Details of the Target

General Information of Target

Target ID LDTP08555
Target Name Cullin-9 (CUL9)
Gene Name CUL9
Gene ID 23113
Synonyms
H7AP1; KIAA0708; PARC; Cullin-9; CUL-9; UbcH7-associated protein 1; p53-associated parkin-like cytoplasmic protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSVLKCGEVGKVGVEEGKA
EHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPRDPGGLDEVAMGEMEADVQ
ALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEP
QIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHMDFDSRYTLLELFAETTSSEEHC
MAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSSPELGAGDQSSPCATREKSRGQREL
EFSMAVGNLISELVRSMGWARNLSEQGMSPPRPTRSIFQPYISGPSLLLPTIVTTPRRQG
WVFRQRSEFSSRSGYGEYVQQTLQPGMRVRMLDDYEEISAGDEGEFRQSNNGIPPVQVFW
QSTGRTYWVHWHMLEILGPEEATEDKASAAVEKGAGATVLGTAFPSWDWNPMDGLYPLPY
LQPEPQKNERVGYLTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLDETLGEKALGEISVS
VEMAESLLQVLSSRFEGSTLNDLLNSQIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKS
EASFSEEETESLKAKAEAPKTEAEPTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEA
ASEMARALRGPGPRSSLDQHVAAVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLV
RPDRSLREKLVKMLVELLTNQVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVC
MQEYKTSVLVQQAGLAALKMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATR
PGSESLLLTVPAAVILMLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRH
SGIAPRTEPMPTTRTILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPS
AELLLDLERVLCREGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVIT
RLLDFPEAMVLPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGA
KEILSKVLDKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRT
HQPINIPFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGST
GSHYITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASR
VILLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI
RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLV
QNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPPGPSP
EPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRAPDFVPR
YCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGG
LIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQ
IGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEE
EAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQN
HPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLS
PELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRSGEALWLIPPQAYLNVEKD
EGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEAWQKGPNPPGTLGHTVAGGVA
CTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMGPCRGQADVPFCGSQSETSKPSP
EAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQETLNLEPDVAQHLLAHSHWGAEQLLQ
SYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEY
LTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWC
TNPQGCDRILCRQGLGCGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMS
VEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCS
AMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLE
QARKVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLL
RADCLSTGMELLRRIQERLLAILQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGP
EAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD
Target Bioclass
Other
Family
Cullin family
Subcellular location
Cytoplasm
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5. Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function.
Uniprot ID
Q8IWT3
Ensemble ID
ENST00000252050.9
HGNC ID
HGNC:15982

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.E513Q DBIA    Probe Info 
CAL148 SNV: p.S865F DBIA    Probe Info 
CAL72 SNV: p.E844K .
COLO320 Insertion: p.T1985NfsTer52 .
DU145 Substitution: p.G958C .
EGI1 Substitution: p.Q1653E .
HCT116 SNV: p.I1083V .
HCT15 SNV: p.G885R; p.R1181Ter .
HT115 SNV: p.R554Ter; p.A1366T .
HT1197 Substitution: p.Q1653E DBIA    Probe Info 
IGROV1 SNV: p.S1116N; p.I1127N .
JURKAT SNV: p.A1882V .
MFE319 SNV: p.R1138I .
RL952 SNV: p.C2113Y .
SUPT1 SNV: p.E1265D .
SW403 SNV: p.L521I .
SW756 SNV: p.D1943Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1340(16.63)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1719(1.24); C1725(1.24); C2300(1.00)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1281(1.49); C1719(0.98); C1725(0.98)  LDD0532  [5]
 LDCM0216  AC100 PaTu 8988t C1281(0.73)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C1281(0.67)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C1281(0.93)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C1281(0.57)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C1281(0.70)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C1281(0.99)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C1281(0.54)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C1281(0.99)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C1281(0.70)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C1281(0.70)  LDD1104  [5]
 LDCM0226  AC11 HCT 116 C1281(0.97); C1719(1.05); C1725(1.05)  LDD0543  [5]
 LDCM0227  AC110 PaTu 8988t C1281(0.68)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C1281(0.51)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C1281(0.75)  LDD1108  [5]
 LDCM0230  AC113 HCT 116 C1281(0.94)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1281(1.24)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1281(1.03)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1281(0.88)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1281(1.12)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1281(1.57)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1281(1.15)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1281(1.26); C1719(0.94); C1725(0.94)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1281(0.82)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1281(1.31)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1281(1.58)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1281(1.28)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1281(1.19)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1281(1.25)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1281(1.29)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1281(1.23)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C2177(1.00); C2181(1.00)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C2177(1.02); C2181(1.02)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C2177(0.78); C2181(0.78)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C2177(0.83); C2181(0.83)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C2177(0.98); C2181(0.98)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C2177(0.80); C2181(0.80)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C2177(1.02); C2181(1.02)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C2177(0.85); C2181(0.85)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C2177(1.04); C2181(1.04)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C2177(0.85); C2181(0.85)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C2177(0.82); C2181(0.82)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C2177(0.83); C2181(0.83)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C1281(1.16); C1719(0.89); C1725(0.89)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C2177(0.85); C2181(0.85)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C2177(0.92); C2181(0.92)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C2177(0.82); C2181(0.82)  LDD0860  [5]
 LDCM0263  AC143 PaTu 8988t C1281(0.78)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C1281(1.48)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C1281(1.24)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C1281(1.38)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C1281(1.12)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C1281(1.14)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C1281(1.02)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C1719(0.99); C1725(0.99); C1281(1.29)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C1281(1.55)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C1281(1.39)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C1281(1.06)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C1281(0.96)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C1281(0.87)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C1281(1.55)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C1281(0.95)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C1281(1.11)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C1281(0.73)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1281(0.44)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1281(1.01)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1719(0.81); C1725(0.81); C2300(1.14)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1281(0.57)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1281(0.56)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1281(0.71)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1281(0.66)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1281(20.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1281(1.14)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1281(1.02)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1281(0.76)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1281(0.77)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1281(0.84)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C1719(1.04); C1725(1.04); C2300(1.14)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1281(0.61)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1281(0.75)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1281(0.75)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1281(0.92)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1281(0.76)  LDD0612  [5]
 LDCM0296  AC35 PaTu 8988t C265(0.96); C288(0.96)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C265(0.98); C288(0.98)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C265(1.08); C288(1.08)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C265(1.21); C288(1.21)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C265(1.10); C288(1.10)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C2300(1.03); C1719(1.07); C1725(1.07)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C265(1.06); C288(1.06)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C265(1.07); C288(1.07)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C265(1.29); C288(1.29)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C265(0.95); C288(0.95)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C265(0.94); C288(0.94)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C265(0.91); C288(0.91)  LDD1186  [5]
 LDCM0308  AC46 HCT 116 C1281(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1281(0.81)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C1281(2.41)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C1281(0.63)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1719(0.91); C1725(0.91); C2300(1.06)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C1281(0.76)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1281(1.14)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1281(1.15)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C1281(0.67)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C1281(0.73)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1281(0.69)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1281(1.00)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1281(0.76); C2300(0.99)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1281(0.78); C2300(0.97)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1281(0.71); C2300(1.04)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C1719(0.97); C1725(0.97); C1281(1.10)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1281(0.74); C2300(1.08)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C2300(0.96); C1281(1.11)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1281(0.78); C2300(0.88)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1281(0.76); C2300(0.99)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1281(0.75); C2300(1.07)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1281(0.95); C2300(0.99)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1281(1.03); C2300(1.08)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1281(0.78); C2300(0.96)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1719(0.52); C1725(0.52); C2300(1.13); C1281(1.67)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1719(0.68); C1725(0.68); C2300(0.87); C1281(2.07)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C1719(1.02); C1725(1.02); C1281(1.42)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1281(0.79); C1719(0.80); C1725(0.80); C2300(1.12)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1719(0.73); C1725(0.73); C2300(1.17); C1281(1.23)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C1719(0.80); C1725(0.80); C2300(0.84); C1281(1.81)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1719(0.82); C1725(0.82); C1281(1.04); C2300(1.20)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1719(0.82); C1725(0.82); C2300(1.17); C1281(1.45)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1719(0.75); C1725(0.75); C2300(1.17); C1281(1.43)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1719(0.78); C1725(0.78); C2300(1.08); C1281(1.16)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1719(0.66); C1725(0.66); C2300(1.13); C1281(2.42)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1719(0.71); C1725(0.71); C2300(0.94); C1281(2.95)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C1719(0.68); C1725(0.68); C1281(0.70); C2300(0.93)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1281(0.93); C1719(1.02); C1725(1.02)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1719(0.67); C1725(0.67); C2300(1.10); C1281(1.11)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1719(0.63); C1725(0.63); C1281(0.94); C2300(1.11)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1719(0.63); C1725(0.63); C2300(1.44); C1281(2.43)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1281(0.33)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1281(0.29)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1281(0.54)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1281(0.70)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1281(0.78)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1281(0.58)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1281(0.37)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1281(0.53)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1281(0.51)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1281(0.25)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1281(0.37)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1281(0.43)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1281(1.68)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1281(0.36)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1281(0.27)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C1281(1.01)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C1281(0.75)  LDD1245  [5]
 LDCM0248  AKOS034007472 HCT 116 C1281(2.45); C1719(0.94); C1725(0.94)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C1719(1.03); C1725(1.03); C1281(1.47)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C1281(0.85); C1719(1.01); C1725(1.01)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C1719(0.98); C1725(0.98); C1281(1.26)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1719(1.05); C1725(1.05); C1281(1.29)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C2300(1.01); C1719(1.12); C1725(1.12)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C1719(0.96); C1725(0.96); C1281(1.39)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1719(1.05); C1725(1.05); C1281(1.74)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1719(1.06); C1725(1.06); C1281(1.56)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C1281(0.99); C1719(0.99); C1725(0.99)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1281(0.57)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1281(0.38)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1281(0.45)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1281(0.27)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1281(0.60)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1281(0.74); C1719(1.01); C1725(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1281(0.68)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1281(0.50)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1281(1.04)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1281(0.71)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1281(1.22)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1281(0.91)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1281(1.02)  LDD0703  [5]
 LDCM0387  CL117 PaTu 8988t C265(0.97); C288(0.97)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C265(0.89); C288(0.89)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C265(1.03); C288(1.03)  LDD1268  [5]
 LDCM0390  CL12 HCT 116 C1281(0.94); C1719(1.08); C1725(1.08)  LDD0707  [5]
 LDCM0391  CL120 PaTu 8988t C265(1.21); C288(1.21)  LDD1270  [5]
 LDCM0392  CL121 HCT 116 C1281(0.41)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1281(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1281(0.75)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1281(0.72)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1281(0.96); C2300(1.11)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C2300(0.86); C1281(0.90)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1281(0.78); C2300(0.91)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1281(0.58); C2300(0.98)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C1719(0.76); C1725(0.76); C1281(0.85)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1281(1.66); C1719(1.67); C1725(1.67)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1719(1.11); C1725(1.11); C1281(1.13)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C1281(0.77)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1281(0.90)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1281(0.84)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1281(0.55)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C1719(0.83); C1725(0.83); C1281(1.19)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1281(0.59)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1281(0.55)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1281(0.56)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1281(0.66)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1281(0.58)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1281(0.60)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1281(0.80)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1281(0.66)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1281(0.61)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1281(0.65)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1281(0.81); C1719(0.83); C1725(0.83)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1281(0.65)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1719(1.05); C1725(1.05); C2300(1.09)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1719(0.90); C1725(0.90); C2300(1.19)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1719(0.94); C1725(0.94); C2300(0.85)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1719(1.07); C1725(1.07); C2300(1.47)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1719(1.12); C1725(1.12); C2300(1.46)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1719(1.17); C1725(1.17); C2300(1.40)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1719(1.12); C1725(1.12); C2300(1.09)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1719(1.02); C1725(1.02); C2300(1.25)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1281(1.95); C1719(0.99); C1725(0.99)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1719(1.07); C1725(1.07); C2300(1.09)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1719(0.91); C1725(0.91); C2300(1.17)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1719(1.12); C1725(1.12); C2300(1.49)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1719(1.00); C1725(1.00); C2300(1.17)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1719(0.99); C1725(0.99); C2300(1.14)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1719(0.94); C1725(0.94); C2300(1.17)  LDD0752  [5]
 LDCM0436  CL46 PaTu 8988t C1281(0.97)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C1281(0.93)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C1281(1.23)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C1281(0.88)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C1281(1.59); C1719(1.18); C1725(1.18)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C1281(0.88)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C1281(0.85)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C1281(0.89)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C1281(0.89)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C1281(1.11)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C1281(0.99)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C1281(1.06)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C1281(0.98)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C1281(0.90)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C1281(0.82)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C1281(1.23); C1719(0.92); C1725(0.92)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C1281(0.98)  LDD1331  [5]
 LDCM0453  CL61 HCT 116 C1281(1.01); C1719(1.02); C1725(1.02)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1281(0.97); C1719(0.98); C1725(0.98)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1281(1.66); C1719(1.05); C1725(1.05)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1281(1.49); C1719(1.11); C1725(1.11)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1281(1.15); C1719(0.96); C1725(0.96)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1281(1.04); C1719(1.03); C1725(1.03)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1281(1.57); C1719(0.90); C1725(0.90)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1281(0.92); C1719(0.95); C1725(0.95)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1281(1.27); C1719(0.87); C1725(0.87)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1281(0.72); C1719(1.06); C1725(1.06)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1281(1.05); C1719(0.89); C1725(0.89)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1281(0.38); C1719(0.97); C1725(0.97)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1281(0.28); C1719(1.03); C1725(1.03)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1281(1.23); C1719(0.97); C1725(0.97)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1281(0.47); C1719(0.89); C1725(0.89)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1719(0.93); C1725(0.93); C2300(1.05)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1719(1.02); C1725(1.02); C2300(0.99)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1719(0.99); C1725(0.99); C2300(1.12)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1719(1.06); C1725(1.06); C2300(1.44)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1281(0.86); C1719(1.09); C1725(1.09)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1719(0.81); C1725(0.81); C2300(1.19)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1719(1.14); C1725(1.14); C2300(1.25)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1719(1.17); C1725(1.17); C2300(1.48)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1719(1.15); C1725(1.15); C2300(1.38)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1719(1.24); C1725(1.24); C2300(1.38)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1719(1.15); C1725(1.15); C2300(1.34)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1719(1.05); C1725(1.05); C2300(1.08)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1719(1.23); C1725(1.23); C2300(1.23)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1719(1.19); C1725(1.19); C2300(1.35)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1719(1.23); C1725(1.23); C2300(1.74)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1281(0.71); C1719(0.72); C1725(0.72)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1719(1.28); C1725(1.28); C2300(1.17)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1719(0.87); C1725(0.87); C2300(1.07)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1719(1.02); C1725(1.02); C2300(0.82)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1719(1.12); C1725(1.12); C2300(1.04)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1719(1.10); C1725(1.10); C2300(0.95)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1719(1.09); C1725(1.09); C2300(0.85)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1719(1.20); C1725(1.20); C2300(0.97)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1719(1.22); C1725(1.22); C2300(1.03)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1719(1.17); C1725(1.17); C2300(0.87)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1719(1.10); C1725(1.10); C2300(0.92)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C1281(1.10); C1108(0.96); C1099(1.15)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C1281(0.78); C1719(0.94); C1725(0.94)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1719(1.10); C1725(1.10); C2300(1.48)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C1281(1.00); C1157(0.92); C76(0.98)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C1340(16.63)  LDD0209  [1]
 LDCM0024  KB05 G361 C2300(1.64)  LDD3311  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840