Details of the Target

General Information of Target

Target ID LDTP09308
Target Name Centrosomal protein of 76 kDa (CEP76)
Gene Name CEP76
Gene ID 79959
Synonyms
C18orf9; Centrosomal protein of 76 kDa; Cep76
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQQHLSTEDLIKALRRRG
IIDDVMKELNFVTDSVEQELPSSPKQPICFDRQSTLKKTNIDPTRRYLYLQVLGGKAFLE
HLQEPEPLPGQVCSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHRESLGDGTRMA
DSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTSLTVELMGVGTESK
VSVGILNIKLEMYPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPS
HNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLDTPRQAARFVNVLGYERAPVIGGGGKQ
EQWCTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGAI
TFWESLTGHRYIHKPTNPDEPPVAEQPKPLYPYRTIGCVFNHQMFLGNCQPSDAVETCVF
DLNDESKWKPMSEEAIKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHR
KDLGLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHF
VYRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL
Target Bioclass
Other
Family
CEP76 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
Uniprot ID
Q8TAP6
Ensemble ID
ENST00000262127.7
HGNC ID
HGNC:25727

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.E6Ter .
COLO678 SNV: p.L366V .
HCT15 SNV: p.L508I .
MDAMB468 SNV: p.K85T .
NCIH2170 Insertion: p.A444CfsTer2 .
SW480 SNV: p.C624F .
TE1 SNV: p.R281L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C612(9.36)  LDD0204  [1]
IPM
 Probe Info  		C612(2.95)  LDD1702  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C612(0.00); C321(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C321(0.00); C414(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C618(0.94); C623(0.94); C624(0.94); C89(0.81)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C618(0.85); C623(0.85); C624(0.85); C89(1.10)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C89(1.14)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C89(1.54)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C89(1.07)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C89(1.43)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C89(1.21)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C89(1.24)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C89(1.39)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C89(1.38)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C89(0.78)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C89(0.96)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C618(0.71); C623(0.71); C624(0.71); C89(0.87)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C89(1.05)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C89(1.06)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C89(1.15)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C618(1.02); C623(1.02); C624(1.02); C89(0.94)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C618(0.83); C623(0.83); C624(1.04); C89(1.07)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C618(0.93); C623(0.93); C624(1.01); C89(1.11)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C618(1.14); C623(1.14); C624(1.13); C89(1.52)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C618(0.98); C623(0.98); C624(0.84); C89(1.02)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C618(1.09); C623(1.09); C624(1.13); C89(1.02)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C618(0.92); C623(0.92); C624(1.28); C89(1.01)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C618(0.83); C623(0.83); C624(0.83); C89(0.90)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C618(1.29); C623(1.29); C624(1.03); C89(1.11)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C618(0.84); C623(0.84); C624(0.92); C89(0.94)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C618(0.93); C623(0.93); C624(0.99); C89(1.10)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C618(1.10); C623(1.10); C624(0.85); C89(0.94)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C618(1.29); C623(1.29); C624(0.95); C89(0.83)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C618(1.08); C623(1.08); C624(1.11); C89(1.07)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C618(1.03); C623(1.03); C624(0.81); C89(1.28)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C618(1.00); C623(1.00); C624(0.93); C89(1.21)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C89(1.13)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C89(0.94)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C89(1.38)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C89(1.16)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C89(1.35)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C89(1.27)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C89(1.13)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C89(1.07)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C89(1.49)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C89(1.18)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C89(0.91)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C89(1.32)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C618(1.00); C623(1.00); C624(1.00); C89(0.82)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C89(1.50)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C89(1.45)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C89(1.27)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C89(0.93)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C89(0.91)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C89(1.02)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C89(0.81)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C89(1.15)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C89(1.27)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C89(0.82)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C618(0.82); C623(0.82); C624(0.82); C89(0.96)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C89(3.21)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C89(2.18)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C89(1.40)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C89(1.47)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C89(1.04)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C89(1.97)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C89(1.80)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C89(1.50)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C89(0.89)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C89(0.85)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C89(0.86)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C89(0.93); C618(0.94); C623(0.94); C624(0.94)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C89(1.14)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C89(0.99)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C89(1.11)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C89(1.25)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C89(0.93)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C624(0.61); C89(1.21)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C624(1.08); C89(1.32)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C624(1.17); C89(1.61)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C624(1.14); C89(1.48)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C624(1.00); C89(1.63)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C89(0.87); C618(0.90); C623(0.90); C624(0.90)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C624(1.10); C89(1.82)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C89(1.03); C624(1.09)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C624(1.32); C89(1.61)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C624(1.09); C89(1.14)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C624(1.00); C89(1.23)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C89(0.88)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C89(1.00)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C89(1.06)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C89(1.03)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C89(1.12)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C89(0.61); C618(0.84); C623(0.84); C624(0.84)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C89(1.05)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C89(0.97)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C89(1.08)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C89(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C89(1.04)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C89(0.99)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C89(1.10)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C89(1.13)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C89(1.19)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C89(1.37)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C89(0.66); C618(0.86); C623(0.86); C624(0.86)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C89(1.38)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C89(1.06)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C89(1.22)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C89(1.32)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C89(1.18)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C89(1.35)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C89(1.65)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C624(0.65); C89(1.22)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C624(1.01); C89(1.32)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C624(0.81); C89(1.35)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C618(0.70); C623(0.70); C624(0.70); C89(1.21)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C89(1.16); C624(1.24)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C624(0.91); C89(1.26)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C624(0.89); C89(1.23)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C624(1.13); C89(1.14)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C624(1.02); C89(1.17)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C624(1.01); C89(1.37)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C624(1.09); C89(1.22)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C624(1.02); C89(1.58)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C89(0.77)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C89(0.68)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C618(0.71); C623(0.71); C624(0.71); C89(1.19)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C89(1.26)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C89(0.83)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C89(1.28)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C89(1.15)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C89(1.21)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C89(1.37)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C89(0.83)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C89(0.97)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C89(0.97)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C89(0.99)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C618(0.78); C623(0.78); C624(0.78); C89(1.18)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C89(0.70)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C89(0.91)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C89(1.06)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C618(0.69); C623(0.69); C624(0.69)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C618(0.77); C623(0.77); C624(0.77)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C618(0.75); C623(0.75); C624(0.75)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C618(0.85); C623(0.85); C624(0.85)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C618(1.01); C623(1.01); C624(1.01)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C618(0.81); C623(0.81); C624(0.81)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C618(0.84); C623(0.84); C624(0.84)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C618(1.55); C623(1.55); C624(1.55)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C618(0.70); C623(0.70); C624(0.70)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C618(0.78); C623(0.78); C624(0.78)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C618(0.88); C623(0.88); C624(0.88)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C618(0.82); C623(0.82); C624(0.82)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C618(0.93); C623(0.93); C624(0.93)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C618(0.70); C623(0.70); C624(0.70)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C618(0.71); C623(0.71); C624(0.71)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C89(1.77)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C89(1.05)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C618(0.80); C623(0.80); C624(0.80); C89(0.85)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C618(0.71); C623(0.71); C624(0.71); C89(0.83)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C618(0.69); C623(0.69); C624(0.69); C89(1.41)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C154(0.93); C156(0.93); C618(1.26); C623(1.26)  LDD2171  [4]
 LDCM0102  BDHI 8 Jurkat C612(9.36)  LDD0204  [1]
 LDCM0367  CL1 HCT 116 C89(1.08)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C89(1.25)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C618(0.80); C623(0.80); C624(0.80); C89(0.89)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C618(0.98); C623(0.98); C624(0.98); C89(1.02)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C618(0.75); C623(0.75); C624(0.75); C89(1.21)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C89(1.03); C618(1.31); C623(1.31); C624(1.31)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C618(0.78); C623(0.78); C624(0.78); C89(1.05)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C89(1.08)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C89(0.88)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C89(0.94)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C89(1.03)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C89(1.21)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C89(1.61)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C89(1.06)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C89(1.49)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C624(0.94); C89(1.46)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C624(0.90); C89(1.68)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C624(0.97); C89(2.02)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C624(0.96); C89(1.64)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C624(0.92); C89(1.20)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C89(1.12)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C89(1.08)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C89(1.06)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C89(0.85)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C89(1.18)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C89(1.03)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C89(1.20)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C89(1.83)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C89(1.39)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C89(1.06); C624(1.17)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C624(1.46); C89(1.56)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C624(1.19); C89(1.29)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C624(0.86); C89(1.46)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C89(0.87)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C89(1.16)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C89(1.13)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C618(1.02); C623(1.02); C624(1.02)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C618(1.33); C623(1.33); C624(1.33)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C618(1.00); C623(1.00); C624(1.00)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C618(1.22); C623(1.22); C624(1.22)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C89(1.01)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C618(0.84); C623(0.84); C624(0.84)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C618(1.15); C623(1.15); C624(1.15)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C618(1.29); C623(1.29); C624(1.29)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C618(1.10); C623(1.10); C624(1.10)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C618(0.98); C623(0.98); C624(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C618(1.24); C623(1.24); C624(1.24)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C618(0.93); C623(0.93); C624(0.93)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C618(1.27); C623(1.27); C624(1.27)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C618(1.21); C623(1.21); C624(1.21)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C618(0.97); C623(0.97); C624(0.97)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C89(0.83)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C618(0.88); C623(0.88); C624(0.88)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C624(1.03); C89(1.22)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C624(1.00); C89(1.07)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C624(1.06); C89(1.18)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C624(1.29); C89(0.96)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C624(0.91); C89(1.49)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C624(1.02); C89(1.06)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C624(0.93); C89(1.10)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C624(1.05); C89(1.04)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C89(0.96)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C624(0.94); C89(1.83)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C624(1.08); C89(1.11)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C624(0.87); C89(1.05)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C624(1.08); C89(1.11)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C624(0.99); C89(1.36)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C624(1.12); C89(1.31)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C89(0.98)  LDD1640  [5]
 LDCM0438  CL48 HEK-293T C89(0.91); C624(1.35)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C612(0.82)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C89(0.79)  LDD0757  [4]
 LDCM0444  CL53 HEK-293T C89(1.15)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C89(1.04)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C89(1.13); C624(1.07)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C89(1.05)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C89(0.96)  LDD1652  [5]
 LDCM0451  CL6 HCT 116 C89(1.06)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C89(1.12); C624(1.16)  LDD1655  [5]
 LDCM0453  CL61 HCT 116 C618(1.06); C623(1.06); C624(1.06)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C618(0.90); C623(0.90); C624(0.95)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C618(1.06); C623(1.06); C624(0.98)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C618(1.23); C623(1.23); C624(1.14)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C618(1.15); C623(1.15); C624(1.06)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C618(0.98); C623(0.98); C624(0.87)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C618(0.85); C623(0.85); C624(0.83)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C618(1.22); C623(1.22); C624(1.01)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C618(1.47); C623(1.47); C624(1.33)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C89(0.87)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C618(1.11); C623(1.11); C624(1.12)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C618(1.12); C623(1.12); C624(1.00)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C618(1.18); C623(1.18); C624(1.07)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C618(1.12); C623(1.12); C624(1.02)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C618(0.91); C623(0.91); C624(1.00)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C89(1.12)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C89(1.14)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C89(1.07)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C89(1.12)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C89(1.44)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C89(1.16)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C89(1.15)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C89(0.97)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C89(1.16)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C89(1.32)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C89(1.19)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C89(0.99)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C89(1.17)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C89(1.22)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C89(1.27)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C89(0.86)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C89(1.54)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C618(0.86); C623(0.86); C624(0.86); C89(0.79)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C618(1.09); C623(1.09); C624(1.09); C89(0.78)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C618(0.82); C623(0.82); C624(0.82); C89(0.68)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C618(1.08); C623(1.08); C624(1.08); C89(0.94)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C618(1.39); C623(1.39); C624(1.39); C89(0.81)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C618(0.95); C623(0.95); C624(0.95); C89(0.72)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C618(0.92); C623(0.92); C624(0.92); C89(1.06)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C618(0.94); C623(0.94); C624(0.94); C89(1.27)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C618(0.84); C623(0.84); C624(0.84); C89(0.76)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C89(1.08); C515(0.97)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C612(2.95)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C618(0.99); C623(0.99); C624(1.06)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C624(0.90); C89(1.93)  LDD0744  [4]
 LDCM0022  KB02 A673 C89(2.83)  LDD2261  [6]
 LDCM0023  KB03 Jurkat C89(6.39)  LDD0209  [1]
 LDCM0024  KB05 PF-382 C89(2.57)  LDD3397  [6]
 LDCM0021  THZ1 HCT 116 C154(0.93); C156(0.93); C618(1.26); C623(1.26)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Helicase family P19447
Lysine-specific demethylase 4D (KDM4D) JHDM3 histone demethylase family Q6B0I6
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Casein kinase I isoform gamma-1 (CSNK1G1) CK1 Ser/Thr protein kinase family Q9HCP0
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
2-hydroxyacyl-CoA lyase 2 (ILVBL) TPP enzyme family A1L0T0
Tuftelin (TUFT1) Tuftelin family Q9NNX1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) . Q9NQ66
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) . O60733
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF128 (RNF128) . Q8TEB7
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) . Q9UBL3
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) Calcium channel beta subunit family P54284
Copper homeostasis protein cutC homolog (CUTC) CutC family Q9NTM9
Nuclear envelope pore membrane protein POM 121 (POM121) POM121 family Q96HA1
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Heat shock factor protein 2 (HSF2) HSF family Q03933
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 653 (ZNF653) Krueppel C2H2-type zinc-finger protein family Q96CK0
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Thyroid hormone receptor alpha (THRA) Nuclear hormone receptor family P10827
Sal-like protein 2 (SALL2) Sal C2H2-type zinc-finger protein family Q9Y467
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) . O75398
Transcription factor 19 (TCF19) . Q9Y242
Zinc finger and BTB domain-containing protein 4 (ZBTB4) . Q9P1Z0
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Beta-crystallin A4 (CRYBA4) Beta/gamma-crystallin family P53673
Protein Tob2 (TOB2) BTG family Q14106
Caveolae-associated protein 3 (CAVIN3) CAVIN family Q969G5
Centromere protein I (CENPI) CENP-I/CTF3 family Q92674
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Cilium assembly protein DZIP1L (DZIP1L) DZIP C2H2-type zinc-finger protein family Q8IYY4
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Ganglioside-induced differentiation-associated protein 2 (GDAP2) GDAP2 family Q9NXN4
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
p53 and DNA damage-regulated protein 1 (PDRG1) Prefoldin subunit beta family Q9NUG6
Ras-associating and dilute domain-containing protein (RADIL) RADIL family Q96JH8
Protein ripply3 (RIPPLY3) Ripply family P57055
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
Protein TALPID3 (KIAA0586) TALPID3 family Q9BVV6
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
U5 small nuclear ribonucleoprotein TSSC4 (TSSC4) TSSC4 family Q9Y5U2
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
Dematin (DMTN) Villin/gelsolin family Q08495
Calcium-binding protein 5 (CABP5) . Q9NP86
Coiled-coil domain-containing protein 92 (CCDC92) . Q53HC0
Corepressor interacting with RBPJ 1 (CIR1) . Q86X95
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Kelch domain-containing protein 4 (KLHDC4) . Q8TBB5
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Methyl-CpG-binding domain protein 3 (MBD3) . O95983
NHL repeat-containing protein 2 (NHLRC2) . Q8NBF2
RNA-binding protein 41 (RBM41) . Q96IZ5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Thioredoxin domain-containing protein 9 (TXNDC9) . O14530
Uncharacterized protein KIAA1143 (KIAA1143) . Q96AT1
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0
Zinc finger protein 185 (ZNF185) . O15231

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840