Details of the Target

General Information of Target

Target ID LDTP06956
Target Name DALR anticodon-binding domain-containing protein 3 (DALRD3)
Gene Name DALRD3
Gene ID 55152
Synonyms
DALR anticodon-binding domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATRRLGVGETLGALNAALGPGGPVWIKETRTRHLRSRDFLAPHRALQARFDDGQVPEHL
LHALACLQGPGVAPVLRCAPTPAGLSLQLQRSAVFERVLSAVAAYATPASPASLGQRVLL
HCPALRSSPCALRLSQLRTVLVADHLARALRAHGVCVRLVPAVRDPHMLTFLQQLRVDWP
AASERASSHTLRSHALEELTSANDGRTLSPGILGRLCLKELVEEQGRTAGYDPNLDNCLV
TEDLLSVLAELQEALWHWPEDSHPGLAGASDTGTGGCLVVHVVSCEEEFQQQKLDLLWQK
LVDKAPLRQKHLICGPVKVAGAPGTLMTAPEYYEFRHTQVCKASALKHGGDLAQDPAWTE
IFGVLSVATIKFEMLSTAPQSQLFLALADSSISTKGTKSGTFVMYNCARLATLFESYKCS
MEQGLYPTFPPVSSLDFSLLHDEGEWLLLFNSILPFPDLLSRTAVLDCTAPGLHIAVRTE
MICKFLVQLSMDFSSYYNRVHILGEPRPHLFGQMFVRLQLLRAVREVLHTGLAMLGLPPL
SHI
Target Bioclass
Other
Function Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B.
Uniprot ID
Q5D0E6
Ensemble ID
ENST00000313778.9
HGNC ID
HGNC:25536

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEL SNV: p.V524A .
HEL9217 SNV: p.V524A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.74  LDD0403  [1]
BTD
 Probe Info  		C156(0.65)  LDD2109  [2]
DBIA
 Probe Info  		C130(54.09)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C122(1.36); C130(0.99); C156(1.12)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C130(1.81); C156(1.19)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C122(0.90); C130(1.39); C156(1.29)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C122(1.09); C130(1.50); C156(1.04)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C122(0.91); C130(1.42); C156(0.95)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C122(0.99); C130(1.60); C156(1.29)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C122(0.93); C130(1.32); C156(0.92)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C122(1.15); C130(1.58); C156(1.01)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C122(1.01); C130(1.24); C156(1.18)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C122(0.94); C130(1.20); C156(1.05)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C122(0.95); C130(1.28); C156(1.03)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C122(0.87); C130(1.02); C156(1.01)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C130(1.20); C156(1.00)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C122(0.97); C130(1.28); C156(1.15)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C122(0.93); C130(1.23); C156(1.03)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C122(0.87); C130(1.22); C156(1.03)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C130(1.06); C156(0.94)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C130(0.96); C156(0.87)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C130(1.03); C156(0.85)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C130(0.95); C156(0.94)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C130(0.94); C156(0.89)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C130(0.92); C156(0.78)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C130(0.96); C156(1.03)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C130(1.04); C156(1.15)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C130(1.00); C156(0.82)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C130(0.79); C156(0.74)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C130(0.94); C156(0.98)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C130(0.87); C156(0.75)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C130(0.87); C156(0.71)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C130(0.99); C156(0.87)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C130(0.94); C156(0.78)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C130(0.91); C156(0.71)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C156(1.00); C130(0.94); C407(0.89)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C156(1.01); C130(1.07); C407(0.91)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C156(0.95); C130(0.82); C407(1.04)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C156(1.20); C130(0.76); C407(0.85)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C156(1.15); C130(1.08); C407(0.90)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C156(0.97); C130(1.05); C407(1.01)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C156(1.21); C130(0.98); C407(0.89)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C156(1.11); C130(1.15); C407(1.31)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C156(0.88); C130(1.13); C407(1.08)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C156(1.03); C130(1.05); C407(1.28)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C156(0.99); C130(1.08); C407(1.30)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C156(0.96); C130(1.06); C407(1.12)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C130(1.49); C156(0.87)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C156(0.99); C130(1.02); C407(0.99)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C156(1.02); C130(1.10); C407(1.01)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C156(1.08); C130(1.04); C407(0.98)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C130(0.97); C156(1.21)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C130(1.20); C156(1.82)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C130(1.26); C156(1.51)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C130(1.27); C156(2.16)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C130(1.17); C156(1.91)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C156(2.56); C130(3.39)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C130(1.54); C156(1.83)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C156(1.05); C130(1.41)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C130(1.19); C156(1.55)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C156(1.12); C130(1.53)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C130(1.51); C156(1.77)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C130(1.70); C156(2.81)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C130(1.15); C156(1.52)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C130(1.40); C156(1.50)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C130(1.35); C156(1.31)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C130(1.48); C156(0.94)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C156(0.92); C130(1.17)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C156(1.12); C130(1.28)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C156(0.98); C130(1.02)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C130(0.89); C122(1.08); C156(1.16)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C130(0.98); C156(0.99)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C130(0.97); C156(1.01)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C156(0.84); C130(1.08)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C156(1.07); C130(1.16)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C156(0.91); C130(1.10)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C130(1.12); C122(1.16)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C130(1.05); C122(1.38)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C130(1.10); C122(1.13)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C130(1.19); C122(1.33)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C130(1.32); C122(1.64)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C130(1.02); C156(1.10); C122(1.23)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C130(1.32); C122(1.63)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C130(1.29); C122(1.35)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C130(1.46); C122(1.66)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C122(1.19); C130(1.32)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C130(1.19); C122(1.23)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C130(0.88); C156(1.00)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C130(0.89); C156(0.91)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C130(0.88); C156(1.01)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C156(0.90); C130(0.93)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C156(1.11); C130(1.15)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C130(1.04); C156(1.18); C122(1.25)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C130(1.07); C156(1.25)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C156(0.89); C130(0.98)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C130(1.07); C156(1.07)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C156(0.93); C130(1.04)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C156(0.94); C130(0.97)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C130(1.03); C156(1.06)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C407(1.02); C156(1.46); C130(1.61)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C407(0.95); C156(1.18); C130(1.29)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C407(0.74); C130(1.32); C156(1.35)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C407(1.07); C130(1.29); C156(1.62)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C130(0.78); C156(1.24); C122(1.26)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C130(1.21); C407(1.28); C156(1.83)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C407(0.95); C130(1.31); C156(1.45)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C407(1.04); C130(1.25); C156(1.33)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C130(0.86); C407(1.07); C156(1.09)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C407(0.83); C130(1.35); C156(1.41)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C130(0.77); C156(1.14); C407(1.16)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C130(0.88); C156(1.40); C407(1.50)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C122(0.93); C156(1.32); C130(1.36)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C122(0.93); C130(1.20); C156(1.48)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C122(1.01); C130(1.19); C156(1.50)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C156(1.24); C130(1.27)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C122(0.95); C130(1.24); C156(1.34)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C122(0.91); C156(1.18); C130(1.23)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C122(0.99); C130(1.22); C156(1.36)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C122(0.90); C130(1.24); C156(1.35)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C122(0.97); C130(1.25); C156(1.67)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C122(1.09); C130(1.43); C156(1.56)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C122(0.99); C156(1.38); C130(1.38)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C122(0.95); C156(1.80); C130(1.96)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C407(0.88); C130(0.99); C156(1.29)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C407(0.93); C130(1.02); C156(1.46)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C156(1.25); C130(1.45)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C407(0.82); C130(1.39); C156(1.51)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C130(1.05); C407(1.10); C156(1.12)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C130(1.27); C156(1.42); C407(1.56)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C130(1.19); C407(1.48); C156(2.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C130(1.15); C407(1.39); C156(1.73)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C130(1.47); C407(2.21); C156(2.25)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C130(1.03); C407(1.16); C156(1.42)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C407(0.96); C156(1.22); C130(1.31)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C130(1.20); C156(1.26); C407(1.47)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C130(1.27); C156(1.39); C407(1.41)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C156(1.15); C130(1.52)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C130(1.13); C407(1.19); C156(1.31)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C407(0.83); C156(1.24); C130(1.25)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C130(1.22); C407(1.31); C156(2.08)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C130(1.13); C407(1.27); C156(1.40)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C407(1.35); C156(1.42); C130(1.44)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C407(1.14); C130(1.23); C156(1.30)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C156(1.09); C407(1.57); C130(1.77)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C156(0.97); C407(1.09); C130(1.74)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C156(0.94); C130(1.39); C407(1.44)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C407(1.07); C156(1.25); C130(1.53)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C407(0.89); C156(0.95); C130(1.81)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C130(1.10); C407(1.17); C156(1.54)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C407(1.35); C130(1.39); C156(1.47)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C407(0.95); C156(1.17); C130(1.37)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C407(0.99); C156(1.27); C130(1.30)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C407(1.01); C156(1.05); C130(1.49)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C407(1.00); C130(1.16); C156(1.42)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C130(1.03); C407(1.06); C156(1.54)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C156(1.07); C122(1.09); C130(1.74)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C156(1.01); C122(1.08); C130(1.76)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C130(1.57); C156(0.93)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C156(1.06); C130(1.54)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C156(1.34); C130(1.98)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 13.74  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C156(0.99); C122(1.13)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C122(1.18); C156(1.48)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C130(1.15); C122(1.20); C156(1.25)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C156(1.20); C130(1.60)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C130(0.99); C156(1.99)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C156(1.29); C130(1.37)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C156(1.07); C130(1.56)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C156(1.30); C130(1.66)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C156(1.70); C130(2.02)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C156(1.49); C130(1.66)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C156(1.42); C130(1.78)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C156(1.18); C130(1.33)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C122(0.96); C156(1.43)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C156(1.79); C130(2.44)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C156(1.22); C130(1.30)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C130(1.01); C122(1.29)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C130(1.20); C122(1.42)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C130(1.46); C122(1.65)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C122(1.31); C130(1.34)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C122(1.19); C130(1.25)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C156(1.25); C130(1.61)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C156(0.93); C130(0.94)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C130(0.94); C156(1.14)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C122(0.99); C156(1.40)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C156(0.92); C130(0.96)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C407(0.61); C130(1.27); C156(1.48)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C407(1.11); C130(1.19); C156(1.31)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C130(1.09); C407(1.45); C156(1.49)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C130(1.22); C407(1.36); C156(1.43)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C122(1.05); C130(1.10); C156(1.13)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C122(0.91); C156(1.15); C130(1.22)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C122(0.96); C130(1.00); C156(1.27)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C122(1.04); C156(1.23); C130(1.53)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C122(0.85); C156(1.30)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C122(1.16); C156(1.37)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C122(1.06); C156(1.74)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C130(1.03); C156(1.06)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C156(1.31); C130(1.56)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C156(0.94); C130(1.15)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C130(1.05); C156(1.14)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C122(0.98); C156(1.05)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C130(1.16); C156(1.24)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C156(1.44); C130(1.85)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C156(1.45); C130(1.57)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C130(1.00); C156(1.05)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C130(1.08); C156(1.10)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C130(1.32); C156(1.33)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C130(1.17); C156(1.00)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C130(1.13); C156(1.02)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C130(1.08); C156(1.08)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C130(1.08); C156(1.08)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C122(0.98); C156(0.88)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C130(0.82); C156(0.90)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C122(0.76); C130(0.86); C156(1.00)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C122(0.70); C130(0.61); C156(1.21)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C122(1.03); C130(0.71); C156(1.21)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C122(0.83); C130(0.97); C156(1.14)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C122(0.82); C130(0.90); C156(1.05)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C122(0.89); C130(0.82); C156(1.50)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C122(0.79); C130(0.96); C156(1.05)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C122(0.80); C130(1.20); C156(1.04)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C122(1.08); C156(1.32)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C122(0.68); C130(0.62); C156(1.52)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C122(0.69); C130(0.77); C156(1.10)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C122(0.73); C130(1.58); C156(1.09)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C122(0.78); C130(0.80); C156(1.13)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C122(0.64); C130(0.72); C156(1.26)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C122(0.76); C130(1.01); C156(1.65)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C130(1.13); C156(1.25)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C130(1.13); C156(1.33)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C130(1.14); C156(1.49)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C130(0.95); C156(1.45)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C122(0.95); C156(1.02)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C130(1.02); C156(1.28)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C130(1.04); C156(1.67)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C130(1.15); C156(1.34)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C130(1.06); C156(1.23)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C130(1.13); C156(1.51)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C130(1.02); C156(1.15)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C130(1.10); C156(1.19)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C130(1.17); C156(1.39)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C130(1.25); C156(1.13)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C130(1.05); C156(1.09)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C122(0.95); C156(1.24)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C130(1.27); C156(1.26)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C122(1.37); C130(1.29); C407(0.98)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C122(1.06); C130(1.38); C407(0.88)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C122(1.49); C130(1.39); C407(0.98)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C122(1.31); C130(2.40); C407(1.27)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C122(1.23); C130(1.36); C407(0.92)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C122(1.17); C130(2.33); C407(0.98)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C122(1.07); C130(1.71); C407(1.31)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C122(1.02); C130(1.92); C407(1.16)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C122(1.18); C130(1.43); C407(1.29)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C122(0.93); C156(1.22)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C122(1.06); C130(1.32); C407(1.00)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C122(1.13); C130(1.56); C407(1.04)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C122(1.30); C130(1.27); C407(1.01)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C122(1.18); C130(2.06); C407(1.40)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C122(1.22); C130(2.23); C407(1.50)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C122(0.99); C130(0.97); C156(1.15); C407(0.87)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C122(0.63); C130(0.95); C156(1.11); C407(0.77)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C122(1.18); C130(0.89); C156(1.16); C407(0.90)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C122(0.87); C130(1.06); C156(1.45); C407(0.84)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C122(1.28); C156(1.74)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C122(1.13); C130(0.93); C156(1.07); C407(0.98)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C122(1.24); C130(1.03); C156(1.19); C407(0.99)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C122(0.97); C130(1.04); C156(1.63); C407(0.98)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C122(0.94); C130(1.11); C156(1.86); C407(1.03)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C122(1.14); C130(1.51); C156(1.96); C407(1.09)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C122(1.04); C130(1.03); C156(1.20); C407(1.06)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C122(1.02); C130(1.21); C156(1.23); C407(0.95)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C122(1.31); C130(1.06); C156(1.54); C407(0.98)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C122(0.91); C130(1.08); C156(1.59); C407(0.90)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C122(1.17); C130(1.00); C156(2.30); C407(0.85)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C122(1.00); C156(1.28)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C122(0.75); C130(1.08); C156(1.77); C407(0.93)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C122(1.00); C130(1.06); C156(1.09)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C122(0.86); C130(1.13); C156(1.32)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C122(0.96); C130(1.05); C156(1.09)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C122(0.86); C130(1.06); C156(1.46)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C122(1.02); C130(1.35); C156(1.53)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C122(0.95); C130(1.03); C156(1.09)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C122(0.96); C130(1.22); C156(1.14)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C122(1.36); C130(1.13); C156(1.40)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C122(1.11); C130(1.04); C156(1.38)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C314(0.95); C468(0.86); C130(1.09); C66(1.03)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C122(1.12); C130(1.66); C407(0.98)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C122(0.85); C130(1.47); C156(1.63)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C130(0.92); C468(1.18)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C130(54.09)  LDD0209  [3]
 LDCM0024  KB05 G361 C156(3.35)  LDD3311  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C156(0.65)  LDD2109  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C156(0.91)  LDD2140  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840