Details of the Target

General Information of Target

Target ID LDTP05515
Target Name Tight junction protein ZO-1 (TJP1)
Gene Name TJP1
Gene ID 7082
Synonyms
ZO1; Tight junction protein ZO-1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANC
VSVLIDHF
Target Bioclass
Transporter and channel
Family
MAGUK family
Subcellular location
Cell membrane
Function
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling. With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus.
Uniprot ID
Q07157
Ensemble ID
ENST00000346128.10
HGNC ID
HGNC:11827
ChEMBL ID
CHEMBL4296026

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K103(3.33); K1184(7.84); K1269(0.67); K191(5.41)  LDD0277  [3]
Probe 1
 Probe Info  		Y520(12.69); Y550(26.37); Y967(7.17); Y1039(11.59)  LDD3495  [4]
HHS-475
 Probe Info  		Y520(0.22); Y1140(0.90)  LDD0264  [5]
DBIA
 Probe Info  		C1718(0.90); C1727(0.81); C1740(0.81)  LDD0531  [6]
5E-2FA
 Probe Info  		H46(0.00); H1559(0.00); H1703(0.00); H1178(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		C1700(0.00); C1718(0.00); C1727(0.00)  LDD0162  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
SF
 Probe Info  		Y1140(0.00); Y520(0.00)  LDD0028  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C1700(0.00); C744(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y1140(1.02); Y1146(1.19); Y1165(1.01); Y520(0.93)  LDD2239  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1718(0.90); C1727(0.81); C1740(0.81)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1718(0.89); C1727(1.26); C1740(1.26)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1718(1.13)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1718(1.13)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1718(0.98)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1718(1.12)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1718(1.03)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1718(1.10)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1718(1.09)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1718(0.92)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1718(1.02)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1718(0.93)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1718(1.56); C1727(1.31); C1740(1.31)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1718(1.04)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1718(0.96)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1718(1.12)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1718(1.08); C1727(1.16); C1740(1.16)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1718(1.00); C1727(1.11); C1740(1.11)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1718(0.99); C1727(1.54); C1740(1.54)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1718(1.08); C1727(1.53); C1740(1.53)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1718(1.10); C1727(1.32); C1740(1.32)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1718(0.96); C1727(1.28); C1740(1.28)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1718(1.07); C1727(1.14); C1740(1.14)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1718(1.00); C1727(1.20); C1740(1.20)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1718(0.93); C1727(1.08); C1740(1.08)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1718(0.85); C1727(1.12); C1740(1.12)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1718(0.91); C1727(0.89); C1740(0.89)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1718(0.79); C1727(1.05); C1740(1.05)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1718(0.89); C1727(1.26); C1740(1.26)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1718(0.81); C1727(1.22); C1740(1.22)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1718(0.92); C1727(1.42); C1740(1.42)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1718(0.85); C1727(1.41); C1740(1.41)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1718(0.98); C1727(1.61); C1740(1.61)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1718(0.99); C1727(1.23); C1740(1.23)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1718(1.12); C1727(1.26); C1740(1.26)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1718(1.16); C1727(1.16); C1740(1.16)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1718(1.21); C1727(0.77); C1740(0.77)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1718(1.15); C1727(1.03); C1740(1.03)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1718(1.08); C1727(0.95); C1740(0.95)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1718(1.02); C1727(1.01); C1740(1.01)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1718(1.09); C1727(0.87); C1740(0.87)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1718(1.07); C1727(1.04); C1740(1.04)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1718(1.18); C1727(1.11); C1740(1.11)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1718(1.16); C1727(0.80); C1740(0.80)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1718(1.24); C1727(1.15); C1740(1.15)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1718(1.30); C1727(0.87); C1740(0.87)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1718(1.15); C1727(0.84); C1740(0.84)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1718(1.12); C1727(0.73); C1740(0.73)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C1718(1.08)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C1718(0.98)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C1718(1.01)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1718(1.09)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C1718(1.21)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C1718(1.13)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C1718(1.20)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C1718(1.09); C1727(1.51); C1740(1.51)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C1718(1.03)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C1718(0.74)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1718(1.41)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C1718(1.07)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1718(1.04)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1718(0.82)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1718(1.23)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1718(1.03)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C1718(0.94); C1727(1.29); C1740(1.29)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C1727(1.10); C1740(1.10); C1718(1.37)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C1718(1.04); C1727(1.46); C1740(1.46)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C1727(0.85); C1740(0.85); C1718(0.85)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C1718(1.02); C1727(1.39); C1740(1.39)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1718(0.97); C1727(1.35); C1740(1.35)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C1718(0.91); C1727(1.07); C1740(1.07)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C1718(0.98); C1727(1.15); C1740(1.15)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C1718(0.92); C1727(1.38); C1740(1.38)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1727(1.00); C1740(1.00); C1718(1.00)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1718(0.98); C1727(1.06); C1740(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1718(0.99); C1727(1.36); C1740(1.36)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1718(0.81); C1727(1.27); C1740(1.27)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1727(1.15); C1740(1.15); C1718(1.47)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C1718(0.81); C1727(0.85); C1740(0.85)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1727(1.28); C1740(1.28); C1718(1.32)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1718(1.03); C1727(1.22); C1740(1.22)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1718(1.17); C1727(1.48); C1740(1.48)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1718(1.10); C1727(1.56); C1740(1.56)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1718(1.37); C1727(1.38); C1740(1.38)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C1727(0.75); C1740(0.75); C1718(0.93)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C1727(0.91); C1740(0.91); C1718(1.01)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C1718(0.86); C1727(1.05); C1740(1.05)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C1727(0.99); C1740(0.99); C1718(1.07)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C1718(1.05); C1727(1.12); C1740(1.12)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C1718(0.80); C1727(0.95); C1740(0.95)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C1718(0.96); C1727(1.11); C1740(1.11)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C1718(0.94); C1727(1.10); C1740(1.10)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C1718(0.98); C1727(1.09); C1740(1.09)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1727(0.84); C1740(0.84); C1718(0.97)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C1718(0.86); C1727(1.03); C1740(1.03)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C1718(0.86); C1727(1.39); C1740(1.39)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C1727(1.19)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C1727(1.10)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C1727(1.12)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C1727(1.35)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C1727(0.75); C1740(0.75); C1718(0.83)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C1727(1.13)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C1727(1.26)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C1727(1.56)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C1727(0.75)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C1727(1.23)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C1727(1.20)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C1727(1.41)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C1718(1.21)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C1718(1.41)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C1718(1.45)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C1718(1.11); C1727(1.33); C1740(1.33)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C1718(1.32)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C1718(1.22)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C1718(1.28)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C1718(1.22)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C1718(1.30)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C1718(1.35)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C1718(1.35)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1718(1.41)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C1727(1.07); C1740(1.07); C1718(1.16)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C1718(0.99); C1727(1.11); C1740(1.11)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C1718(1.03); C1727(1.08); C1740(1.08)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C1727(0.89); C1740(0.89); C1718(1.18)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C1727(0.83); C1740(0.83); C1718(1.12)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C1727(1.10); C1740(1.10); C1718(1.16)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C1718(1.09); C1727(1.44); C1740(1.44)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C1718(0.97); C1727(1.17); C1740(1.17)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C1718(1.02); C1727(1.61); C1740(1.61)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C1718(0.90); C1727(1.15); C1740(1.15)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C1718(1.09); C1727(1.33); C1740(1.33)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C1727(0.89); C1740(0.89); C1718(0.98)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C1727(0.93); C1740(0.93); C1718(1.13)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1718(0.97); C1727(1.28); C1740(1.28)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C1718(0.89); C1727(1.06); C1740(1.06)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1727(0.68); C1740(0.68); C1718(1.16)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1718(1.10); C1727(1.37); C1740(1.37)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C1718(1.16)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C1718(1.07)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C1718(1.10)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C1718(1.21)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C1718(1.07)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C1718(1.11)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1718(1.10)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C1718(1.19)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C1718(1.03)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C1718(1.06)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1718(1.16)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C1718(1.14)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C1718(1.17)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C1718(1.11)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C1718(1.30)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C1718(1.27)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1718(1.02)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C1718(0.94); C1727(1.08); C1740(1.08)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C1727(1.16); C1740(1.16); C1718(1.16)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1718(1.00); C1727(2.06); C1740(2.06)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.41  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1727(0.77); C1740(0.77)  LDD2171  [6]
 LDCM0367  CL1 HCT 116 C1718(1.22)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C1718(0.89)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C1727(0.88); C1740(0.88); C1718(0.93)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1718(1.17); C1727(1.52); C1740(1.52)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C1727(1.29); C1740(1.29); C1718(1.33)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C1727(1.31); C1740(1.31); C1718(1.51)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C1727(1.20); C1740(1.20); C1718(1.29)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C1718(1.06); C1727(1.28); C1740(1.28)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1718(1.20); C1727(1.35); C1740(1.35)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1718(1.10); C1727(1.35); C1740(1.35)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1718(1.31); C1727(1.43); C1740(1.43)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C1718(1.13); C1727(1.62); C1740(1.62)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1718(1.09)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1718(1.31); C1727(1.43); C1740(1.43)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1727(1.19); C1740(1.19); C1718(1.19)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1727(1.05); C1740(1.05); C1718(1.25)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1727(1.28); C1740(1.28); C1718(1.45)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1727(0.98); C1740(0.98); C1718(1.78)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1727(1.11); C1740(1.11); C1718(1.51)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1727(1.02); C1740(1.02); C1718(1.17)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C1718(0.96); C1727(1.21); C1740(1.21)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C1727(0.91); C1740(0.91); C1718(1.04)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C1718(0.96); C1727(1.15); C1740(1.15)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C1718(1.00)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C1727(0.90); C1740(0.90); C1718(0.96)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C1727(1.56)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C1727(1.41)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C1727(1.71)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C1727(1.41)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C1718(1.10)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C1718(1.08)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C1718(1.14)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C1718(1.32)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C1718(0.98)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C1718(0.99)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C1718(1.07)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C1718(1.21); C1727(1.59); C1740(1.59)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C1718(1.22); C1727(1.56); C1740(1.56)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C1718(1.05); C1727(2.04); C1740(2.04)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C1718(1.05); C1727(2.31); C1740(2.31)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C1718(1.06)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C1718(1.10); C1727(1.72); C1740(1.72)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C1718(1.14); C1727(2.03); C1740(2.03)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C1718(0.94); C1727(3.77); C1740(3.77)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1718(1.07); C1727(1.83); C1740(1.83)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1718(0.95); C1727(2.46); C1740(2.46)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1718(1.04); C1727(1.92); C1740(1.92)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1718(1.05); C1727(1.50); C1740(1.50)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1718(0.95); C1727(1.83); C1740(1.83)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1718(1.08); C1727(1.80); C1740(1.80)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1718(0.98); C1727(2.35); C1740(2.35)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1718(1.12)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1718(1.05); C1727(1.58); C1740(1.58)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1718(1.13); C1727(1.17); C1740(1.17)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1718(1.05); C1727(0.91); C1740(0.91)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1718(1.03); C1727(0.92); C1740(0.92)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1718(1.07); C1727(1.44); C1740(1.44)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1718(1.32); C1727(1.52); C1740(1.52)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1718(1.25); C1727(1.28); C1740(1.28)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1718(1.22); C1727(1.67); C1740(1.67)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1718(0.93); C1727(1.16); C1740(1.16)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1718(1.59)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1718(1.44); C1727(1.47); C1740(1.47)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1718(0.96); C1727(1.11); C1740(1.11)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1718(1.15); C1727(1.80); C1740(1.80)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1718(0.89); C1727(1.63); C1740(1.63)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1718(0.96); C1727(1.23); C1740(1.23)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1718(1.05); C1727(1.35); C1740(1.35)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1718(0.94); C1727(0.93); C1740(0.93)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1718(0.96); C1727(0.97); C1740(0.97)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1718(0.92); C1727(1.07); C1740(1.07)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1718(0.93); C1727(1.06); C1740(1.06)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1718(1.09)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1718(0.99); C1727(1.35); C1740(1.35)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1718(1.02); C1727(0.95); C1740(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1718(1.00); C1727(1.06); C1740(1.06)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1718(0.97); C1727(1.09); C1740(1.09)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1718(0.92); C1727(0.96); C1740(0.96)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1718(0.87); C1727(0.93); C1740(0.93)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1718(1.01); C1727(1.81); C1740(1.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1718(0.96); C1727(1.17); C1740(1.17)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1718(0.90); C1727(0.96); C1740(0.96)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1718(0.96); C1727(1.25); C1740(1.25)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1718(1.06)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1718(0.95); C1727(1.04); C1740(1.04)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1718(1.00)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1718(1.07)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1718(1.18)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1718(1.38)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1718(1.04)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1718(1.38)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1718(1.38)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1718(1.41)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1718(1.16)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1718(0.99)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1718(1.18)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1718(1.31)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1718(1.08)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1718(1.32)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1718(1.21)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1718(0.96); C1727(1.15); C1740(1.15)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1718(1.04); C1727(1.48); C1740(1.48)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1718(1.01); C1727(1.17); C1740(1.17)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1718(1.07); C1727(1.32); C1740(1.32)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1718(1.12)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1718(0.96); C1727(1.00); C1740(1.00)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1718(0.87); C1727(1.23); C1740(1.23)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1718(0.75); C1727(1.96); C1740(1.96)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1718(0.92); C1727(1.33); C1740(1.33)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1718(0.96); C1727(2.18); C1740(2.18)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1718(0.86); C1727(1.07); C1740(1.07)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1718(0.84); C1727(0.81); C1740(0.81)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1718(0.89); C1727(1.09); C1740(1.09)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1718(0.84); C1727(1.50); C1740(1.50)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1718(0.83); C1727(1.73); C1740(1.73)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1718(1.19)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1718(1.02); C1727(0.87); C1740(0.87)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1718(1.02); C1727(0.93); C1740(0.93)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1718(1.09); C1727(0.95); C1740(0.95)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1718(0.78); C1727(0.98); C1740(0.98)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1718(0.98); C1727(1.29); C1740(1.29)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1718(1.02); C1727(1.21); C1740(1.21)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1718(0.95); C1727(1.07); C1740(1.07)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1718(1.10); C1727(1.00); C1740(1.00)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1718(0.90); C1727(0.93); C1740(0.93)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1718(0.96); C1727(1.03); C1740(1.03)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C1718(0.93); C1727(0.86); C1740(1.20)  LDD1698  [18]
 LDCM0468  Fragment33 HCT 116 C1718(1.15)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C1718(1.87); C1727(2.27); C1740(2.27)  LDD0744  [6]
 LDCM0116  HHS-0101 DM93 Y520(0.22); Y1140(0.90)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1140(0.65); Y520(0.87)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y520(0.63); Y1140(0.79)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y520(0.27); Y1140(0.70)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y520(0.48); Y1140(1.11)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C1718(0.95); C1740(1.18)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C1718(0.96); C1740(1.03)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C1700(1.19)  LDD3310  [19]
 LDCM0109  NEM HeLa H1630(0.00); H1168(0.00)  LDD0223  [14]
 LDCM0021  THZ1 HCT 116 C1727(0.77); C1740(0.77)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction alpha-1 protein (GJA1) Connexin family P17302
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kin of IRRE-like protein 1 (KIRREL1) Immunoglobulin superfamily Q96J84
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-4 (ACTN4) Alpha-actinin family O43707
Gap junction delta-3 protein (GJD3) Connexin family Q8N144

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840