Details of the Target

General Information of Target

Target ID LDTP07994
Target Name [F-actin]-monooxygenase MICAL3 (MICAL3)
Gene Name MICAL3
Gene ID 57553
Synonyms
KIAA0819; KIAA1364; [F-actin]-monooxygenase MICAL3; EC 1.14.13.225; Molecule interacting with CasL protein 3; MICAL-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEERKHETMNPAHVLFDRFVQATTCKGTLKAFQELCDHLELKPKDYRSFYHKLKSKLNYW
KAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDA
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVN
VEFQGLIQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGK
LAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFV
MTAKKQSLLDKGVILHDYADTELLLSRENVDQEALLSYAREAADFSTQQQLPSLDFAINH
YGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMD
SAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNINVNFLR
PSQVRHLYDTGETKDIHLEMESLVNSRTTPKLTRNESVARSSKLLGWCQRQTDGYAGVNV
TDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKE
MASVGEPDKLSMVMYLTQFYEMFKDSLPSSDTLDLNAEEKAVLIASTRSPISFLSKLGQT
ISRKRSPKDKKEKDLDGAGKRRKTSQSEEEEAPRGHRGERPTLVSTLTDRRMDVAVGNQN
KVKYMATQLLAKFEENAPAQSIGIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAE
GKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKE
AKGPLQDGATTDANGRANAVASSTERTPGSGVNGLEEPSIAKRLRGTPERIELENYRLSL
RQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEEEEPRLPPSDLGG
VPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAG
NQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP
AEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSEDEEKL
PASPKHQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPE
PLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPI
CSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRR
SDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLL
KPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTL
GSQSFNTSDSAMLTPPSSPPPPPPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPRE
PAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPP
LAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMARQLSRM
QQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSG
GPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLW
KSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLS
SDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQ
VEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARE
LELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLR
EREEDKDLEAAMLSKGFSLNWS
Target Bioclass
Enzyme
Family
Mical family
Subcellular location
Cytoplasm
Function
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Uniprot ID
Q7RTP6
Ensemble ID
ENST00000383094.7
HGNC ID
HGNC:24694

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R1598Ter DBIA    Probe Info 
ABC1 SNV: p.G1657S DBIA    Probe Info 
CCK81 SNV: p.G397R .
FADU SNV: p.M612I DBIA    Probe Info 
HCT116 Deletion: p.Q1373RfsTer65; p.K1834RfsTer60 DBIA    Probe Info 
HCT15 SNV: p.R770W DBIA    Probe Info 
HEC1 SNV: p.P1721Q DBIA    Probe Info 
HS936T SNV: p.E1795Q DBIA    Probe Info 
HT SNV: p.S1700P DBIA    Probe Info 
KYSE180 Substitution: p.H1378_L1379delinsQF DBIA    Probe Info 
LS123 SNV: p.I1853L .
MEWO Substitution: p.T1668I DBIA    Probe Info 
MKN45 SNV: p.H1044Y DBIA    Probe Info 
NCIH1155 SNV: p.P1460S DBIA    Probe Info 
NCIH1666 SNV: p.R1850L DBIA    Probe Info 
NCIH2172 SNV: p.G222V DBIA    Probe Info 
NCIH23 Substitution: p.G1064L DBIA    Probe Info 
NCIH358 SNV: p.P1170L DBIA    Probe Info 
SKMEL2 SNV: p.P1199L DBIA    Probe Info 
SKNSH SNV: p.H1558P .
SNGM SNV: p.T1304N; p.E1843G .
SUPT1 Deletion: p.A1313LfsTer17 .
SW1783 SNV: p.A62T DBIA    Probe Info 
SW948 SNV: p.T532I DBIA    Probe Info 
TOV21G SNV: p.L1024I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.77  LDD0402  [1]
STPyne
 Probe Info  		K117(5.00); K974(0.73)  LDD0277  [2]
BTD
 Probe Info  		C25(0.70)  LDD2091  [3]
DBIA
 Probe Info  		C1760(14.24)  LDD0209  [4]
IPM
 Probe Info  		C25(1.56)  LDD1702  [3]
IA-alkyne
 Probe Info  		C554(0.00); C528(0.00); C1760(0.00); C25(0.00)  LDD0165  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
YN-1
 Probe Info  		N.A.  LDD0447  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C25(1.36)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C1760(0.88)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C1760(1.28)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C25(0.86); C97(0.87)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C25(0.94); C97(0.88)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C25(1.12); C97(0.98)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C25(0.82); C97(1.00)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C25(0.93); C97(0.83)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C25(0.96); C97(1.03)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C25(0.92); C97(0.84)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C25(0.78); C97(0.93)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C25(0.81); C97(0.87)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C25(0.88); C97(0.85)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C1760(1.25)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C25(0.87); C97(0.88)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C25(0.85); C97(0.84)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C25(0.75); C97(0.76)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C97(1.05)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C97(1.02)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C97(1.06)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C97(0.98)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C97(0.92)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C97(1.03)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C97(1.15)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C1760(1.25)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C97(0.92)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C97(0.92)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C97(0.99)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C97(0.99)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C97(1.01)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C97(0.95)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C97(0.99)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C97(1.02)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C89(0.92); C97(1.18)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C89(1.00); C97(1.17)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C89(1.04); C97(1.16)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C89(1.43); C97(1.33)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C89(1.18); C97(1.20)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C89(1.17); C97(1.18)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C89(0.94); C97(1.06)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C89(1.22); C97(1.23)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C89(1.35); C97(1.36)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C89(1.00); C97(1.13)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C89(0.88); C97(1.08)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C89(0.93); C97(1.16)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C1760(1.12)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C89(1.12); C97(1.20)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C89(1.36); C97(1.31)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C89(1.48); C97(1.42)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C97(0.82)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C97(0.64)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C97(0.72)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C97(0.73)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C97(0.84)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C97(0.85)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C97(0.80)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C1760(0.97)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C97(0.91)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C97(0.70)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C97(0.70)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C97(0.64)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C97(0.83)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C97(0.66)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C97(0.97)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C97(0.81)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C25(0.94); C1760(1.15)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C25(0.75); C1760(1.33)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C25(0.52); C1760(1.48)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C1760(0.85)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C25(0.88); C1760(1.21)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C25(0.73); C1760(1.50)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C1760(1.20); C25(1.21)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C25(0.56); C1760(1.24)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C25(0.82); C1760(1.23)  LDD0601  [9]
 LDCM0285  AC25 HEK-293T C1760(0.85); C554(0.91); C97(0.88)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C1760(0.62); C554(0.84); C97(0.81)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C1760(0.71); C554(0.69); C97(1.00)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C1760(0.57); C554(0.60); C97(0.95)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C1760(0.65); C554(0.67); C97(0.93)  LDD0887  [9]
 LDCM0290  AC3 HCT 116 C1760(0.81)  LDD0607  [9]
 LDCM0291  AC30 HEK-293T C1760(0.67); C554(0.73); C97(0.95)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C1760(0.79); C554(0.92); C97(1.02)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C1760(0.65); C554(0.76); C97(1.08)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C1760(0.71); C554(0.74); C97(0.91)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C1760(0.70); C554(0.97); C97(0.93)  LDD0893  [9]
 LDCM0296  AC35 HCT 116 C97(0.86); C25(0.99)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C25(0.86); C97(0.95)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C25(0.95); C97(1.24)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C25(0.91); C97(1.02)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C97(0.78); C25(1.20)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C1760(0.82)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C97(0.90); C25(0.90)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C25(0.95); C97(1.06)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C97(0.89); C25(0.94)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C25(0.85); C97(0.86)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C25(1.10); C97(1.31)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C25(1.07); C97(1.50)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C97(1.08); C1760(1.36)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C1760(0.90); C97(1.01)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C97(0.93); C1760(1.14)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C97(0.95); C1760(1.29)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C1760(0.73)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C97(0.91); C1760(1.23)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C97(1.08); C1760(1.54)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C1760(0.91); C97(1.05)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C1760(0.96); C97(1.04)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C1760(0.96); C97(1.05)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C97(0.99); C1760(1.03)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C97(0.86); C1760(1.39)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C25(1.02); C89(1.13); C97(1.13)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C25(0.86); C89(1.11); C97(1.11)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C89(0.95); C97(0.95); C25(1.12)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C1760(1.08)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C89(0.78); C97(0.78); C25(1.00)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C25(0.97); C89(1.15); C97(1.15)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C89(0.85); C97(0.85); C25(0.92)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C89(0.74); C97(0.74); C25(0.89)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C89(0.81); C97(0.81); C25(1.02)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C89(0.95); C97(0.95); C25(1.23)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C89(1.03); C97(1.03); C25(1.11)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C89(0.79); C97(0.79); C25(0.89)  LDD0648  [9]
 LDCM0332  AC68 HEK-293T C1549(1.00); C1760(1.03); C528(0.77); C554(1.08)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C1549(1.05); C1760(1.07); C528(1.07); C554(1.07)  LDD0931  [9]
 LDCM0334  AC7 HCT 116 C1760(0.96)  LDD0651  [9]
 LDCM0335  AC70 HEK-293T C1549(0.83); C1760(0.91); C528(0.89); C554(0.92)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C1549(1.00); C1760(0.90); C528(0.90); C554(0.80)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C1549(1.14); C1760(0.91); C528(0.82); C554(0.91)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C1549(1.18); C1760(1.07); C528(0.75); C554(0.98)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C1549(0.93); C1760(0.86); C528(0.69); C554(1.12)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C1549(1.12); C1760(0.89); C528(0.76); C554(0.90)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C1549(1.16); C1760(1.09); C528(0.81); C554(0.83)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C1549(1.08); C1760(1.01); C528(0.85); C554(0.88)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C1549(1.27); C1760(1.01); C528(0.82); C554(0.88)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C1549(1.00); C1760(1.04); C528(0.75); C554(0.90)  LDD0942  [9]
 LDCM0345  AC8 HCT 116 C1760(1.26)  LDD0662  [9]
 LDCM0346  AC80 HEK-293T C1549(1.18); C1760(0.91); C528(0.86); C554(0.82)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C1549(1.06); C1760(0.97); C528(0.90); C554(0.93)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C1549(1.34); C1760(0.96); C528(0.71); C554(0.94)  LDD0946  [9]
 LDCM0349  AC83 HEK-293T C1549(1.27); C1760(1.26); C554(1.29); C764(0.74)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C1549(1.32); C1760(1.06); C554(0.98); C764(0.79)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C1549(1.16); C1760(0.98); C554(1.01); C764(0.68)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C1549(1.60); C1760(1.08); C554(0.92); C764(0.83)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C1549(1.42); C1760(1.15); C554(0.98); C764(0.95)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C1549(1.59); C1760(1.19); C554(1.00); C764(0.66)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C1549(1.74); C1760(1.09); C554(0.89); C764(0.70)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C1549(1.57); C1760(1.02); C554(1.00); C764(0.70)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C1549(1.45); C1760(0.99); C554(0.80); C764(0.55)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C1549(1.46); C1760(1.10); C554(0.98); C764(0.55)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C1549(1.25); C1760(1.03); C554(0.90); C764(0.48)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C1549(1.47); C1760(1.22); C554(0.88); C764(0.92)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C1549(1.37); C1760(1.11); C554(0.96); C764(0.87)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C1549(1.45); C1760(1.20); C554(0.67); C764(0.52)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C1549(1.29); C1760(0.94); C554(1.09); C764(0.71)  LDD0962  [9]
 LDCM0365  AC98 HCT 116 C97(0.94); C25(0.95)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C25(0.89); C97(1.01)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C1760(1.16)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C1760(1.41)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C1760(1.07)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 14.07  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C25(0.70)  LDD2091  [3]
 LDCM0367  CL1 HCT 116 C1760(0.99)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C1760(1.10)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C1760(0.91)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C1760(1.10)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C1760(1.02)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C1760(0.93)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C1760(0.93)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C25(0.66); C1760(1.17)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C25(0.60); C1760(1.65)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C25(0.86); C1760(1.27)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C25(0.72); C1760(1.40)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C25(0.83); C1760(1.40)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C1760(0.94)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C25(0.80); C1760(1.51)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C25(0.71); C1760(1.31)  LDD0698  [9]
 LDCM0382  CL112 HEK-293T C1760(0.74); C554(0.82); C97(0.97)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C1760(0.88); C554(0.79); C97(0.90)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C1760(0.61); C554(0.66); C97(0.85)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C1760(0.53); C554(0.68); C97(0.89)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C1760(0.67); C554(0.66); C97(0.89)  LDD0984  [9]
 LDCM0387  CL117 HCT 116 C25(0.81); C97(1.17)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C97(0.88); C25(1.00)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C25(0.84); C97(1.00)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C1760(1.15)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C25(0.86); C97(0.88)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C97(0.90); C1760(0.94)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C1760(1.13); C97(1.15)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C1760(0.96); C97(1.06)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C97(1.11); C1760(1.42)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C89(1.10); C97(1.10); C25(1.30)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C25(1.03); C89(1.13); C97(1.13)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C89(0.99); C97(0.99); C25(1.07)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C25(1.00); C89(1.13); C97(1.13)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C1760(1.01)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C1760(1.01)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C1760(0.84)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C89(1.00); C97(1.00)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C89(0.96); C97(1.21)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C89(0.75); C97(0.95)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C89(0.82); C97(0.95)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C1760(0.99)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C89(0.82); C97(0.95)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C89(0.74); C97(1.19)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C89(0.62); C97(0.81)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C89(0.91); C97(1.02)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C89(0.87); C97(0.92)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C89(0.98); C97(1.16)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C89(0.98); C97(1.04)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C89(1.00); C97(1.03)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C89(0.82); C97(0.97)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C89(0.85); C97(0.96)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C1760(0.99)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C89(0.91); C97(1.09)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C89(0.93); C97(0.96)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C89(0.86); C97(0.83)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C89(0.90); C97(0.75)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C89(0.91); C97(0.93)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C89(1.04); C97(0.91)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C89(1.01); C97(0.87)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C89(0.99); C97(0.86)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C89(0.87); C97(0.85)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C1760(1.03)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C89(1.06); C97(0.93)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C89(0.94); C97(1.04)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C89(0.82); C97(0.84)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C89(0.85); C97(1.00)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C89(0.80); C97(0.86)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C89(0.84); C97(0.78)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C1760(1.43); C97(1.00)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C1760(0.90); C97(1.09)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C1760(1.02); C97(1.04)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C1760(0.93); C97(0.93)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C1760(0.90)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C1760(0.99); C97(1.01)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C1760(1.05); C97(1.07)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C1760(1.07); C97(1.27)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C1760(1.14); C97(0.95)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C1760(1.04); C97(0.80)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C1760(0.92); C97(0.86)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C1760(0.82); C97(1.02)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C1760(0.88); C97(1.17)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C1760(0.98); C97(0.90)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C1760(1.00); C97(0.89)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C1760(0.91)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C1760(1.00); C97(1.01)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C1760(0.83); C25(1.12); C89(1.28); C97(1.28)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C1760(1.08); C25(0.92); C89(1.16); C97(1.16)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C1760(1.04); C25(0.91); C89(1.22); C97(1.22)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C1760(0.88); C25(0.96); C89(1.18); C97(1.18)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C1760(0.88); C25(1.07); C89(1.21); C97(1.21)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C1760(0.96); C25(0.98); C89(1.07); C97(1.07)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C1760(0.82); C25(1.03); C89(0.97); C97(0.97)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C1760(0.94); C25(0.95); C89(0.96); C97(0.96)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C1760(1.06); C25(0.95); C89(1.04); C97(1.04)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C1760(0.95)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C1760(1.07); C25(0.94); C89(0.94); C97(0.94)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C1760(1.01); C25(0.89); C89(1.15); C97(1.15)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C1760(0.86); C25(1.05); C89(1.42); C97(1.42)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C1760(0.96); C25(0.95); C89(1.04); C97(1.04)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C1760(1.00); C25(1.08); C89(1.24); C97(1.24)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C97(1.07)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C97(1.26)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C97(1.04)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C97(1.26)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C1760(0.97)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C97(1.35)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C97(1.17)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C97(1.28)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C97(1.08)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C97(0.99)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C97(0.97)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C97(1.01)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C97(1.04)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C97(1.04)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C97(1.17)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C1760(0.99)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C97(1.31)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C1760(0.86)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C1760(0.84)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C1760(0.84)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C1760(1.00)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C1760(0.74)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C1760(0.80)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C1760(0.87)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C1760(0.98)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C1760(0.80)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C1121(1.16); C1549(1.09)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C25(1.56)  LDD1702  [3]
 LDCM0625  F8 Ramos C25(0.68)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C25(0.69)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C25(3.08)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C25(0.53)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C25(0.97)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C25(1.78)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C25(0.45)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C25(0.92)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C25(0.83)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C25(0.88)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C25(0.94)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C25(1.12)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C25(1.02)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C25(0.48)  LDD2201  [11]
 LDCM0468  Fragment33 HCT 116 C1760(0.83); C25(0.98); C89(1.06); C97(1.06)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C25(1.19)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C25(0.83)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C89(0.80); C97(0.83)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C25(1.31)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C25(1.25)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C25(0.67)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C25(0.55)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C1549(0.97); C1121(1.23)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C1760(14.24)  LDD0209  [4]
 LDCM0024  KB05 HMCB C25(4.15); C554(2.64)  LDD3312  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C25(0.72)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C25(0.68)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C25(0.66)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C25(0.97)  LDD2127  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C25(0.89)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(0.43)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIF23 (KIF23) Kinesin family Q02241

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840