Details of the Target

General Information of Target

Target ID LDTP08616
Target Name Zinc finger CCCH domain-containing protein 3 (ZC3H3)
Gene Name ZC3H3
Gene ID 23144
Synonyms
KIAA0150; SMICL; ZC3HDC3; Zinc finger CCCH domain-containing protein 3; Smad-interacting CPSF-like factor
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRR
GYSSHHGPSWRKKYSLVNRPPGPSDPPADHAVRPLHGARGGQPPVPQQHVLERQVQLSQG
QNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTG
VALGRKLGSHSVASCAPQLLGDRRVDAGHTDQPVPSGSVGGPARPASGPRQAREASLVVT
CRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRP
AVGHSGLKPLSGETPLSAYKVKSRTKIIRRRSSTSLPGDKKSGTSPAATAKSHLSLRRRQ
ALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKG
YRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTGRLDPAGSCSRSLASRAVQRSLAIIR
QARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPD
FARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGPSDATARSRVSASHGPRKPSASQRPT
RQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAA
ACSNRLCKLPSFISLQSSPSPGAQPRVRAPRAPLTKDSGKPLHIKPRL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage.
Uniprot ID
Q8IXZ2
Ensemble ID
ENST00000262577.6
HGNC ID
HGNC:28972

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.S391del DBIA    Probe Info 
CCK81 Deletion: p.G101AfsTer102
SNV: p.N683S		 DBIA    Probe Info 
COLO792 Substitution: p.L760F DBIA    Probe Info 
COLO829 SNV: p.S879F DBIA    Probe Info 
HCT116 SNV: p.P199H DBIA    Probe Info 
HS839T Substitution: p.A438F DBIA    Probe Info 
ICC9 SNV: p.V721A DBIA    Probe Info 
IGR1 SNV: p.P779L DBIA    Probe Info 
JURKAT Deletion: p.K485RfsTer6 .
KP4 SNV: p.K428M DBIA    Probe Info 
LS180 SNV: p.C742Ter DBIA    Probe Info 
MEWO Substitution: p.P167S DBIA    Probe Info 
MFE319 Deletion: p.T182PfsTer21
SNV: p.P839H		 DBIA    Probe Info 
MOLT4 SNV: p.R302Q .
NCIH1155 SNV: p.G82R DBIA    Probe Info 
NUGC3 SNV: p.Q792P .
RH30 SNV: p.K709N DBIA    Probe Info 
RKO SNV: p.R789C DBIA    Probe Info 
SKNSH SNV: p.G635V .
SNGM SNV: p.C708Y DBIA    Probe Info 
SNU478 SNV: p.A807T DBIA    Probe Info 
TOV21G Deletion: p.G101AfsTer102
SNV: p.G785V		 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C301(1.04)  LDD2093  [2]
DBIA
 Probe Info  		C183(0.94); C192(0.94)  LDD0078  [3]
IA-alkyne
 Probe Info  		C643(0.00); C673(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C183(0.83); C192(0.83); C338(0.93); C603(0.80)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C183(0.85); C192(0.85); C338(2.05); C603(1.08)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C338(1.18); C603(0.94); C643(1.03); C729(1.11)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C338(1.09); C603(0.98); C643(1.28); C729(1.30)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C338(1.03); C603(1.04); C643(1.13); C729(1.18)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C338(1.50); C603(1.26); C643(1.46); C729(1.40)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C338(1.32); C603(1.14); C643(1.25); C729(1.11)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C338(1.27); C603(1.15); C643(1.29); C729(1.26)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C338(1.45); C603(1.32); C643(1.33); C729(1.28)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C338(1.48); C603(1.06); C643(1.41); C729(1.24)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C338(0.92); C603(0.67); C643(0.94); C729(1.26)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C338(0.83); C603(0.67); C643(0.89); C729(1.03)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C183(1.14); C192(1.14); C338(1.36); C603(1.07)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C338(0.93); C603(0.69); C643(1.14); C729(1.43)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C338(0.96); C603(0.67); C643(0.95); C729(1.43)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C338(1.24); C603(0.86); C643(1.32); C729(1.40)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C183(1.07); C192(1.07); C603(1.00); C729(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C183(1.05); C192(1.05); C603(1.15); C729(1.09)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C183(1.17); C192(1.17); C603(1.33); C729(1.09)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C183(1.10); C192(1.10); C603(1.26); C729(1.17)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C183(1.10); C192(1.10); C603(1.08); C729(1.11)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C183(0.96); C192(0.96); C603(1.01); C729(1.05)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C183(1.09); C192(1.09); C603(1.22); C729(0.94)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C183(0.80); C192(0.80); C338(1.35); C603(0.96)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C183(0.99); C192(0.99); C603(1.20); C729(1.07)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C183(0.88); C192(0.88); C603(0.94); C729(0.89)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C183(1.10); C192(1.10); C603(1.09); C729(1.15)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C183(1.09); C192(1.09); C603(0.99); C729(0.82)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C183(1.19); C192(1.19); C603(0.97); C729(1.04)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C183(1.05); C192(1.05); C603(1.12); C729(1.19)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C183(1.37); C192(1.37); C603(1.38); C729(1.05)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C183(1.29); C192(1.29); C603(1.30); C729(0.99)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C183(0.76); C192(0.76); C603(0.95)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C183(0.77); C192(0.77); C603(0.83)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C183(0.96); C192(0.96); C603(0.99)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C183(0.98); C192(0.98); C603(0.77)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C183(0.48); C192(0.48); C603(0.92)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C183(0.58); C192(0.58); C603(0.98)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C183(0.61); C192(0.61); C603(1.10)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C183(0.54); C192(0.54); C603(0.97)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C183(0.58); C192(0.58); C603(0.92)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C183(0.44); C192(0.44); C603(0.98)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C183(0.45); C192(0.45); C603(1.09)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C183(0.55); C192(0.55); C603(1.03)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C183(0.97); C192(0.97); C338(1.88); C603(0.88)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C183(0.60); C192(0.60); C603(1.15)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C183(0.50); C192(0.50); C603(1.02)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C183(0.44); C192(0.44); C603(0.87)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C729(0.94); C183(1.08); C192(1.08); C603(1.17)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C729(0.94); C603(1.21); C192(1.24); C183(1.31)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C729(0.89); C192(0.99); C183(1.03); C603(1.07)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C729(0.89); C192(0.93); C183(1.04); C603(1.14)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C729(0.95); C183(1.10); C192(1.15); C603(1.30)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C729(1.02); C183(1.29); C192(1.30); C603(1.47)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C729(1.01); C192(1.07); C183(1.13); C603(1.28)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C183(0.66); C192(0.66); C603(0.98); C338(1.58)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C729(0.89); C183(0.97); C192(0.98); C603(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C729(0.95); C603(1.14); C192(1.22); C183(1.22)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C729(1.04); C192(1.21); C603(1.22); C183(1.28)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C729(0.89); C192(1.60); C603(1.66); C183(1.77)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C183(1.51); C192(1.47); C338(1.74); C603(1.18)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C183(1.59); C192(1.45); C338(1.81); C603(1.13)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C183(1.24); C192(1.12); C338(1.33); C603(0.97)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C183(1.76); C192(1.73); C338(1.10); C603(1.03)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C183(0.18); C192(0.18); C603(1.11)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C183(0.26); C192(0.26); C603(1.35)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C183(0.18); C192(0.18); C603(1.10)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C338(0.74); C183(0.87); C192(0.87); C603(0.98)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C183(0.17); C192(0.17); C603(1.12)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C183(0.19); C192(0.19); C603(1.24)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C183(0.18); C192(0.18); C603(1.06)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C183(0.20); C192(0.20); C603(1.13)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C183(0.14); C192(0.14); C603(1.02)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C603(1.16)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C603(1.20)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C603(1.33)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C603(1.37)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C603(1.29)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C183(0.75); C192(0.75); C338(0.87); C603(1.00)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C603(1.21)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C603(1.09)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C603(1.27)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C603(1.49)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C603(1.52)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C603(1.07)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C603(1.18)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C603(1.08)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C603(1.23)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C603(1.13)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C183(0.62); C192(0.62); C603(0.95); C338(1.04)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C603(1.25)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C603(1.23)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C603(1.33)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C603(1.24)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C603(1.11)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C603(1.19)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C603(1.25)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C603(1.13)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C603(1.12)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C603(0.96)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C183(0.67); C192(0.67); C338(0.79); C603(1.04)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C603(0.99)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C603(0.93)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C603(1.26)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C603(1.26)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C603(0.87)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C603(1.47)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C603(1.62)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C183(0.71); C192(0.71); C603(1.28)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C183(1.00); C192(1.00); C603(1.33)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C183(0.82); C192(0.82); C603(1.30)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C183(1.05); C192(1.05); C603(1.12); C338(1.82)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C183(0.81); C192(0.81); C603(1.29)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C183(0.81); C192(0.81); C603(1.42)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C183(0.87); C192(0.87); C603(1.28)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C183(0.81); C192(0.81); C603(1.34)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C183(0.76); C192(0.76); C603(1.40)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C183(0.17); C192(0.17); C603(1.26)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C183(0.18); C192(0.18); C603(1.17)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C183(0.20); C192(0.20); C603(1.42)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C643(0.90); C183(1.03); C192(1.03); C603(1.21)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C643(0.83); C183(0.95); C192(0.95); C603(1.40)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C183(0.90); C192(0.90); C603(1.02); C338(1.38)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C643(0.84); C183(0.89); C192(0.89); C603(1.41)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C183(0.82); C192(0.82); C643(1.04); C603(1.10)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C183(1.26); C192(1.26); C643(1.29); C603(1.31)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C643(1.31); C183(1.48); C192(1.48); C603(1.88)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C183(1.14); C192(1.14); C643(1.35); C603(1.75)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C643(0.89); C183(1.71); C192(1.71); C603(2.01)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C183(0.95); C192(0.95); C643(1.05); C603(1.36)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C643(0.95); C183(1.11); C192(1.11); C603(1.36)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C643(0.86); C183(1.15); C192(1.15); C603(1.15)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C643(0.87); C183(1.13); C192(1.13); C603(1.21)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C183(0.81); C192(0.81); C603(1.08); C338(1.21)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C643(0.97); C603(1.37); C183(1.46); C192(1.46)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C643(0.90); C603(1.12); C183(1.33); C192(1.33)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C643(0.95); C183(1.17); C192(1.17); C603(2.14)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C603(1.19); C183(1.33); C192(1.33); C338(1.50)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C183(1.02); C192(1.02); C603(1.12); C338(1.46)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C183(0.79); C192(0.79); C338(1.12); C603(1.20)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C183(0.88); C192(0.88); C338(1.02); C603(1.29)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C338(0.96); C183(1.00); C192(1.00); C603(1.13)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C338(1.13); C603(1.22); C183(1.27); C192(1.27)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C603(1.17); C183(1.31); C192(1.31); C338(1.49)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C338(0.79); C183(1.18); C192(1.18); C603(1.22)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C603(1.08); C183(1.42); C192(1.42); C338(1.71)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C603(1.10); C183(1.39); C192(1.39); C338(1.51)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C338(1.11); C603(1.13); C183(1.16); C192(1.16)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C183(0.93); C192(0.93); C338(1.12); C603(1.20)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C603(1.27); C338(1.30); C183(1.33); C192(1.33)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C603(1.08); C338(1.09); C183(1.26); C192(1.26)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C603(1.34); C183(1.49); C192(1.49); C338(1.72)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C729(1.29); C603(1.54); C338(1.66); C643(2.08)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C643(0.88); C603(0.91); C338(0.94); C729(1.25)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C183(0.89); C192(0.89); C338(1.08); C603(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C603(0.98); C183(1.15); C192(1.15); C338(1.66)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C183(0.76); C192(0.76); C603(1.30); C338(2.31)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C183(0.94); C192(0.94)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C183(0.93); C192(0.93); C729(0.95); C603(1.22)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C603(0.91); C729(0.92); C183(0.95); C192(0.95)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C603(0.90); C183(0.92); C192(0.92); C338(1.11)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C603(1.01); C183(1.01); C192(1.01); C338(2.01)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C603(0.95); C183(1.23); C192(1.23); C338(1.26)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C183(0.90); C192(0.90); C603(1.04); C338(1.08)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C183(0.87); C192(0.87); C603(1.03); C338(1.84)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C183(0.20); C192(0.20); C603(1.20)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C183(0.16); C192(0.16); C603(1.39)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C183(0.18); C192(0.18); C603(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C183(0.14); C192(0.14); C603(1.45)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C183(0.22); C192(0.22); C603(1.30)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C183(0.77); C192(0.77); C729(1.08); C603(1.15)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C183(0.14); C192(0.14); C603(1.41)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C183(0.14); C192(0.14); C603(1.20)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C603(1.04)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C603(1.37)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C603(1.33)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C603(1.28)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C603(1.35)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C603(1.29)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C603(1.16)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C603(1.16)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C183(0.89); C192(0.89); C603(0.90); C729(1.10)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C603(1.22)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C603(1.26)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C603(1.10)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C603(2.08)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C603(1.42)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C183(0.84); C192(0.84); C603(1.05)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C183(0.60); C192(0.60); C603(1.21)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C183(1.08); C192(1.08); C603(1.17)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C183(0.78); C192(0.78); C603(1.28)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C183(0.79); C192(0.79); C603(0.86); C729(1.09)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C729(0.97); C183(0.98); C192(0.98); C603(1.00)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C183(0.86); C192(0.86); C729(0.89); C603(1.01)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C729(1.00); C183(1.02); C192(1.02); C603(1.06)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C729(0.90); C183(1.02); C192(1.02); C603(1.06)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C183(1.05); C192(1.05); C603(1.06); C729(1.47)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C183(0.87); C192(0.87); C603(1.02); C729(1.15)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C183(0.88); C192(0.88); C729(0.96); C603(1.01)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C183(0.89); C192(0.89); C603(1.04); C729(1.18)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C183(0.79); C192(0.79); C729(1.03); C603(1.45)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C183(0.57); C192(0.57); C729(1.37); C603(1.41)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C183(0.89); C192(0.89); C603(1.16); C729(1.39)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C183(0.80); C192(0.80); C603(1.20); C729(1.22)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C183(0.77); C192(0.77); C603(1.24); C729(1.11)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C183(1.06); C192(1.06); C603(1.03); C729(1.28)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C183(0.99); C192(0.99); C603(1.14); C729(0.98)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C183(0.95); C192(0.95); C603(1.27); C729(1.22)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C183(0.91); C192(0.91); C603(1.12); C729(1.11)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C183(1.12); C192(1.12); C603(0.84); C643(1.02)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C183(0.88); C192(0.88); C603(1.07); C729(1.12)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C603(1.11)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C183(0.93); C192(0.93); C603(1.10)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C183(1.30); C192(1.30); C603(1.50)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C183(0.83); C192(0.83); C603(1.14)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C183(0.87); C192(0.87); C603(1.07)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C183(0.64); C192(0.64); C603(1.02)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C183(0.69); C192(0.69); C603(1.10)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C183(0.93); C192(0.93); C603(1.09)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C183(0.91); C192(0.91); C603(1.25); C643(1.08)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C183(1.06); C192(1.06); C603(1.44)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C183(0.98); C192(0.98); C603(1.08)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C183(0.77); C192(0.77); C603(0.96)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C183(0.89); C192(0.89); C603(1.03)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C183(0.64); C192(0.64); C603(1.07)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C183(0.81); C192(0.81); C603(1.17)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C729(0.70)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C729(0.70)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C729(0.81)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C729(0.88)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C183(0.90); C192(0.90); C603(0.92); C643(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C729(0.70)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C729(0.73)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C729(0.78)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C729(0.74)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C729(0.72)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C729(0.73)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C729(0.72)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C729(0.74)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C729(0.82)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C729(0.82)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C183(1.09); C192(1.09); C603(0.96); C643(1.34)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C729(0.80)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C643(1.05)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C643(0.96)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C643(1.09)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C643(0.97)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C643(1.02)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C643(1.05)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C643(1.02)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C643(0.83)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C643(1.11)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C183(0.75); C192(0.75); C603(0.90); C643(1.19)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C643(1.04)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C643(0.99)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C643(0.99)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C643(1.04)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C643(1.03)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C183(0.61); C192(0.61); C603(1.14); C729(0.87)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C183(0.58); C192(0.58); C603(1.00); C729(0.74)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C183(0.80); C192(0.80); C603(1.28); C729(0.69)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C183(0.66); C192(0.66); C603(0.90); C729(0.77)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C183(1.19); C192(1.19); C603(1.68); C643(1.03)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C183(0.69); C192(0.69); C603(0.96); C729(0.67)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C183(0.54); C192(0.54); C603(0.91); C729(0.73)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C183(0.50); C192(0.50); C603(0.85); C729(0.68)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C183(0.68); C192(0.68); C603(1.01); C729(0.68)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C183(0.78); C192(0.78); C603(1.11); C729(0.93)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C183(0.74); C192(0.74); C603(1.02); C729(0.82)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C183(0.66); C192(0.66); C603(1.00); C729(0.69)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C183(0.54); C192(0.54); C603(0.88); C729(0.61)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C183(0.64); C192(0.64); C603(0.92); C729(0.76)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C183(0.58); C192(0.58); C603(1.07); C729(0.81)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C183(0.94); C192(0.94); C603(0.97); C643(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C183(0.56); C192(0.56); C603(1.57); C729(0.83)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C183(0.84); C192(0.84); C338(0.87); C603(0.92)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C183(0.91); C192(0.91); C338(0.95); C603(0.99)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C183(0.76); C192(0.76); C338(0.86); C603(0.98)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C183(0.95); C192(0.95); C338(0.84); C603(0.98)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C183(1.07); C192(1.07); C338(0.93); C603(1.05)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C183(0.89); C192(0.89); C338(1.04); C603(0.89)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C183(0.83); C192(0.83); C338(0.78); C603(1.05)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C183(0.80); C192(0.80); C338(0.84); C603(0.99)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C183(0.89); C192(0.89); C338(0.88); C603(0.88)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C338(1.03); C756(1.11); C603(1.10); C729(1.08)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C338(2.36)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C643(0.90)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C183(0.78); C192(0.78); C603(1.55)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C183(3.42); C192(3.42); C729(1.89)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C183(1.87); C192(1.87); C729(2.07)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C183(3.18); C192(3.18); C729(1.64)  LDD0082  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C301(1.04)  LDD2093  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C301(0.73)  LDD2119  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C301(0.59)  LDD2140  [2]
 LDCM0021  THZ1 HCT 116 C183(1.25); C192(1.25)  LDD2173  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402