Details of the Target

General Information of Target

Target ID LDTP04588
Target Name E3 ubiquitin-protein ligase TTC3 (TTC3)
Gene Name TTC3
Gene ID 7267
Synonyms
DCRR1; RNF105; TPRD; E3 ubiquitin-protein ligase TTC3; EC 2.3.2.27; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; TPR repeat protein D; Tetratricopeptide repeat protein 3; TPR repeat protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSER
NLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEI
NLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGDVTI
LTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNE
EFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPK
GHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRTANK
DPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVD
DCDCHPEFSPPSSQPPKHKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAH
QDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVLVVY
GLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFE
KARTLIYRLPGVLTWPTSNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYS
KIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEG
VISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEA
KKLAQERMEEDLRESNPPKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAM
LLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELKEVE
PKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYF
SEPASLKEARCLIWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVK
NKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDVEEF
EALYDQHSNEYVVRNKKLWDMNPKQKCSTLYDYFSQFLEEHGPLDMSNKMFSAEYEFFPE
ETRQILEKAGGLKPFLLGCPRFVVIDNCIALKKVASRLKKKRKKKNIKTKVEEISKAGEY
VRVKLQLNPAAREFKPDVKSKPVSDSSSAPAFENVKPKPVSANSPKPACEDVKAKPVSDN
SSRQVSEDGQPKGVSSNSPKPGSEDANYKRVSCNSPKPVLEDVKPTYWAQSHLVTGYCTY
LPFQRFDITQTPPAYINVLPGLPQYTSIYTPLASLSPEYQLPRSVPVVPSFVANDRADKN
AAAYFEGHHLNAENVAGHQIASETQILEGSLGISVKSHCSTGDAHTVLSESNRNDEHCGN
SNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIEKEHQ
VLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQ
QEKKEIQERLKSLKKKIKKVSNASEMYTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIE
EYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAY
PDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTV
HPELLPESSGDDGQGLVTSASDVTGNHAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPE
ATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNS
TELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPV
TRSSQGSPSVVVAPSPKTKGQKAEDVPVRIALGASSCEICHEVFKSKNVRVLKCGHKYHK
GCFKQWLKGQSACPACQGRDLLTEESPSGRGWPSQNQELPSCSSR
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation.
Uniprot ID
P53804
Ensemble ID
ENST00000354749.6
HGNC ID
HGNC:12393

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.S1278F DBIA    Probe Info 
AGS SNV: p.P797T .
HCC1937 SNV: p.K1289M .
HCT15 SNV: p.A602T; p.I936N; p.G1953C; p.L2002M .
HEL SNV: p.T357I DBIA    Probe Info 
HEL9217 SNV: p.T357I DBIA    Probe Info 
HT SNV: p.V48A .
Ishikawa (Heraklio) 02 ER SNV: p.I486T DBIA    Probe Info 
JHH7 SNV: p.P1928L .
MCC13 SNV: p.F275S DBIA    Probe Info 
MEWO SNV: p.K324N; p.S1063F .
OZ SNV: p.A479G .
RKO Deletion: p.K778RfsTer18 DBIA    Probe Info 
SW756 SNV: p.Q1310E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C1001(1.19)  LDD2099  [1]
DBIA
 Probe Info  		C422(0.97); C424(0.97)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		C813(0.00); C109(0.00); C1419(0.00)  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		11.50  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C813(1.06); C971(1.07)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C813(1.11); C971(1.40)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C227(1.16); C859(1.72); C971(0.94)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C227(1.06); C859(1.11); C971(0.87)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C227(1.14); C859(1.19); C971(1.03)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C227(1.21); C859(1.30); C971(0.94)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C227(1.15); C859(1.08); C971(0.84)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C227(1.09); C859(3.35); C971(1.02)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C227(1.06); C859(1.22); C971(1.01)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C227(1.15); C859(0.96); C971(0.99)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C227(1.31); C859(1.25); C971(0.81)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C227(1.21); C859(1.20); C971(1.04)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C813(1.35); C971(1.04)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C227(1.52); C859(2.08); C971(1.21)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C227(1.69); C859(2.26); C971(1.12)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C227(1.55); C859(1.71); C971(0.97)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C813(1.00); C971(1.00)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C813(0.94); C971(0.92)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C813(1.21); C971(1.04)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C813(1.19); C971(1.06)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C813(1.07); C971(0.94)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C813(0.90); C971(1.18)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C813(0.99); C971(1.06)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C813(1.10); C971(0.99)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C813(1.40); C971(1.01)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C813(0.82); C971(1.32)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C813(0.71); C971(1.16)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C813(0.64); C971(0.92)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C813(0.82); C971(0.98)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C813(0.91); C971(1.01)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C813(0.81); C971(0.91)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C813(0.69); C971(1.13)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C1438(1.13); C227(0.94); C713(0.92); C718(0.90)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C1438(1.07); C227(1.04); C713(1.04); C718(1.24)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C1438(1.09); C227(1.12); C713(1.32); C718(1.06)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C1438(1.15); C227(0.97); C713(1.04); C718(1.30)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C1438(1.03); C227(1.01); C713(1.06); C718(1.11)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C1438(1.46); C227(1.22); C713(1.13); C718(0.98)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C1438(1.24); C227(1.22); C713(1.15); C718(1.19)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C1438(1.26); C227(1.19); C713(0.99); C718(1.51)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C1438(1.24); C227(1.20); C713(1.18); C718(1.48)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C1438(1.26); C227(1.48); C713(1.44); C718(1.14)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C1438(1.49); C227(1.48); C713(1.60); C718(1.83)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C1438(1.66); C227(1.25); C713(1.19); C718(1.43)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C813(0.89); C971(0.84)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C1438(0.99); C227(1.23); C713(1.25); C718(1.11)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C1438(1.29); C227(1.26); C713(1.36); C718(1.46)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C1438(1.33); C227(1.14); C713(1.29); C718(1.31)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C971(0.94)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C971(1.14)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C971(1.05)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C971(1.15)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C971(1.20)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C971(1.35)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C971(1.13)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C971(0.98); C813(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C971(0.99)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C971(1.07)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C971(0.99)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C971(1.49)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C971(1.16)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C971(1.05)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C971(0.97)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C971(0.89)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C813(0.79); C971(1.04)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C971(1.19); C813(1.43)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C813(0.78); C971(1.23)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C971(1.03); C813(1.32)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C813(0.58); C971(1.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C971(1.08); C813(1.14)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C813(0.89); C971(1.02)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C813(0.73); C971(1.06)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C813(0.78); C971(0.99)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C971(1.05); C813(1.06)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C971(1.19); C813(1.31)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C971(1.23); C813(1.60)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C971(1.21); C813(1.24)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C813(0.98); C971(1.34)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C813(1.12); C971(1.20)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C813(0.96); C971(1.28)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C813(1.04); C971(1.21)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C971(1.43); C813(1.74)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C971(1.35); C813(1.47)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C971(1.45); C813(1.65)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C227(1.40); C718(0.76); C859(0.71)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C227(0.84); C718(0.85); C859(0.75)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C227(1.14); C718(0.97); C859(0.81)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C227(1.23); C718(0.89); C859(0.88)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C227(0.97); C718(0.97); C859(1.17)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C971(1.14); C813(1.42)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C227(0.84); C718(0.88); C859(1.01)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C227(1.78); C718(0.97); C859(0.80)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C227(1.07); C718(0.89); C859(0.82)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C227(1.17); C718(1.14); C859(1.38)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C227(1.24); C718(0.86); C859(1.14)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C227(1.15); C718(0.87); C859(0.68)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C813(0.93); C971(0.98)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C813(0.93); C971(1.17)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C813(0.84); C971(1.10)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C813(0.88); C971(1.17)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C813(0.96); C971(1.28)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C813(0.86); C971(1.27)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C813(0.79); C971(1.11)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C813(0.87); C971(0.94)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C813(0.76); C971(0.98)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C813(0.86); C971(1.08)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C813(0.92); C971(1.09)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C813(0.82); C971(1.16)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C971(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C971(0.87)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C971(1.05)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C813(1.15); C971(1.18)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C971(0.99)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C971(0.83)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C971(0.97)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C971(0.84)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C971(1.10)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C971(1.35)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C971(1.09)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C971(1.35)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C813(0.77); C971(1.22)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C813(0.72); C971(1.10)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C813(1.10); C971(1.24)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C813(0.86); C971(1.40)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C813(0.78); C971(1.18)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C813(0.84); C971(1.21)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C813(0.86); C971(1.89)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C813(0.77); C971(1.84)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C813(0.79); C971(2.07)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C813(0.72); C971(1.37)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C813(0.72); C971(1.60)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C813(0.70); C971(1.11)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C813(0.77); C971(1.16)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C813(1.10); C971(1.17)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C813(0.72); C971(1.25)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C813(0.76); C971(0.94)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C813(0.76); C971(2.10)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C813(1.36)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C813(1.36)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C813(0.96)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C813(0.86)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C813(1.09)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C813(0.78)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C813(1.15)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C813(0.81)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C813(0.52)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C813(0.68)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C813(0.76)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C813(0.53)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C813(0.69)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C813(0.70)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C813(0.56)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C227(1.09); C859(1.55); C971(1.03)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C227(0.99); C859(0.90); C971(1.13)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C813(1.21); C971(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C813(1.13); C971(1.24)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C971(1.03); C813(1.10)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C422(0.97); C424(0.97)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C971(1.02)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C971(1.13)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C971(1.13); C813(1.20)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C971(1.05); C813(1.11)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C971(0.95); C813(1.40)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C971(0.92); C813(1.08)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C971(0.92); C813(0.98)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C813(1.21); C971(1.23)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C813(1.20); C971(1.46)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C813(0.91); C971(1.41)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C813(1.10); C971(1.51)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C813(0.96); C971(1.22)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C971(1.11)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C813(0.96); C971(1.20)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C813(1.07); C971(1.18)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C971(1.09); C813(1.11)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C813(1.34); C971(1.47)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C813(1.19); C971(1.45)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C813(1.22); C971(1.40)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C971(1.28); C813(1.36)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C227(1.11); C718(0.99); C859(1.11)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C227(0.97); C718(0.92); C859(0.55)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C227(1.12); C718(0.96); C859(0.68)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C971(1.13)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C227(1.43); C718(1.00); C859(0.85)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C971(0.87); C813(0.92)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C813(0.90); C971(1.17)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C813(1.04); C971(1.21)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C813(0.91); C971(1.14)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C971(0.86)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C971(0.54)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C971(0.83)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C971(1.02)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C971(1.07)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C971(1.25)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C971(0.92)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C713(1.01); C971(1.15)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C971(0.92); C813(1.15)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C971(0.90); C813(1.25)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C813(1.10); C971(1.24)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C971(0.87)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C813(0.77); C971(1.41)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C813(1.15); C971(1.25)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C971(0.85); C813(2.64)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C971(1.02); C813(1.16)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C813(1.23); C971(1.10)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C813(1.34); C971(1.22)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C813(1.29); C971(1.13)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C813(1.36); C971(1.11)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C813(1.17); C971(1.17)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C813(1.43); C971(1.03)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C971(0.85)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C813(1.19); C971(1.04)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C813(0.88); C971(1.13)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C971(1.19)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C971(1.16)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C971(1.14)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C971(1.11)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C971(1.16)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C971(1.08)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C971(1.11)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C971(0.85)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C971(1.30)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C971(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C971(1.16)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C971(1.26)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C971(1.26)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C971(1.22)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C813(1.10)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C813(1.07)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C813(1.06)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C813(1.02)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C971(0.93)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C813(0.97)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C813(1.30)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C813(1.25)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C813(1.28)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C813(1.13)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C813(0.84)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C813(0.88)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C813(1.09)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C813(0.92)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C813(0.84)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C971(0.95)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C813(1.05)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C813(1.19)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C813(1.12)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C813(1.20)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C813(1.62)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C813(1.01)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C813(1.71)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C813(1.36)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C813(1.50)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C813(1.07)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C971(1.11)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C813(1.33)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C813(1.28)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C813(1.04)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C813(1.28)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C813(1.31)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C971(0.97)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C971(1.00)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C971(1.04)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C971(0.85)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C971(0.94)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C971(1.01)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C971(1.05)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C971(0.94)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C971(0.97)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C971(1.05)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C971(0.72)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C971(0.79)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C971(0.96)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C971(1.03)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C971(0.49)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C971(0.97)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C971(0.03)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C813(1.11); C971(1.05)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C813(0.94); C971(0.95)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C813(1.10); C971(1.04)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C813(1.21); C971(1.23)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C813(1.34); C971(1.11)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C813(1.20); C971(1.16)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C813(1.53); C971(1.14)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C813(1.02); C971(1.19)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C813(1.20); C971(1.02)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C1107(0.94); C109(0.81)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C813(1.11)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C971(1.19)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C422(2.75); C424(2.75)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C422(1.75); C424(1.75)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C422(2.26); C424(2.26)  LDD0082  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1001(1.19)  LDD2099  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1001(0.81)  LDD2109  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1001(0.82)  LDD2125  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1001(0.92)  LDD2140  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1001(1.43)  LDD2144  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
RAC-beta serine/threonine-protein kinase (AKT2) AGC Ser/Thr protein kinase family P31751
RAC-gamma serine/threonine-protein kinase (AKT3) AGC Ser/Thr protein kinase family Q9Y243
E3 ubiquitin-protein ligase SMURF2 (SMURF2) . Q9HAU4

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402