Details of the Target

General Information of Target

Target ID LDTP04362
Target Name Serpin B9 (SERPINB9)
Gene Name SERPINB9
Gene ID 5272
Synonyms
PI9; Serpin B9; Cytoplasmic antiproteinase 3; CAP-3; CAP3; Peptidase inhibitor 9; PI-9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METLSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSL
NTEEDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELS
FIRAAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYT
REMPFKINQEEQRPVQMMYQEATFKLAHVGEVRAQLLELPYARKELSLLVLLPDDGVELS
TVEKSLTFEKLTAWTKPDCMKSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGKADL
SAMSAERDLCLSKFVHKSFVEVNEEGTEAAAASSCFVVAECCMESGPRFCADHPFLFFIR
HNRANSILFCGRFSSP
Target Bioclass
Other
Family
Serpin family, Ov-serpin subfamily
Subcellular location
Cytoplasm
Function Granzyme B inhibitor.
Uniprot ID
P50453
Ensemble ID
ENST00000380698.5
HGNC ID
HGNC:8955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
STPyne
 Probe Info  		K130(5.26); K138(8.38); K139(3.61); K143(5.88)  LDD0277  [2]
Probe 1
 Probe Info  		Y278(9.17)  LDD3495  [3]
m-APA
 Probe Info  		12.70  LDD0403  [4]
BTD
 Probe Info  		C98(0.68)  LDD2091  [5]
IPM
 Probe Info  		C259(3.17); C370(2.10)  LDD1701  [5]
Acrolein
 Probe Info  		N.A.  LDD0223  [6]
DBIA
 Probe Info  		C341(1.25); C342(1.25); C335(1.07); C98(0.87)  LDD0078  [7]
IA-alkyne
 Probe Info  		C350(0.00); C370(0.00)  LDD0165  [8]
AOyne
 Probe Info  		14.90  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0070  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C98(0.65)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C370(1.10)  LDD2117  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C98(0.61); C259(0.67)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C98(0.58)  LDD2131  [5]
 LDCM0214  AC1 HEK-293T C259(1.02)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C259(0.92)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C98(1.08)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C98(1.03)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C98(0.93)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C98(0.89)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C98(1.01)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C98(1.01)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C98(1.05)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C98(1.10)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C98(0.87)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C98(0.90)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C259(0.83)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C98(0.92)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C98(0.83)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C98(0.94)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C259(1.20); C98(1.06)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C259(1.13); C98(1.08)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C259(0.87); C98(1.05)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C259(0.93); C98(0.94)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C259(1.06); C98(1.16)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C259(0.90); C98(1.06)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C259(0.87); C98(1.02)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C259(0.93)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C259(0.74); C98(0.96)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C259(1.07); C98(1.18)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C259(0.89); C98(1.13)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C259(1.10); C98(1.52)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C259(1.03); C98(1.12)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C259(0.94); C98(1.13)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C259(1.14); C98(1.00)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C259(0.90); C98(1.21)  LDD0562  [7]
 LDCM0259  AC14 HCT 116 C259(0.94)  LDD0576  [7]
 LDCM0270  AC15 HCT 116 C259(0.97)  LDD0587  [7]
 LDCM0276  AC17 HCT 116 C259(0.98); C98(1.29)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C259(0.85); C98(1.29)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C259(0.91); C98(1.24)  LDD0595  [7]
 LDCM0280  AC20 HCT 116 C98(1.04); C259(1.12)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C259(0.98); C98(1.38)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C259(0.92); C98(1.10)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C259(1.03); C98(1.16)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C259(0.92); C98(1.29)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C259(1.00)  LDD1524  [11]
 LDCM0287  AC27 HEK-293T C259(0.85)  LDD1526  [11]
 LDCM0289  AC29 HEK-293T C259(1.03); C98(0.90)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C259(0.91)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C259(0.99)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C259(1.23)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C259(1.01)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C259(0.90)  LDD1533  [11]
 LDCM0296  AC35 PaTu 8988t C350(0.88); C259(0.75)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C350(0.88); C259(0.78)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C350(1.16); C259(1.19)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C350(0.74); C259(1.17)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C350(0.86); C259(1.00)  LDD1179  [7]
 LDCM0302  AC40 PaTu 8988t C350(0.89); C259(1.35)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C350(0.97); C259(0.99)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C350(0.99); C259(1.13)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C350(0.90); C259(1.09)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C350(0.79); C259(1.19)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C350(0.99); C259(1.24)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C259(1.00)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C259(1.08)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C259(1.06)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C259(1.12)  LDD1190  [7]
 LDCM0312  AC5 HEK-293T C259(1.05); C98(0.97)  LDD1551  [11]
 LDCM0313  AC50 PaTu 8988t C259(1.20)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C259(0.77)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C259(1.06)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C259(1.20)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C259(1.31)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C259(1.05)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C259(1.05)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C259(0.95)  LDD1559  [11]
 LDCM0322  AC59 HEK-293T C259(0.93)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C259(0.96)  LDD0640  [7]
 LDCM0325  AC61 HEK-293T C259(1.03); C98(1.16)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C259(0.88)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C259(1.24)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C259(1.08)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C98(1.03)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C98(1.00)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C259(1.04)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C98(0.84)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C98(1.18)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C98(1.00)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C98(0.73)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C98(0.74)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C98(0.34)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C98(1.13)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C98(1.10)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C98(0.98)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C98(1.07)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C259(0.93)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C98(1.34)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C98(0.97)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C98(0.14)  LDD0665  [7]
 LDCM0365  AC98 HCT 116 C98(0.52)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C98(1.02)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C259(0.93)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C259(0.89)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C259(1.04)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.70  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C341(1.25); C342(1.25); C335(1.07); C98(0.87)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C98(0.68)  LDD2091  [5]
 LDCM0367  CL1 PaTu 8988t C350(0.99)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C350(0.74)  LDD1247  [7]
 LDCM0369  CL100 HEK-293T C259(0.91); C98(1.15)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C259(0.88)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C259(0.75)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C259(0.84)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C259(0.90)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C259(0.80); C98(1.51)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C259(0.92); C98(1.32)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C259(1.08); C98(1.22)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C259(1.06); C98(1.41)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C259(1.00); C98(1.18)  LDD0695  [7]
 LDCM0379  CL11 PaTu 8988t C350(0.75)  LDD1258  [7]
 LDCM0380  CL110 HCT 116 C259(0.81); C98(1.07)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C259(0.83); C98(1.05)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C259(0.90); C98(1.04)  LDD1586  [11]
 LDCM0384  CL114 HEK-293T C259(1.07)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C259(1.38); C98(1.04)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C259(1.07); C98(1.05)  LDD1590  [11]
 LDCM0387  CL117 PaTu 8988t C350(0.96); C259(1.02)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C350(0.78); C259(0.94)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C350(0.90); C259(1.02)  LDD1268  [7]
 LDCM0390  CL12 PaTu 8988t C350(0.97)  LDD1269  [7]
 LDCM0391  CL120 PaTu 8988t C350(0.76); C259(1.03)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C259(0.95)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C259(1.04)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C259(1.05)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C259(1.34)  LDD1274  [7]
 LDCM0397  CL126 HEK-293T C259(1.02)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C259(1.05); C98(1.08)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C259(0.97); C98(1.19)  LDD1603  [11]
 LDCM0400  CL13 PaTu 8988t C350(0.60)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C350(0.64)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C350(0.90)  LDD1281  [7]
 LDCM0403  CL16 HCT 116 C98(0.74)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C259(0.84); C98(0.98)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C259(0.88); C98(1.00)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C98(1.04); C259(1.07)  LDD0723  [7]
 LDCM0407  CL2 PaTu 8988t C350(0.79)  LDD1286  [7]
 LDCM0408  CL20 HCT 116 C259(0.94); C98(1.05)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C259(0.86); C98(1.18)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C98(1.11); C259(1.34)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C98(0.69); C259(1.22)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C259(1.06); C98(1.02)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C259(0.97); C98(0.82)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C259(1.09); C98(0.63)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C259(1.24); C98(1.19)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C259(0.81); C98(1.00)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C259(1.12); C98(1.20)  LDD0734  [7]
 LDCM0418  CL3 PaTu 8988t C350(0.73)  LDD1297  [7]
 LDCM0419  CL30 HCT 116 C259(0.63); C98(1.16)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C259(0.93); C98(0.94)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C259(0.95); C98(0.74)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C259(0.94); C98(0.63)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C259(0.95); C98(0.74)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C259(0.85); C98(0.80)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C259(0.81); C98(0.97)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C259(0.95); C98(0.82)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C259(1.06); C98(0.83)  LDD0745  [7]
 LDCM0429  CL4 PaTu 8988t C350(0.76)  LDD1308  [7]
 LDCM0430  CL40 HCT 116 C259(0.94); C98(0.84)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C259(1.04); C98(0.94)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C259(0.94); C98(0.43)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C259(0.99); C98(0.72)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C259(1.17); C98(0.69)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C259(1.09); C98(0.64)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C259(1.17)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C259(1.12)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C259(1.22)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C259(0.97)  LDD0756  [7]
 LDCM0440  CL5 PaTu 8988t C350(0.80)  LDD1319  [7]
 LDCM0441  CL50 HCT 116 C259(1.09)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C259(0.91)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C259(1.08)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C259(1.15)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C259(1.05)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C259(1.00)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C259(1.13)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C259(1.10)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C259(1.19)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C259(1.09)  LDD0767  [7]
 LDCM0451  CL6 PaTu 8988t C350(0.88)  LDD1330  [7]
 LDCM0452  CL60 HCT 116 C259(1.09)  LDD0769  [7]
 LDCM0453  CL61 PaTu 8988t C259(1.36)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C259(1.43)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C259(1.08)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C259(1.19)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C259(1.14)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C259(1.29)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C259(1.19)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C259(1.13)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C259(1.16)  LDD1340  [7]
 LDCM0462  CL7 PaTu 8988t C350(1.04)  LDD1341  [7]
 LDCM0463  CL70 PaTu 8988t C259(1.06)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C259(1.11)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C259(1.13)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C259(1.34)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C259(1.14)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C98(0.93)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C98(0.89)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C98(1.03)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C98(0.95)  LDD0789  [7]
 LDCM0473  CL8 PaTu 8988t C350(0.62)  LDD1352  [7]
 LDCM0474  CL80 HCT 116 C98(1.08)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C98(0.98)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C98(0.97)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C98(0.93)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C98(0.70)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C98(1.01)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C98(1.16)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C98(0.95)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C98(0.92)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C98(0.46)  LDD0800  [7]
 LDCM0484  CL9 PaTu 8988t C350(0.87)  LDD1363  [7]
 LDCM0485  CL90 HCT 116 C98(0.77)  LDD0802  [7]
 LDCM0486  CL91 HEK-293T C259(0.92)  LDD1689  [11]
 LDCM0488  CL93 HEK-293T C259(0.92); C98(1.41)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C259(0.93)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C259(0.79)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C259(1.06)  LDD1694  [11]
 LDCM0493  CL98 HEK-293T C259(1.11)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C259(1.16); C98(1.26)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C259(0.90); C98(1.10)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C370(1.21)  LDD1702  [5]
 LDCM0625  F8 Ramos C370(0.34); C98(0.65); C259(1.28); C108(1.06)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C370(0.57); C98(0.60); C259(0.81); C350(0.24)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C370(0.38); C259(0.92); C108(1.56); C350(0.38)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C370(0.61); C98(0.64); C259(0.84); C350(0.21)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C370(0.82); C98(0.89); C259(0.97)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C370(0.46); C259(0.74); C108(0.66); C350(1.17)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C370(0.52); C98(0.53); C259(0.82); C350(0.20)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C370(0.89); C98(0.82); C259(0.80); C350(0.55)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C370(0.75); C98(0.44); C259(0.41); C350(0.84)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C370(0.91); C98(0.93); C259(0.90); C350(0.88)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C370(0.78); C98(0.74); C259(0.60); C350(0.81)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C370(0.93); C98(0.90); C259(1.49); C350(0.55)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C370(1.10); C98(1.06); C259(1.04); C350(0.85)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C370(0.60); C98(0.59); C259(0.88); C350(0.19)  LDD2201  [12]
 LDCM0468  Fragment33 PaTu 8988t C259(1.18)  LDD1347  [7]
 LDCM0596  Fragment38 Ramos C370(0.70); C98(0.82); C259(0.89); C350(2.48)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C370(0.56); C98(0.80); C259(0.89); C108(1.51)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C259(0.99); C98(0.62)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C370(0.91); C98(1.04); C259(3.07); C350(1.50)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C370(1.38); C98(0.86); C259(1.06); C350(0.80)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C370(0.43); C98(0.69); C259(0.81); C108(0.65)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C370(0.53); C98(0.54); C259(0.80); C350(0.20)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C259(1.14)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C259(1.03)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C98(2.05)  LDD3310  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C370(0.78)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C98(1.32)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C370(0.99); C98(1.10); C108(1.21); C310(0.91)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C370(0.58); C98(1.05)  LDD2109  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C370(1.45); C108(1.37)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C98(1.02)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C370(0.92); C98(1.38)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C370(1.02)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C370(1.83)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C370(1.43); C98(1.81)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C310(1.09)  LDD2140  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C98(0.66)  LDD2150  [5]
 LDCM0021  THZ1 HCT 116 C335(1.15); C341(1.15); C342(1.06)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Raloxifene Small molecular drug DB00481

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840