Details of the Target

General Information of Target

Target ID LDTP04608
Target Name Telomeric repeat-binding factor 1 (TERF1)
Gene Name TERF1
Gene ID 7013
Synonyms
PIN2; TRBF1; TRF; TRF1; Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEDVSSAAPSPRGCADGRDADPTEEQMAETERNDEEQFECQELLECQVQVGAPEEEEEE
EEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTACQL
RTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQA
IAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKI
KSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDK
QSAVTESSEGTVSLLRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKESRRATES
RIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVML
KDRWRTMKKLKLISSDSED
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
TTD ID
T80042
Uniprot ID
P54274
DrugMap ID
TT1Y6J2
Ensemble ID
ENST00000276602.10
HGNC ID
HGNC:11728

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.A53PfsTer63 .
CCK81 Deletion: p.D282del
SNV: p.R100G		 .
HT SNV: p.F90C .
JHH6 Deletion: p.D282del .
NCIH2172 SNV: p.E400G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C126(1.27)  LDD0531  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C118(0.00); C126(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C118(0.00); C126(0.00)  LDD0037  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C126(1.27)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C126(1.02)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C126(0.83)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C126(0.92)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C126(0.85)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C126(0.89)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C126(0.98)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C126(0.86)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C126(0.82)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C126(0.91)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C126(1.03)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C126(0.92)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C126(1.28)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C126(0.86)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C126(0.92)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C126(0.95)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C126(0.97)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C126(0.98)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C126(1.15)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C126(1.05)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C126(1.01)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C126(1.08)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C126(1.02)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C126(1.00)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C126(1.00)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C126(1.08)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C126(0.98)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C126(1.08)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C126(1.12)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C126(1.08)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C126(1.10)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C126(1.09)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C126(1.16)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C126(0.90)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C126(0.84)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C126(0.84)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C126(0.90)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C126(1.07)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C126(1.10)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C126(0.85)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C126(0.92)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C126(0.92)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C126(1.00)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C126(0.83)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C126(1.18)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C126(1.02)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C126(1.02)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C126(0.79)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C126(0.94); C118(1.13)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C118(1.09); C126(1.10)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C126(0.95); C118(1.22)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C126(1.04); C118(1.21)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C118(0.92); C126(1.05)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C118(1.28); C126(1.32)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C126(1.06); C118(1.29)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C126(1.19)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C118(0.92); C126(1.01)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C126(0.97); C118(1.07)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C118(1.08); C126(1.16)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C118(1.05); C126(1.34)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C118(1.11); C126(1.04)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C118(1.31); C126(1.04)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C118(1.16); C126(0.97)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C118(0.83); C126(0.94)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C126(1.02); C118(1.20)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C126(0.98); C118(1.05)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C126(0.99); C118(1.13)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C126(1.29)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C126(1.00); C118(1.35)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C126(1.01); C118(1.25)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C126(1.00); C118(1.07)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C126(0.92); C118(1.21)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C126(1.07); C118(1.23)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C118(0.74); C126(0.98)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C126(0.88); C118(0.91)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C126(0.94); C118(1.16)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C126(0.91); C118(1.30)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C126(0.95); C118(1.43)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C126(1.52)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C126(0.98); C118(1.45)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C126(0.91); C118(1.26)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C126(0.91); C118(1.42)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C126(0.96); C118(1.08)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C126(1.01); C118(1.28)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C126(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C126(0.92)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C126(0.94)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C126(0.91)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C126(0.88)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C126(1.79)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C126(1.13)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C126(0.91)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C126(0.99)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C126(1.02)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C126(1.10)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C126(1.03)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C126(0.84)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C126(0.94)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C126(0.89)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C126(1.06)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C126(1.93)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C126(1.01)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C126(0.89)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C126(0.90)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C126(1.04)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C126(1.05)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C126(1.04)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C126(1.22)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C126(1.00)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C126(1.02)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C126(1.14)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C126(1.12)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C126(1.10)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C126(1.00)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C126(1.14)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C126(1.16)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C126(1.23)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C126(1.17)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C126(1.23)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C126(1.15)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C126(1.01)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C126(1.05)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C126(0.94)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C126(0.96)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C126(0.99)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C126(0.99)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C126(1.25)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C126(1.29)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C126(1.41)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C126(1.09)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C126(1.04)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C126(0.96)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C126(1.02)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C126(1.02)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C126(1.15)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C126(0.92)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C126(1.41)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C126(1.18)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C126(1.13)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C126(1.02)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C126(1.02)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C126(1.13)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C126(1.06)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C126(1.15)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C126(1.12)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C126(1.19)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C126(1.13)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C126(1.21)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C126(0.95)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C126(0.98)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C126(1.06)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C126(1.10)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C126(1.06)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C126(0.76)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C126(1.11)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C126(1.03)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C126(1.03)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C126(0.82)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C126(1.00)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C126(1.61)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C126(0.86)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C126(1.24)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C126(1.02)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C126(1.10)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C126(0.95); C118(1.00)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C118(0.81); C126(1.04)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C118(0.92); C126(1.06)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C126(1.19); C118(1.29)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C118(0.99); C126(1.02)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C126(1.04)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C126(1.06); C118(1.11)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C126(0.97); C118(1.45)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C126(0.99); C118(1.30)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C126(0.96); C118(1.33)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C126(0.89); C118(1.80)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C126(0.86); C118(1.96)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C126(0.86); C118(1.04)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C126(1.35)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C126(0.97)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C126(0.96)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C126(1.13)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C126(0.83)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C126(0.94)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C126(0.89)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C126(0.94)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C126(0.98)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C126(1.07)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C126(0.97)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C126(1.16)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C126(1.05)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C126(1.11)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C126(0.96)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C126(0.96)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C118(0.77); C126(1.07)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C118(0.77); C126(0.90)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C118(0.78); C126(0.98)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C118(0.98); C126(1.04)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C126(0.87)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C118(1.14); C126(1.18)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C118(0.82); C126(1.20)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C118(1.11); C126(1.42)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C118(0.74); C126(1.10)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C118(1.46); C126(1.20)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C118(0.92); C126(1.12)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C118(1.25); C126(1.13)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C118(1.65); C126(1.12)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C118(1.93); C126(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C118(0.71); C126(1.18)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C126(0.96)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C118(0.93); C126(1.07)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C126(0.87)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C126(0.88)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C126(0.82)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C126(1.00)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C126(1.21)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C126(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C126(1.18)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C126(0.98)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C126(0.96)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C126(1.13)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C126(1.09)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C126(1.45)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C126(1.13)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C126(0.85)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C126(1.04)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C126(0.84)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C126(0.85)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C126(0.90)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C126(1.01)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C126(1.06)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C126(1.05)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C126(0.89)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C126(0.82)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C126(0.95)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C126(0.81)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C126(0.97)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C126(0.87)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C126(0.89)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C126(0.93)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C126(0.93)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C126(0.97)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C126(0.85)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C126(0.75)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C126(0.86)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C126(0.74)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C126(0.74)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C126(0.95)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C126(0.69)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C126(0.83)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C126(0.77)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C126(0.59)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C126(1.09)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C126(0.70)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C126(0.68)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C126(0.65)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C126(0.74)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C126(0.71)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C126(1.05)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C126(0.98)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C126(1.06)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C126(1.13)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C126(1.11)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C126(1.08)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C126(1.12)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C126(1.29)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C126(1.19)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C126(1.45)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C126(0.98)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C126(1.08)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C126(1.01)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C126(1.26)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C126(1.52)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C126(0.89)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C126(0.98)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C126(1.13)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C126(1.23)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C126(1.18)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C126(1.35)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C126(1.16)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C126(1.31)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C126(1.09)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C126(1.23)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C126(1.33)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C118(1.22)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C126(0.63)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C126(1.31)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C118(0.97)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C118(1.06)  LDD1497  [8]
 LDCM0024  KB05 SiSo C15(2.33)  LDD3421  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxymethyl-dUMP N-hydrolase (DNPH1) 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family O43598
Poly [ADP-ribose] polymerase tankyrase-1 (TNKS) ARTD/PARP family O95271
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
tRNA (guanine(26)-N(2))-dimethyltransferase (TRMT1) Trm1 family Q9NXH9
Tryptophan--tRNA ligase, cytoplasmic (WARS1) Class-I aminoacyl-tRNA synthetase family P23381
ATP-dependent RNA helicase DDX19B (DDX19B) DEAD box helicase family Q9UMR2
Probable ATP-dependent RNA helicase DDX23 (DDX23) DEAD box helicase family Q9BUQ8
ATP-dependent RNA helicase DDX39A (DDX39A) DEAD box helicase family O00148
Glutathione synthetase (GSS) Eukaryotic GSH synthase family P48637
ATP-dependent DNA helicase Q4 (RECQL4) Helicase family O94761
RecQ-like DNA helicase BLM (BLM) Helicase family P54132
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Homogentisate 1,2-dioxygenase (HGD) Homogentisate dioxygenase family Q93099
L-lactate dehydrogenase B chain (LDHB) LDH family P07195
Malate dehydrogenase, cytoplasmic (MDH1) MDH type 2 family P40925
Sterol O-acyltransferase 1 (SOAT1) Membrane-bound acyltransferase family P35610
AMP deaminase 2 (AMPD2) Adenosine and AMP deaminases family Q01433
Ketimine reductase mu-crystallin (CRYM) Ornithine cyclodeaminase/mu-crystallin family Q14894
Caspase-6 (CASP6) Peptidase C14A family P55212
Aminoacylase-1 (ACY1) Peptidase M20A family Q03154
Xaa-Pro dipeptidase (PEPD) Peptidase M24B family P12955
Peroxiredoxin-1 (PRDX1) Peroxiredoxin family Q06830
Peroxiredoxin-6 (PRDX6) Peroxiredoxin family P30041
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
Protein phosphatase 1G (PPM1G) PP2C family O15355
Serine/threonine-protein kinase PAK 4 (PAK4) STE Ser/Thr protein kinase family O96013
Tyrosine-protein kinase Fes/Fps (FES) Tyr protein kinase family P07332
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) Protein-tyrosine phosphatase family P54829
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
Spermidine synthase (SRM) Spermidine/spermine synthase family P19623
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) Thiolase family Q9BWD1
Transketolase (TKT) Transketolase family P29401
Triosephosphate isomerase (TPI1) Triosephosphate isomerase family P60174
Probable tRNA(His) guanylyltransferase (THG1L) TRNA(His) guanylyltransferase family Q9NWX6
E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) . Q6UWE0
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Transportin-2 (TNPO2) Importin beta family O14787
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Gamma-synuclein (SNCG) Synuclein family O76070
Optineurin (OPTN) . Q96CV9
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-crystallin B1 (CRYBB1) Beta/gamma-crystallin family P53674
Centrosomal protein of 85 kDa (CEP85) CEP85 family Q6P2H3
Protein CUSTOS (CUSTOS) CUSTOS family Q96C57
Large ribosomal subunit protein eL19 (RPL19) Eukaryotic ribosomal protein eL19 family P84098
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Prelamin-A/C (LMNA) Intermediate filament family P02545
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Nucleosome assembly protein 1-like 1 (NAP1L1) Nucleosome assembly protein (NAP) family P55209
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) PACSIN family Q9UNF0
PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) PINX1 family Q96BK5
RNA polymerase II-associated protein 3 (RPAP3) RPAP3 family Q9H6T3
Nucleolar protein 12 (NOL12) RRP17 family Q9UGY1
Cohesin subunit SA-1 (STAG1) SCC3 family Q8WVM7
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Transcription elongation factor SPT5 (SUPT5H) SPT5 family O00267
Telomere repeats-binding bouquet formation protein 1 (TERB1) TERB1 family Q8NA31
Dynein axonemal assembly factor 11 (DNAAF11) TilB family Q86X45
Tubulin beta-3 chain (TUBB3) Tubulin family Q13509
Gelsolin (GSN) Villin/gelsolin family P06396
Coronin-1B (CORO1B) WD repeat coronin family Q9BR76
Amphiphysin (AMPH) . P49418
Band 4.1-like protein 1 (EPB41L1) . Q9H4G0
DnaJ homolog subfamily B member 1 (DNAJB1) . P25685
Hematopoietic lineage cell-specific protein (HCLS1) . P14317
Kelch domain-containing protein 4 (KLHDC4) . Q8TBB5
Merlin (NF2) . P35240
Moesin (MSN) . P26038
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
NEDD8 ultimate buster 1 (NUB1) . Q9Y5A7
PCNA-associated factor (PCLAF) . Q15004
Reticulon-3 (RTN3) . O95197
Rho guanine nucleotide exchange factor 3 (ARHGEF3) . Q9NR81
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
SH3 domain-binding protein 1 (SH3BP1) . Q9Y3L3
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Stress-induced-phosphoprotein 1 (STIP1) . P31948
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840