Details of the Target

General Information of Target

Target ID LDTP07172
Target Name DEP domain-containing protein 1A (DEPDC1)
Gene Name DEPDC1
Gene ID 55635
Synonyms
DEPDC1A; DEP domain-containing protein 1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNN
SNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDNNQLFRFPATSPLKTLPRRYP
ELRKNNIENFSKDKDSIFKLRNLSRRTPKRHGLHLSQENGEKIKHEIINEDQENAIDNRE
LSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNMANTSKRGVVILQNKS
DDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFV
NILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLNNLNSFKSTECLLLSLLHREKNKEESD
STERLQISNPGFQERCAKKMQLVNLRNRRVSANDIMGGSCHNLIGLSNMHDLSSNSKPRC
CSLEGIVDVPGNSSKEASSVFHQSFPNIEGQNNKLFLESKPKQEFLLNLHSEENIQKPFS
AGFKRTSTLTVQDQEELCNGKCKSKQLCRSQSLLLRSSTRRNSYINTPVAEIIMKPNVGQ
GSTSVQTAMESELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAID
ALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEE
VDLDELLAGRLVSFLMDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYS
YCKQISAQEFDEQKVSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFP
TTESEAALFGDKPTIKQPMLILRKPKFRSLR
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
TTD ID
T96365
Uniprot ID
Q5TB30
DrugMap ID
TT8S9CM
Ensemble ID
ENST00000370966.9
HGNC ID
HGNC:22949

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C722(2.24)  LDD0172  [1]
IA-alkyne
 Probe Info  		C722(2.66)  LDD2214  [2]
DBIA
 Probe Info  		C722(4.88)  LDD0080  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
AOyne
 Probe Info  		14.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [7]
STS-2
 Probe Info  		N.A.  LDD0139  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C722(2.24)  LDD0172  [1]
 LDCM0214  AC1 HEK-293T C253(1.11); C653(1.01); C656(0.83); C657(0.96)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C253(0.95); C420(1.10); C421(1.10)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C253(0.65); C420(0.74); C421(0.74); C722(0.59)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C253(0.82); C420(0.81); C421(0.81); C722(0.65)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C253(0.73); C420(0.72); C421(0.72); C722(0.73)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C253(0.64); C420(1.04); C421(1.04); C722(0.75)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C253(0.84); C420(0.90); C421(0.90); C722(0.77)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C253(0.64); C420(0.88); C421(0.88); C722(0.68)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C253(0.73); C420(0.86); C421(0.86); C722(0.92)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C253(0.58); C420(0.82); C421(0.86); C722(0.70)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C253(0.62); C420(0.79); C421(0.59); C722(0.51)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C253(0.72); C420(0.85); C421(0.69); C722(0.64)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C253(0.88); C420(1.38); C421(1.38)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C253(0.91); C420(0.79); C421(0.81); C722(0.53)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C253(0.75); C420(0.79); C421(0.74); C722(0.64)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C253(0.63); C420(0.84); C421(0.86); C722(0.70)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C653(1.06); C656(1.16)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C653(1.04); C656(1.04)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C653(1.18); C656(1.07)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C653(1.11); C656(0.78)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C653(1.26); C656(0.77)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C653(1.41); C656(0.73)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C653(1.50); C656(0.68)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C253(0.80); C420(0.90); C421(0.90)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C653(1.43); C656(0.72)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C653(1.46); C656(0.75)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C653(1.89); C656(0.66)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C653(1.83); C656(0.80)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C653(1.55); C656(0.65)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C653(1.85); C656(0.63)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C653(2.54); C656(0.73)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C653(2.76); C656(0.91)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C253(1.74); C420(1.12); C421(1.12)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C253(1.21); C420(0.81); C421(0.81)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C253(2.03); C420(0.92); C421(0.92)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C253(1.23); C420(0.73); C421(0.73)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C253(1.22); C420(0.81); C421(0.81)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C253(1.83); C420(0.80); C421(0.80)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C253(1.99); C420(0.96); C421(0.96)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C253(1.84); C420(1.00); C421(1.00)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C253(1.58); C420(0.75); C421(0.75)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C253(1.36); C420(0.77); C421(0.77)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C253(1.77); C420(0.88); C421(0.88)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C253(2.14); C420(0.90); C421(0.90)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C253(0.88); C420(1.52); C421(1.52)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C253(2.36); C420(0.97); C421(0.97)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C253(1.30); C420(0.88); C421(0.88)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C253(1.47); C420(0.74); C421(0.74)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C253(1.61)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C253(1.32)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C253(1.14)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C253(1.78)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C253(1.42)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C253(1.60)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C253(1.62)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C253(0.87); C420(0.95); C421(0.95)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C253(1.87)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C253(1.10)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C253(1.69)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C253(1.71)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C253(1.10)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C253(1.51)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C253(1.08)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C253(0.84)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C420(0.53); C421(0.53); C722(0.92)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C420(0.75); C421(0.75); C722(0.89)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C420(0.58); C421(0.58); C722(0.90)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C253(1.14); C653(1.06); C656(0.74); C657(0.70)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C420(0.64); C421(0.64); C722(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C420(0.56); C421(0.56); C722(0.96)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C420(0.51); C421(0.51); C722(1.01)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C420(0.52); C421(0.52); C722(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C420(0.51); C421(0.51); C722(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C722(1.10)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C722(1.44)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C722(1.17)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C722(1.05)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C722(1.01)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C253(0.85); C653(0.84); C656(0.94); C657(0.59)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C722(1.09)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C722(1.18)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C722(1.01)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C722(1.14)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C722(1.24)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C420(0.95); C421(0.95); C253(1.11); C722(1.12)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C420(1.02); C421(1.02); C253(1.09); C722(1.18)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C420(0.87); C421(0.87); C253(1.08); C722(1.28)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C420(0.88); C421(0.88); C722(1.22); C253(1.37)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C420(0.97); C421(0.97); C722(1.15); C253(1.19)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C253(0.81); C653(0.87); C656(0.99); C657(0.99)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C420(0.94); C421(0.94); C253(1.18); C722(1.30)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C420(0.86); C421(0.86); C253(1.28); C722(1.41)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C420(0.91); C421(0.91); C253(1.29); C722(1.40)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C420(0.93); C421(0.93); C722(1.13); C253(1.17)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C420(1.00); C421(1.00); C722(1.26); C253(1.33)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C420(0.99); C421(0.99); C722(1.31); C253(1.51)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C253(1.10)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C253(1.08)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C253(1.17)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C253(1.14)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C253(1.09); C653(0.99); C656(0.79); C657(0.90)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C253(1.30)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C253(1.05)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C253(1.15)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C253(1.02)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C253(1.03)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C253(1.19)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C253(1.42)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C420(0.67); C421(0.67); C722(1.06)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C420(0.95); C421(0.95); C722(1.23)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C722(0.85); C420(1.08); C421(1.08)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C253(1.02); C420(1.28); C421(1.28)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C420(0.84); C421(0.84); C722(0.98)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C420(0.74); C421(0.74); C722(0.93)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C722(0.81); C420(1.24); C421(1.24)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C722(0.78); C420(1.02); C421(1.02)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C722(0.73); C420(0.82); C421(0.82)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C420(0.75); C421(0.75); C722(0.92)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C420(0.56); C421(0.56); C722(0.86)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C420(0.66); C421(0.66); C722(0.74)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C722(1.10); C253(1.13)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C722(0.95); C253(1.17)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C253(0.96); C420(1.03); C421(1.03)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C253(0.89); C722(0.90)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C722(0.80); C253(0.93)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C722(0.99); C253(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C722(0.88); C253(1.15)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C722(0.77); C253(1.30)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C722(0.83); C253(1.58)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C253(0.93); C722(1.04)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C253(1.09); C722(1.32)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C253(0.88); C722(0.91)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C722(0.91); C253(1.12)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C420(0.91); C421(0.91); C253(0.97)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C722(0.88); C253(0.95)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C722(0.89); C253(1.33)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C722(0.93); C253(1.50)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C420(1.79); C421(1.79)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C420(1.41); C421(1.41)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C420(1.15); C421(1.15)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C420(1.31); C421(1.31)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C420(1.14); C421(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C420(1.24); C421(1.24)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C420(1.36); C421(1.36)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C420(1.04); C421(1.04)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C420(1.60); C421(1.60)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C420(1.61); C421(1.61)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C420(1.20); C421(1.20)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C420(1.37); C421(1.37)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C420(1.34); C421(1.34)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C420(1.44); C421(1.44)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C420(1.53); C421(1.53)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C722(0.60); C253(1.08); C420(1.09); C421(1.09)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C253(0.48); C420(0.65); C421(0.65); C722(0.68)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C253(0.83); C420(0.90); C421(0.90)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C253(0.76); C420(1.29); C421(1.29)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C420(0.90); C421(0.90); C253(1.01)  LDD0592  [3]
 LDCM0630  CCW28-3 231MFP C722(2.66)  LDD2214  [2]
 LDCM0367  CL1 HCT 116 C253(1.03); C420(1.31); C421(1.31)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C253(0.89); C420(1.00); C421(1.00)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C253(1.25); C653(1.21); C656(0.75); C657(0.76)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C253(0.98); C420(1.47); C421(1.47)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C253(0.94); C420(1.32); C421(1.32)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C253(0.89); C420(1.15); C421(1.15)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C253(1.02); C420(1.11); C421(1.11)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C420(0.56); C421(0.56); C722(0.79)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C420(0.51); C421(0.51); C722(0.79)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C420(0.55); C421(0.55); C722(0.83)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C420(0.44); C421(0.44); C722(0.85)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C420(0.56); C421(0.56); C722(1.00)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C253(0.98); C420(1.08); C421(1.08)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C420(0.51); C421(0.51); C722(0.95)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C420(0.57); C421(0.57); C722(1.19)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C722(1.19)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C722(1.09)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C722(1.34)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C722(1.29)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C722(1.25)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C420(1.11); C421(1.11); C722(1.24); C253(1.34)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C420(0.98); C421(0.98); C722(1.07); C253(1.20)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C722(1.06); C253(1.10); C420(1.15); C421(1.15)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C420(0.82); C421(0.82); C253(0.87)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C420(0.86); C421(0.86); C253(1.13); C722(1.14)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C253(1.03)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C253(1.17)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C253(1.57)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C253(1.31)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C420(0.58); C421(0.58); C722(0.88)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C420(0.83); C421(0.83); C722(0.87)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C420(0.74); C421(0.74); C722(0.93)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C722(0.91); C420(1.07); C421(1.07)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C420(0.88); C421(0.88); C253(1.00)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C253(0.87); C420(1.05); C421(1.05)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C253(0.87); C420(1.29); C421(1.29)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C253(0.97); C420(1.01); C421(1.01)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C722(1.24); C420(1.27); C421(1.27)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C420(1.11); C421(1.11); C722(1.16)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C420(1.13); C421(1.13); C722(1.18)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C253(0.90); C420(1.03); C421(1.03)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C420(1.24); C421(1.24); C722(1.36)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C420(1.50); C421(1.50); C722(1.53)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C722(1.20); C420(1.40); C421(1.40)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C722(1.18); C420(1.33); C421(1.33)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C722(0.99); C420(1.22); C421(1.22)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C420(1.32); C421(1.32); C722(1.09)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C420(1.29); C421(1.29); C722(0.97)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C420(1.10); C421(1.10); C722(1.09)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C420(1.23); C421(1.23); C722(1.09)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C420(1.18); C421(1.18); C722(1.25)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C253(1.10); C420(1.07); C421(1.07)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C420(1.12); C421(1.12); C722(1.22)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C253(1.10); C722(1.01)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C253(1.43); C420(0.90); C421(0.90)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C253(1.23); C420(1.39); C421(1.39)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C253(1.54); C420(0.94); C421(0.94)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C253(1.38); C420(0.71); C421(0.71)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C253(1.21); C420(1.01); C421(1.01)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C253(1.49); C420(0.70); C421(0.70)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C253(1.17); C420(1.19); C421(1.19)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C253(0.69); C420(1.01); C421(1.01)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C253(1.02); C420(0.97); C421(0.97)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C253(1.13); C420(1.24); C421(1.24)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C253(1.78); C420(0.73); C421(0.73)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C253(1.32); C420(1.05); C421(1.05)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C253(1.48); C420(0.65); C421(0.65)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C253(1.29); C420(0.64); C421(0.64)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C420(0.70); C421(0.70)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C420(0.62); C421(0.62)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C420(0.99); C421(0.99)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C420(0.83); C421(0.83)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C253(0.99); C420(0.98); C421(0.98)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C420(1.04); C421(1.04)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C420(0.71); C421(0.71)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C420(1.30); C421(1.30)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C420(1.45); C421(1.45)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C420(1.19); C421(1.19)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C420(0.90); C421(0.90)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C420(1.27); C421(1.27)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C420(0.91); C421(0.91)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C420(1.48); C421(1.48)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C420(0.78); C421(0.78)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C253(0.88); C420(1.28); C421(1.28)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C420(0.82); C421(0.82)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C253(1.04); C722(1.09)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C253(1.21); C722(1.06)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C253(1.57); C722(1.25)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C253(1.22); C722(1.09)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C253(1.48); C722(1.19)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C253(1.58); C722(0.99)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C253(1.20); C722(1.04)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C253(1.32); C722(1.45)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C253(1.21); C722(1.00)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C253(1.05); C420(0.75); C421(0.75)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C253(1.19); C722(1.02)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C253(1.52); C722(1.12)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C253(1.25); C722(1.29)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C253(1.12); C722(1.30)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C253(1.30); C722(1.14)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C253(1.09)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C253(1.28)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C253(1.13)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C253(1.40)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C253(0.98); C420(1.50); C421(1.50)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C253(1.10)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C253(1.13)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C253(1.26)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C253(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C253(1.21)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C253(1.16)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C253(1.08)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C253(0.92)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C253(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C253(1.10)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C253(1.02); C420(0.83); C421(0.83)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C253(1.39)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C253(1.01); C653(0.94); C656(1.04); C657(1.15)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C253(0.91); C653(1.00); C656(0.82); C657(0.63)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C253(1.04); C653(0.91); C656(0.91); C657(0.93)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C253(1.47); C653(1.22); C656(0.68); C657(0.99)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C253(1.49); C653(1.32); C656(0.52); C657(0.62)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C253(1.31); C653(1.02); C656(0.73); C657(0.75)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C253(0.98); C653(1.00); C656(0.85); C657(0.61)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C253(0.99); C653(1.00); C656(0.94); C657(0.93)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C253(0.94); C653(0.89); C656(0.94); C657(0.80)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C253(1.05); C722(1.07)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C253(0.93); C722(1.07)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C253(1.55); C420(1.06); C421(1.06)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C722(4.88)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C722(1.96)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C722(3.80)  LDD0082  [3]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402