Details of the Target

General Information of Target

Target ID LDTP07615
Target Name E3 ubiquitin-protein ligase TRAF7 (TRAF7)
Gene Name TRAF7
Gene ID 84231
Synonyms
RFWD1; RNF119; E3 ubiquitin-protein ligase TRAF7; EC 2.3.2.-; EC 2.3.2.27; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTP
SSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLV
FAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQ
IGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCP
PLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHE
MHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASM
LNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTI
KVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDN
PVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQT
IKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVG
TVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGA
VDSTVKVWTC
Target Bioclass
Enzyme
Family
WD repeat TRAF7 family
Subcellular location
Cytoplasmic vesicle
Function
E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis. Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response. Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B.
Uniprot ID
Q6Q0C0
Ensemble ID
ENST00000326181.11
HGNC ID
HGNC:20456

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.E578K .
HELA SNV: p.E334Q .
JURKAT SNV: p.R71W; p.T540I .
KPNYN SNV: p.H261P DBIA    Probe Info 
LN18 SNV: p.I90F DBIA    Probe Info 
MFE296 SNV: p.L512F DBIA    Probe Info 
MOLT4 SNV: p.M360V; p.W628Ter IA-alkyne    Probe Info 
OVK18 Deletion: p.K498RfsTer13 DBIA    Probe Info 
RKO Deletion: p.K514del DBIA    Probe Info 
RPMI8226 SNV: p.G375A DBIA    Probe Info 
TOV21G SNV: p.P110T; p.V665M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C233(1.18); C239(1.18); C130(1.05); C131(1.05)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
TFBX
 Probe Info  		C210(0.00); C483(0.00)  LDD0148  [3]
AOyne
 Probe Info  		10.20  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C146(0.83); C151(0.83); C161(1.11); C210(0.93)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C135(0.85); C146(0.95); C151(0.95); C233(1.00)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C146(1.03); C151(1.03); C210(1.09); C233(0.88)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C146(0.92); C151(0.92); C210(1.20); C233(0.85)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C146(0.96); C151(0.96); C210(1.16); C233(0.94)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C146(0.97); C151(0.97); C210(1.24); C233(0.99)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C146(1.03); C151(1.03); C210(1.10); C233(0.94)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C146(1.02); C151(1.02); C210(1.20); C233(1.02)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C146(1.06); C151(1.06); C210(1.12); C233(1.02)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C146(1.15); C151(1.07); C210(1.11); C233(1.03)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C146(0.99); C151(1.13); C210(1.02); C233(1.05)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C146(0.88); C151(0.90); C210(1.00); C233(0.88)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C135(0.66); C146(1.00); C151(1.00); C233(1.06)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C146(1.06); C151(1.08); C210(1.24); C233(0.98)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C146(0.84); C151(0.89); C210(1.24); C233(0.94)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C146(0.98); C151(0.91); C210(1.25); C233(0.91)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C146(1.09); C151(1.09); C210(0.90); C233(1.06)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C146(1.03); C151(1.07); C210(0.57); C233(1.10)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C146(1.15); C151(1.15); C210(0.77); C233(1.24)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C146(1.10); C151(1.15); C210(0.86); C233(1.28)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C146(0.89); C151(0.90); C210(0.90); C233(1.07)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C146(0.94); C151(0.95); C210(0.80); C233(1.12)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C146(0.91); C151(0.91); C210(1.31); C233(1.04)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C135(0.71); C146(1.03); C151(1.03); C233(1.13)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C146(1.12); C151(1.01); C210(0.60); C233(0.95)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C146(0.92); C151(0.92); C210(0.69); C233(1.10)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C146(1.03); C151(0.96); C210(0.59); C233(1.20)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C146(0.91); C151(0.90); C210(1.38); C233(0.99)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C146(0.87); C151(0.92); C210(0.77); C233(1.09)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C146(0.96); C151(1.06); C210(0.69); C233(1.12)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C146(1.18); C151(1.08); C210(0.77); C233(1.17)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C146(1.00); C151(0.97); C210(0.83); C233(1.13)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C146(0.99); C151(0.99); C210(0.65); C233(0.89)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C146(0.88); C151(0.88); C210(0.53); C233(0.71)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C146(0.95); C151(0.95); C210(0.56); C233(0.72)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C146(0.93); C151(0.93); C210(0.65); C233(0.82)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C146(0.95); C151(0.95); C210(0.59); C233(0.81)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C146(1.03); C151(1.03); C210(0.59); C233(0.85)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C146(0.92); C151(0.92); C210(0.74); C233(0.76)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C146(1.03); C151(1.03); C210(0.60); C233(1.09)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C146(1.03); C151(1.03); C210(0.65); C233(0.85)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C146(0.87); C151(0.87); C210(0.68); C233(0.76)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C146(0.98); C151(0.98); C210(0.88); C233(0.81)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C146(0.85); C151(0.85); C210(0.73); C233(0.80)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C135(0.72); C146(0.96); C151(0.96); C233(1.07)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C146(1.05); C151(1.05); C210(0.81); C233(0.90)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C146(0.91); C151(0.91); C210(0.80); C233(0.86)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C146(0.92); C151(0.92); C210(0.64); C233(0.88)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C266(0.91); C282(0.91); C146(1.00); C151(1.00)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C266(0.93); C282(0.93); C161(0.98); C426(1.23)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C266(0.71); C282(0.71); C161(0.90); C426(1.14)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C266(0.98); C282(0.98); C161(1.06); C146(1.11)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C161(0.93); C266(1.00); C282(1.00); C146(1.14)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C266(0.92); C282(0.92); C161(1.08); C426(1.48)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C266(1.10); C282(1.10); C161(1.22); C146(1.30)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C135(0.70); C266(0.82); C282(0.82); C146(1.03)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C146(1.00); C151(1.00); C161(1.07); C426(1.13)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C266(0.98); C282(0.98); C161(1.02); C426(1.04)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C266(1.03); C282(1.03); C161(1.09); C426(1.26)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C266(0.89); C282(0.89); C161(1.36); C146(1.37)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C146(1.48); C151(1.48); C161(1.16); C233(1.20)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C146(1.20); C151(1.20); C161(1.00); C233(1.45)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C146(1.07); C151(1.07); C161(1.08); C233(1.18)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C146(1.41); C151(1.41); C161(1.13); C233(1.15)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C210(0.76); C266(0.87); C282(0.87); C233(0.89)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C210(0.89); C233(0.89); C239(0.89); C146(0.90)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C210(0.78); C266(0.94); C282(0.94); C146(1.03)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C210(0.77); C146(0.78); C151(0.78); C266(0.96)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C426(0.90); C210(0.92); C146(0.93); C151(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C210(0.86); C426(0.87); C146(0.88); C151(0.88)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C210(0.77); C266(0.92); C282(0.92); C233(0.94)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C210(0.79); C146(0.81); C151(0.81); C266(0.88)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C210(0.77); C146(0.82); C151(0.82); C233(0.92)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C233(0.83); C239(0.83); C146(0.99); C151(0.99)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C146(0.87); C151(0.87); C233(0.87); C239(0.87)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C233(1.06); C239(1.06); C146(1.09); C151(1.09)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C233(0.94); C239(0.94); C146(0.99); C151(0.99)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C146(0.84); C151(0.84); C233(1.02); C239(1.02)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C210(0.67); C266(0.80); C282(0.80); C146(0.81)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C233(1.02); C239(1.02); C146(1.03); C151(1.03)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C233(1.06); C239(1.06); C146(1.09); C151(1.09)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C146(0.85); C151(0.85); C233(1.01); C239(1.01)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C146(0.85); C151(0.85); C233(1.15); C239(1.15)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C233(0.98); C239(0.98); C146(1.04); C151(1.04)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C266(0.91); C282(0.91); C426(0.94); C146(1.01)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C266(0.82); C282(0.82); C426(0.97); C146(0.99)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C146(0.93); C151(0.93); C266(0.95); C282(0.95)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C426(0.99); C266(1.05); C282(1.05); C233(1.15)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C266(0.96); C282(0.96); C146(1.01); C151(1.01)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C210(0.67); C266(0.78); C282(0.78); C233(0.90)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C233(1.05); C239(1.05); C146(1.13); C151(1.13)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C266(0.87); C282(0.87); C146(1.03); C151(1.03)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C146(1.00); C151(1.00); C266(1.09); C282(1.09)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C146(1.06); C151(1.06); C426(1.11); C266(1.12)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C426(1.02); C146(1.08); C151(1.08); C233(1.10)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C266(0.95); C282(0.95); C146(0.98); C151(0.98)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C233(1.00); C239(1.00); C426(1.04); C266(1.20)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C266(0.91); C282(0.91); C426(1.03); C233(1.08)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C233(1.06); C239(1.06); C426(1.07); C266(1.32)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C426(1.06); C233(1.19); C239(1.19); C266(1.38)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C210(0.75); C233(0.94); C239(0.94); C266(0.95)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C266(1.13); C282(1.13); C233(1.21); C239(1.21)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C426(0.90); C233(1.16); C239(1.16); C266(1.27)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C426(0.95); C233(1.17); C239(1.17); C266(1.62)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C266(0.63); C282(0.63); C426(1.02); C233(1.21)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C426(0.96); C233(1.17); C239(1.17); C266(1.19)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C266(0.68); C282(0.68); C233(1.36); C239(1.36)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C266(1.02); C282(1.02); C426(1.31); C233(1.45)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C266(0.76); C282(0.76); C233(0.87); C239(0.87)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C233(0.84); C239(0.84); C266(0.93); C282(0.93)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C146(1.00); C151(1.00); C233(1.01); C239(1.01)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C266(0.80); C282(0.80); C135(0.94); C426(1.11)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C233(0.94); C239(0.94); C266(1.09); C282(1.09)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C146(0.87); C151(0.87); C233(1.02); C239(1.02)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C233(0.92); C239(0.92); C146(1.01); C151(1.01)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C266(0.92); C282(0.92); C233(0.92); C239(0.92)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C266(0.96); C282(0.96); C146(0.96); C151(0.96)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C146(0.91); C151(0.91); C233(0.94); C239(0.94)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C146(0.80); C151(0.80); C233(0.90); C239(0.90)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C146(0.61); C151(0.61); C233(0.93); C239(0.93)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C135(0.73); C146(0.80); C151(0.80); C266(1.13)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C135(0.73); C146(0.79); C151(0.79); C266(0.99)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C135(0.69); C266(0.94); C282(0.94); C146(1.00)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C266(0.78); C282(0.78); C135(0.78); C146(0.84)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C146(0.70); C151(0.70); C266(0.77); C282(0.77)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C266(0.88); C282(0.88); C146(0.88); C151(0.88)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C135(0.85); C146(0.86); C151(0.86); C266(0.98)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C146(0.79); C151(0.79); C266(1.04); C282(1.04)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C266(0.95); C282(0.95); C146(1.07); C151(1.07)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C266(0.80); C282(0.80); C135(0.80); C146(0.84)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C135(0.83); C146(0.88); C151(0.88); C266(0.89)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C146(0.75); C151(0.75); C266(0.81); C282(0.81)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C135(0.69); C146(0.79); C151(0.79); C266(0.88)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C135(0.62); C266(0.67); C282(0.67); C146(1.01)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C135(0.90); C146(0.92); C151(0.92); C266(0.93)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C146(0.83); C151(0.83); C135(0.96); C266(1.09)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C146(0.77); C151(0.77); C266(0.96); C282(0.96)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C233(1.05); C239(1.05); C146(1.29); C151(1.29)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C233(0.89); C239(0.89); C266(1.31); C282(1.31)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C233(0.88); C239(0.88); C426(1.25); C266(1.41)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C266(1.03); C282(1.03); C233(1.12); C239(1.12)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C233(1.01); C239(1.01); C266(1.03); C282(1.03)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C266(1.00); C282(1.00); C426(1.16); C146(1.24)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C266(1.15); C282(1.15); C233(1.15); C239(1.15)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C266(0.86); C282(0.86); C426(1.20); C233(1.25)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C266(1.17); C282(1.17); C426(1.52); C233(1.65)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C266(1.16); C282(1.16); C233(1.17); C239(1.17)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C233(1.09); C239(1.09); C426(1.15); C266(1.21)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C266(1.02); C282(1.02); C233(1.19); C239(1.19)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C266(0.94); C282(0.94); C233(1.09); C239(1.09)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C266(0.96); C282(0.96); C233(1.05); C239(1.05)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C233(1.13); C239(1.13); C266(1.16); C282(1.16)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C233(0.91); C239(0.91); C146(1.01); C151(1.01)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C426(0.80); C146(0.85); C151(0.85); C233(0.86)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C135(0.79); C146(0.88); C151(0.88); C233(1.04)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C266(0.66); C282(0.66); C135(0.67); C233(1.05)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C135(0.74); C266(0.82); C282(0.82); C146(1.21)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C233(1.18); C239(1.18); C130(1.05); C131(1.05)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C233(0.90); C239(0.90); C146(0.96); C151(0.96)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C233(1.05); C239(1.05); C426(1.10); C146(1.41)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C233(0.84); C239(0.84); C210(0.85); C146(0.93)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C135(0.65); C266(0.80); C282(0.80); C233(1.17)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C135(0.52); C266(0.80); C282(0.80); C233(0.97)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C266(0.55); C282(0.55); C135(0.69); C426(0.87)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C135(0.60); C266(0.65); C282(0.65); C146(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C210(0.70); C233(0.76); C239(0.76); C146(0.80)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C210(0.68); C233(0.85); C239(0.85); C146(0.97)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C210(0.77); C233(0.86); C239(0.86); C146(0.87)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C210(0.60); C233(0.85); C239(0.85); C146(0.96)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C210(0.60); C233(0.84); C239(0.84); C266(0.94)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C233(1.10); C239(1.10); C146(1.17); C151(1.17)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C210(0.55); C146(0.82); C151(0.82); C233(0.85)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C210(0.72); C233(0.77); C239(0.77); C146(0.77)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C146(0.81); C151(0.81); C233(0.82); C239(0.82)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C233(0.94); C239(0.94); C146(0.94); C151(0.94)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C233(0.73); C239(0.73); C146(0.90); C151(0.90)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C233(0.92); C239(0.92); C146(0.97); C151(0.97)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C146(0.86); C151(0.86); C233(0.93); C239(0.93)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C146(0.85); C151(0.85); C233(0.96); C239(0.96)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C266(1.02); C282(1.02); C426(1.06); C233(1.11)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C146(0.98); C151(0.98); C266(1.05); C282(1.05)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C426(1.03); C233(1.30); C239(1.30); C146(1.90)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C266(0.78); C282(0.78); C426(0.96); C146(1.05)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C266(1.07); C282(1.07); C426(1.34); C233(1.42)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C426(1.10); C233(1.11); C239(1.11); C266(2.01)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C233(0.99); C239(0.99); C426(1.30); C266(1.77)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C233(1.04); C239(1.04); C266(1.05); C282(1.05)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C233(0.77); C239(0.77); C266(0.89); C282(0.89)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C233(0.87); C239(0.87); C266(0.88); C282(0.88)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C146(0.85); C151(0.85); C233(0.92); C239(0.92)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C233(0.90); C239(0.90); C146(1.01); C151(1.01)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C233(1.02); C239(1.02); C146(1.04); C151(1.04)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C426(0.97); C233(1.02); C239(1.02); C146(1.10)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C233(1.09); C239(1.09); C146(1.09); C151(1.09)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C210(1.07); C233(1.09); C239(1.09); C426(1.11)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C210(0.90); C135(0.91); C146(1.05); C151(1.05)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C210(1.03); C426(1.11); C161(1.32); C146(1.38)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C210(0.92); C161(1.09); C266(1.11); C282(1.11)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C426(0.93); C233(0.93); C239(0.93); C146(1.03)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C210(1.07); C135(1.07); C266(1.16); C282(1.16)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C210(0.84); C135(1.04); C161(1.25); C146(1.32)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C210(1.14); C135(1.20); C146(1.33); C151(1.33)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C210(0.99); C426(1.16); C161(1.30); C146(1.46)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C135(2.19); C146(1.61); C151(1.61); C161(1.47)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C135(1.13); C146(1.24); C151(1.24); C161(1.56)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C135(1.41); C146(1.47); C151(1.47); C161(1.22)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C135(1.24); C146(1.41); C151(1.41); C161(1.20)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C135(1.06); C146(1.53); C151(1.53); C161(1.12)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C135(1.64); C146(1.60); C151(1.60); C161(1.35)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C146(1.15); C151(1.15); C233(1.00); C239(1.00)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C135(1.16); C146(1.51); C151(1.51); C161(1.29)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C146(0.92); C151(0.92); C161(0.72); C233(0.72)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C146(1.01); C151(1.01); C161(0.91); C210(1.04)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C146(0.78); C151(0.78); C161(1.07); C210(0.95)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C146(0.90); C151(0.90); C161(0.82); C210(1.05)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C146(1.24); C151(1.24); C161(0.85); C210(0.67)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C146(0.84); C151(0.84); C161(0.87); C210(0.91)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C146(0.92); C151(0.92); C161(0.82); C210(0.79)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C146(0.91); C151(0.91); C161(0.85); C210(0.97)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C146(1.04); C151(1.04); C233(1.09); C239(1.09)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C146(0.99); C151(0.99); C161(0.74); C210(0.89)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C146(0.88); C151(0.88); C161(0.69); C210(1.10)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C146(0.82); C151(0.82); C161(0.67); C210(0.87)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C146(1.03); C151(1.03); C161(0.84); C210(1.01)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C146(1.02); C151(1.02); C161(0.82); C210(0.68)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C146(1.09); C151(1.09); C161(0.65); C210(0.74)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C146(0.73); C151(0.82); C161(1.42); C210(0.92)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C146(0.90); C151(0.90); C161(0.91); C210(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C146(0.94); C151(0.93); C161(1.04); C210(1.01)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C146(0.91); C151(0.91); C161(1.04); C210(0.99)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C146(1.13); C151(1.13); C233(1.12); C239(1.12)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C146(0.94); C151(1.03); C161(0.97); C210(0.99)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C146(0.79); C151(1.01); C161(0.80); C210(0.81)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C146(0.99); C151(0.94); C161(1.03); C210(0.94)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C146(0.98); C151(0.91); C161(0.73); C210(1.10)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C146(0.87); C151(0.83); C161(0.95); C210(1.09)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C146(1.07); C151(1.00); C161(1.04); C210(0.95)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C146(0.95); C151(0.95); C161(1.03); C210(1.07)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C146(0.76); C151(0.76); C161(0.87); C210(1.02)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C146(1.05); C151(0.95); C161(1.14); C210(0.99)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C146(1.04); C151(1.03); C161(1.23); C210(1.00)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C146(1.26); C151(1.26); C233(1.00); C239(1.00)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C146(1.05); C151(1.01); C161(1.14); C210(1.09)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C146(0.60); C151(0.60); C161(0.99); C210(1.06)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C146(0.55); C151(0.55); C161(1.01); C210(1.17)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C146(0.68); C151(0.68); C161(0.75); C210(1.11)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C146(0.79); C151(0.79); C161(0.93); C210(1.04)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C146(0.63); C151(0.63); C161(1.01); C210(1.09)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C146(0.73); C151(0.73); C161(0.91); C210(1.06)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C146(0.89); C151(0.89); C161(1.18); C210(1.48)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C146(0.68); C151(0.68); C161(0.78); C210(1.62)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C146(0.60); C151(0.60); C161(1.26); C210(1.42)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C146(1.44); C151(1.44); C233(1.34); C239(1.34)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C146(0.79); C151(0.79); C161(1.02); C210(1.16)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C146(0.70); C151(0.70); C161(0.92); C210(1.11)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C146(0.84); C151(0.84); C161(1.31); C210(1.29)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C146(0.77); C151(0.77); C161(0.96); C210(1.25)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C146(0.70); C151(0.70); C161(1.05); C210(1.39)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C135(0.95); C146(0.98); C151(0.98); C210(0.83)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C135(0.84); C146(0.93); C151(0.93); C210(0.82)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C135(0.85); C146(0.94); C151(0.94); C210(0.80)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C135(1.27); C146(1.05); C151(1.05); C210(0.98)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C146(0.90); C151(0.90); C233(1.05); C239(1.05)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C135(1.14); C146(1.29); C151(1.29); C210(0.85)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C135(0.89); C146(0.95); C151(0.95); C210(0.77)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C135(1.15); C146(1.19); C151(1.19); C210(0.62)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C135(0.94); C146(0.88); C151(0.88); C210(0.77)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C135(1.07); C146(1.08); C151(1.08); C210(0.80)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C135(1.15); C146(1.06); C151(1.06); C210(0.90)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C135(1.03); C146(0.84); C151(0.84); C210(0.84)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C135(1.17); C146(0.89); C151(0.89); C210(0.67)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C135(1.05); C146(1.04); C151(1.04); C210(0.66)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C135(1.12); C146(1.08); C151(1.08); C210(0.90)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C146(1.14); C151(1.14); C233(1.06); C239(1.06)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C135(0.93); C146(0.70); C151(0.70); C210(0.66)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C146(0.96); C151(0.96); C161(1.13); C210(0.88)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C146(0.78); C151(0.78); C161(0.98); C210(0.76)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C146(0.71); C151(0.71); C161(1.10); C210(0.61)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C146(0.96); C151(0.96); C161(0.98); C210(0.85)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C146(0.76); C151(0.76); C161(0.97); C210(0.70)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C146(0.82); C151(0.82); C161(0.94); C210(0.68)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C146(0.92); C151(0.92); C161(1.09); C210(0.76)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C146(0.85); C151(0.85); C161(1.13); C210(0.87)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C146(0.91); C151(0.91); C161(1.07); C210(0.80)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C226(0.97); C426(0.98); C161(1.07); C233(0.79)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C146(0.76); C151(0.76); C161(1.33); C210(1.07)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C146(0.92); C151(0.92); C161(0.61); C210(0.79)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C266(2.07); C282(2.07); C233(1.71); C239(1.71)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C266(3.65); C282(3.65); C233(2.04); C239(2.04)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C266(1.97); C282(1.97); C233(1.47); C239(1.47)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C266(1.14); C282(1.14)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) STE Ser/Thr protein kinase family Q99759

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402