Details of the Target

General Information of Target

Target ID LDTP07279
Target Name Anoctamin-1 (ANO1)
Gene Name ANO1
Gene ID 55107
Synonyms
DOG1; ORAOV2; TAOS2; TMEM16A; Anoctamin-1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR
KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH
EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF
FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL
LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM
DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA
ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI
PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY
RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK
SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL
CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE
PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA
KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV
SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL
VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC
NHHNTKACPDSLGSPAPSHAYHGGVL
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Anoctamin family
Subcellular location
Apical cell membrane
Function
Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment. Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC. However, was shown in another study not to be required for MUC5AC expression. Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset. In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity. Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae. Acts as a heat sensor in nociceptive neurons. In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs. In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells.; [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability.; [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+).
TTD ID
T05089
Uniprot ID
Q5XXA6
DrugMap ID
TTOJI4S
Ensemble ID
ENST00000316296.9
HGNC ID
HGNC:21625
ChEMBL ID
CHEMBL2046267

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.S387R DBIA    Probe Info 
CALU1 SNV: p.G103C DBIA    Probe Info 
EFO27 Deletion: p.E114SfsTer43 .
HCC1395 SNV: p.P45L DBIA    Probe Info 
HT115 SNV: p.R647Q .
HUH7 SNV: p.I919T DBIA    Probe Info 
KYM1 SNV: p.K313T .
KYSE510 SNV: p.P554H .
MEWO SNV: p.R219K DBIA    Probe Info 
MFE319 Deletion: p.G655AfsTer3 DBIA    Probe Info 
NCIH1155 SNV: p.T847M .
NCIH2291 Deletion: p.R890GfsTer15 .
NCIH358 SNV: p.G336V DBIA    Probe Info 
OCILY3 SNV: p.H833R DBIA    Probe Info 
RKO Deletion: p.L101CfsTer56
SNV: p.P684L		 DBIA    Probe Info 
SKMEL28 SNV: p.F126L; p.S978R DBIA    Probe Info 
SUPT1 SNV: p.P116L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C166(0.79); C395(0.75); C706(1.15)  LDD0531  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C166(0.79); C395(0.75); C706(1.15)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C166(0.87); C395(0.77); C706(1.10)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C395(1.08)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C395(1.24)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C395(1.15)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C395(1.64)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C395(1.01)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C395(0.97)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C395(0.71)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C395(0.61)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C395(0.62)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C395(0.51)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C166(0.87); C395(0.91); C706(1.05)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C395(0.69)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C395(0.66)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C395(0.65)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C166(1.00); C395(0.81)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C166(0.93); C395(0.68)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C166(0.80); C395(0.79)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C166(0.89); C395(0.87)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C166(0.98); C395(0.95)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C166(1.01); C395(0.94)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C166(0.93); C395(0.81)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C166(1.02); C395(1.15); C706(0.96)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C166(1.01); C395(0.78)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C166(1.00); C395(0.75)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C166(0.90); C395(0.83)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C166(0.97); C395(0.63)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C166(1.05); C395(0.85)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C166(1.08); C395(0.96)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C166(0.87); C395(0.78)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C166(0.88); C395(0.80)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C166(0.92); C395(0.42)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C166(1.26); C395(0.47)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C166(0.84); C395(0.49)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C166(1.15); C395(0.58)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C166(1.10); C395(0.52)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C166(0.94); C395(0.48)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C166(0.91); C395(0.65)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C166(0.88); C395(0.52)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C166(0.96); C395(0.60)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C166(1.05); C395(0.47)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C166(0.91); C395(0.67)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C166(0.94); C395(0.81)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C166(0.91); C395(0.81); C706(1.06)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C166(0.93); C395(0.67)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C166(0.89); C395(0.69)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C166(1.04); C395(0.59)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C166(0.71); C395(1.05)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C166(0.55); C395(1.64)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C166(0.67); C395(1.38)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C166(0.45); C395(0.84)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C166(0.49); C395(1.04)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C166(0.40); C395(0.95)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C166(0.42); C395(0.78)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C166(0.88); C706(0.95); C395(1.09)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C395(0.84); C166(0.85)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C166(0.78); C395(0.86)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C166(0.53); C395(0.68)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C166(0.36); C395(1.14)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C166(0.59); C395(0.85)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C166(0.62); C395(0.82)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C166(0.99); C395(0.79)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C166(0.89); C395(0.97)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C706(0.87); C395(0.94); C166(1.05)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C395(0.84); C166(0.91); C706(1.21)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C395(0.81); C706(0.89); C166(1.03)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C166(0.85); C395(0.90); C706(1.05)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C706(0.78); C166(1.00); C395(1.16)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C395(0.86); C166(0.97); C706(1.13)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C395(0.80); C706(0.84); C166(1.04)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C706(0.84); C166(0.94); C395(1.06)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C706(0.84); C395(0.89); C166(1.18)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C166(0.93); C706(1.05); C395(1.06)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C166(0.87); C706(1.23); C395(1.26)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C395(0.86); C166(0.92); C706(1.01)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C166(0.99); C395(0.99); C706(1.27)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C166(0.88); C706(1.09); C395(1.11)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C395(0.78); C166(0.82); C706(0.95)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C166(0.80); C395(1.19); C706(1.34)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C166(0.90); C395(1.30); C706(1.37)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C166(0.77); C395(1.17); C706(1.52)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C166(0.75); C395(0.95); C706(1.12)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C166(0.78); C706(1.12); C395(1.12)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C395(0.99); C166(1.15)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C166(1.03); C395(1.16)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C166(0.98); C395(1.18)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C166(1.00); C395(1.09)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C166(0.90); C395(0.99)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C395(0.81); C166(0.86); C706(1.17)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C166(0.91); C395(1.04)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C166(0.91); C395(1.23)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C166(0.89); C395(1.23)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C166(0.78); C395(1.12)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C166(0.85); C395(1.02)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C166(0.76); C395(1.08)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C166(0.88); C395(1.07); C706(1.37)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C166(0.95); C395(0.96); C706(1.17)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C166(0.65); C395(1.11); C706(1.24)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C166(0.75); C395(0.99); C706(1.33)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C395(0.78); C166(0.91); C706(1.21)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C166(0.75); C395(0.98); C706(1.18)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C706(0.94); C166(1.01); C395(1.15)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C166(0.90); C395(1.05); C706(1.05)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C166(0.95); C395(1.06); C706(1.08)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C166(0.86); C706(1.06); C395(1.09)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C166(1.04); C395(1.08); C706(1.11)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C166(0.72); C395(0.94); C706(1.31)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C395(0.86)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C395(0.73)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C395(0.85)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C395(0.77); C166(0.81); C706(1.16)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C395(0.85)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C395(0.70)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C395(0.75)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C395(0.89)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C395(0.72)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C395(0.88)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C395(0.74)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C395(0.84)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C395(1.04)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C395(0.94)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C395(0.81); C166(0.97); C706(1.05)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C395(0.91)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C395(1.16)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C395(0.95)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C395(0.92)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C395(0.93)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C395(0.87)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C395(0.97)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C395(1.10)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C395(0.94)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C395(1.10)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C395(0.83); C166(0.89); C706(1.15)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C395(0.93)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C395(1.27)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C395(0.76)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C166(0.68); C395(1.03)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C166(0.70); C395(1.09)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C166(0.72); C395(0.95)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C166(0.90); C395(1.16)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C166(0.91); C395(1.05)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C166(0.93); C395(1.20)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C166(0.83); C395(1.18)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C395(1.19); C166(1.23)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C166(0.72); C395(0.99)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C166(0.77); C395(1.04)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C166(0.85); C395(1.02)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C166(0.72); C395(1.22)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C166(0.87); C395(1.34)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C166(0.67); C395(1.02)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C166(0.82); C395(1.10)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C395(1.49)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C395(1.14)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C166(1.01); C395(0.74); C706(1.01)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C395(0.72); C166(0.96); C706(1.05)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C166(0.66); C395(0.99); C706(1.46)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C706(0.87)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C395(1.10); C166(1.29)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C166(0.54); C395(1.04)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C395(0.85); C166(0.93); C706(1.43)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C395(0.73); C166(0.81); C706(1.16)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C166(0.97); C706(1.00); C395(1.05)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C166(1.02); C706(1.03); C395(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C395(0.89); C166(0.98); C706(1.17)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C395(0.72); C166(0.84); C706(1.13)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C166(0.67); C395(0.72); C706(1.32)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C395(0.78); C166(0.85); C706(1.42)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C166(0.87); C395(0.88); C706(1.35)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C166(0.89); C395(1.04); C706(1.12)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C166(0.62); C395(1.25)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C395(0.79); C166(0.85); C706(1.00)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C395(0.85); C166(0.94); C706(1.00)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C706(1.04); C395(1.07); C166(1.16)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C166(0.85); C395(1.13); C706(1.23)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C166(0.82); C706(1.01); C395(1.36)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C166(0.88); C395(1.12); C706(1.40)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C166(0.82); C395(1.16); C706(1.55)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C166(0.75); C395(1.09)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C166(0.91); C395(1.10)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C166(0.84); C395(1.01)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C166(0.74); C395(0.89)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C166(0.89); C395(1.22)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C166(0.89); C395(0.93); C706(1.26)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C166(0.74); C706(1.10); C395(1.11)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C166(0.85); C395(1.12); C706(1.23)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C166(0.78); C395(1.07); C706(1.21)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C395(1.15)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C395(0.73)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C395(0.80)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C395(0.83)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C166(0.56); C395(1.23)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C166(1.02); C395(1.18)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C166(0.55); C395(1.10)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C166(0.90); C395(1.07); C706(1.15)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C166(0.64); C395(0.91); C706(0.95)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C166(0.57); C395(1.25); C706(1.37)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C166(0.50); C395(1.22); C706(1.24)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C395(1.20); C166(1.22)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C166(0.57); C706(1.12); C395(1.36)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C166(0.44); C395(1.00); C706(1.61)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C166(0.46); C395(1.36); C706(2.15)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C166(0.67); C395(1.11); C706(1.24)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C166(0.57); C395(1.35); C706(1.44)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C166(0.61); C395(1.29); C706(1.42)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C166(0.64); C395(1.41); C706(1.52)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C166(0.63); C395(1.29); C706(1.33)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C166(0.56); C395(1.24); C706(1.47)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C166(0.55); C395(1.27); C706(1.12)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C166(1.14); C395(1.26)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C166(0.82); C395(1.44); C706(1.33)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C166(0.74); C395(0.76); C706(0.88)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C166(0.46); C395(0.91); C706(1.01)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C166(0.56); C395(1.06); C706(0.94)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C166(0.45); C395(0.97); C706(0.94)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C166(0.54); C395(1.02); C706(1.05)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C166(0.60); C395(1.32); C706(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C166(0.50); C395(0.91); C706(0.98)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C166(0.53); C395(0.89); C706(1.02)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C166(1.08); C395(1.31)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C166(0.56); C395(1.00); C706(1.13)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C166(0.57); C395(0.96); C706(0.94)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C166(0.40); C395(0.88); C706(0.80)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C166(0.51); C395(1.01); C706(0.93)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C166(0.45); C395(1.00); C706(1.07)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C166(0.35); C395(0.99); C706(0.88)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C166(1.26); C706(0.90)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C166(1.10); C706(1.05)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C166(1.18); C706(0.93)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C166(1.13); C706(0.99)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C166(0.90); C395(0.91)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C166(1.32); C706(0.87)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C166(1.29); C706(0.96)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C166(1.08); C706(1.01)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C166(1.30); C706(0.93)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C166(0.97); C706(0.87)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C166(1.00); C706(0.95)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C166(1.04); C706(0.99)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C166(1.10); C706(0.92)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C166(1.15); C706(0.92)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C166(0.93); C706(1.06)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C166(0.57); C395(1.15)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C166(1.11); C706(1.19)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C166(0.96); C395(0.80); C706(0.98)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C166(1.02); C395(0.63); C706(1.20)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C166(0.94); C395(0.65); C706(1.20)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C166(0.95); C395(1.13); C706(1.15)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C166(1.09); C395(0.78); C706(1.19)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C166(0.94); C395(1.04); C706(1.50)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C166(0.98); C395(0.71); C706(1.30)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C166(0.85); C395(0.46); C706(1.37)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C166(0.98); C395(0.78); C706(1.10)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C166(0.83); C395(1.09)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C166(0.85); C395(1.14); C706(1.17)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C166(0.86); C395(1.85); C706(1.32)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C166(1.08); C395(1.11); C706(1.07)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C166(0.94); C395(0.87); C706(1.15)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C166(0.96); C395(0.94); C706(1.27)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C166(0.83); C395(1.30); C706(1.20)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C166(0.90); C395(1.21); C706(0.93)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C166(1.14); C395(0.88); C706(1.10)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C166(0.89); C395(0.90); C706(1.49)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C166(0.62); C395(1.02)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C166(0.76); C395(0.76); C706(1.22)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C166(0.98); C395(1.06); C706(1.12)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C166(0.88); C395(1.16); C706(1.80)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C166(0.88); C395(1.00); C706(1.71)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C166(0.75); C395(1.44); C706(1.82)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C166(1.12); C395(1.32); C706(1.26)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C166(1.19); C395(1.00); C706(1.00)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C166(0.92); C395(1.01); C706(1.45)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C166(0.91); C395(1.31); C706(1.66)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C166(0.72); C395(0.75); C706(2.59)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C166(0.98); C395(1.52)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C166(1.05); C395(1.00); C706(1.22)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C166(0.90); C395(0.78); C706(1.12)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C166(1.01); C395(0.91); C706(1.15)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C166(0.98); C395(0.74); C706(1.20)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C166(1.09); C395(0.68); C706(1.41)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C166(0.94); C395(0.91); C706(1.62)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C166(0.81); C395(0.83); C706(1.20)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C166(0.90); C395(0.73); C706(1.16)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C166(0.81); C395(0.87); C706(1.19)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C166(0.82); C395(0.79); C706(1.23)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C166(1.01); C395(0.77); C706(1.15)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C166(0.45); C395(0.83); C706(1.03)  LDD0744  [1]
 LDCM0022  KB02 22RV1 C395(2.40)  LDD2243  [3]
 LDCM0023  KB03 22RV1 C395(4.01)  LDD2660  [3]
 LDCM0024  KB05 HMCB C395(1.89)  LDD3312  [3]
 LDCM0021  THZ1 HCT 116 C706(0.87)  LDD2173  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzbromarone Small molecular drug D0Z3DY
Crofelemer Small molecular drug D09VXM
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
9-anthroic Acid Small molecular drug D0O6KR
Dcdpc Small molecular drug D02DAJ
Dids Small molecular drug D0PW7B
Ins(3,4,5,6)P4 Small molecular drug D0W1GH
Nppb Small molecular drug D08DQL
Sits Small molecular drug D0A2UX
Tannic Acid Small molecular drug D0R4WJ

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840