Details of the Target

General Information of Target

Target ID LDTP07133
Target Name PHD finger protein 19 (PHF19)
Gene Name PHF19
Gene ID 26147
Synonyms
PCL3; PHD finger protein 19; Polycomb-like protein 3; hPCL3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKI
KRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCG
LGYHQQCHIPIAGSADQPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQP
EELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYL
FFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGK
LTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPN
ENSASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLA
SIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAK
AYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKSSIT
NYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY
Target Bioclass
Transcription factor
Family
Polycomblike family
Subcellular location
Nucleus
Function
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Uniprot ID
Q5T6S3
Ensemble ID
ENST00000312189.10
HGNC ID
HGNC:24566

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.T426M .
HCC1395 SNV: p.P499L .
HELA SNV: p.G327D .
IM95 Insertion: p.R395KfsTer13 .
Ishikawa (Heraklio) 02 ER SNV: p.K370T DBIA    Probe Info 
JURKAT SNV: p.E565K .
KMRC1 Substitution: p.D136P .
LS180 SNV: p.L400R .
MOLT4 SNV: p.R167S; p.R340H .
NCIH23 SNV: p.G249C DBIA    Probe Info 
OPM2 SNV: p.A452S DBIA    Probe Info 
RL952 SNV: p.E205Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C99(2.97); C102(1.16)  LDD1701  [1]
DBIA
 Probe Info  		C102(0.85); C99(0.85)  LDD0078  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C102(1.00); C224(0.93); C227(0.93); C99(1.00)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C102(0.96); C224(0.95); C227(0.95); C99(0.96)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C102(0.65); C99(0.65)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C102(0.65); C99(0.65)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C102(0.71); C99(0.71)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C102(0.58); C99(0.58)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C102(0.63); C99(0.63)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C102(0.65); C99(0.65)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C102(0.70); C99(0.70)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C102(1.37); C99(0.66)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C102(0.84); C99(0.62)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C102(0.79); C99(0.66)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C102(0.89); C224(0.65); C227(0.65); C99(0.89)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C102(0.85); C99(0.69)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C102(0.83); C99(0.66)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C102(1.07); C99(0.66)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C102(1.01); C99(1.01)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C102(0.89); C99(0.95)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C102(0.83); C99(1.01)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C102(0.98); C99(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C102(0.90); C99(0.86)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C102(0.95); C99(1.02)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C102(0.86); C99(0.86)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C102(0.99); C224(0.88); C227(0.88); C99(0.99)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C102(0.88); C99(0.97)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C102(1.09); C99(0.91)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C102(1.16); C99(1.10)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C102(0.74); C99(0.85)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C102(1.03); C99(0.99)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C102(0.96); C99(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C102(1.00); C99(1.05)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C102(0.94); C99(0.94)  LDD0562  [2]
 LDCM0246  AC128 PaTu 8988t C102(1.15); C99(1.15)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C102(1.05); C99(1.05)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C102(1.11); C99(1.11)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C102(1.00); C99(1.00)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C102(0.93); C99(0.93)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C102(0.94); C99(0.94)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C102(1.01); C99(1.01)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C102(1.01); C99(1.01)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C102(1.02); C99(1.02)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C102(1.00); C99(1.00)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C102(1.11); C99(1.11)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C102(1.06); C99(1.06)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C102(1.17); C224(1.23); C227(1.23); C99(1.17)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C102(1.08); C99(1.08)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C102(0.99); C99(0.99)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C102(1.04); C99(1.04)  LDD1141  [2]
 LDCM0263  AC143 HCT 116 C102(0.97); C99(0.97)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C102(1.03); C99(1.03)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C102(0.98); C99(0.98)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C102(1.22); C99(1.22)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C102(0.94); C99(0.94)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C102(1.11); C99(1.11)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C102(1.06); C99(1.06)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C224(0.75); C227(0.75); C102(0.94); C99(0.94)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C102(0.87); C99(0.87)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C102(0.96); C99(0.96)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C102(1.02); C99(1.02)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C102(1.05); C99(1.05)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C102(0.89); C99(0.89)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C102(0.98); C99(0.98)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C102(1.04); C99(1.04)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C102(0.97); C99(0.97)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C224(0.85); C227(0.85)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C224(0.63); C227(0.63)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C224(0.81); C227(0.81)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C102(0.98); C99(0.98); C224(1.10); C227(1.10)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C224(1.01); C227(1.01)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C224(0.73); C227(0.73)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C224(0.81); C227(0.81)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C224(0.80); C227(0.80)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C224(1.05); C227(1.05)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C224(0.88); C227(0.88); C102(1.01); C99(1.01)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C102(1.01); C99(1.01); C224(1.05); C227(1.05)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C224(0.85); C227(0.85); C102(0.92); C99(0.92)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C102(0.86); C99(0.86); C224(0.87); C227(0.87)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C102(0.88); C99(0.88); C224(0.94); C227(0.94)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C102(0.97); C99(0.97); C224(1.02); C227(1.02)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C224(0.97); C227(0.97); C102(1.01); C99(1.01)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C224(1.02); C227(1.02); C102(1.03); C99(1.03)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C224(0.97); C227(0.97); C102(0.99); C99(0.99)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C224(0.93); C227(0.93); C102(1.02); C99(1.02)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C102(0.90); C99(0.90); C224(0.93); C227(0.93)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C102(1.03); C99(1.03); C224(1.20); C227(1.20)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C102(1.00); C99(1.00); C224(1.02); C227(1.02)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C102(1.14); C99(1.14); C224(1.23); C227(1.23)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C102(0.93); C99(0.93); C224(1.38); C227(1.38)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C102(1.13); C99(1.13); C224(1.14); C227(1.14)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C224(0.77); C227(0.77); C102(0.99); C99(0.99)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C102(0.97); C99(0.97); C224(1.35); C227(1.35)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C102(1.13); C99(1.13); C224(1.25); C227(1.25)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C102(1.04); C99(1.04); C224(1.27); C227(1.27)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C102(1.06); C99(1.06); C224(1.42); C227(1.42)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C102(1.05); C99(1.05); C224(1.21); C227(1.21)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C102(1.10); C99(1.10); C224(1.25); C227(1.25)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C224(1.16); C227(1.16)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C224(1.12); C227(1.12)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C224(1.95); C227(1.95)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C224(1.62); C227(1.62)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C224(0.96); C227(0.96); C102(1.00); C99(1.00)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C224(1.21); C227(1.21)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C224(1.51); C227(1.51)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C224(1.19); C227(1.19)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C224(1.08); C227(1.08)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C224(1.22); C227(1.22)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C224(1.45); C227(1.45)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C224(1.76); C227(1.76)  LDD0636  [2]
 LDCM0320  AC57 PaTu 8988t C102(1.12); C99(1.12); C224(0.73); C227(0.73)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C102(1.07); C99(1.07); C224(0.68); C227(0.68)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C102(1.15); C99(1.15); C224(1.00); C227(1.00)  LDD1201  [2]
 LDCM0323  AC6 HCT 116 C224(0.85); C227(0.85); C102(0.98); C99(0.98)  LDD0640  [2]
 LDCM0324  AC60 PaTu 8988t C102(1.16); C99(1.16); C224(0.78); C227(0.78)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C102(1.07); C99(1.07); C224(0.87); C227(0.87)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C102(1.24); C99(1.24); C224(0.98); C227(0.98)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C102(1.05); C99(1.05); C224(0.69); C227(0.69)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C102(1.11); C99(1.11); C224(0.94); C227(0.94)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C102(1.00); C99(1.00); C224(0.97); C227(0.97)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C102(0.92); C99(0.92); C224(0.84); C227(0.84)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C102(1.15); C99(1.15); C224(0.83); C227(0.83)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C102(1.01); C99(1.01); C224(0.99); C227(0.99)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C102(1.11); C99(1.11); C224(1.01); C227(1.01)  LDD1212  [2]
 LDCM0334  AC7 HCT 116 C224(0.98); C227(0.98); C102(1.09); C99(1.09)  LDD0651  [2]
 LDCM0335  AC70 PaTu 8988t C102(1.02); C99(1.02); C224(1.02); C227(1.02)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C102(1.08); C99(1.08); C224(0.86); C227(0.86)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C102(1.11); C99(1.11); C224(1.40); C227(1.40)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C102(0.93); C99(0.93); C224(0.93); C227(0.93)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C102(1.06); C99(1.06); C224(0.92); C227(0.92)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C102(1.04); C99(1.04); C224(1.02); C227(1.02)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C102(1.07); C99(1.07); C224(0.98); C227(0.98)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C102(0.96); C99(0.96); C224(1.04); C227(1.04)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C102(1.01); C99(1.01); C224(1.03); C227(1.03)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C102(1.05); C99(1.05); C224(0.84); C227(0.84)  LDD1223  [2]
 LDCM0345  AC8 HCT 116 C102(0.90); C99(0.90); C224(0.95); C227(0.95)  LDD0662  [2]
 LDCM0346  AC80 PaTu 8988t C102(0.98); C99(0.98); C224(1.41); C227(1.41)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C102(0.97); C99(0.97); C224(1.41); C227(1.41)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C102(1.06); C99(1.06); C224(0.89); C227(0.89)  LDD1227  [2]
 LDCM0349  AC83 HCT 116 C102(0.88); C99(0.88)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C102(0.89); C99(0.89)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C102(0.86); C99(0.86)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C102(0.89); C99(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C102(0.89); C99(0.89)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C102(0.93); C99(0.93)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C102(0.91); C99(0.91)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C102(1.04); C99(1.04)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C102(0.96); C99(0.96)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C102(0.94); C99(0.94)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C102(0.89); C99(0.89)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C102(0.93); C99(0.93)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C102(0.90); C99(0.90)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C102(0.87); C99(0.87)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C102(0.93); C99(0.93)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C102(0.40); C99(0.40)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C102(0.64); C99(0.64)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C102(0.97); C224(1.05); C227(1.05); C99(0.97)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C102(1.00); C99(1.00); C224(1.05); C227(1.05)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C224(0.68); C227(0.68); C102(1.04); C99(1.04)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C102(0.85); C99(0.85)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C102(0.90); C99(0.90); C224(1.21); C227(1.21)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C102(0.99); C99(0.99); C224(1.27); C227(1.27)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C224(0.83); C227(0.83); C102(0.95); C99(0.95)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C224(0.80); C227(0.80); C102(1.07); C99(1.07)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C224(0.99); C227(0.99); C102(1.08); C99(1.08)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C102(0.94); C99(0.94); C224(1.13); C227(1.13)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C224(0.84); C227(0.84); C102(0.97); C99(0.97)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C224(0.77); C227(0.77)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C224(0.83); C227(0.83)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C224(0.66); C227(0.66)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C224(0.70); C227(0.70)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C224(0.80); C227(0.80)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C102(0.95); C99(0.95); C224(1.16); C227(1.16)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C224(0.72); C227(0.72)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C224(0.79); C227(0.79)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C102(0.92); C99(0.92); C224(1.24); C227(1.24)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C224(0.81); C227(0.81); C102(0.91); C99(0.91)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C102(0.90); C99(0.90); C224(1.01); C227(1.01)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C102(0.92); C99(0.92); C224(0.97); C227(0.97)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C102(1.00); C99(1.00); C224(1.03); C227(1.03)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C102(0.99); C99(0.99); C224(1.33); C227(1.33)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C102(1.07); C99(1.07); C224(1.21); C227(1.21)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C102(1.03); C99(1.03); C224(1.21); C227(1.21)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C224(0.93); C227(0.93); C102(1.17); C99(1.17)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C102(1.03); C99(1.03); C224(1.23); C227(1.23)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C224(3.48); C227(3.48)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C224(1.34); C227(1.34)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C224(1.68); C227(1.68)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C224(1.92); C227(1.92)  LDD0712  [2]
 LDCM0396  CL125 PaTu 8988t C102(0.99); C99(0.99); C224(0.77); C227(0.77)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C102(0.96); C99(0.96); C224(0.76); C227(0.76)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C102(0.96); C99(0.96); C224(0.94); C227(0.94)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C102(1.03); C99(1.03); C224(0.75); C227(0.75)  LDD1278  [2]
 LDCM0400  CL13 HCT 116 C102(1.01); C99(1.01); C224(1.07); C227(1.07)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C102(0.93); C99(0.93); C224(0.98); C227(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C102(1.26); C99(1.26); C224(1.95); C227(1.95)  LDD0719  [2]
 LDCM0403  CL16 PaTu 8988t C200(0.71); C224(1.42); C227(1.42)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C200(0.80); C224(0.86); C227(0.86)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C200(0.96); C224(0.77); C227(0.77)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C200(1.10); C224(0.96); C227(0.96)  LDD1285  [2]
 LDCM0407  CL2 HCT 116 C102(1.02); C99(1.02); C224(1.29); C227(1.29)  LDD0724  [2]
 LDCM0408  CL20 PaTu 8988t C200(1.29); C224(1.12); C227(1.12)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C200(1.16); C224(0.71); C227(0.71)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C200(1.05); C224(0.79); C227(0.79)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C200(1.24); C224(0.60); C227(0.60)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C200(0.81); C224(0.98); C227(0.98)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C200(0.72); C224(0.67); C227(0.67)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C200(0.95); C224(0.69); C227(0.69)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C200(1.07); C224(0.84); C227(0.84)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C200(0.91); C224(0.88); C227(0.88)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C200(1.31); C224(0.88); C227(0.88)  LDD1296  [2]
 LDCM0418  CL3 HCT 116 C102(0.88); C224(1.15); C227(1.15); C99(0.88)  LDD0735  [2]
 LDCM0419  CL30 PaTu 8988t C200(1.19); C224(0.64); C227(0.64)  LDD1298  [2]
 LDCM0420  CL31 HCT 116 C224(1.14); C227(1.14)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C224(1.59); C227(1.59)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C224(1.08); C227(1.08)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C224(1.31); C227(1.31)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C224(1.12); C227(1.12)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C224(0.87); C227(0.87)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C224(1.16); C227(1.16)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C224(1.10); C227(1.10)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C102(1.00); C224(1.13); C227(1.13); C99(1.00)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C224(1.10); C227(1.10)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C224(0.95); C227(0.95)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C224(1.59); C227(1.59)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C224(1.06); C227(1.06)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C224(1.20); C227(1.20)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C224(1.19); C227(1.19)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C102(0.98); C224(0.79); C227(0.79); C99(0.98)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C102(0.94); C224(0.91); C227(0.91); C99(0.94)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C102(1.01); C224(0.76); C227(0.76); C99(1.01)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C102(0.96); C224(0.98); C227(0.98); C99(0.96)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C102(0.92); C224(0.85); C227(0.85); C99(0.92)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C102(0.98); C224(1.15); C227(1.15); C99(0.98)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C102(1.02); C224(0.70); C227(0.70); C99(1.02)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C102(1.04); C224(0.58); C227(0.58); C99(1.04)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C102(0.85); C224(0.69); C227(0.69); C99(0.85)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C102(0.98); C224(0.84); C227(0.84); C99(0.98)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C102(1.04); C224(0.80); C227(0.80); C99(1.04)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C102(0.98); C224(0.78); C227(0.78); C99(0.98)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C102(0.98); C224(0.82); C227(0.82); C99(0.98)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C102(1.00); C224(1.05); C227(1.05); C99(1.00)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C102(1.00); C224(0.68); C227(0.68); C99(1.00)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C102(1.04); C224(0.98); C227(0.98); C99(1.04)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C102(0.90); C224(0.87); C227(0.87); C99(0.90)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C224(0.53); C227(0.53)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C224(0.64); C227(0.64)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C224(0.53); C227(0.53)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C224(0.42); C227(0.42)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C224(0.57); C227(0.57)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C224(0.38); C227(0.38)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C224(0.43); C227(0.43)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C224(0.93); C227(0.93)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C224(0.64); C227(0.64)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C102(1.02); C224(1.12); C227(1.12); C99(1.02)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C224(0.49); C227(0.49)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C224(0.38); C227(0.38)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C224(1.00); C227(1.00)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C224(0.59); C227(0.59)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C224(0.51); C227(0.51)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C102(0.98); C99(0.98)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C102(0.82); C99(0.82)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C102(1.05); C99(1.05)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C102(1.01); C99(1.01)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C102(1.28); C224(1.49); C227(1.49); C99(1.28)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C102(1.00); C99(1.00)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C102(0.86); C99(0.86)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C102(0.95); C99(0.95)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C102(0.95); C99(0.95)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C102(1.01); C99(1.01)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C102(0.94); C99(0.94)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C102(0.90); C99(0.90)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C102(0.88); C99(0.88)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C102(0.96); C99(0.96)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C102(1.00); C99(1.00)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C102(0.89); C224(0.81); C227(0.81); C99(0.89)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C102(0.74); C99(0.74)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C102(0.98); C224(0.97); C227(0.97); C99(0.98)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C102(0.84); C224(0.89); C227(0.89); C99(0.84)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C102(0.98); C224(1.37); C227(1.37); C99(0.98)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C102(0.99); C224(0.92); C227(0.92); C99(0.99)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C102(0.91); C224(0.85); C227(0.85); C99(0.91)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C102(1.00); C224(0.79); C227(0.79); C99(1.00)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C102(0.99); C224(0.88); C227(0.88); C99(0.99)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C102(0.89); C224(0.88); C227(0.88); C99(0.89)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C102(1.00); C224(0.72); C227(0.72); C99(1.00)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C224(0.42); C227(0.42)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C224(1.08); C227(1.08)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C99(1.63); C102(1.63)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C99(2.30); C102(2.30)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C99(2.01); C102(2.01)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C102(1.27); C99(1.27); C148(1.10)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Histone-lysine N-methyltransferase SUV39H2 (SUV39H2) Histone-lysine methyltransferase family Q9H5I1
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
THAP domain-containing protein 7 (THAP7) . Q9BT49
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
POTE ankyrin domain family member B3 (POTEB3) POTE family A0JP26
BAG family molecular chaperone regulator 4 (BAG4) . O95429
INO80 complex subunit E (INO80E) . Q8NBZ0
PRKCA-binding protein (PICK1) . Q9NRD5
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
YTH domain-containing protein 1 (YTHDC1) . Q96MU7

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.