Details of the Target

General Information of Target

Target ID LDTP06815
Target Name Pleckstrin homology domain-containing family N member 1 (PLEKHN1)
Gene Name PLEKHN1
Gene ID 84069
Synonyms
CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPG
TDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELF
PAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGPLPAPLLVLCPSRAELDR
WLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWD
RLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCA
SYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPS
TRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRG
PVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFL
SAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKD
GGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGG
PEASGGLVQWI
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Controls the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol. Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon cancer cells.
Uniprot ID
Q494U1
Ensemble ID
ENST00000379407.7
HGNC ID
HGNC:25284

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C238(1.18); C247(1.18)  LDD0078  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C238(0.78); C247(0.78); C407(1.05)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C238(0.91); C247(0.91)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C238(0.76); C247(0.76); C407(0.67)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C238(0.92); C247(0.92); C407(0.67)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C238(0.90); C247(0.90); C407(0.68)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C238(0.99); C247(0.99); C407(0.74)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C238(0.74); C247(0.74); C407(0.77)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C238(0.95); C247(0.95); C407(0.67)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C238(1.24); C247(1.24); C407(0.77)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C238(0.94); C247(1.08); C407(0.91)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C238(0.68); C247(0.67); C407(0.58)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C238(0.79); C247(0.77); C407(0.57)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C238(0.86); C247(0.86)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C238(0.97); C247(0.90); C407(0.54)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C238(0.92); C247(0.95); C407(0.62)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C238(0.98); C247(1.00); C407(0.83)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C238(0.97); C247(0.97)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C238(0.88); C247(0.89)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C238(1.02); C247(1.04)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C238(1.72); C247(1.63)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C238(1.41); C247(1.23)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C238(0.81); C247(0.81)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C238(1.02); C247(1.00)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C238(0.72); C247(0.72)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C238(0.82); C247(0.88)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C238(1.20); C247(1.03)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C238(0.80); C247(0.79)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C238(0.96); C247(0.97)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C238(1.09); C247(1.03)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C238(1.01); C247(0.93)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C238(1.00); C247(1.06)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C238(1.26); C247(1.25)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C238(0.82); C247(0.82)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C238(0.72); C247(0.72)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C238(0.59); C247(0.59)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C238(0.74); C247(0.74)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C238(0.75); C247(0.75)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C238(0.68); C247(0.68)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C238(0.96); C247(0.96)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C238(0.72); C247(0.72)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C238(0.77); C247(0.77)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C238(0.79); C247(0.79)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C238(1.11); C247(1.11)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C238(0.96); C247(0.96)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C238(0.87); C247(0.87)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C238(1.01); C247(1.01)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C238(0.97); C247(0.97)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C238(0.75); C247(0.75)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C238(0.94); C247(0.94)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C238(1.12); C247(1.12)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C238(0.99); C247(0.99)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C238(1.29); C247(1.29)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C238(1.25); C247(1.25)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C238(1.53); C247(1.53)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C238(1.33); C247(1.33)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C238(0.96); C247(0.96)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C238(0.90); C247(0.90)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C238(1.03); C247(1.03)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C238(1.14); C247(1.14)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C238(1.49); C247(1.49)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C238(1.15); C247(1.15)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C238(1.04); C247(1.04)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C238(1.02); C247(1.02)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C238(1.23); C247(1.23)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C238(1.03); C247(1.03)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C238(1.10); C247(1.10)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C238(1.22); C247(1.22)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C407(0.91); C238(0.91); C247(0.91)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C238(1.16); C247(1.16)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C238(1.26); C247(1.26)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C238(1.07); C247(1.07)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C238(1.03); C247(1.03)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C238(1.18); C247(1.18)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C238(0.80); C247(0.80)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C238(0.86); C247(0.86)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C238(0.68); C247(0.68)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C238(0.85); C247(0.85)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C238(1.31); C247(1.31)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C238(0.84); C247(0.84); C407(0.98)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C238(0.83); C247(0.83)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C238(0.77); C247(0.77)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C238(0.78); C247(0.78)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C238(1.06); C247(1.06)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C238(0.97); C247(0.97)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C238(0.76); C247(0.76); C407(1.06)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C238(0.91); C247(0.91); C407(1.12)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C407(1.06); C238(1.40); C247(1.40)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C407(0.89); C238(0.99); C247(0.99)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C238(0.89); C247(0.89); C407(1.02)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C238(1.02); C247(1.02); C407(1.05)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C407(1.05); C238(1.08); C247(1.08)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C407(1.19); C238(1.20); C247(1.20)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C407(1.01); C238(1.41); C247(1.41)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C238(1.06); C247(1.06); C407(1.14)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C238(0.96); C247(0.96); C407(1.14)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C238(0.99); C247(0.99); C407(1.10)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C238(0.97); C247(0.97); C407(1.03)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C238(0.95); C247(0.95); C407(1.04)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C407(1.01); C238(1.24); C247(1.24)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C407(1.31); C238(1.45); C247(1.45)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C238(0.95); C247(0.95); C407(1.01)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C407(1.26); C238(1.43); C247(1.43)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C407(0.93); C238(1.17); C247(1.17)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C407(0.99); C238(1.39); C247(1.39)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C407(1.09); C238(1.20); C247(1.20)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C238(1.05); C247(1.05); C407(1.06)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C238(1.07); C247(1.07); C407(1.33)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C238(1.09); C247(1.09); C407(1.54)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C238(1.07); C247(1.07)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C238(1.22); C247(1.22)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C238(1.09); C247(1.09)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C238(1.04); C247(1.04)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C238(1.42); C247(1.42)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C238(1.06); C247(1.06)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C238(1.32); C247(1.32)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C238(1.20); C247(1.20)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C238(1.20); C247(1.20)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C238(1.28); C247(1.28)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C238(1.20); C247(1.20)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C238(1.33); C247(1.33)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C407(0.86); C238(1.24); C247(1.24)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C407(0.77); C238(1.00); C247(1.00)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C238(0.90); C247(0.90)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C407(0.99); C238(1.06); C247(1.06)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C407(0.75); C238(1.14); C247(1.14)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C238(1.07); C247(1.07); C407(1.34)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C407(0.81); C238(1.06); C247(1.06)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C407(0.86); C238(0.99); C247(0.99)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C407(0.89); C238(1.18); C247(1.18)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C407(0.73); C238(1.06); C247(1.06)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C407(0.93); C238(1.15); C247(1.15)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C407(0.97); C238(1.07); C247(1.07)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C407(0.84); C238(1.24); C247(1.24)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C238(0.79); C247(0.79)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C238(1.07); C247(1.07); C407(1.28)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C407(1.05); C238(1.11); C247(1.11)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C407(0.83); C238(1.02); C247(1.02)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C238(1.26); C247(1.26)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C238(1.24); C247(1.24)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C238(1.14); C247(1.14)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C238(1.33); C247(1.33)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C238(0.99); C247(0.99)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C238(1.13); C247(1.13)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C238(1.34); C247(1.34)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C238(1.23); C247(1.23)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C238(1.58); C247(1.58)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C238(1.62); C247(1.62)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C238(1.03); C247(1.03)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C238(1.08); C247(1.08)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C238(1.16); C247(1.16)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C238(1.54); C247(1.54)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C238(1.37); C247(1.37)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C238(0.98); C247(0.98); C407(1.12)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C407(0.69); C238(0.93); C247(0.93)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C238(0.75); C247(0.75)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C238(0.85); C247(0.85)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C238(0.98); C247(0.98)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C238(1.18); C247(1.18)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C407(0.92); C238(1.44); C247(1.44)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C407(0.91); C238(1.86); C247(1.86)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C238(0.93); C247(0.93); C407(0.98)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C238(1.12); C247(1.12)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C238(1.22); C247(1.22)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C238(1.04); C247(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C238(0.92); C247(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C238(1.12); C247(1.12)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C238(1.32); C247(1.32)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C238(1.07); C247(1.07)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C238(1.21); C247(1.21)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C238(1.43); C247(1.43)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C407(0.92); C238(1.40); C247(1.40)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C238(1.44); C247(1.44)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C238(1.25); C247(1.25)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C238(0.83); C247(0.83)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C238(0.68); C247(0.68)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C238(1.50); C247(1.50)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C238(0.73); C247(0.73)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C238(0.96); C247(0.96)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C238(1.11); C247(1.11); C407(1.23)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C407(1.05); C238(1.16); C247(1.16)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C238(0.83); C247(0.83); C407(1.09)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C407(0.98); C238(1.53); C247(1.53)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C238(0.96); C247(0.96); C407(1.16)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C238(1.36); C247(1.36); C407(1.39)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C238(0.96); C247(0.96); C407(1.13)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C407(1.13); C238(1.46); C247(1.46)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C407(1.34); C238(1.49); C247(1.49)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C238(1.15); C247(1.15)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C238(1.51); C247(1.51)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C238(1.20); C247(1.20)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C238(1.23); C247(1.23)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C407(0.82); C238(1.08); C247(1.08)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C407(0.94); C238(1.90); C247(1.90)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C407(0.89); C238(1.72); C247(1.72)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C238(1.07); C247(1.07)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C238(1.37); C247(1.37)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C238(0.90); C247(0.90)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C238(1.26); C247(1.26)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C407(0.83); C238(1.05); C247(1.05)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C238(1.33); C247(1.33)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C238(1.68); C247(1.68)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C238(1.29); C247(1.29)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C238(1.02); C247(1.02)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C238(1.08); C247(1.08)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C238(1.50); C247(1.50)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C238(0.96); C247(0.96)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C238(0.98); C247(0.98)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C238(0.99); C247(0.99)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C238(1.13); C247(1.13)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C238(1.09); C247(1.09); C407(0.89)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C238(1.09); C247(1.09)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C238(1.18); C247(1.18)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C238(0.90); C247(0.90)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C238(1.75); C247(1.75)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C238(1.00); C247(1.00)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C238(0.88); C247(0.88)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C238(0.94); C247(0.94)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C238(1.01); C247(1.01)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C238(1.05); C247(1.05)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C238(1.21); C247(1.21); C407(0.94)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C238(0.90); C247(0.90)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C238(1.11); C247(1.11)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C238(0.77); C247(0.77)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C238(1.02); C247(1.02)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C238(1.15); C247(1.15)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C238(0.88); C247(0.88)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C238(1.23); C247(1.23)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C238(1.03); C247(1.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C238(1.09); C247(1.09)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C238(1.21); C247(1.21)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C238(1.00); C247(1.00); C407(0.85)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C238(1.12); C247(1.12)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C238(1.30); C247(1.30)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C238(1.41); C247(1.41)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C238(1.40); C247(1.40)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C238(1.29); C247(1.29)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C238(1.19); C247(1.19)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C238(1.11); C247(1.11)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C238(1.33); C247(1.33)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C238(1.39); C247(1.39)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C238(1.05); C247(1.05)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C238(1.70); C247(1.70); C407(0.93)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C238(1.06); C247(1.06)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C238(0.86); C247(0.86); C407(1.19)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C238(0.89); C247(0.89); C407(0.92)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C238(1.01); C247(1.01); C407(1.15)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C238(1.02); C247(1.02); C407(0.97)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C238(0.92); C247(0.92); C407(0.79)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C238(0.91); C247(0.91); C407(0.91)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C238(0.94); C247(0.94); C407(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C238(1.10); C247(1.10); C407(0.96)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C238(1.04); C247(1.04); C407(1.02)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C238(1.26); C247(1.26); C407(0.75)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C238(0.91); C247(0.91); C407(0.86)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C238(0.99); C247(0.99); C407(0.84)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C238(0.95); C247(0.95); C407(0.94)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C238(1.08); C247(1.08); C407(0.98)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C238(1.21); C247(1.21); C407(0.88)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C238(1.05); C247(1.05)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C238(2.20); C247(2.20)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C238(0.93); C247(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C238(1.10); C247(1.10)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C238(2.19); C247(2.19); C407(1.41)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C238(1.13); C247(1.13)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C238(1.25); C247(1.25)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C238(1.40); C247(1.40)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C238(1.49); C247(1.49)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C238(1.57); C247(1.57)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C238(1.24); C247(1.24)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C238(0.83); C247(0.83)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C238(1.14); C247(1.14)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C238(1.41); C247(1.41)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C238(1.20); C247(1.20)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C238(1.14); C247(1.14); C407(0.80)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C238(1.99); C247(1.99)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C238(1.08); C247(1.08); C407(0.93)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C238(1.23); C247(1.23); C407(1.03)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C238(1.02); C247(1.02); C407(0.86)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C238(2.70); C247(2.70); C407(1.06)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C238(1.12); C247(1.12); C407(1.02)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C238(1.28); C247(1.28); C407(0.95)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C238(0.99); C247(0.99); C407(1.02)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C238(1.04); C247(1.04); C407(0.99)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C238(1.00); C247(1.00); C407(0.93)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C238(0.88); C247(0.88); C407(0.92)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C238(1.15); C247(1.15)  LDD0744  [1]
 LDCM0022  KB02 ICC108 C562(2.56)  LDD2381  [3]
 LDCM0023  KB03 ICC108 C562(2.62)  LDD2798  [3]
 LDCM0024  KB05 SNU-245 C562(2.41)  LDD3440  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Protein phosphatase 1J (PPM1J) PP2C family Q5JR12
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Ataxin-1 (ATXN1) ATXN1 family P54253
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type II cuticular Hb3 (KRT83) Intermediate filament family P78385
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Leupaxin (LPXN) Paxillin family O60711
PIH1 domain-containing protein 1 (PIH1D1) PIH1 family Q9NWS0
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TNF receptor-associated factor 1 (TRAF1) . Q13077
Vinexin (SORBS3) . O60504
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840