Details of the Target

General Information of Target

Target ID LDTP06050
Target Name Tripartite motif-containing protein 14 (TRIM14)
Gene Name TRIM14
Gene ID 9830
Synonyms
KIAA0129; Tripartite motif-containing protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGL
ALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRL
LLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQA
YTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLS
DPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPV
PVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQ
SWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRAT
FQEPLYPALRLWEGAISIPRLP
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Mitochondrion outer membrane
Function
Plays an essential role in the innate immune defense against viruses and bacteria. Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication. Plays also a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner. Inhibits also OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation.
Uniprot ID
Q14142
Ensemble ID
ENST00000341469.7
HGNC ID
HGNC:16283

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.C39S DBIA    Probe Info 
HCT116 SNV: p.R359H DBIA    Probe Info 
HEL SNV: p.G113E .
HEL9217 SNV: p.G113E .
NCIH1993 SNV: p.P269H .
NCIH2286 SNV: p.D173Y .
SNU1 Deletion: p.R440GfsTer38 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.77  LDD0402  [1]
BTD
 Probe Info  		C75(0.79)  LDD2109  [2]
DBIA
 Probe Info  		C20(0.98)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
Compound 10
 Probe Info  		C20(0.00); C237(0.00)  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		C75(0.00); C291(0.00)  LDD0148  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C151(1.11); C20(0.98); C42(1.08); C44(1.08)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C151(1.04); C20(0.98); C42(0.83); C44(0.86)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C151(1.38); C20(0.87); C42(0.81); C44(0.77)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C151(1.02); C20(0.97); C42(0.73); C44(0.74)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C151(1.08); C20(0.87); C42(0.98); C44(0.98)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C151(1.23); C20(1.19); C42(0.73); C44(0.74)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C151(1.18); C20(0.97); C42(0.69); C44(0.70)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C151(1.10); C20(1.04); C42(0.74); C44(0.75)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C151(1.21); C20(1.18); C42(0.72); C44(0.70)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C151(1.12); C20(0.78); C42(0.72); C44(0.70)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C151(1.47); C20(0.73); C42(0.71); C44(0.72)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C151(1.06); C20(0.74); C42(0.79); C44(0.72)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C151(0.92); C20(1.00); C42(0.80); C44(0.93)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C151(1.03); C20(0.63); C42(0.67); C44(0.91)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C151(1.36); C20(0.72); C42(0.75); C44(0.74)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C151(1.15); C20(0.72); C42(0.79); C44(0.80)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C151(0.97); C20(0.94); C42(0.92); C44(0.92)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C151(1.16); C20(1.17); C42(1.11); C44(1.11)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C151(0.87); C20(1.28); C42(1.08); C44(1.08)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C151(0.93); C20(1.40); C42(1.24); C44(1.24)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C151(1.10); C20(1.16); C42(1.23); C44(1.23)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C151(1.01); C20(1.02); C42(1.19); C44(1.19)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C151(1.01); C20(1.11); C42(1.28); C44(1.28)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C151(0.93); C20(1.14); C42(0.80); C44(0.97)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C151(0.90); C20(0.97); C42(1.10); C44(1.10)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C151(1.12); C20(1.04); C42(1.04); C44(1.04)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C151(1.02); C20(1.10); C42(0.96); C44(0.96)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C151(1.16); C20(1.06); C42(1.11); C44(1.11)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C151(1.05); C20(1.04); C42(1.13); C44(1.13)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C151(0.93); C20(1.15); C42(1.39); C44(1.39)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C151(0.93); C20(1.38); C42(1.13); C44(1.13)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C151(0.99); C20(1.49); C42(1.51); C44(1.51)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C151(1.00); C20(1.38); C42(1.06); C47(1.06)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C151(1.15); C20(0.93); C42(0.93); C47(0.93)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C151(1.03); C20(1.26); C42(1.07); C47(1.07)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C151(1.10); C20(1.03); C42(0.88); C47(0.88)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C151(1.29); C20(1.10); C42(0.96); C47(0.96)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C151(1.30); C20(1.15); C42(1.00); C47(1.00)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C151(1.45); C20(1.22); C42(0.91); C47(0.91)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C151(1.24); C20(1.33); C42(1.05); C47(1.05)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C151(1.15); C20(1.09); C42(0.93); C47(0.93)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C151(1.15); C20(1.05); C42(1.01); C47(1.01)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C151(1.09); C20(1.27); C42(0.99); C47(0.99)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C151(1.40); C20(1.27); C42(1.08); C47(1.08)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C151(0.85); C20(0.75); C42(0.83); C44(0.89)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C151(1.41); C20(1.28); C42(1.32); C47(1.32)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C151(1.30); C20(1.15); C42(1.03); C47(1.03)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C151(1.09); C20(1.00); C42(1.03); C47(1.03)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C42(0.66); C44(0.66); C47(0.66); C151(1.07)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C151(1.04); C42(1.13); C44(1.13); C47(1.13)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C151(0.94); C42(1.09); C44(1.09); C47(1.09)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C42(0.94); C44(0.94); C47(0.94); C151(1.03)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C42(0.89); C44(0.89); C47(0.89); C151(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C151(0.96); C42(0.99); C44(0.99); C47(0.99)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C42(0.88); C44(0.88); C47(0.88); C151(1.06)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C20(0.84); C42(0.87); C47(0.87); C151(0.91)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C42(1.11); C44(1.11); C47(1.11); C20(1.12)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C151(0.92); C42(1.09); C44(1.09); C47(1.09)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C42(0.82); C44(0.82); C47(0.82); C151(0.94)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C151(0.98); C42(1.10); C44(1.10); C47(1.10)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C151(1.04); C20(1.26); C42(1.29); C44(1.29)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C151(0.90); C20(1.18); C42(1.07); C44(1.07)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C151(1.02); C20(1.10); C42(1.08); C44(1.08)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C151(0.89); C20(0.96); C42(0.98); C44(0.98)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C42(0.78); C44(0.78); C47(0.78); C151(1.05)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C42(0.79); C44(0.79); C47(0.79); C20(1.07)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C42(0.85); C44(0.85); C47(0.85); C20(1.05)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C20(0.83); C151(1.12); C42(1.39); C44(1.39)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C42(0.74); C44(0.74); C47(0.74); C20(0.87)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C20(0.74); C42(0.75); C44(0.75); C47(0.75)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C42(0.77); C44(0.77); C47(0.77); C151(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C42(0.89); C44(0.89); C47(0.89); C151(1.10)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C42(0.78); C44(0.78); C47(0.78); C20(0.93)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C151(0.89); C42(1.04); C44(1.04); C47(1.04)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C42(0.92); C44(0.92); C47(0.92); C151(0.98)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C151(0.89); C42(0.89); C44(0.89); C47(0.89)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C42(0.90); C44(0.90); C47(0.90); C151(0.93)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C151(0.92); C42(0.93); C44(0.93); C47(0.93)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C20(0.83); C42(1.06); C44(1.06); C47(1.06)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C151(0.87); C42(1.04); C44(1.04); C47(1.04)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C151(0.84); C42(1.00); C44(1.00); C47(1.00)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C151(0.87); C42(0.90); C44(0.90); C47(0.90)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C151(0.89); C42(0.96); C44(0.96); C47(0.96)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C42(0.83); C44(0.83); C47(0.83); C151(0.88)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C44(0.15); C42(0.65); C47(0.65); C151(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C20(0.80); C44(0.87); C42(0.93); C47(0.93)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C44(0.49); C20(0.70); C42(0.75); C47(0.75)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C44(0.71); C20(0.72); C42(0.87); C47(0.87)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C44(0.89); C151(0.96); C42(1.03); C47(1.03)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C20(0.79); C42(1.13); C44(1.13); C47(1.13)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C42(0.92); C47(0.92); C44(0.93); C151(1.07)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C44(0.53); C20(0.69); C42(0.69); C47(0.69)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C44(0.72); C42(0.83); C47(0.83); C151(0.90)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C44(0.71); C42(0.81); C47(0.81); C20(0.88)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C42(0.92); C47(0.92); C44(0.93); C151(1.01)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C44(0.77); C42(0.79); C47(0.79); C151(0.89)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C151(0.87); C42(0.95); C47(0.95); C44(1.01)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C42(0.97); C47(0.97); C151(0.98); C44(0.98)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C42(1.04); C47(1.04); C44(1.07); C151(1.11)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C42(0.83); C47(0.83); C44(0.84); C151(1.12)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C20(0.87); C151(1.14); C42(1.24); C44(1.24)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C42(0.93); C47(0.93); C44(0.94); C151(1.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C151(1.05); C42(1.24); C47(1.24); C44(1.30)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C42(0.91); C47(0.91); C151(0.93); C44(0.93)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C151(0.89); C42(0.96); C47(0.96); C44(0.97)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C44(0.83); C42(0.83); C47(0.83); C151(0.89)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C151(0.91); C42(0.95); C47(0.95); C44(0.99)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C44(0.97); C42(0.97); C47(0.97); C151(1.22)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C42(0.93); C47(0.93); C151(1.07); C20(1.65)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C42(0.82); C47(0.82); C151(0.94); C20(1.76)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C151(0.93); C42(0.96); C47(0.96); C20(1.61)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C151(0.91); C44(0.94); C42(1.04); C47(1.04)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C42(0.76); C47(0.76); C151(0.90); C20(1.57)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C42(0.75); C47(0.75); C151(1.02); C20(1.52)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C42(0.95); C47(0.95); C151(1.00); C20(1.80)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C151(0.88); C42(1.06); C47(1.06); C20(1.67)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C151(0.87); C42(0.94); C47(0.94); C20(1.90)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C42(0.83); C47(0.83); C151(0.96); C20(1.61)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C151(1.03); C42(1.12); C47(1.12); C20(1.56)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C42(0.72); C47(0.72); C151(1.03); C20(1.59)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C20(1.02); C42(1.22); C44(1.24); C47(1.24)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C20(0.96); C42(1.10); C44(1.15); C47(1.15)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C151(0.95); C42(1.01); C47(1.01); C44(1.02)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C20(1.00); C151(1.34); C42(1.52); C44(1.60)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C20(0.90); C151(1.23); C42(1.41); C44(1.44)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C151(0.83); C42(0.89); C44(0.97); C47(0.97)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C151(1.22); C20(1.27); C42(1.28); C44(1.40)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C151(1.38); C42(1.54); C44(1.59); C47(1.59)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C151(1.29); C20(1.38); C42(1.43); C44(1.50)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C20(1.02); C151(1.08); C42(1.12); C44(1.25)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C151(0.99); C20(1.20); C42(1.25); C44(1.39)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C20(0.98); C151(0.99); C42(1.02); C44(1.08)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C42(1.20); C151(1.21); C20(1.26); C44(1.26)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C42(0.76); C47(0.76); C20(0.79); C151(1.07)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C42(1.09); C151(1.10); C20(1.18); C44(1.20)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C42(0.82); C44(0.87); C47(0.87); C20(1.09)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C20(1.23); C42(1.61); C44(1.70); C47(1.70)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C42(0.85); C44(0.85); C47(0.85); C151(0.99)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C42(0.86); C44(0.86); C47(0.86); C151(1.05)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C20(1.07); C42(1.09); C44(1.09); C47(1.09)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C42(0.99); C44(0.99); C47(0.99); C151(1.25)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C42(0.88); C44(0.88); C47(0.88); C20(1.09)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C42(0.92); C44(0.92); C47(0.92); C20(1.05)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C42(1.01); C44(1.01); C47(1.01); C20(1.11)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C20(0.91); C42(0.99); C44(0.99); C47(0.99)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C42(0.95); C44(0.95); C47(0.95); C151(1.20)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C42(0.98); C44(0.98); C47(0.98); C151(1.13)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C42(0.87); C44(0.87); C47(0.87); C20(0.99)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C20(1.05); C42(1.16); C44(1.16); C47(1.16)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C42(0.79); C44(0.79); C47(0.79); C20(0.98)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C42(0.92); C44(0.92); C47(0.92); C20(1.19)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C42(0.84); C44(0.84); C47(0.84); C20(1.08)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C42(0.64); C47(0.64); C44(0.64); C151(1.31)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C44(0.64); C42(0.66); C47(0.66); C20(0.83)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C151(0.97); C20(1.19); C42(1.12); C44(1.08)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C42(0.85); C47(0.85); C20(0.89); C44(0.97)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C42(0.77); C47(0.77); C151(0.96); C44(0.99)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C20(0.98)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C20(1.00); C42(1.00); C44(1.00); C47(1.00)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C151(1.17); C42(1.20); C44(1.20); C47(1.20)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C151(1.05); C20(1.06); C42(1.09); C44(1.09)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C151(0.68); C20(0.88); C42(0.89); C47(0.89)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C20(0.75); C151(0.77); C42(1.08); C47(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C20(0.85); C151(0.85); C42(1.09); C47(1.09)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C20(0.73); C151(0.97); C42(1.03); C47(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C151(0.89); C42(0.95); C44(0.95); C47(0.95)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C42(0.78); C44(0.78); C47(0.78); C151(1.07)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C42(0.87); C44(0.87); C47(0.87); C151(1.10)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C42(0.92); C44(0.92); C47(0.92); C151(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C42(0.91); C44(0.91); C47(0.91); C151(0.97)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C151(1.00); C42(1.17); C44(1.17); C47(1.17)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C42(0.95); C44(0.95); C47(0.95); C151(1.02)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C42(0.85); C44(0.85); C47(0.85); C151(1.04)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C42(0.79); C44(0.79); C47(0.79); C151(0.88)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C151(0.84); C42(0.93); C44(0.93); C47(0.93)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C42(0.76); C44(0.76); C47(0.76); C151(0.87)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C151(0.86); C42(0.92); C44(0.92); C47(0.92)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C151(0.77); C42(0.96); C44(0.96); C47(0.96)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C44(0.80); C42(0.82); C47(0.82); C151(1.12)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C44(0.87); C20(0.88); C151(0.97); C42(0.99)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C151(0.89); C44(0.93); C42(0.99); C47(0.99)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C42(1.13); C44(1.13); C47(1.13); C151(1.15)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C20(0.88); C42(0.96); C47(0.96); C44(0.98)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C151(1.02); C42(1.20); C47(1.20); C44(1.60)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C151(0.80); C44(0.93); C42(0.95); C47(0.95)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C42(0.95); C47(0.95); C44(1.06); C151(1.48)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C151(0.88); C42(0.98); C47(0.98); C44(1.02)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C151(0.92); C42(0.99); C47(0.99); C20(1.13)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C151(0.72); C42(0.93); C47(0.93); C20(1.23)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C42(0.94); C47(0.94); C151(0.99); C20(1.18)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C42(0.74); C47(0.74); C151(0.93); C20(1.73)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C42(0.92); C44(0.92); C47(0.92); C151(1.09)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C151(0.94); C42(0.97); C44(0.97); C47(0.97)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C42(0.91); C44(0.91); C47(0.91); C151(1.00)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C151(0.82); C42(0.85); C47(0.85); C44(0.89)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C151(0.61); C44(0.80); C42(0.94); C47(0.94)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C151(0.71); C42(0.95); C47(0.95); C44(0.98)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C151(0.75); C44(0.90); C42(0.94); C47(0.94)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C42(0.77); C44(0.77); C47(0.77); C20(0.84)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C44(0.77); C151(0.77); C42(0.84); C47(0.84)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C151(0.71); C42(0.95); C47(0.95); C44(1.00)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C151(0.72); C44(0.77); C42(0.84); C47(0.84)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C151(0.89); C42(1.10); C47(1.10); C44(1.11)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C151(0.81); C20(1.38); C42(0.98); C44(1.05)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C151(0.69); C20(1.11); C42(0.90); C44(0.90)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C151(0.83); C20(0.94); C42(0.94); C44(1.07)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C151(0.67); C20(1.36); C42(0.95); C44(0.95)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C151(0.49); C20(1.39); C42(0.97); C44(1.09)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C151(0.67); C20(1.42); C42(0.88); C44(0.88)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C151(1.05); C20(1.31); C42(1.08); C44(1.08)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C151(0.61); C20(1.07); C42(0.85); C44(0.71)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C151(0.97); C20(1.38); C42(0.89); C44(0.89)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C151(1.02); C20(1.15); C42(0.75); C44(0.75)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C151(0.95); C20(1.45); C42(1.10); C44(1.10)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C151(0.84); C20(1.77); C42(0.97); C44(0.97)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C151(0.95); C20(1.48); C42(0.85); C44(0.85)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C151(0.76); C20(1.30); C42(0.64); C44(0.64)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C151(0.99); C20(2.08); C42(1.20); C44(1.20)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C151(0.85); C20(1.93); C42(0.79); C44(0.79)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C151(0.93); C20(1.24); C42(0.88); C44(0.88)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C151(0.85); C20(1.23); C42(0.92); C44(0.92)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C151(0.86); C20(1.45); C42(0.78); C44(0.78)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C151(1.01); C20(2.40); C42(0.75); C44(0.75)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C151(1.06); C20(1.59); C42(0.91); C44(0.91)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C151(0.96); C20(1.35); C42(0.84); C44(0.84)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C151(1.05); C20(2.45); C42(0.89); C44(0.89)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C151(1.03); C20(1.19); C42(0.25); C44(0.25)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C151(0.93); C20(0.94); C42(1.22); C44(1.22)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C151(1.12); C20(0.96); C42(0.90); C44(0.90)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C151(1.28); C20(1.13); C42(1.02); C44(1.02)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C151(1.13); C20(1.10); C42(1.02); C44(1.02)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C151(1.23); C20(1.11); C42(1.01); C44(1.01)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C151(1.15); C20(1.49); C42(1.22); C44(1.22)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C151(1.05); C20(1.45); C42(0.89); C44(0.89)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C151(1.21); C20(1.20); C42(0.84); C44(0.84)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C151(0.97); C20(0.88); C42(0.81); C44(0.81)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C151(1.06); C20(1.04); C42(1.05); C44(1.05)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C151(0.83); C20(0.62); C42(0.64); C44(0.64)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C151(0.93); C20(0.80); C42(1.04); C44(1.04)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C151(0.91); C20(1.01); C42(1.02); C44(1.02)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C151(0.87); C20(0.82); C42(0.89); C44(0.89)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C151(0.96); C20(1.12); C42(1.08); C44(1.08)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C151(0.95); C20(1.01); C42(0.88); C44(0.88)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C151(0.79); C20(1.24)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C151(0.63); C20(1.00)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C151(0.63); C20(1.22)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C151(0.96); C20(1.81)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C151(0.90); C20(1.51)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C151(1.00); C20(1.68)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C151(0.49); C20(1.28)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C151(0.61); C20(1.78)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C151(0.68); C20(1.38)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C151(0.93); C20(1.48); C42(0.96); C44(0.96)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C151(0.91); C20(1.34)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C151(0.66); C20(1.18)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C151(0.79); C20(2.16)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C151(1.01); C20(1.04)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C151(0.76); C20(1.71)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C151(0.92); C42(0.51); C44(0.14); C47(0.51)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C151(0.78); C42(1.00); C44(1.07); C47(1.00)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C151(1.03); C42(0.93); C44(1.00); C47(0.93)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C151(0.94); C42(0.79); C44(0.67); C47(0.79)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C151(0.95); C20(2.44); C42(1.24); C44(1.24)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C151(0.96); C42(1.18); C44(1.24); C47(1.18)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C151(0.90); C42(1.01); C44(0.92); C47(1.01)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C151(1.17); C42(0.97); C44(1.00); C47(0.97)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C151(1.07); C42(0.72); C44(0.61); C47(0.72)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C151(1.22); C42(0.86); C44(0.68); C47(0.86)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C151(1.05); C42(0.85); C44(0.51); C47(0.85)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C151(0.90); C42(0.72); C44(0.46); C47(0.72)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C151(1.01); C42(1.40); C44(1.82); C47(1.40)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C151(0.99); C42(0.83); C44(0.61); C47(0.83)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C151(1.37); C42(0.88); C44(0.76); C47(0.88)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C151(1.09); C20(1.36); C42(1.01); C44(1.01)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C151(1.29); C42(1.70); C44(2.51); C47(1.70)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C151(0.90); C20(0.82); C42(1.00); C44(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C151(0.94); C20(0.81); C42(1.04); C44(1.04)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C151(1.08); C20(0.73); C42(1.19); C44(1.19)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C151(0.90); C20(1.06); C42(1.24); C44(1.24)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C151(1.02); C20(0.96); C42(1.18); C44(1.18)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C151(0.86); C20(1.02); C42(1.23); C44(1.23)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C151(1.07); C20(0.92); C42(1.19); C44(1.19)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C151(0.97); C20(1.20); C42(1.10); C44(1.10)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C151(1.07); C20(0.92); C42(1.20); C44(1.20)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C291(4.85)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C151(0.87); C20(1.69)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C151(1.06); C20(2.20); C42(0.75); C44(0.75)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C20(2.75); C151(1.36)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C20(2.06); C151(1.69)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C20(2.22); C151(1.16)  LDD0082  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C75(0.79)  LDD2109  [2]
 LDCM0021  THZ1 HCT 116 C20(1.07)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Helicase family P19447
Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) Protein-tyrosine phosphatase family Q16825
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) CKS family P61024
SMC5-SMC6 complex localization factor protein 2 (SLF2) FAM178 family Q8IX21
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Vimentin (VIM) Intermediate filament family P08670
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.