Details of the Target

General Information of Target

Target ID LDTP05731
Target Name Striatin-3 (STRN3)
Gene Name STRN3
Gene ID 29966
Synonyms
GS2NA; SG2NA; Striatin-3; Cell cycle autoantigen SG2NA; S/G2 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP
QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM
LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR
QYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS
SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE
ALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERK
GKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFP
SGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHF
DGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLA
ISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQ
LLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYD
LETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMV
AHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSS
KAYIASAGADALAKVFV
Target Bioclass
Other
Family
WD repeat striatin family
Subcellular location
Cytoplasm
Function Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
Uniprot ID
Q13033
Ensemble ID
ENST00000355683.9
HGNC ID
HGNC:15720

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
OE33 SNV: p.D190V .
RH41 SNV: p.I417L .
SKMEL2 SNV: p.V674I .
SNU1 SNV: p.P694H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.38  LDD0402  [1]
TH211
 Probe Info  		Y123(7.37)  LDD0260  [2]
HHS-475
 Probe Info  		Y137(7.42)  LDD0264  [3]
DBIA
 Probe Info  		C621(1.61); C623(1.61)  LDD0531  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C604(0.00); C757(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C604(0.00); C757(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C604(0.00); C757(0.00)  LDD0037  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		C757(0.00); C604(0.00)  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C621(1.61); C623(1.61)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C621(0.78); C623(0.78)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C621(0.65); C623(0.65); C757(0.66)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C621(0.62); C623(0.62); C757(0.71)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C621(0.69); C623(0.69); C757(0.67)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C621(0.68); C623(0.68); C757(0.80)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C621(0.66); C623(0.66); C757(0.73)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C621(0.65); C623(0.65); C757(0.78)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C621(0.65); C623(0.65); C757(0.84)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C621(0.59); C623(0.59); C757(0.79)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C621(0.69); C623(0.69); C757(0.62)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C621(0.71); C623(0.71); C757(0.74)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C621(0.84); C623(0.84)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C621(0.69); C623(0.69); C757(0.64)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C621(0.64); C623(0.64); C757(0.72)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C621(0.66); C623(0.66); C757(0.69)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C621(0.89); C623(0.89); C757(0.71)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C621(0.74); C623(0.74); C757(0.68)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C621(0.82); C623(0.82); C757(0.67)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C621(0.79); C623(0.79); C757(0.71)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C621(0.78); C623(0.78); C757(0.69)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C621(0.80); C623(0.80); C757(0.87)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C621(0.80); C623(0.80); C757(0.81)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C621(0.79); C623(0.79)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C621(0.89); C623(0.89); C757(0.55)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C621(0.85); C623(0.85); C757(0.63)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C621(0.98); C623(0.98); C757(0.57)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C621(0.94); C623(0.94); C757(0.90)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C621(0.89); C623(0.89); C757(0.52)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C621(0.89); C623(0.89); C757(0.65)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C621(0.87); C623(0.87); C757(0.63)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C621(0.87); C623(0.87); C757(0.64)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C621(0.93); C623(0.93); C757(1.29)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C621(0.81); C623(0.81); C757(1.30)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C621(0.86); C623(0.86); C757(1.26)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C621(0.97); C623(0.97); C757(1.32)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C621(0.84); C623(0.84); C757(1.12)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C621(0.88); C623(0.88); C757(1.16)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C621(0.90); C623(0.90); C757(1.43)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C621(0.83); C623(0.83); C757(1.34)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C621(0.81); C623(0.81); C757(1.42)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C621(0.85); C623(0.85); C757(1.04)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C621(0.78); C623(0.78); C757(1.28)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C621(0.92); C623(0.92); C757(1.34)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C621(0.94); C623(0.94)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C621(0.85); C623(0.85); C757(0.98)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C621(0.84); C623(0.84); C757(1.17)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C621(0.91); C623(0.91); C757(1.26)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C621(0.77); C623(0.77); C757(1.12)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C621(0.78); C623(0.78); C757(1.55)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C621(0.79); C623(0.79); C757(1.34)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C621(0.91); C623(0.91); C757(1.75)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C621(0.91); C623(0.91); C757(1.61)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C621(0.77); C623(0.77); C757(2.07)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C621(0.86); C623(0.86); C757(1.87)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C621(0.80); C623(0.80)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C621(0.88); C623(0.88); C757(1.22)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C621(0.77); C623(0.77); C757(1.39)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C621(0.85); C623(0.85); C757(1.39)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C621(0.84); C623(0.84); C757(2.25)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C621(0.77); C623(0.77); C757(1.65)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C621(0.78); C623(0.78); C757(1.37)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C621(0.86); C623(0.86); C757(1.25)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C621(0.91); C623(0.91); C757(1.46)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C621(0.65); C623(0.65)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C621(2.46); C623(2.46)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C621(0.89); C623(0.89)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C621(0.93); C623(0.93)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C621(0.66); C623(0.66)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C621(1.01); C623(1.01)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C621(0.52); C623(0.52)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C621(0.58); C623(0.58)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C621(1.07); C623(1.07)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C621(0.57); C623(0.57); C757(1.18)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C621(0.39); C623(0.39); C757(1.23)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C621(0.85); C623(0.85); C757(0.95)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C621(0.52); C623(0.52); C757(1.19)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C621(0.55); C623(0.55); C757(1.16)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C621(1.20); C623(1.20)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C621(0.61); C623(0.61); C757(0.97)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C621(0.64); C623(0.64); C757(1.12)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C621(0.65); C623(0.65); C757(1.19)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C621(0.48); C623(0.48); C757(1.13)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C621(0.63); C623(0.63); C757(1.08)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C621(1.16); C623(1.16)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C621(1.17); C623(1.17)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C621(1.26); C623(1.26)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C621(0.75); C623(0.75)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C621(1.01); C623(1.01)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C621(1.34); C623(1.34)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C621(0.77); C623(0.77)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C621(0.95); C623(0.95)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C621(0.84); C623(0.84)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C621(1.01); C623(1.01)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C621(1.25); C623(1.25)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C621(0.97); C623(0.97)  LDD0624  [4]
 LDCM0308  AC46 PaTu 8988t C621(1.23); C623(1.23)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C621(1.03); C623(1.03)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C621(0.98); C623(0.98)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C621(0.99); C623(0.99)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C621(1.19); C623(1.19)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C621(1.04); C623(1.04)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C621(1.07); C623(1.07)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C621(0.96); C623(0.96)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C621(1.18); C623(1.18)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C621(1.19); C623(1.19)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C621(1.07); C623(1.07)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C621(1.36); C623(1.36)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C757(1.10); C621(1.15); C623(1.15)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C621(1.12); C623(1.12); C757(1.59)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C621(0.97); C623(0.97); C757(1.21)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C621(0.79); C623(0.79)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C757(1.30); C621(1.35); C623(1.35)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C757(1.67); C621(1.82); C623(1.82)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C621(1.02); C623(1.02); C757(1.06)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C757(1.17); C621(1.22); C623(1.22)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C621(1.16); C623(1.16); C757(1.28)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C621(1.35); C623(1.35); C757(1.51)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C757(1.28); C621(1.55); C623(1.55)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C621(1.29); C623(1.29); C757(1.33)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C757(1.18); C621(1.22); C623(1.22)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C621(1.29); C623(1.29); C757(1.38)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C621(0.84); C623(0.84)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C621(1.12); C623(1.12); C757(1.38)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C621(1.25); C623(1.25); C757(1.26)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C757(1.19); C621(1.30); C623(1.30)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C621(1.15); C623(1.15); C757(2.27)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C621(1.37); C623(1.37); C757(1.73)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C621(1.02); C623(1.02); C757(2.32)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C621(1.04); C623(1.04); C757(1.43)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C621(0.99); C623(0.99); C757(1.56)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C757(1.15); C621(1.30); C623(1.30)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C621(0.97); C623(0.97); C757(1.31)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C621(0.80); C623(0.80)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C621(0.93); C623(0.93); C757(1.79)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C757(0.85); C621(1.46); C623(1.46)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C621(0.95); C623(0.95); C757(1.92)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C621(0.86); C623(0.86); C757(0.94)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C621(0.99); C623(0.99); C757(1.03)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C757(0.88); C621(0.94); C623(0.94)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C621(0.73); C623(0.73); C757(0.83)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C757(1.02); C621(1.05); C623(1.05)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C621(0.82); C623(0.82); C757(0.84)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C621(0.92); C623(0.92); C757(0.92)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C621(0.94); C623(0.94); C757(0.98)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C621(0.79); C623(0.79); C757(0.95)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C621(0.81); C623(0.81); C757(0.91)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C757(0.90); C621(0.94); C623(0.94)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C757(0.84); C621(0.89); C623(0.89)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C757(1.66); C621(1.92); C623(1.92)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C621(0.89); C623(0.89); C757(0.92)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C621(0.77); C623(0.77); C757(0.83)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C621(0.50); C623(0.50); C757(0.64)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C621(0.67); C623(0.67); C757(0.69)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C621(0.84); C623(0.84)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C621(0.72); C623(0.72)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C621(0.84); C623(0.84)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C621(0.86); C623(0.86); C757(0.86)  LDD2171  [4]
 LDCM0367  CL1 HCT 116 C757(0.90); C621(0.97); C623(0.97)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C757(1.01); C621(1.24); C623(1.24)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C621(1.14); C623(1.14)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C621(0.89); C623(0.89)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C621(0.80); C623(0.80)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C621(0.84); C623(0.84)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C621(0.84); C623(0.84)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C621(0.41); C623(0.41)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C621(1.09); C623(1.09)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C621(0.52); C623(0.52)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C621(0.58); C623(0.58)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C621(0.63); C623(0.63)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C757(1.09); C621(1.50); C623(1.50)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C621(0.80); C623(0.80)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C621(0.87); C623(0.87)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C621(0.75); C623(0.75); C757(0.90)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C621(0.65); C623(0.65); C757(1.05)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C621(0.66); C623(0.66); C757(1.04)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C621(0.61); C623(0.61); C757(1.05)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C621(0.65); C623(0.65); C757(1.07)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C621(0.99); C623(0.99)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C621(1.26); C623(1.26)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C621(1.03); C623(1.03)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C621(0.97); C623(0.97); C757(1.51)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C621(0.93); C623(0.93)  LDD0708  [4]
 LDCM0392  CL121 PaTu 8988t C621(1.06); C623(1.06)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C621(1.57); C623(1.57)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C621(1.00); C623(1.00)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C621(1.02); C623(1.02)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C621(1.04); C623(1.04); C757(1.07)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C757(1.08); C621(1.08); C623(1.08)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C621(1.03); C623(1.03); C757(1.25)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C621(0.85); C623(0.85); C757(1.20)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C757(1.18); C621(1.24); C623(1.24)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C757(0.93); C621(1.36); C623(1.36)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C757(1.05); C621(1.33); C623(1.33)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C757(0.90); C621(0.98); C623(0.98)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C621(0.95); C623(0.95); C757(0.98)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C757(1.57); C621(1.97); C623(1.97)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C757(1.00); C621(1.04); C623(1.04)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C757(1.02); C621(1.07); C623(1.07)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C621(0.76); C623(0.76); C757(1.07)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C621(0.89); C623(0.89); C757(1.09)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C621(1.14); C623(1.14); C757(1.21)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C621(1.00); C623(1.00); C757(1.04)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C621(0.96); C623(0.96); C757(1.19)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C621(0.89); C623(0.89); C757(1.05)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C621(0.98); C623(0.98); C757(1.09)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C621(0.90); C623(0.90); C757(0.96)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C621(0.88); C623(0.88); C757(1.02)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C621(0.84); C623(0.84); C757(0.96)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C621(1.23); C623(1.23); C757(0.95)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C621(0.94); C623(0.94); C757(0.94)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C621(0.61); C623(0.61)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C621(0.96); C623(0.96)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C621(0.86); C623(0.86)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C621(0.73); C623(0.73)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C621(0.78); C623(0.78)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C621(0.49); C623(0.49)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C621(0.45); C623(0.45)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C621(0.66); C623(0.66)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C621(0.99); C623(0.99); C757(1.16)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C621(0.90); C623(0.90)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C621(0.41); C623(0.41)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C621(0.43); C623(0.43)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C621(0.54); C623(0.54)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C621(0.72); C623(0.72)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C621(0.77); C623(0.77)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C621(0.91); C623(0.91); C757(0.77)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C621(0.86); C623(0.86); C757(0.76)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C621(0.97); C623(0.97); C757(0.86)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C621(0.82); C623(0.82); C757(0.94)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C621(1.04); C623(1.04); C757(1.22)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C621(0.90); C623(0.90); C757(1.17)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C621(0.86); C623(0.86); C757(0.96)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C621(0.86); C623(0.86); C757(1.13)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C621(0.89); C623(0.89); C757(0.93)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C621(1.00); C623(1.00); C757(0.90)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C621(0.90); C623(0.90); C757(1.07)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C621(0.79); C623(0.79); C757(0.99)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C621(0.75); C623(0.75); C757(0.95)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C621(0.83); C623(0.83); C757(0.93)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C621(0.84); C623(0.84); C757(0.96)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C621(1.83); C623(1.83); C757(1.28)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C621(1.08); C623(1.08); C757(0.88)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C621(0.72); C623(0.72)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C621(0.84); C623(0.84)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C621(0.84); C623(0.84)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C621(0.95); C623(0.95)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C621(0.95); C623(0.95)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C621(0.81); C623(0.81)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C621(0.88); C623(0.88)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C621(1.19); C623(1.19)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C621(1.22); C623(1.22)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C621(1.65); C623(1.65); C757(1.23)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C621(0.96); C623(0.96)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C621(0.82); C623(0.82)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C621(0.81); C623(0.81)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C621(0.93); C623(0.93)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C621(0.79); C623(0.79)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C621(1.31); C623(1.31)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C621(1.24); C623(1.24)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C621(0.86); C623(0.86)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C621(0.98); C623(0.98)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C621(1.06); C623(1.06); C757(1.03)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C621(1.36); C623(1.36)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C621(0.89); C623(0.89)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C621(1.11); C623(1.11)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C621(1.12); C623(1.12)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C621(1.18); C623(1.18)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C621(1.03); C623(1.03)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C621(0.90); C623(0.90)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C621(1.04); C623(1.04)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C621(1.20); C623(1.20)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C621(1.24); C623(1.24)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C621(1.29); C623(1.29); C757(1.20)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C621(0.91); C623(0.91)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C621(1.58); C623(1.58)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C621(1.27); C623(1.27)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C621(1.63); C623(1.63)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C621(1.33); C623(1.33)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C621(0.94); C623(0.94)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C621(1.42); C623(1.42)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C621(1.32); C623(1.32)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C621(1.32); C623(1.32)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C621(1.52); C623(1.52)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C757(0.96); C604(0.99); C621(1.02)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C621(0.97); C623(0.97)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C621(0.70); C623(0.70)  LDD0744  [4]
 LDCM0116  HHS-0101 DM93 Y137(7.42)  LDD0264  [3]
 LDCM0118  HHS-0301 DM93 Y137(0.42)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y137(11.85)  LDD0267  [3]
 LDCM0022  KB02 HEK-293T C757(1.12); C604(0.77); C621(0.95)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C757(1.06); C604(1.08); C621(0.97)  LDD1497  [10]
 LDCM0024  KB05 Hs 936.T C604(2.16)  LDD3313  [11]
 LDCM0021  THZ1 HCT 116 C621(0.86); C623(0.86); C757(0.86)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
MOB-like protein phocein (MOB4) MOB1/phocein family Q9Y3A3
Suppressor of IKBKE 1 (SIKE1) SIKE family Q9BRV8
Striatin (STRN) WD repeat striatin family O43815
CTTNBP2 N-terminal-like protein (CTTNBP2NL) . Q9P2B4
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840