)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C813(1.03)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C813(1.20)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C813(1.01)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C813(1.24)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C813(1.15)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C813(1.55)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C813(1.21)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C813(1.24)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C887(1.04); C813(1.01); C169(0.98); C983(1.11)  LDD1518  [14]
 LDCM0280  AC20 HCT 116 C813(1.46)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C813(1.10)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C813(1.16)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C813(1.26)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C813(1.53)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C813(1.09)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C813(0.71)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C813(0.88)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C813(0.78)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C813(1.17)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C887(0.94); C813(1.27); C983(1.00)  LDD1529  [14]
 LDCM0291  AC30 HCT 116 C813(0.99)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C813(0.82)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C813(0.77)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C813(0.92)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C813(1.30)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C813(0.71)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C813(0.55)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C813(0.79)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C813(1.15)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C813(0.55)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C887(1.04); C983(0.99)  LDD1540  [14]
 LDCM0302  AC40 HCT 116 C813(0.87)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C813(0.71)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C813(0.84)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C813(0.76)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C813(0.61)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C813(0.66)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C813(1.49)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C813(0.67)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C813(0.77)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C813(1.33)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C887(0.84); C169(0.76); C983(1.07)  LDD1551  [14]
 LDCM0313  AC50 HCT 116 C813(0.89)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C813(1.29)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C813(1.02)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C813(1.28)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C813(0.99)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C813(0.86)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C813(1.20)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C813(0.91)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C813(0.85)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C813(0.84)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C813(1.80)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C813(1.21)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C813(0.85)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C813(0.88)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C813(0.96)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C813(0.90)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C813(0.98)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C813(0.74)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C813(1.06)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C813(1.08)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C813(1.19)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C813(1.39)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C813(1.00)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C813(1.32)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C813(1.12)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C813(1.50)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C813(1.61)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C813(1.19)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C813(0.97)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C813(1.14)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C813(1.04)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C813(0.98)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C813(1.31)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C813(1.07)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C813(1.19)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C813(1.15)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C813(0.48)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C813(0.69)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C813(0.52)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C813(0.38)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C813(0.48)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C813(0.59)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C813(0.45)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C813(0.43)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C813(0.47)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C813(0.40)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C813(0.63)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C813(0.59)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C813(0.47)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C813(1.00)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C813(0.35)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C813(0.33)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C813(0.55)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C813(1.98)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C813(2.19)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C813(2.24)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 11.75  LDD0403  [3]
 LDCM0367  CL1 HCT 116 C813(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C813(1.03)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C887(1.07); C813(1.06); C169(0.89); C983(0.96)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C813(1.55)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C813(1.47)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C813(1.42)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C813(1.69)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C813(1.08)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C813(1.04)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C813(1.14)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C813(1.32)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C813(1.01)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C813(0.86)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C813(0.90)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C813(1.31)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C813(0.81)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C813(0.96)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C813(1.13)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C813(1.03)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C813(0.84)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C813(0.68)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C813(0.59)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C813(0.82)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C813(0.85)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C813(0.44)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C813(0.63)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C813(0.85)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C813(1.21)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C813(0.90)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C813(1.00)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C813(1.11)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C813(1.40)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C813(1.06)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C813(1.09)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C813(1.22)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C813(0.77)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C813(1.00)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C813(1.07)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C813(1.18)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C813(0.92)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C813(1.17)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C813(0.98)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C813(1.02)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C813(1.42)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C813(1.62)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C813(0.98)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C813(1.09)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C813(1.08)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C813(1.01)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C813(1.15)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C813(1.06)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C813(1.49)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C813(1.32)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C813(1.06)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C813(1.15)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C813(1.65)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C813(1.32)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C813(1.90)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C813(1.07)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C813(1.33)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C813(1.02)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C813(0.99)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C813(0.93)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C813(0.97)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C813(1.00)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C813(1.58)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C813(1.47)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C813(1.49)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C813(0.74)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C813(0.73)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C813(0.80)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C813(0.98)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C813(0.92)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C813(0.99)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C813(0.87)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C813(0.78)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C813(1.34)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C813(1.74)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C813(0.89)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C813(1.23)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C813(1.14)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C813(1.24)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C813(1.09)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C813(0.66)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C813(1.14)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C887(1.01); C813(1.07); C983(1.08)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C887(1.12); C983(1.05)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C887(1.00); C813(1.11); C169(1.06); C983(1.09)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C887(1.12); C813(1.25); C169(1.05); C983(0.96)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C887(0.96); C813(1.15); C983(1.09)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C887(1.15); C813(1.11); C169(1.12); C983(0.97)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C887(1.11); C813(0.88); C983(0.99)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C887(1.11); C983(0.99)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C887(0.94); C169(0.88); C983(0.94)  LDD1664  [14]
 LDCM0462  CL7 HCT 116 C813(0.90)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C887(1.15); C813(0.90); C983(0.94)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C887(1.27); C983(0.94)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C887(1.17); C813(1.03); C169(1.29); C983(1.05)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C887(0.96); C813(1.02); C983(1.02)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C887(1.00); C983(1.01)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C813(1.29)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C813(1.01)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C813(1.28)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C813(1.06)  LDD1070  [6]
 LDCM0473  CL8 HCT 116 C813(1.01)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C813(1.39)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C813(1.28)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C813(1.10)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C813(1.08)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C813(1.45)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C813(1.27)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C813(1.40)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C813(1.15)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C813(1.08)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C813(1.17)  LDD1081  [6]
 LDCM0484  CL9 HCT 116 C813(1.31)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C813(1.22)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C887(1.01); C813(1.11); C983(1.08)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C887(0.96); C983(0.97)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C887(0.98); C169(0.77); C983(0.90)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C887(1.29); C813(0.82); C983(0.98)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C887(1.09); C983(0.75)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C887(0.94); C813(1.42); C169(1.15); C983(0.92)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C887(0.94); C813(1.29); C983(1.03)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C887(1.13); C983(0.95)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C887(0.94); C813(0.90); C169(0.70); C983(1.07)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C887(0.94); C813(0.92); C169(0.94); C983(1.07)  LDD1698  [14]
 LDCM0625  F8 Ramos C813(1.21)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C813(0.06)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C813(4.58)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C813(1.08)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C813(5.42)  LDD2193  [15]
 LDCM0580  Fragment21 Ramos C813(1.36)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C813(1.12)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C813(0.89)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C813(1.34)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C813(2.00)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C813(1.64)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C813(3.42)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C887(1.05); C813(1.12); C169(0.86); C983(1.08)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C813(1.23)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C813(3.61)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C813(1.43)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C813(1.52)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C813(1.05)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C813(7.18)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C169(1.16); C887(0.96); C813(0.91); C983(1.07)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C169(1.12); C887(0.93); C813(0.97); C983(1.06)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C965(2.01); C813(2.88)  LDD3310  [16]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C965(0.78)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C965(0.21)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deleted in azoospermia protein 1 (DAZ1) RRM DAZ family Q9NQZ3
Protein boule-like (BOLL) RRM DAZ family Q8N9W6

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.