Details of the Target

General Information of Target

Target ID LDTP09163
Target Name Transcription factor SPT20 homolog (SUPT20H)
Gene Name SUPT20H
Gene ID 55578
Synonyms
C13orf19; FAM48A; Transcription factor SPT20 homolog; p38-interacting protein; p38IP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRN
VNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEEL
PPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSI
TSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKR
YSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNL
AIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGD
PLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCP
VKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNY
FTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRTTATQVMAN
SAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQ
AASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQLSQFTPQQPQQPTTCSPQQ
PGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRF
QLSSAFQQQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPTTPKF
Target Bioclass
Other
Family
SPT20 family
Subcellular location
Nucleus
Function
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy.
Uniprot ID
Q8NEM7
Ensemble ID
ENST00000350612.11
HGNC ID
HGNC:20596

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 SNV: p.M170T DBIA    Probe Info 
HCT15 SNV: p.S503R .
IGROV1 SNV: p.Q324P .
IM95 Deletion: p.N95TfsTer34 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.R26GfsTer32 DBIA    Probe Info 
JHH7 Deletion: p.E190KfsTer12 .
JURKAT Deletion: p.N95TfsTer34 .
MEC1 SNV: p.L124F; p.D126Y .
MEWO SNV: p.G276S DBIA    Probe Info 
NCIH2172 SNV: p.Q408Ter .
ONS76 SNV: p.P233S .
YSCCC SNV: p.E144Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y364(13.84)  LDD0257  [1]
DBIA
 Probe Info  		C138(1.86); C289(1.38)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		14.30  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C138(0.90); C140(1.27); C289(0.89)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C138(1.00); C140(1.10); C289(1.32)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C289(0.88)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C289(1.30)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C289(1.15)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C289(1.19)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C289(0.88)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C289(1.08)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C289(1.21)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C289(1.18)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C289(0.96)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C289(0.92)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C138(0.92); C140(1.00); C289(1.13)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C289(0.84)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C289(0.89)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C289(1.08)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C138(0.84); C140(0.84); C289(0.99)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C138(0.60); C140(0.60); C289(0.90)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C138(0.73); C140(0.73); C289(0.93)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C138(0.96); C140(0.96); C289(1.05)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C138(0.79); C140(0.79); C289(0.94)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C138(0.86); C140(0.86); C289(0.97)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C138(0.86); C140(0.86); C289(1.10)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C138(0.81); C140(0.91); C289(0.88)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C138(1.06); C140(1.06); C289(1.05)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C138(0.85); C140(0.85); C289(1.05)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C138(0.87); C140(0.87); C289(1.02)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C138(0.68); C140(0.68); C289(0.91)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C138(0.90); C140(0.90); C289(0.99)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C138(0.89); C140(0.89); C289(1.00)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C138(0.95); C140(0.95); C289(0.95)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C138(0.79); C140(0.79); C289(1.03)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C138(1.04); C140(1.04); C289(0.49)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C138(1.04); C140(1.04); C289(0.50)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C138(0.89); C140(0.89); C289(0.53)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C138(0.68); C140(0.68); C289(0.46)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C138(1.18); C140(1.18); C289(0.50)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C138(0.96); C140(0.96); C289(0.53)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C138(0.86); C140(0.86); C289(0.60)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C138(0.72); C140(0.72); C289(0.59)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C138(0.81); C140(0.81); C289(0.53)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C138(0.97); C140(0.97); C289(0.53)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C138(0.74); C140(0.74); C289(0.58)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C138(1.05); C140(1.05); C289(0.54)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C138(0.89); C140(0.93); C289(1.04)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C138(0.82); C140(0.82); C289(0.57)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C138(0.83); C140(0.83); C289(0.57)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C138(0.96); C140(0.96); C289(0.50)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C138(0.70); C289(1.31)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C138(0.79); C289(1.29)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C138(0.89); C289(1.22)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C138(0.80); C289(1.16)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C138(0.90); C289(1.22)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C138(0.81); C289(1.53)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C138(0.79); C289(1.44)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C140(1.03); C138(1.09); C289(1.15)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C138(0.92); C289(1.18)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C138(0.86); C289(1.49)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C138(0.87); C289(1.19)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C138(0.71); C289(1.81)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C138(0.75); C289(1.12)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C138(0.68); C289(1.13)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C138(0.80); C289(1.15)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C138(0.66); C289(1.68)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C289(1.03)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C289(1.16)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C289(1.04)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C289(0.98); C138(1.10); C140(1.49)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C289(1.05)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C289(1.32)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C289(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C289(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C289(0.89)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C255(0.79); C289(0.86); C138(1.12)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C289(0.96); C255(1.38); C138(1.38)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C289(1.04); C255(1.19); C138(1.23)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C255(1.05); C289(1.17); C138(1.74)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C289(0.80); C255(1.09); C138(1.81)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C289(0.92); C138(1.01); C140(1.42)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C289(0.94); C255(1.24); C138(1.97)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C289(0.91); C255(1.30); C138(1.35)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C255(1.16); C289(1.37); C138(2.02)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C255(0.93); C289(1.02); C138(1.31)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C255(0.54); C289(0.98); C138(1.48)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C289(0.80)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C289(0.80)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C289(1.00)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C289(0.93)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C289(0.81)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C138(0.83); C289(0.87); C140(1.08)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C289(1.16)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C289(0.98)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C289(0.76)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C289(0.91)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C289(0.97)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C289(1.07)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C138(0.65); C140(0.69); C289(0.65); C341(0.86)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C138(0.82); C140(0.72); C289(0.82); C341(1.20)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C138(0.67); C140(0.58); C289(0.67); C341(0.88)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C138(0.91); C140(0.64); C289(0.91); C341(0.85)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C289(0.90); C138(0.92); C140(1.16)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C138(0.59); C140(0.61); C289(0.59); C341(0.98)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C138(0.45); C140(0.47); C289(0.45); C341(0.80)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C138(0.44); C140(0.46); C289(0.44); C341(0.73)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C138(0.75); C140(0.73); C289(0.75); C341(0.96)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C138(0.49); C140(0.45); C289(0.49); C341(0.69)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C138(0.60); C140(0.63); C289(0.60); C341(0.89)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C138(0.64); C140(0.62); C289(0.64); C341(0.86)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C140(0.74); C138(0.77); C289(1.23)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C140(0.85); C138(0.90); C289(1.22)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C138(0.81); C140(0.88); C289(1.20)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C289(1.01); C140(1.02); C138(1.12)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C140(0.91); C138(0.96); C289(1.23)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C138(0.96); C140(0.99); C289(1.12)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C138(0.72); C140(0.74); C289(1.18)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C138(0.73); C140(0.76); C289(1.19)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C138(0.75); C140(0.84); C289(1.15)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C289(0.74); C138(0.94); C140(0.97)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C289(0.73); C138(0.95); C140(1.03)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C289(0.74); C138(0.82); C140(0.85)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C138(0.79); C289(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C138(0.94); C289(0.99)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C289(0.90); C138(1.08); C140(1.18)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C138(0.76); C289(1.15)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C138(0.85); C289(1.06)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C138(0.74); C289(1.13)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C138(0.90); C289(1.35)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C138(1.02); C289(1.29)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C138(1.07); C289(1.44)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C138(0.95); C289(1.17)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C138(0.92); C289(1.09)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C138(0.75); C289(1.02)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C138(0.98); C289(1.05)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C140(0.86); C138(0.92); C289(1.27)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C289(1.02); C138(1.19)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C138(0.89); C289(0.99)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C138(1.00); C289(1.65)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C138(0.65); C140(0.65); C289(1.35)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C138(0.66); C140(0.66); C289(1.22)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C138(0.77); C140(0.77); C289(1.23)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C138(0.74); C140(0.74); C289(1.18)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C138(1.14); C140(1.14); C289(1.22)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C138(1.05); C140(1.05); C289(1.27)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C138(0.70); C140(0.70); C289(1.24)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C138(0.87); C140(0.87); C289(1.35)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C138(0.69); C140(0.69); C289(1.15)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C138(0.60); C140(0.60); C289(1.33)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C138(0.80); C140(0.80); C289(0.95)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C138(0.88); C140(0.88); C289(1.23)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C138(0.96); C140(0.96); C289(1.28)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C138(0.72); C140(0.72); C289(1.05)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C138(0.82); C140(0.82); C289(1.27)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C289(1.27)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C289(1.04)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C138(0.93); C140(1.06); C289(1.25)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C138(0.87); C140(0.92); C289(1.08)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C138(1.09); C140(1.22); C289(1.43)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C255(1.04); C138(1.19); C140(1.19)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C138(1.25); C140(1.25); C255(1.50)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C138(0.76); C289(0.88); C140(0.99)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C289(1.15); C138(1.17); C140(1.32)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C289(0.80); C138(0.93); C140(1.07)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C138(0.92); C140(1.05); C289(1.11)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C138(0.95); C140(0.98); C289(1.17)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C289(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C289(1.20)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C289(1.23)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C289(1.16)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C289(1.15)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C138(0.90); C140(0.90); C255(1.27)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C289(0.98)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C289(1.19)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C289(0.87); C255(0.96); C138(1.27)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C255(0.79); C289(1.06); C138(1.69)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C255(0.67); C289(0.83); C138(1.95)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C255(0.91); C289(0.97); C138(1.79)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C255(0.71); C289(1.06); C138(1.28)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C289(1.38)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C289(0.89)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C289(0.82)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C138(0.59); C140(0.59); C255(1.77)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C289(1.18)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C138(0.60); C140(0.65); C289(0.60); C341(0.95)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C138(0.81); C140(0.59); C289(0.81); C341(0.84)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C138(0.68); C140(0.79); C289(0.68); C341(1.13)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C138(0.64); C140(0.65); C289(0.64); C341(0.87)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C140(0.97); C138(1.02); C289(1.04)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C289(1.00); C140(1.03); C138(1.11)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C289(0.94); C138(0.94); C140(0.96)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C140(0.81); C138(0.83); C289(1.23)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C138(0.99); C140(0.99); C255(1.15)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C138(1.26); C140(1.26); C255(1.57)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C138(1.23); C140(1.23); C255(1.34)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C255(0.85); C138(1.29); C140(1.29); C289(1.43)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C255(1.35)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C255(1.15)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C255(1.23)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C138(1.19); C140(1.19); C255(2.44)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C255(1.44)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C255(1.33)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C255(1.11)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C255(0.88)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C255(1.35)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C255(1.06)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C255(1.09)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C255(1.03)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C255(1.21)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C255(1.19)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C138(1.09); C140(1.09); C255(1.00)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C255(1.04)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C138(1.08); C140(0.95); C255(0.94)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C138(1.15); C140(1.21)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C138(1.54); C140(1.80)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C138(1.23); C140(1.07)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C138(0.98); C140(0.89)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C138(1.00); C140(0.95)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C138(1.13); C140(1.16)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C138(1.09); C140(1.23)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C138(1.06); C140(1.06); C255(1.12)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C138(1.65); C140(0.91)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C138(0.93); C140(0.89)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C138(1.06); C140(0.93)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C138(1.00); C140(0.87)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C138(1.02); C140(1.00)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C138(1.55); C140(0.98)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C138(0.92); C255(1.08)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C138(1.02); C255(1.12)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C138(1.48); C255(1.28)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C138(0.80); C255(1.04)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C138(0.90); C140(0.90); C255(1.03)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C138(0.86); C255(1.06)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C138(1.09); C255(1.10)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C138(0.98); C255(1.06)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C138(1.06); C255(1.03)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C138(1.17); C255(0.88)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C138(0.95); C255(0.95)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C138(0.74); C255(1.13)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C138(1.45); C255(1.01)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C138(0.92); C255(0.87)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C138(0.90); C255(0.92)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C138(1.25); C140(1.25); C255(1.46)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C138(0.94); C255(0.87)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C138(0.70); C140(0.70); C341(1.30)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C138(0.83); C140(0.83); C341(0.76)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C138(0.71); C140(0.71); C341(0.56)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C138(1.13); C140(1.13); C341(0.74)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C138(0.87); C140(0.87); C341(0.75)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C138(0.72); C140(0.72); C341(0.59)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C138(0.77); C140(0.77); C341(0.80)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C138(0.92); C140(0.92); C341(0.66)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C138(0.91); C140(0.91); C341(0.87)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C138(0.77); C140(0.77); C255(2.32)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C138(0.64); C140(0.64); C341(0.87)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C138(0.63); C140(0.63); C341(0.79)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C138(0.81); C140(0.81); C341(0.85)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C138(0.83); C140(0.83); C341(0.55)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C138(0.81); C140(0.81); C341(0.23)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C138(0.94)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C138(1.11)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C138(0.92)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C138(1.15)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C138(0.63); C140(0.63); C255(0.99)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C138(1.15)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C138(1.17)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C138(1.19)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C138(1.08)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C138(1.12)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C138(0.99)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C138(0.98)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C138(0.97)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C138(1.04)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C138(0.91)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C138(0.94); C140(0.94); C255(1.41)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C138(2.03)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C138(1.07); C140(1.16); C289(0.97)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C138(1.02); C140(1.06); C289(0.87)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C138(0.98); C140(1.37); C289(0.86)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C138(0.94); C140(1.13); C289(1.05)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C138(1.03); C140(1.26); C289(0.83)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C138(0.94); C140(1.10); C289(0.94)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C138(1.01); C140(1.35); C289(0.86)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C138(0.88); C140(1.02); C289(0.99)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C138(1.03); C140(1.36); C289(1.05)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C289(0.97); C138(0.99)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C138(0.79); C140(0.79); C341(0.67)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C138(1.65); C140(1.20)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C138(1.86); C289(1.38)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C138(4.55); C289(1.45)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C138(3.11); C289(0.91)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy-related protein 9A (ATG9A) ATG9 family Q7Z3C6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402