Details of the Target

General Information of Target

Target ID LDTP07211
Target Name Centrosome-associated protein 350 (CEP350)
Gene Name CEP350
Gene ID 9857
Synonyms
CAP350; KIAA0480; Centrosome-associated protein 350; Cep350; Centrosome-associated protein of 350 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDS
VMDTKKSSTSATRKISRKDGRYLDDSWVNAPISKSTKSRKEKSRSPLRATTLESNVKKNN
RVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSV
NNMAHDTDPKALRLTDSSPSSTSTSNSQRLDILKRRQHDVKLEKLKERIRKQWEHSEETN
GRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHL
ISTSSWRDGQKLVKKILGPAPRMEPKEQRTASSDRGGRERTAKSGGHIGRAESDPRLDVL
HRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYI
VRQQEERKRKQNEEKKAQKEATEQKNKRLQELYRKQKEAFTKVKNVPPSEPSATRRLQET
YSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILP
TRKNHNMASRPLTFTPQPYVTSPAAYTDALLKPSASQYKSKLDRIEALKATAASLSSRIE
SEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSS
SDMQACSQDKAKISLGSSIDSVSEGPLLSEGSLSEEEGDQDGQPLLKVAEILKEKEFCPG
ERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSN
RKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTEWLDSFTGNVQNSLLDEE
KAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRF
SPAGLHHRMAAELSYLNAIEESVRQLSDVERVRGISLAQQESVSLAQIIKAQQQRHERDL
ALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQQSE
TARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTETDR
KSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSCKEN
EKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTEDEIE
EQSFRSLLPSESHRRFNMEKRRGHHDDSDEEASPEKTTLSTAKELNMPFSGGQDSFSKFT
MEMVRQYMKEEEMRAAHQSSLLRLREKALKEKTKAELAWLEHQKKHLRDKGEDDKMPPLR
KKQRGLLLRLQQEKAEIKRLQEANKAARKERQLILKQQEEIEKIRQTTIKLQEKLKSAGE
SKLDSHSDDDTKDNKATSPGPTDLETRSPSPISISSSETSSIMQKLKKMRSRMDEKFLTK
REQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE
QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMIC
SQELESSTSPSKHSLPKSCTSVSKQESSKGSHRTGGQCHLPIKSHQHCYSWSDESLSMTQ
SETTSDQSDIEGRIRALKDELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEF
IKKTEAELSQDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRG
SLESIAEHVDASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESG
DSLENVPALHLLKELNATSRILDMSDGKVGESSKKSEIKEIEYTKLKKSKIEDAFSKEGK
SDVLLKLVLEQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNH
SPNIQSGKDIHEQKNTKEKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS
SLLSLRKDSQSCRDKPQPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKS
PTELMKSKERSDVEHEQQVTESPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETS
FAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFAPPQKISHIPENFDDYVDINEDE
DCYSDERYQCYNQEQNDTEGPKDREKDVSEYFYEKSLPSVNDIEASVNRSRSLKIETDNV
QDISGVLEAHVHQQSSVDSQISSKENKDLISDATEKVSIAAEDDTLDNTFSEELEKQQQF
TEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQLKSSLNEEKKSKQQLEKISLLTDSLLK
VFVKDTVNQLQQIKKTRDEKIQLSNQELLGDDQKKVTPQDLSQNVEEQSPSISGCFLSSE
LEDEKEEISSPDMCPRPESPVFGASGQEELAKRLAELELSREFLSALGDDQDWFDEDFGL
SSSHKIQKNKAEETIVPLMAEPKRVTQQPCETLLAVPHTAEEVEILVHNAAEELWKWKEL
GHDLHSISIPTKLLGCASKGLDIESTSKRVYKQAVFDLTKEIFEEIFAEDPNLNQPVWMK
PCRINSSYFRRVKNPNNLDEIKSFIASEVLKLFSLKKEPNHKTDWQKMMKFGRKKRDRVD
HILVQELHEEEAQWVNYDEDELCVKMQLADGIFETLIKDTIDVLNQISEKQGRMLLV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation.
Uniprot ID
Q5VT06
Ensemble ID
ENST00000367607.8
HGNC ID
HGNC:24238

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1384(1.22)  LDD0277  [1]
Probe 1
 Probe Info  		Y2708(12.47)  LDD3495  [2]
BTD
 Probe Info  		C2956(0.64)  LDD2143  [3]
AHL-Pu-1
 Probe Info  		C2716(5.10); C153(2.13)  LDD0168  [4]
DBIA
 Probe Info  		C2590(1.01)  LDD0078  [5]
CY-1
 Probe Info  		E1915(0.00); E1920(0.00)  LDD0246  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C2716(0.00); C2412(0.00)  LDD0162  [8]
NAIA_4
 Probe Info  		C1432(0.00); C2716(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		C2716(0.00); C211(0.00)  LDD0005  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C2716(5.10); C153(2.13)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2910(2.65); C2716(3.01); C153(3.46)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C2590(1.14)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C2590(1.48)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C2590(0.95)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C2590(0.96)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C2590(0.70)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C2590(1.29)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C2590(1.08)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C2590(1.23)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C2590(1.18)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C2590(1.18)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C2590(0.97)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C2590(0.71)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C2590(1.43)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C2590(0.67)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C2590(0.99)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C2590(0.91)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C2590(1.12)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C2590(1.39)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C2590(1.37)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C2590(1.56)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C2590(1.42)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C2590(1.26)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C2590(1.23)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C2590(1.15)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C2590(0.88)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C2590(1.12)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C2590(1.14)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C2590(1.22)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C2590(1.12)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C2590(1.49)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C2590(1.99)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C2590(2.31)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C2590(1.09)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C2590(0.82)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C2590(1.56)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C2590(0.95)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C2590(0.96)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C2590(1.15)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C2590(1.00)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C2590(0.91)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C2590(0.77)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C2590(0.73)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C2590(1.04)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C2590(1.08)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C2590(1.30)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C2590(1.09)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C2590(1.08)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C2590(1.31)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C2590(1.13)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C2590(2.50)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C2590(1.13)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C2590(2.28)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C2590(2.51)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C2590(3.60)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C2590(2.58)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C2590(1.25)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C2590(1.22)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C2590(1.79)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C2590(2.42)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C2590(2.92)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C2590(2.11)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C2590(1.78)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C2590(1.21)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C2590(2.09)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C2590(0.95)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C2590(1.39)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C2590(1.21)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C2590(1.09)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C2590(0.98)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C2590(1.14)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C2590(0.96)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C2590(0.95)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C2590(1.09)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C1018(0.70); C966(0.70)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C1018(0.78); C966(0.78)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C1018(0.89); C966(0.89)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C1018(1.60); C966(1.60)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C1018(1.30); C966(1.30)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C2590(1.07)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C1018(0.74); C966(0.74)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C1018(0.68); C966(0.68)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C1018(0.70); C966(0.70)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C1018(1.03); C966(1.03)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C1018(0.59); C966(0.59)  LDD0893  [5]
 LDCM0296  AC35 HCT 116 C2590(0.78)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C2590(0.67)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C2590(0.77)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C2590(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C2590(0.88)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C2590(1.25)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C2590(0.92)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C2590(0.63)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C2590(0.85)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C2590(0.92)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C2590(0.94)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C2590(1.08)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C2590(1.13)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C2590(1.24)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C2590(1.05)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C2590(1.55)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C2590(1.13)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C2590(1.77)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C2590(0.98)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C2590(0.97)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C2590(1.12)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C2590(1.18)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C2590(1.81)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C2590(2.89)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C2590(1.09)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C2590(1.38)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C2590(0.98)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C2590(1.36)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C2590(0.88)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C2590(1.06)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C2590(1.34)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C2590(0.88)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C2590(0.94)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C2590(1.17)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C2590(1.09)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C2590(1.11)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C2590(0.95)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C2590(0.94)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C2590(1.29)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C2590(1.08)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C2590(0.98)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C2590(1.20)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C2590(1.29)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C2590(1.04)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C2590(1.06)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C2590(1.09)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C2590(1.27)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C2590(0.89)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C2590(0.88)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C2590(1.71)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C2590(1.15)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C2590(1.17)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C2590(1.27)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C2590(1.83)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C2590(1.70)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C2590(1.23)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C2590(1.48)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C2590(1.09)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C2590(1.26)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C2590(1.56)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C2590(1.16)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C2590(2.10)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C2590(2.12)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C2590(1.25)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C2590(1.17)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C2590(1.10)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C2590(1.86)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C2590(1.36)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C2590(1.51)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C2590(0.72)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C2590(1.12)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C2590(1.25)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C2590(1.92)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C2590(1.01)  LDD0078  [5]
 LDCM0367  CL1 HEK-293T C2590(1.48)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C2590(0.99)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C2590(1.22)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C2590(1.29)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C2590(0.95)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C2590(1.03)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C2590(1.34)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C2590(1.15)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C2590(1.49)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C2590(1.46)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C2590(1.53)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C2590(1.27)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C2590(0.99)  LDD0977  [5]
 LDCM0380  CL110 HCT 116 C2590(1.28)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C2590(0.95)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C1018(0.96); C966(0.96)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C1018(0.68); C966(0.68)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C1018(1.14); C966(1.14)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C1018(0.89); C966(0.89)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C1018(0.71); C966(0.71)  LDD0984  [5]
 LDCM0387  CL117 HCT 116 C2590(1.65)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C2590(0.86)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C2590(1.10)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C2590(0.95)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C2590(0.91)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C2590(1.40)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C2590(1.03)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C2590(1.15)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C2590(1.27)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C2590(0.81)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C2590(0.71)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C2590(0.83)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C2590(1.15)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C2590(0.95)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C2590(1.17)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C2590(1.34)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C413(0.77)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C413(1.27)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C413(1.14)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C413(1.03)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C2590(1.18)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C413(1.06)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C413(1.27)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C413(1.00)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C413(0.97)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C413(0.98)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C413(1.18)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C413(0.98)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C413(1.02)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C413(0.96)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C413(1.02)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C2590(1.37)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C413(1.09)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C2590(0.76)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C2590(1.01)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C2590(1.01)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C2590(1.18)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C2590(1.17)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C2590(1.08)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C2590(1.03)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C2590(0.91)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C2590(1.27)  LDD1027  [5]
 LDCM0430  CL40 HCT 116 C2590(0.79)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C2590(1.07)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C2590(0.78)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C2590(0.96)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C2590(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C2590(0.90)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C1018(1.11); C966(1.11)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C1018(1.22); C966(1.22)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C1018(0.67); C966(0.67)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C1018(1.25); C966(1.25)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C2590(1.30)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C1018(1.98); C966(1.98)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C1018(1.27); C966(1.27)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C1018(0.97); C966(0.97)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C1018(1.00); C966(1.00)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C1018(1.69); C966(1.69)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C1018(1.15); C966(1.15)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C1018(0.94); C966(0.94)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C1018(1.16); C966(1.16)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C1018(1.14); C966(1.14)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C1018(1.40); C966(1.40)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C2590(1.07)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C1018(1.60); C966(1.60)  LDD1050  [5]
 LDCM0453  CL61 PaTu 8988t C2590(1.00)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C2590(1.01)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C2590(1.06)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C2590(1.40)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C2590(1.08)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C2590(1.10)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C2590(1.31)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C2590(1.39)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C2590(1.43)  LDD1340  [5]
 LDCM0462  CL7 HEK-293T C2590(1.24)  LDD1060  [5]
 LDCM0463  CL70 PaTu 8988t C2590(1.36)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C2590(1.00)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C2590(0.98)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C2590(1.24)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C2590(1.30)  LDD1346  [5]
 LDCM0469  CL76 HCT 116 C2590(1.73)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C2590(1.02)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C2590(1.47)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C2590(2.07)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C2590(0.42)  LDD1071  [5]
 LDCM0474  CL80 HCT 116 C2590(1.45)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C2590(1.53)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C2590(1.98)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C2590(2.04)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C2590(2.25)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C2590(1.61)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C2590(1.01)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C2590(1.29)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C2590(1.56)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C2590(3.02)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C2590(0.52)  LDD1082  [5]
 LDCM0485  CL90 HCT 116 C2590(0.84)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C2590(1.12)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C2590(0.92)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C2590(0.89)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C2590(1.10)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C2590(1.00)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C2590(1.22)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C2590(0.99)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C2590(1.09)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C2590(1.09)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C211(1.12); C2716(1.10); C1557(1.08); C1432(1.33)  LDD1698  [13]
 LDCM0468  Fragment33 PaTu 8988t C2590(1.19)  LDD1347  [5]
 LDCM0427  Fragment51 HCT 116 C2590(0.76)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C1557(1.95); C2590(1.78)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C1557(1.15); C2590(1.12)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C1557(1.38); C2590(1.32)  LDD0082  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2956(0.64)  LDD2143  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin alpha-1 (CTNNA1) Vinculin/alpha-catenin family P35221

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402