Details of the Target

General Information of Target

Target ID LDTP08121
Target Name E3 ubiquitin-protein ligase SH3RF1 (SH3RF1)
Gene Name SH3RF1
Gene ID 57630
Synonyms
KIAA1494; POSH; POSH1; RNF142; SH3MD2; E3 ubiquitin-protein ligase SH3RF1; EC 2.3.2.27; Plenty of SH3s; Protein POSH; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGV
EELPSNILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQ
PRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEG
MLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTK
KRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAA
AAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQD
GWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQER
PTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRASAPLACAA
AAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLL
KLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGP
VTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSY
PPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
Target Bioclass
Enzyme
Family
SH3RF family
Subcellular location
Cytoplasm, perinuclear region
Function
Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly.; (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
Uniprot ID
Q7Z6J0
Ensemble ID
ENST00000284637.14
HGNC ID
HGNC:17650

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.G75D DBIA    Probe Info 
HEC1B SNV: p.G75D .
ICC3 SNV: p.A676G DBIA    Probe Info 
IPC298 SNV: p.S304F DBIA    Probe Info 
JURKAT SNV: p.A805T .
MEWO SNV: p.S315F DBIA    Probe Info 
MONOMAC6 SNV: p.Q566K .
NALM6 SNV: p.R342Q .
SNU1196 SNV: p.I40V DBIA    Probe Info 
SUPT1 Deletion: p.K717RfsTer4 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K721(10.00); K729(0.72); K868(9.09)  LDD0277  [1]
m-APA
 Probe Info  		11.47  LDD0403  [2]
DBIA
 Probe Info  		C816(1.21); C831(1.21); C28(0.90); C33(0.90)  LDD0078  [3]
IA-alkyne
 Probe Info  		C36(0.00); C107(0.00)  LDD0162  [4]
NAIA_4
 Probe Info  		C107(0.00); C658(0.00); C773(0.00)  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
AOyne
 Probe Info  		13.20  LDD0443  [8]
NAIA_5
 Probe Info  		C93(0.00); C201(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C816(0.92); C831(0.92)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C816(1.33); C831(1.33); C107(1.10); C478(1.47)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C816(0.54); C831(0.54); C107(1.02)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C816(0.56); C831(0.56); C107(1.13)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C816(0.44); C831(0.44); C107(0.98)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C816(0.47); C831(0.47); C107(1.35)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C816(0.77); C831(0.77); C107(1.19)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C816(0.61); C831(0.61); C107(1.19)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C816(0.37); C831(0.37); C107(1.54)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C816(0.48); C831(0.49); C107(1.46)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C816(0.39); C831(0.48); C107(0.94)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C816(0.69); C831(0.31); C107(0.85)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C816(1.51); C831(1.51); C107(1.19); C478(1.31)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C816(0.43); C831(0.30); C107(0.92)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C816(0.48); C831(0.47); C107(1.07)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C816(0.54); C831(0.66); C107(1.31)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C816(1.18); C831(1.18); C107(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C816(0.96); C831(1.03); C107(0.89)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C816(0.93); C831(0.97); C107(0.91)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C816(1.45); C831(1.40); C107(1.03)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C816(0.88); C831(0.88); C107(0.80)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C816(0.98); C831(1.05); C107(0.89)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C816(1.03); C831(1.07); C107(0.83)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C816(1.03); C831(1.03); C107(1.05); C478(1.16)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C816(1.18); C831(1.16); C107(1.08)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C816(1.00); C831(0.96); C107(0.78)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C816(1.00); C831(0.94); C107(0.85)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C816(1.03); C831(0.94); C107(0.73)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C816(0.85); C831(0.86); C107(0.88)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C816(1.02); C831(1.06); C107(0.99)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C816(1.03); C831(0.98); C107(1.06)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C816(0.97); C831(1.00); C107(0.90)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C816(1.13); C831(1.13); C107(1.20); C478(1.31)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C816(1.09); C831(1.09); C107(0.87); C478(0.80)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C816(1.24); C831(1.24); C107(1.07); C478(1.04)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C816(1.29); C831(1.29); C107(0.89); C478(0.75)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C816(1.46); C831(1.46); C107(0.82); C478(0.99)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C816(1.17); C831(1.17); C107(0.90); C478(1.17)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C816(1.72); C831(1.72); C107(0.99); C478(1.12)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C816(1.21); C831(1.21); C107(0.98); C478(1.20)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C816(1.68); C831(1.68); C107(0.98); C478(1.12)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C816(1.47); C831(1.47); C107(0.83); C478(1.01)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C816(1.73); C831(1.73); C107(0.85); C478(1.30)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C816(2.00); C831(2.00); C107(0.91); C478(1.07)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C816(1.20); C831(1.20); C107(0.96); C478(1.40)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C816(1.97); C831(1.97); C107(0.95); C478(1.21)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C816(2.03); C831(2.03); C107(0.85); C478(1.24)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C816(1.49); C831(1.49); C107(0.72); C478(1.11)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C816(2.03); C831(2.03); C478(1.04); C107(1.17)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C831(0.59); C816(1.00); C478(1.26); C107(1.56)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C831(0.72); C107(1.17); C816(1.35); C478(1.35)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C831(0.82); C478(1.36); C816(1.61); C107(1.65)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C831(0.57); C816(1.20); C478(1.48); C107(1.52)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C831(0.63); C816(1.50); C478(1.64); C107(2.09)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C831(0.54); C816(0.96); C478(1.49); C107(1.72)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C107(1.23); C816(1.26); C831(1.26); C478(1.48)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C831(0.49); C816(1.16); C107(1.19); C478(1.35)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C831(0.74); C816(0.87); C107(1.06); C478(1.16)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C831(0.65); C816(1.12); C107(1.42); C478(1.45)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C831(0.78); C478(1.58); C816(1.95); C107(2.32)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C816(1.71); C831(0.75); C107(1.51); C478(1.30)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C816(1.40); C831(0.89); C107(1.65); C478(1.19)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C816(1.39); C831(0.91); C107(1.28); C478(0.99)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C816(1.07); C831(1.06); C107(1.20); C478(0.86)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C478(1.00); C107(1.01); C816(1.36); C831(1.36)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C478(1.14); C107(1.21); C816(2.15); C831(2.15)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C107(1.00); C478(1.02); C816(1.31); C831(1.31)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C816(0.79); C831(0.79)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C478(1.02); C107(1.19); C816(1.61); C831(1.61)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C478(1.05); C816(1.37); C831(1.37); C107(1.52)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C478(0.98); C107(1.20); C816(1.32); C831(1.32)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C478(0.98); C107(1.02); C816(1.79); C831(1.79)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C478(1.00); C107(1.11); C816(1.31); C831(1.31)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C478(1.13); C107(1.18); C816(1.18); C831(1.18)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C816(0.99); C831(0.99); C478(1.11); C107(1.13)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C816(1.10); C831(1.10); C107(1.22); C478(1.42)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C478(1.09); C816(1.17); C831(1.17); C107(1.55)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C478(1.27); C816(1.31); C831(1.31); C107(1.39)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C816(0.89); C831(0.89)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C107(1.12); C478(1.36); C816(1.39); C831(1.39)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C816(1.12); C831(1.12); C107(1.21); C478(1.44)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C816(1.32); C831(1.32); C478(1.41); C107(1.54)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C816(1.16); C831(1.16); C107(1.47); C478(1.55)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C816(1.13); C831(1.13); C478(1.44); C107(1.62)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C478(0.82); C107(0.97); C816(1.31); C831(1.31)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C478(0.86); C816(0.89); C831(0.89); C107(0.99)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C478(0.97); C107(1.01); C816(1.05); C831(1.05)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C478(1.00); C816(1.06); C831(1.06); C107(1.08)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C816(0.96); C831(0.96); C478(1.00); C107(1.26)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C816(1.40); C831(1.40)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C478(1.11); C816(1.49); C831(1.49); C107(1.51)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C816(0.89); C831(0.89); C478(0.98); C107(1.23)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C478(0.98); C816(1.15); C831(1.15); C107(1.21)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C478(1.03); C816(1.16); C831(1.16); C107(1.23)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C816(1.06); C831(1.06); C478(1.22); C107(1.34)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C816(1.08); C831(1.08); C478(1.16); C107(1.61)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C816(1.01); C831(1.01); C107(1.14)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C107(0.99); C816(1.17); C831(1.17)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C816(0.81); C831(0.81); C107(1.04)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C816(1.10); C831(1.10); C107(1.58)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C816(0.88); C831(0.88)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C816(1.55); C831(1.55); C107(1.56)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C816(1.05); C831(1.05); C107(1.09)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C816(0.89); C831(0.89); C107(1.15)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C816(1.16); C831(1.16); C107(1.31)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C816(1.14); C831(1.14); C107(1.28)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C816(1.28); C831(1.28); C107(1.39)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C107(1.73); C816(2.34); C831(2.34)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C816(1.00); C831(1.00); C107(1.25); C478(1.54)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C107(1.23); C478(1.50); C816(1.82); C831(1.82)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C107(1.40); C816(1.46); C831(1.46); C478(1.63)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C107(1.11); C478(1.30); C816(1.32); C831(1.32)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C107(1.30); C478(1.32); C816(1.47); C831(1.47)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C107(1.09); C816(1.10); C831(1.10); C478(1.60)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C816(1.03); C831(1.03); C107(1.25); C478(1.66)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C816(1.24); C831(1.24); C478(1.32); C107(1.57)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C816(1.20); C831(1.20); C107(1.26); C478(1.74)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C107(0.93); C816(1.27); C831(1.27); C478(2.10)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C107(0.90); C816(1.25); C831(1.25); C478(1.95)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C107(1.08); C816(1.44); C831(1.44); C478(2.00)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C816(0.72); C831(0.72); C107(1.02); C478(1.69)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C816(0.60); C831(0.60); C107(1.11); C478(1.24)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C107(0.96); C478(1.29); C816(1.31); C831(1.31)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C816(0.74); C831(0.74); C478(1.02); C107(1.11)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C816(0.82); C831(0.82); C107(0.89); C478(1.16)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C816(1.08); C831(1.08); C107(1.15); C478(1.25)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C816(0.80); C831(0.80); C107(1.55); C478(1.66)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C816(0.88); C831(0.88); C478(1.27); C107(1.33)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C816(0.82); C831(0.82); C107(1.67); C478(1.82)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C816(0.70); C831(0.70); C107(1.17); C478(1.52)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C816(0.44); C831(0.44); C107(1.23); C478(1.43)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C816(0.64); C831(0.64); C478(1.01); C107(1.08)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C107(1.03); C478(1.12); C816(1.14); C831(1.14)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C107(1.12); C816(1.17); C831(1.17); C478(1.21)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C816(0.53); C831(0.53); C478(1.17); C107(1.20)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C816(0.74); C831(0.74); C107(0.96); C478(1.01)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C816(0.68); C831(0.68); C478(1.35); C107(1.59)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C816(1.32); C831(1.32); C478(1.43); C107(1.78)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C478(1.26); C816(1.63); C831(1.63); C107(1.74)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C478(1.14); C816(1.20); C831(1.20); C107(1.39)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C478(1.25); C107(1.33); C816(1.40); C831(1.40)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C478(1.03); C107(1.17); C816(1.53); C831(1.53)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C478(1.18); C107(1.30); C816(1.83); C831(1.83)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C478(1.23); C107(1.46); C816(1.83); C831(1.83)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C107(0.93); C478(0.97); C816(1.22); C831(1.22)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C816(1.48); C831(1.48); C478(1.49); C107(1.98)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C478(1.45); C816(1.53); C831(1.53); C107(1.79)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C478(0.97); C816(1.33); C831(1.33); C107(1.43)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C478(1.04); C816(1.25); C831(1.25); C107(1.39)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C478(0.92); C107(1.31); C816(1.43); C831(1.43)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C478(1.18); C816(1.41); C831(1.41); C107(1.60)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C478(1.25); C107(1.71); C816(1.98); C831(1.98)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C816(0.31); C831(0.31); C107(1.84)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C816(0.38); C831(0.38); C107(1.06)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C816(1.09); C831(1.09); C107(1.06); C478(1.05)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C107(1.09); C816(1.10); C831(1.10); C478(1.21)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C107(1.61); C478(1.96); C816(2.12); C831(2.12)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C816(1.21); C831(1.21); C28(0.90); C33(0.90)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C773(20.00); C773(0.34)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C107(0.61); C478(0.76); C816(0.88); C831(0.88)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C107(0.44); C816(0.69); C831(0.69); C478(1.03)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C816(0.96); C831(0.96)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C107(1.18); C816(1.48); C831(1.48); C478(1.50)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C107(0.92); C816(1.19); C831(1.19); C478(1.43)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C107(1.03); C478(1.08); C816(1.33); C831(1.33)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C107(1.10); C478(1.22); C816(1.23); C831(1.23)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C107(1.03); C478(1.15); C816(1.23); C831(1.23)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C107(1.24); C478(1.24); C816(2.04); C831(2.04)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C107(1.01); C478(1.36); C816(1.80); C831(1.80)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C107(1.04); C478(1.35); C816(1.87); C831(1.87)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C478(1.13); C107(1.18); C816(2.06); C831(2.06)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C107(0.37); C478(1.19); C816(4.06); C831(4.06)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C478(1.11); C107(1.16); C816(2.11); C831(2.11)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C107(0.92); C478(1.02); C816(2.19); C831(2.19)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C107(0.98); C816(1.12); C831(1.12); C478(1.22)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C478(1.21); C816(1.44); C831(1.44); C107(1.50)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C478(1.09); C107(1.20); C816(1.32); C831(1.32)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C107(1.20); C478(1.28); C816(1.30); C831(1.30)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C107(1.10); C816(1.15); C831(1.15); C478(1.40)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C816(1.30); C831(1.30); C478(1.35); C107(1.52)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C816(0.88); C831(0.88); C107(0.89); C478(0.96)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C478(0.98); C816(1.04); C831(1.04); C107(1.09)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C107(0.51); C816(0.56); C831(0.56); C478(1.36)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C816(0.88); C831(0.88); C478(1.00); C107(1.03)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C107(1.06); C816(1.57); C831(1.57)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C816(1.02); C831(1.02); C107(1.05)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C107(1.10); C816(1.50); C831(1.50)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C107(1.28); C816(1.35); C831(1.35)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C107(0.94); C816(0.98); C831(0.98); C478(1.05)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C107(0.88); C478(1.22); C816(1.26); C831(1.26)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C107(1.01); C478(1.26); C816(1.57); C831(1.57)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C107(1.16); C816(1.25); C831(1.25); C478(1.48)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C107(0.39); C816(0.89); C831(0.89); C478(1.22)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C107(0.56); C816(0.80); C831(0.80); C478(1.14)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C107(0.34); C478(1.12); C816(1.25); C831(1.25)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C107(1.02)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C816(1.22)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C816(0.82)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C816(1.13)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C107(0.76); C478(0.85); C816(1.27); C831(1.27)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C816(0.90)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C816(0.91)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C816(0.94)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C816(0.82)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C816(0.75)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C816(1.02)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C816(0.97)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C816(0.77)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C816(0.83)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C816(0.86)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C816(0.63); C831(0.63); C107(0.58); C478(0.96)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C816(1.00)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C816(1.01); C831(1.01)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C816(0.85); C831(0.85); C107(1.17)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C816(1.66); C831(1.66); C107(1.02)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C816(1.56); C831(1.56); C107(0.91)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C816(1.82); C831(1.82); C107(1.02)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C816(1.86); C831(1.86); C107(0.88)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C816(1.65); C831(1.65); C107(0.94)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C816(1.26); C831(1.26); C107(1.11)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C816(2.01); C831(2.01); C107(0.66); C478(0.87)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C816(1.31); C831(1.31); C107(1.03)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C816(1.37); C831(1.37); C107(0.99)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C816(2.53); C831(2.53); C107(0.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C816(1.39); C831(1.39); C107(1.06)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C816(1.68); C831(1.68); C107(0.90)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C816(1.86); C831(1.86); C107(0.89)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C816(0.73); C831(0.73); C107(1.05); C478(0.75)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C816(1.34); C831(1.34); C107(0.86); C478(0.77)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C816(0.96); C831(0.96); C107(0.96); C478(0.74)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C816(0.86); C831(0.86); C107(0.95); C478(0.78)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C816(0.91); C831(0.91); C107(0.61); C478(0.94)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C816(1.10); C831(1.10); C107(1.06); C478(0.76)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C816(1.01); C831(1.01); C107(0.97); C478(0.78)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C816(0.99); C831(0.99); C107(1.16); C478(0.92)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C816(1.27); C831(1.27); C107(1.09); C478(0.78)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C816(0.77); C831(0.77); C107(0.96); C478(0.78)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C816(0.84); C831(0.84); C107(0.87); C478(0.80)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C816(0.93); C831(0.93); C107(0.86); C478(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C816(1.63); C831(1.63); C107(0.88); C478(0.76)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C816(0.89); C831(0.89); C107(0.95); C478(0.72)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C816(0.91); C831(0.91); C107(0.94); C478(0.84)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C816(0.94); C831(0.94); C107(0.60); C478(0.96)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C816(0.98); C831(0.98); C107(0.96); C478(0.88)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C816(0.78); C831(0.78); C107(0.94); C478(1.04)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C816(0.86); C831(0.86); C107(1.26); C478(0.89)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C816(0.93); C831(0.93); C107(1.06); C478(0.94)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C816(0.73); C831(0.73); C107(1.05); C478(0.90)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C816(0.83); C831(0.83); C107(0.88); C478(0.87)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C816(0.80); C831(0.80); C107(0.87); C478(0.94)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C816(0.97); C831(0.97); C107(0.93); C478(0.77)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C816(1.08); C831(1.08); C107(0.83); C478(0.79)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C816(0.89); C831(0.89); C107(1.07); C478(0.96)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C816(0.63); C831(0.63); C107(0.47); C478(1.33)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C816(0.95); C831(0.95); C107(0.98); C478(1.08)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C816(1.15); C831(1.15); C107(1.00); C478(1.03)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C816(1.15); C831(1.15); C107(0.95); C478(1.28)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C816(1.05); C831(1.05); C107(0.96); C478(0.56)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C816(0.86); C831(0.86); C107(0.98); C478(0.86)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C816(0.81); C831(0.81)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C816(1.29); C831(1.29)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C816(1.07); C831(1.07)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C816(1.38); C831(1.38)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C816(20.00); C831(20.00); C107(0.55); C478(1.47)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C816(1.13); C831(1.13)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C816(0.97); C831(0.97)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C816(1.41); C831(1.41)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C816(1.62); C831(1.62)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C816(1.30); C831(1.30)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C816(1.38); C831(1.38)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C816(1.06); C831(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C816(1.31); C831(1.31)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C816(1.42); C831(1.42)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C816(0.79); C831(0.79)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C816(0.94); C831(0.94); C107(0.78); C478(1.12)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C816(1.86); C831(1.86)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C816(1.03); C831(1.03)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C816(0.91); C831(0.91)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C816(0.87); C831(0.87)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C816(1.20); C831(1.20)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C816(1.59); C831(1.59)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C816(1.50); C831(1.50)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C816(1.46); C831(1.46)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C816(1.05); C831(1.05)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C816(1.03); C831(1.03)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C93(1.22); C658(1.15); C33(0.95)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C107(1.47)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C816(0.85); C831(0.85); C107(0.82); C478(1.01)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C816(3.35); C831(3.35); C107(1.00)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C816(17.87); C831(17.87)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C816(1.77); C831(1.77)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C816(6.42); C831(6.42)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C816(1.24); C831(1.24); C28(1.26); C33(1.26)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH2 (SIAH2) SINA (Seven in absentia) family O43255
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761