Details of the Target

General Information of Target

Target ID LDTP07876
Target Name Ubiquitin carboxyl-terminal hydrolase 30 (USP30)
Gene Name USP30
Gene ID 84749
Synonyms
Ubiquitin carboxyl-terminal hydrolase 30; EC 3.4.19.12; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Mitochondrion outer membrane
Function
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
TTD ID
T52910
Uniprot ID
Q70CQ3
DrugMap ID
TTQ9EDI
Ensemble ID
ENST00000257548.10
HGNC ID
HGNC:20065
ChEMBL ID
CHEMBL4523357

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C513(0.00); C234(0.00)  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C142(2.04)  LDD0170  [2]
DBIA
 Probe Info  		C284(1.20); C287(1.20)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C142(2.04)  LDD0170  [2]
 LDCM0214  AC1 HCT 116 C129(1.50); C142(1.50)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C129(1.49); C142(1.49)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C142(1.80); C234(1.49)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C142(1.58); C234(1.71)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C142(1.77); C234(0.69)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C142(1.64); C234(0.79)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C142(1.95); C234(1.01)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C142(1.12); C234(0.79)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C142(1.26); C234(0.96)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C142(1.76); C234(1.01)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C142(1.10); C234(0.87)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C142(1.39); C234(0.84)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C129(1.68); C142(1.68)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C142(3.62); C234(0.91)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C142(1.12); C234(1.15)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C142(1.24); C234(1.29)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C142(0.87)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C142(1.06)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C142(1.25)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C142(0.85)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C142(1.20)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C142(1.03)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C142(1.51)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C129(1.13); C142(1.13)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C142(1.78)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C142(1.34)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C142(2.87)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C142(1.51)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C142(1.19)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C142(2.63)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C142(3.19)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C142(2.63)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C142(1.01)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C142(2.24)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C142(1.83)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C142(1.01)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C142(1.41)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C142(1.79)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C142(1.50)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C142(2.01)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C142(1.85)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C142(2.60)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C142(2.65)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C142(2.54)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C129(1.48); C142(1.48)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C142(2.08)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C142(2.35)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C142(1.93)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C142(1.02)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C142(1.86)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C142(1.28)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C142(1.51)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C142(1.46)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C142(0.78)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C142(0.74)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C129(1.40); C142(1.40)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C142(1.10)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C142(1.06)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C142(1.34)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C142(1.08)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C142(1.43)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C142(0.95)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C142(1.79)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C142(1.80)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C142(1.74); C320(1.42)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C142(1.57); C320(1.28)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C142(1.33); C320(1.11)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C129(1.14); C142(1.14)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C142(1.94); C320(1.34)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C142(2.12); C320(1.30)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C142(1.66); C320(1.27)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C142(1.93); C320(1.41)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C142(1.32); C320(1.10)  LDD0882  [3]
 LDCM0285  AC25 HCT 116 C129(1.09); C142(1.09)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C129(1.06); C142(1.06)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C129(1.86); C142(1.86)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C129(1.51); C142(1.51)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C129(1.46); C142(1.46)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C129(1.14); C142(1.14)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C129(1.79); C142(1.79)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C129(1.30); C142(1.30)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C129(1.78); C142(1.78)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C129(1.59); C142(1.59)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C129(1.47); C142(1.47)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C129(0.78); C142(0.78)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C129(0.70); C142(0.70)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C129(1.06); C142(1.06)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C129(1.13); C142(1.13)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C129(1.37); C142(1.37)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C129(1.25); C142(1.25)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C129(1.18); C142(1.18)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C129(0.99); C142(0.99)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C129(1.24); C142(1.24)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C129(1.15); C142(1.15)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C129(1.07); C142(1.07)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C129(1.23); C142(1.23)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C129(0.90); C142(0.90)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C129(0.99); C142(0.99)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C129(1.26); C142(1.26)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C129(1.64); C142(1.64)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C129(1.48); C142(1.48)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C129(1.23); C142(1.23)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C129(0.58); C142(0.58)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C129(1.06); C142(1.06)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C129(1.18); C142(1.18)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C129(1.02); C142(1.02)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C129(1.27); C142(1.27)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C129(1.78); C142(1.78)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C129(1.01); C142(1.07); C234(1.46); C320(0.91)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C129(1.08); C142(0.99); C234(1.31); C320(0.88)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C129(1.25); C142(1.32); C234(0.95); C320(0.96)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C129(1.33); C142(1.33)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C129(1.01); C142(1.13); C234(1.03); C320(0.80)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C129(1.29); C142(1.41); C234(1.37); C320(1.01)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C129(0.88); C142(0.99); C234(0.70); C320(0.95)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C129(1.20); C142(1.78); C234(0.99); C320(0.75)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C129(1.39); C142(1.38); C234(0.83); C320(0.99)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C129(1.92); C142(1.74); C234(0.95); C320(1.18)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C129(1.13); C142(1.17); C234(0.98); C320(0.83)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C129(1.49); C142(1.60); C234(0.92); C320(1.06)  LDD0929  [3]
 LDCM0332  AC68 HCT 116 C129(1.19); C142(1.19)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C129(1.16); C142(1.16)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C129(1.06); C142(1.06)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C129(0.87); C142(0.87)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C129(1.38); C142(1.38)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C129(1.04); C142(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C129(2.15); C142(2.15)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C129(1.98); C142(1.98)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C129(1.86); C142(1.86)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C129(1.60); C142(1.60)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C129(0.85); C142(0.85)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C129(0.98); C142(0.98)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C129(1.27); C142(1.27)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C129(1.21); C142(1.21)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C129(1.66); C142(1.66)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C129(1.33); C142(1.33)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C129(2.69); C142(2.69)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C142(1.23); C320(1.60); C284(0.81)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C142(1.85); C320(20.00); C284(0.80)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C142(1.50); C320(0.84); C284(0.94)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C142(1.27); C320(0.72); C284(0.88)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C142(1.31); C320(0.50); C284(1.08)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C142(1.90); C320(0.77); C284(0.77)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C142(1.95); C320(1.09); C284(0.66)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C142(1.75); C320(0.72); C284(0.70)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C142(1.53); C320(0.70); C284(0.82)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C142(1.87); C320(0.69); C284(0.74)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C142(1.98); C320(0.71); C284(0.95)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C142(1.85); C320(0.93); C284(0.72)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C142(1.69); C320(0.93); C284(0.92)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C142(1.49); C320(1.42); C284(0.81)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C142(1.75); C320(1.77); C284(0.11)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C142(1.09); C234(0.66)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C142(1.60); C234(0.81)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C129(1.21); C142(1.21)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C129(1.23); C142(1.23)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C129(2.08); C142(2.08)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C513(1.43); C513(1.33)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C129(0.87); C142(0.87)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C129(1.99); C142(1.99)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C129(1.31); C142(1.31)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C129(1.24); C142(1.24)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C129(1.33); C142(1.33)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C129(1.38); C142(1.38)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C129(1.05); C142(1.05)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C142(1.27); C320(1.08)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C142(1.29); C320(1.15)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C142(1.30); C320(1.17)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C142(0.95); C320(1.19)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C142(1.26); C320(1.09)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C129(1.71); C142(1.71)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C142(1.20); C320(1.11)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C142(1.20); C320(1.14)  LDD0979  [3]
 LDCM0382  CL112 HCT 116 C129(1.53); C142(1.53)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C129(1.29); C142(1.29)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C129(1.26); C142(1.26)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C129(1.63); C142(1.63)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C129(1.60); C142(1.60)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C129(1.84); C142(1.84)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C129(1.35); C142(1.35)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C129(1.78); C142(1.78)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C129(1.64); C142(1.64)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C129(1.06); C142(1.06)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C129(1.68); C142(1.68)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C129(1.24); C142(1.24)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C129(1.61); C142(1.61)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C129(1.19); C142(1.19)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C129(1.35); C142(0.99); C234(1.31); C320(1.01)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C129(1.11); C142(0.96); C234(0.62); C320(0.82)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C129(1.02); C142(0.89); C234(0.92); C320(0.84)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C129(0.93); C142(0.89); C234(0.80); C320(0.87)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C129(1.71); C142(1.71)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C129(1.46); C142(1.46)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C129(1.37); C142(1.37)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C129(1.07); C142(1.07)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C129(0.80); C142(0.80)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C129(0.78); C142(0.78)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C129(0.91); C142(0.91)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C129(0.87); C142(0.87)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C129(0.53); C142(0.53)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C129(1.74); C142(1.74)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C129(2.07); C142(2.07)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C129(1.10); C142(1.10)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C129(0.98); C142(0.98)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C129(1.03); C142(1.03)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C129(0.86); C142(0.86)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C129(0.71); C142(0.71)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C129(1.13); C142(1.13)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C129(1.01); C142(1.01)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C129(1.03); C142(1.03)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C129(0.78); C142(0.78)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C129(0.94); C142(0.94)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C129(1.03); C142(1.03)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C129(1.07); C142(1.07)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C129(1.43); C142(1.43)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C129(1.05); C142(1.05)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C129(1.29); C142(1.29)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C129(1.40); C142(1.40)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C129(1.70); C142(1.70)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C129(1.22); C142(1.22)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C129(1.28); C142(1.28)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C129(1.23); C142(1.23)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C129(2.16); C142(2.16)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C129(1.62); C142(1.62)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C129(1.18); C142(1.18)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C129(1.69); C142(1.69)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C129(2.17); C142(2.01); C234(1.28); C320(1.64)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C129(1.07); C142(1.43); C234(0.98); C320(1.42)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C129(1.61); C142(1.39); C234(1.15); C320(1.35)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C129(0.93); C142(1.34); C234(1.11); C320(1.17)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C129(1.07); C142(1.07)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C129(1.30); C142(1.50); C234(1.24); C320(1.37)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C129(0.98); C142(1.28); C234(0.98); C320(1.34)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C129(0.77); C142(0.73); C234(0.97); C320(1.07)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C129(0.83); C142(0.98); C234(0.88); C320(0.99)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C129(1.08); C142(1.40); C234(0.88); C320(1.35)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C129(1.34); C142(1.82); C234(1.11); C320(1.67)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C129(1.10); C142(1.26); C234(0.77); C320(1.30)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C129(1.17); C142(1.35); C234(0.98); C320(1.54)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C129(0.70); C142(1.11); C234(1.00); C320(1.09)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C129(1.24); C142(1.91); C234(0.96); C320(1.52)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C129(1.34); C142(1.34)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C129(1.42); C142(2.50); C234(1.14); C320(1.72)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C129(1.01); C142(1.01)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C129(1.12); C142(1.12)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C129(1.02); C142(1.02)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C129(1.63); C142(1.63)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C129(1.28); C142(1.28)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C129(1.46); C142(1.46)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C129(1.49); C142(1.49)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C129(1.37); C142(1.37)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C129(1.07); C142(1.07)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C129(1.37); C142(1.37)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C129(1.23); C142(1.23)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C129(1.37); C142(1.37)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C129(0.94); C142(0.94)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C129(1.23); C142(1.23)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C129(1.17); C142(1.17)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C129(1.25); C142(1.25)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C129(0.89); C142(0.89)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C129(1.45); C142(1.45)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C129(1.68); C142(1.68)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C129(2.91); C142(2.91)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C129(1.00); C142(1.00)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C129(1.16); C142(1.16)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C129(1.89); C142(1.89)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C129(1.49); C142(1.49)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C129(2.23); C142(2.23)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C129(1.15); C142(1.15)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C129(0.78); C142(0.78)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C129(2.03); C142(2.03)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C129(2.23); C142(2.23)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C129(3.72); C142(3.72)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C129(1.24); C142(1.24)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C129(1.57); C142(1.57)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C129(1.54); C142(1.54)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C129(0.92); C142(0.92)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C129(0.99); C142(0.99)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C129(1.62); C142(1.62)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C129(1.29); C142(1.29)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C129(1.70); C142(1.70)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C129(1.23); C142(1.23)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C129(1.76); C142(1.76)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C129(1.24); C142(1.24)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C237(1.05); C234(0.93); C284(1.05); C320(1.01)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C129(1.37); C142(1.37)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C129(1.61); C142(1.61)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C284(1.20); C287(1.20)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C284(0.63); C287(0.63)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C284(1.09); C287(1.09)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nc043 Small molecular drug DAQ4G0

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402