Details of the Target

General Information of Target

Target ID LDTP07853
Target Name PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)
Gene Name PHLPP2
Gene ID 23035
Synonyms
KIAA0931; PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; EC 3.1.3.16; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSS
DLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPV
RIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTC
LIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQ
RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQ
LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTL
PEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV
DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF
SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV
PVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLN
ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFP
ASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDL
SCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVT
STFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLL
EEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGT
CQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYP
WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSY
GCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEF
SSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSS
NQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARG
SCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE
VPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFD
TAL
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity.
Uniprot ID
Q6ZVD8
Ensemble ID
ENST00000393524.6
HGNC ID
HGNC:29149
ChEMBL ID
CHEMBL1275209

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.F314L .
HCT116 SNV: p.R102Q DBIA    Probe Info 
KELLY SNV: p.N941S .
LS180 SNV: p.S252R .
MEWO SNV: p.S481F .
NCIH358 SNV: p.D724Y .
SNU1 SNV: p.C1174R .
SUPT1 SNV: p.G290R; p.M1029L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1234(4.25)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2242  [2]
IPM
 Probe Info  		C1234(0.00); C143(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C460(0.76); C467(0.76)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C1234(1.75)  LDD1094  [1]
 LDCM0216  AC100 HEK-293T C1234(1.06)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C1234(1.29)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C1234(1.02)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C1234(1.07)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C1234(0.92)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C1234(1.25)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C1234(1.71)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C1234(1.18)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C1234(1.09)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C1234(1.12)  LDD0823  [1]
 LDCM0226  AC11 PaTu 8988t C1234(1.48)  LDD1105  [1]
 LDCM0227  AC110 HEK-293T C1234(1.01)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C1234(1.08)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C1234(0.95)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C467(0.98)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C467(1.34)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C467(1.12)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C467(1.13)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C467(1.20)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C467(1.09)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C467(1.08)  LDD0553  [1]
 LDCM0237  AC12 PaTu 8988t C1234(1.52)  LDD1116  [1]
 LDCM0238  AC120 HCT 116 C467(1.22)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C467(1.01)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C467(1.23)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C467(1.08)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C467(0.98)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C467(1.12)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C467(1.13)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C467(0.92)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C1234(1.04)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C1234(1.15)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C1234(1.08)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C1234(1.01)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C1234(1.33)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C1234(1.22)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C1234(1.12)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C1234(1.13)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C1234(1.03)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C1234(1.06)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C1234(1.02)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C1234(1.13)  LDD0856  [1]
 LDCM0259  AC14 PaTu 8988t C1234(2.02)  LDD1138  [1]
 LDCM0260  AC140 HEK-293T C1234(1.17)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C1234(1.12)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C1234(1.31)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C1234(1.09)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C1234(1.16)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C1234(1.27)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C1234(0.95)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C1234(1.21)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C1234(1.04)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C1234(0.90)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C1234(2.48)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C1234(0.83)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C1234(0.90)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C1234(0.82)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C1234(1.17)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C1234(0.99)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C1234(0.85)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C1234(0.79)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C1234(0.91)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C1234(1.10)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C1234(1.53)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C1234(0.89)  LDD1157  [1]
 LDCM0279  AC2 HCT 116 C460(1.01); C467(1.01)  LDD0596  [1]
 LDCM0280  AC20 PaTu 8988t C1234(0.95)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C1234(1.10)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C1234(1.04)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C1234(1.61)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C1234(1.35)  LDD1163  [1]
 LDCM0285  AC25 HCT 116 C1234(1.09)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C1234(1.13)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C1234(1.26)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C1234(1.25)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C1234(1.35)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C460(0.84); C467(0.84)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C1234(1.42)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C1234(1.15)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C1234(1.30)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C1234(1.26)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C1234(1.21)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C1234(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1234(1.13)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1234(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1234(1.16)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1234(1.16)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C460(1.12); C467(1.12)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C1234(1.15)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1234(1.22)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1234(1.02)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1234(1.15)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1234(1.02)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1234(0.96)  LDD0624  [1]
 LDCM0308  AC46 PaTu 8988t C460(0.77); C467(0.77)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C460(0.75); C467(0.75)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C460(0.53); C467(0.53)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C460(0.49); C467(0.49)  LDD1190  [1]
 LDCM0312  AC5 HCT 116 C460(0.85); C467(0.85)  LDD0629  [1]
 LDCM0313  AC50 PaTu 8988t C460(0.67); C467(0.67)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C460(0.16); C467(0.16)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C460(0.64); C467(0.64)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C460(0.74); C467(0.74)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C460(0.53); C467(0.53)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C460(0.39); C467(0.39)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C460(0.42); C467(0.42)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C460(0.58); C467(0.58)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C460(0.76); C467(0.76)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C460(0.70); C467(0.70)  LDD1201  [1]
 LDCM0323  AC6 PaTu 8988t C1234(1.50)  LDD1202  [1]
 LDCM0324  AC60 PaTu 8988t C460(0.54); C467(0.54)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C460(0.76); C467(0.76)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C460(0.56); C467(0.56)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C460(0.75); C467(0.75)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C460(0.83); C467(0.83)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C460(0.80); C467(0.80)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C460(0.78); C467(0.78)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C460(0.79); C467(0.79)  LDD1210  [1]
 LDCM0332  AC68 HEK-293T C1234(0.70)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C1234(0.82)  LDD0931  [1]
 LDCM0334  AC7 PaTu 8988t C1234(1.25)  LDD1213  [1]
 LDCM0335  AC70 HEK-293T C1234(0.75)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C1234(0.77)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C1234(0.94)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C1234(0.64)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C1234(0.64)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C1234(0.57)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C1234(0.57)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C1234(0.84)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C1234(0.70)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C1234(0.72)  LDD0942  [1]
 LDCM0345  AC8 PaTu 8988t C1234(2.00)  LDD1224  [1]
 LDCM0346  AC80 HEK-293T C1234(0.45)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C1234(0.40)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C1234(0.88)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C1234(0.97)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1234(1.01)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1234(1.18)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1234(1.04)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1234(0.98)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1234(0.97)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1234(1.01)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1234(1.02)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1234(1.04)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1234(1.08)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1234(1.16)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1234(1.47)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1234(1.13)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1234(1.18)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1234(1.23)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C1234(1.29)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C1234(1.11)  LDD0964  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C1234(2.20)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C1234(2.81)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C1234(1.91)  LDD1154  [1]
 LDCM0367  CL1 HCT 116 C460(1.10); C467(1.10)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C460(0.86); C467(0.86)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C460(0.86); C467(0.86)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C1234(1.08)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C1234(1.15)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C1234(1.94)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C1234(1.59)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C1234(1.06)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C1234(1.14)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C1234(0.74)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C1234(0.84)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C1234(1.24)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C460(0.79); C467(0.79)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C1234(2.10)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C1234(1.67)  LDD1260  [1]
 LDCM0382  CL112 HCT 116 C1234(1.13)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C1234(1.09)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C1234(1.45)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C1234(1.40)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C1234(1.18)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C1234(1.30)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1234(1.04)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1234(1.04)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C460(1.03); C467(1.03)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C1234(1.04)  LDD0708  [1]
 LDCM0392  CL121 PaTu 8988t C460(0.69); C467(0.69)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C460(0.70); C467(0.70)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C460(0.52); C467(0.52)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C460(0.66); C467(0.66)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C460(0.71); C467(0.71)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C460(1.03); C467(1.03)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C460(0.79); C467(0.79)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C460(0.66); C467(0.66)  LDD1278  [1]
 LDCM0400  CL13 HCT 116 C460(0.93); C467(0.93)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C460(1.23); C467(1.23)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C460(0.83); C467(0.83)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C1234(0.94)  LDD0720  [1]
 LDCM0404  CL17 PaTu 8988t C460(0.74); C467(0.74)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C460(0.60); C467(0.60)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C460(0.65); C467(0.65)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C460(1.02); C467(1.02)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C460(0.59); C467(0.59)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C460(0.75); C467(0.75)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C460(0.75); C467(0.75)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C460(0.72); C467(0.72)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C460(0.56); C467(0.56)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C460(0.72); C467(0.72)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C460(0.58); C467(0.58)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C460(0.66); C467(0.66)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C460(0.84); C467(0.84)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C460(0.70); C467(0.70)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C460(1.15); C467(1.15)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C460(0.57); C467(0.57)  LDD1298  [1]
 LDCM0420  CL31 HCT 116 C460(1.09); C467(1.09)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C1234(1.13); C460(0.62); C467(0.62)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1234(1.29); C460(0.94); C467(0.94)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1234(0.93); C460(1.14); C467(1.14)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1234(0.98); C460(1.03); C467(1.03)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1234(0.85); C460(0.80); C467(0.80)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1234(0.92); C460(0.80); C467(0.80)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1234(1.06); C460(0.92); C467(0.92)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C460(0.96); C467(0.96)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C1234(1.21); C460(0.96); C467(0.96)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1234(1.13); C460(1.06); C467(1.06)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1234(0.81); C460(0.82); C467(0.82)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1234(0.95); C460(1.04); C467(1.04)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1234(0.88); C460(1.12); C467(1.12)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1234(0.81); C460(0.84); C467(0.84)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C1234(1.05)  LDD1640  [4]
 LDCM0438  CL48 HEK-293T C1234(1.01)  LDD1642  [4]
 LDCM0440  CL5 HCT 116 C460(0.94); C467(0.94)  LDD0757  [1]
 LDCM0444  CL53 HEK-293T C1234(1.02)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C1234(1.08)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C1234(1.02)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C1234(1.22)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C1234(1.06)  LDD1652  [4]
 LDCM0451  CL6 HCT 116 C460(1.04); C467(1.04)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C1234(1.21)  LDD1655  [4]
 LDCM0453  CL61 HCT 116 C1234(0.86)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C1234(0.94)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C1234(0.98)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C1234(0.73)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C1234(0.82)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C1234(0.78)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C1234(0.81)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C1234(0.79)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C1234(0.96)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C460(0.94); C467(0.94)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C1234(0.87)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C1234(0.82)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C1234(0.93)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C1234(0.77)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C1234(1.00)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C1234(1.06); C460(0.60); C467(0.60)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1234(0.92); C460(0.55); C467(0.55)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1234(1.06); C460(0.74); C467(0.74)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1234(1.01); C460(0.87); C467(0.87)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C460(0.97); C467(0.97)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C1234(0.91); C460(0.49); C467(0.49)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1234(0.95); C460(0.66); C467(0.66)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1234(0.78); C460(0.72); C467(0.72)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1234(0.88); C460(0.80); C467(0.80)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1234(1.19); C460(0.58); C467(0.58)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1234(1.06); C460(0.77); C467(0.77)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1234(0.91); C460(0.71); C467(0.71)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1234(0.81); C460(0.73); C467(0.73)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1234(0.84); C460(0.58); C467(0.58)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1234(0.89); C460(0.70); C467(0.70)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C460(0.98); C467(0.98)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C1234(1.23); C460(1.01); C467(1.01)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C460(0.92); C467(0.92)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C460(0.88); C467(0.88)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C460(0.98); C467(0.98)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C460(0.94); C467(0.94)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C460(0.93); C467(0.93)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C460(0.75); C467(0.75)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C460(1.06); C467(1.06)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C460(0.76); C467(0.76)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C460(0.71); C467(0.71)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C1234(1.21)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C1234(0.72)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C1234(1.00); C460(1.10); C467(1.10)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C1234(4.25)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1234(2.07)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1234(2.66)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) . O14745

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402