Details of the Target

General Information of Target

Target ID LDTP05330
Target Name A-kinase anchor protein 17A (AKAP17A)
Gene Name AKAP17A
Gene ID 8227
Synonyms
CXYorf3; DXYS155E; SFRS17A; XE7; A-kinase anchor protein 17A; AKAP-17A; 721P; B-lymphocyte antigen; Protein XE7; Protein kinase A-anchoring protein 17A; PRKA17A; Splicing factor, arginine/serine-rich 17A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAATIVHDTSEAVELCPAYGLYLKPITKMTISVALPQLKQPGKSISNWEVMERLKGMVQ
NHQFSTLRISKSTMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKID
FPTRHDWDSFFRDAKDMNETLPGERPDTIHLEGLPCKWFALKESGSEKPSEDVLVKVFEK
FGEIRNVDIPMLDPYREEMTGRNFHTFSFGGHLNFEAYVQYREYMGFIQAMSALRGMKLM
YKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQKLQELEQQREEQKRREKEAEERQR
AEERKQKELEELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEE
RKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQEAELRRVEEE
KERALGLQRKERELRERLLSILLSKKPDDSHTHDELGVAHADLLQPVLDILQTVSSGCVS
ATTLHPLGGQPPAGAPKESPAHPEADGAPKSVNGSVAEEAPCKEVQSSCRVVPEDGSPEK
RCPGGVLSCIPDNNQQPKGIPACEQNVSRKDTRSEQDKCNREPSKGRGRATGDGLADRHK
RERSRARRASSREDGRPRKERRPHKKHAYKDDSPRRRSTSPDHTRSRRSHSKDRHRRERS
RERRGSASRKHSRHRRRSERSRSRSPSRHRSTWNR
Target Bioclass
Other
Subcellular location
Nucleus speckle
Function Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.
Uniprot ID
Q02040
Ensemble ID
ENST00000313871.9
HGNC ID
HGNC:18783

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Y629H DBIA    Probe Info 
C32 SNV: p.E167K DBIA    Probe Info 
HEC1B SNV: p.R145Q .
IGR1 SNV: p.E404K DBIA    Probe Info 
IGROV1 Deletion: p.L487SfsTer26
SNV: p.S633G		 DBIA    Probe Info 
JURKAT Substitution: p.R607I .
MOLT4 SNV: p.G57D; p.V255I IA-alkyne    Probe Info 
NALM6 SNV: p.R222H DBIA    Probe Info 
NCIH1703 SNV: p.Q351H DBIA    Probe Info 
NCIH358 SNV: p.E280Ter DBIA    Probe Info 
PC14 SNV: p.S610N DBIA    Probe Info 
SNU1 SNV: p.G477C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K111(5.88); K362(10.00)  LDD0277  [1]
BTD
 Probe Info  		C579(1.80)  LDD2096  [2]
AHL-Pu-1
 Probe Info  		C522(2.59)  LDD0168  [3]
DBIA
 Probe Info  		C563(1.04); C542(0.97); C549(0.97)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C529(0.00); C95(0.00); C563(0.00); C522(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C563(0.00); C522(0.00); C95(0.00); C251(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		10.00  LDD0443  [15]
NAIA_5
 Probe Info  		C579(0.00); C17(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C522(2.59)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C563(2.04); C522(2.83)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C529(1.03); C563(0.88); C95(0.93)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C563(0.84); C95(1.22)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C95(0.83)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C95(0.91)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C95(0.91)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C95(0.87)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C95(0.90)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C95(0.88)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C95(0.93)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C95(0.86)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C95(0.85)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C95(0.79)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C563(0.77); C95(1.24)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C95(0.92)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C95(0.90)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C95(0.86)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C95(0.94)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C95(0.94)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C95(1.06)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C95(0.93)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C95(0.93)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C95(0.88)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C95(0.99)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C563(0.80); C95(1.11)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C95(0.88)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C95(0.89)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C95(0.92)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C95(0.89)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C95(0.89)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C95(0.92)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C95(0.92)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C95(0.88)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C563(1.15); C549(1.31)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C563(0.93); C549(1.90)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C563(0.90); C549(1.37)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C563(0.95); C549(0.91)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C563(0.89); C549(1.34)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C563(0.99); C549(1.09)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C563(0.95); C549(1.20)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C563(0.91); C549(1.86)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C563(0.91); C549(1.06)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C563(1.12); C549(1.11)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C563(1.17); C549(1.45)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C563(1.09); C549(1.92)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C563(0.93); C95(1.32)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C563(0.95); C549(1.54)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C563(1.00); C549(1.64)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C563(0.89); C549(1.40)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C563(1.52)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C563(1.21)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C563(1.80)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C563(1.26)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C563(0.86)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C563(1.07)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C563(1.91)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C563(0.66); C95(1.20)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C563(0.91)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C563(0.84)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C563(0.91)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C563(1.29)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C563(0.90)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C563(1.01)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C563(0.93)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C563(1.10)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C529(0.77); C95(1.08)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C529(0.85); C95(1.16)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C529(0.81); C95(1.10)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C563(0.91); C95(1.00); C529(1.26)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C529(0.85); C95(1.01)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C529(0.79); C95(0.97)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C529(0.73); C95(1.00)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C529(0.68); C95(0.96)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C529(0.56); C95(1.09)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C563(0.76); C542(0.42); C549(0.75)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C563(0.74); C542(0.65); C549(0.96)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C563(0.75); C542(0.34); C549(0.77)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C563(0.93); C542(0.46); C549(0.81)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C563(0.71); C542(0.57); C549(0.82)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C563(0.85); C95(1.06); C529(1.18)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C563(0.72); C542(0.41); C549(0.82)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C563(0.83); C542(0.47); C549(0.82)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C563(0.75); C542(0.41); C549(0.83)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C563(0.70); C542(0.66); C549(0.93)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C563(0.74); C542(0.32); C549(0.76)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C529(0.95)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C529(0.91)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C529(1.07)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C529(1.01)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C529(1.20)  LDD0898  [4]
 LDCM0301  AC4 HCT 116 C563(0.74); C529(0.97); C95(1.01)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C529(0.72)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C529(0.79)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C529(0.87)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C529(0.75)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C529(0.69)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C529(0.80)  LDD0905  [4]
 LDCM0308  AC46 HCT 116 C95(1.06)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C95(1.10)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C95(1.12)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C95(1.37)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C563(0.81); C95(0.96); C529(1.03)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C95(1.25)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C95(0.97)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C95(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C95(1.21)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C95(1.14)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C95(1.36)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C95(1.56)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C95(1.09)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C95(1.11)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C95(1.24)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C563(0.81); C95(1.25)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C95(1.24)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C95(1.19)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C95(1.23)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C95(1.13)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C95(1.31)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C95(1.33)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C95(1.22)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C95(1.42)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C563(1.00); C95(1.02)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C95(1.02); C563(1.49)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C95(1.07); C563(1.15)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C95(0.96); C563(1.17)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C563(0.96); C95(0.96)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C95(0.96); C563(1.57)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C95(1.26); C563(1.97)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C95(1.15); C563(1.65)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C95(1.31); C563(2.61)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C95(1.08); C563(1.19)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C95(1.06); C563(1.39)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C95(0.98); C563(1.14)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C95(1.00); C563(1.13)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C563(0.62); C95(1.18)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C95(1.03); C563(1.40)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C95(0.99); C563(1.51)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C95(1.20); C563(2.79)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C95(1.00)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C95(1.14)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C95(1.02)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C95(0.98)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C95(0.90)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C95(1.06)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C95(0.91)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C95(1.07)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C95(1.02)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C95(1.07)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C95(1.01)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C95(1.23)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C95(0.93)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C95(1.16)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C95(1.10)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C95(0.85)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C95(0.83)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C563(0.81); C95(1.14)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C563(0.82); C95(1.16)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C563(0.77); C95(1.59)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C563(1.04); C542(0.97); C549(0.97)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C17(0.15); C579(0.14)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C563(0.34); C95(0.96); C529(1.21)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C563(0.53); C95(1.09); C529(1.10)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C563(0.93); C95(0.94); C529(0.96)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C563(0.91); C95(1.20)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C563(0.71); C95(1.16)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C563(0.88); C95(1.05)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C563(0.81); C95(1.08)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C529(0.72); C95(1.12)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C529(0.76); C95(1.15)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C529(0.92); C95(1.10)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C529(0.68); C95(1.29)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C529(0.85); C95(1.03)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C563(0.34); C95(1.20); C529(1.23)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C529(0.66); C95(1.22)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C529(0.77); C95(1.12)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C563(0.79); C542(0.55); C549(0.80)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C563(0.72); C542(0.29); C549(0.71)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C563(0.74); C542(0.46); C549(0.89)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C563(0.77); C542(0.50); C549(0.82)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C563(0.68); C542(0.40); C549(0.87)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C529(0.89)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C529(1.01)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C529(0.66)  LDD0987  [4]
 LDCM0390  CL12 HCT 116 C563(0.55); C95(1.06); C529(1.36)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C529(0.85)  LDD0989  [4]
 LDCM0392  CL121 HCT 116 C95(1.10)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C95(1.24)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C95(1.08)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C95(1.30)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C95(0.99)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C95(0.99)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C95(1.10)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C95(1.15)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C563(0.48); C95(1.09); C529(1.15)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C563(0.41); C95(0.94); C529(1.29)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C563(0.39); C529(1.03); C95(1.06)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C563(1.83)  LDD1001  [4]
 LDCM0404  CL17 HCT 116 C529(1.15)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C529(1.10)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C529(1.21)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C563(0.38); C95(1.04); C529(1.19)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C529(1.01)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C529(1.34)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C529(0.92)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C529(0.63)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C529(1.30)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C529(1.21)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C529(1.27)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C529(1.16)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C529(1.30)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C529(1.13)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C529(1.22); C563(0.42); C95(0.92)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C529(0.96)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C529(1.27); C95(1.03)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C95(1.09)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C95(1.02)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C95(1.06)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C95(1.02)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C95(1.04)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C95(0.93)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C95(0.95)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C529(0.98); C563(0.42); C95(1.00)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C95(0.97)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C95(0.97)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C95(0.90)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C95(1.04)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C95(0.99)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C95(1.04)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C563(1.48); C529(1.05); C549(1.03)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C563(1.09); C529(0.77); C549(1.43)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C563(1.08); C529(1.51); C549(0.90)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C563(1.09); C529(0.90); C549(0.98)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C529(1.42); C563(0.38); C95(1.04)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C563(1.24); C529(1.13); C549(0.96)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C563(1.17); C529(0.86); C549(1.17)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C563(1.18); C529(1.97); C549(1.09)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C563(1.27); C529(1.23); C549(1.21)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C563(1.81); C529(1.36); C549(1.45)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C563(0.95); C529(1.01); C549(1.51)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C563(1.12); C529(1.15); C549(1.18)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C563(1.90); C529(2.88); C549(1.39)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C563(1.13); C529(1.85); C549(1.37)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C563(1.05); C529(1.36); C549(1.02)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C529(1.21); C563(0.32); C95(1.11)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C563(1.06); C529(1.27); C549(1.15)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C529(0.92); C95(1.15)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C529(0.84); C95(1.10)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C529(0.92); C95(1.11)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C529(1.07); C95(1.16)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C529(0.95); C95(1.12)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C529(0.84); C95(1.31)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C529(1.14); C95(0.99)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C529(0.93); C95(1.07)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C529(1.29); C95(1.13)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C529(1.68); C563(0.37); C95(1.17)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C529(0.96); C95(1.02)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C529(1.05); C95(1.00)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C529(0.94); C95(1.10)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C529(1.06); C95(1.18)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C529(1.03); C95(0.97)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C95(1.15)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C95(1.24)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C95(1.18)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C95(1.15)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C529(0.88); C563(0.31); C95(1.03)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C95(1.09)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C95(1.19)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C95(1.11)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C95(0.96)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C95(1.13)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C95(1.03)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C95(1.10)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C95(1.32)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C95(0.98)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C95(0.93)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C529(1.16); C563(0.63); C95(0.98)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C95(1.32)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C529(1.31); C563(0.96); C95(0.79)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C529(1.01); C563(0.94); C95(0.78)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C529(0.86); C563(0.70); C95(0.93)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C529(1.07); C563(0.92); C95(0.91)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C529(0.93); C563(0.77); C95(0.80)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C529(1.38); C563(0.86); C95(0.87)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C529(1.00); C563(0.91); C95(0.93)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C529(0.94); C563(1.07); C95(1.04)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C529(0.91); C563(0.82); C95(0.94)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C579(0.95); C522(1.00); C156(1.01); C95(1.00)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C156(5.10)  LDD1702  [2]
 LDCM0625  F8 Ramos C579(2.67)  LDD2187  [17]
 LDCM0573  Fragment11 Ramos C579(9.18)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C579(0.81)  LDD2193  [17]
 LDCM0586  Fragment28 Ramos C579(0.37)  LDD2198  [17]
 LDCM0468  Fragment33 HCT 116 C529(0.94); C95(1.17)  LDD0785  [4]
 LDCM0566  Fragment4 Ramos C579(0.80)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C95(0.90)  LDD0744  [4]
 LDCM0569  Fragment7 Ramos C579(0.91)  LDD2186  [17]
 LDCM0022  KB02 HCT 116 C542(4.53); C549(4.53); C522(1.55)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C542(2.28); C549(2.28); C522(1.12)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C542(2.51); C549(2.51); C522(1.40)  LDD0082  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C579(1.80)  LDD2096  [2]
 LDCM0021  THZ1 HCT 116 C529(1.22)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
HMG domain-containing protein 4 (HMGXB4) . Q9UGU5
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Zinc finger Ran-binding domain-containing protein 2 (ZRANB2) ZRANB2 family O95218
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Syntenin-2 (SDCBP2) . Q9H190
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578