Details of the Target

General Information of Target

Target ID LDTP03863
Target Name Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Gene Name CDKN1A
Gene ID 1026
Synonyms
CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE
GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV
PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
Target Type
Literature-reported
Target Bioclass
Other
Family
CDI family
Subcellular location
Cytoplasm
Function
Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
TTD ID
T39855
Uniprot ID
P38936
DrugMap ID
TT9GUW0
Ensemble ID
ENST00000244741.10
HGNC ID
HGNC:1784
ChEMBL ID
CHEMBL5021

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C117(0.51)  LDD2214  [1]
IPM
 Probe Info  		C13(0.93)  LDD1701  [2]
DBIA
 Probe Info  		C13(1.26); C34(1.03); C41(1.03)  LDD0531  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C13(1.26); C34(1.03); C41(1.03)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C13(1.22); C34(0.76); C41(0.76)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C13(1.33); C34(0.84); C41(0.84)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C13(1.21); C34(1.06); C41(1.06)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C13(1.31); C34(0.93); C41(0.93)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C13(1.71); C34(1.16); C41(1.16)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C13(1.26); C34(0.96); C41(0.96)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C13(1.42); C34(0.98); C41(0.98)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C13(1.73); C34(1.00); C41(1.00)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C13(1.52); C34(1.02); C41(1.07)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C13(1.12); C34(1.19); C41(1.06)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C13(0.96); C34(1.10); C41(0.94)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C13(1.06); C34(0.95); C41(0.95)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C13(0.98); C34(1.03); C41(0.98)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C13(1.43); C34(1.21); C41(1.08)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C13(1.48); C34(0.98); C41(0.97)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C117(0.80); C13(1.00); C34(1.05); C41(1.05)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C117(0.56); C13(1.29); C34(1.08); C41(1.08)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C117(0.92); C13(1.45); C34(1.18); C41(1.18)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C117(1.34); C13(1.19); C34(1.22); C41(1.22)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C117(0.69); C13(1.28); C34(1.33); C41(1.33)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C117(0.70); C13(1.29); C34(1.19); C41(1.19)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C117(1.19); C13(1.37); C34(1.10); C41(1.10)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C13(1.00); C34(0.86); C41(0.86)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C117(0.67); C13(1.38); C34(1.00); C41(1.00)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C117(0.73); C13(1.12); C34(1.29); C41(1.29)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C117(0.76); C13(1.31); C34(1.02); C41(1.02)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C117(0.76); C13(1.30); C34(1.32); C41(1.32)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C117(0.57); C13(1.01); C34(0.99); C41(0.99)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C117(0.76); C13(1.09); C34(1.07); C41(1.07)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C117(1.40); C13(1.38); C34(1.26); C41(1.26)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C117(1.08); C13(1.35); C34(1.19); C41(1.19)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C117(1.26); C13(1.27); C34(1.20); C41(1.20)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C117(0.77); C13(0.93); C34(1.22); C41(1.22)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C117(0.79); C13(0.88); C34(1.12); C41(1.12)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C117(1.19); C13(1.00); C34(1.02); C41(1.02)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C117(1.06); C13(1.07); C34(0.96); C41(0.96)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C117(1.04); C13(1.03); C34(0.93); C41(0.93)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C117(0.95); C13(1.30); C34(1.05); C41(1.05)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C117(0.90); C13(1.05); C34(1.11); C41(1.11)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C117(0.75); C13(1.22); C34(1.35); C41(1.35)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C117(0.77); C13(1.03); C34(1.05); C41(1.05)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C117(0.90); C13(1.39); C34(1.27); C41(1.27)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C117(0.95); C13(1.22); C34(1.28); C41(1.28)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C13(1.11); C34(0.80); C41(0.80)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C117(0.86); C13(1.54); C34(1.29); C41(1.29)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C117(1.04); C13(1.58); C34(1.22); C41(1.22)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C117(1.59); C13(1.01); C34(1.10); C41(1.10)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C34(1.02); C41(1.02)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C34(0.98); C41(0.98)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C34(1.03); C41(1.03)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C34(0.82); C41(0.82)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C34(0.93); C41(0.93)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C34(0.98); C41(0.98)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C34(0.88); C41(0.88)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C34(0.86); C41(0.86); C13(1.25)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C34(0.89); C41(0.89)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C34(0.95); C41(0.95)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C34(0.81); C41(0.81)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C34(0.89); C41(0.89)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C34(0.91); C41(0.91)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C34(0.96); C41(0.96)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C34(0.86); C41(0.86)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C34(0.90); C41(0.90)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C13(1.00); C34(1.12); C41(1.12)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C13(1.01); C34(1.05); C41(1.05)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C13(0.67); C34(1.03); C41(1.03)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C34(1.15); C41(1.15); C13(1.21)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C13(1.01); C34(1.04); C41(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C34(1.06); C41(1.06); C13(1.09)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C13(0.80); C34(1.04); C41(1.04)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C13(0.70); C34(0.93); C41(0.93)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C13(0.47); C34(1.11); C41(1.11)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C34(0.95); C41(0.95); C13(1.25)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C34(1.12); C41(1.12); C13(1.56)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C34(1.10); C41(1.10); C13(1.45)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C34(1.18); C41(1.18); C13(1.58)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C34(1.21); C41(1.21); C13(1.94)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C13(0.92); C34(1.13); C41(1.13)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C34(1.08); C41(1.08); C13(2.14)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C34(1.06); C41(1.06); C13(1.53)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C34(1.26); C41(1.26); C13(2.19)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C34(1.07); C41(1.07); C13(1.89)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C34(1.24); C41(1.24); C13(1.96)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C13(0.68); C34(0.82); C41(0.82)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C13(0.73); C34(0.88); C41(0.88)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C34(0.90); C41(0.90); C13(0.91)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C13(0.91); C34(1.02); C41(1.02)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C13(0.93); C34(0.96); C41(0.96)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C13(1.01); C34(1.13); C41(1.13)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C34(1.03); C41(1.03); C13(1.11)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C34(0.96); C41(0.96); C13(1.07)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C13(0.96); C34(1.05); C41(1.05)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C13(0.97); C34(1.03); C41(1.03)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C13(0.86); C34(0.90); C41(0.90)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C34(1.00); C41(1.00); C13(1.37)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C13(0.75); C34(1.12); C41(1.12)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C13(0.76); C34(1.17); C41(1.17)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C13(1.01); C34(1.14); C41(1.14)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C34(1.42); C41(1.42); C13(1.42)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C34(1.26); C41(1.26); C13(1.48)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C34(1.46); C41(1.46); C13(2.03)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C13(0.64); C34(1.08); C41(1.08)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C13(0.74); C34(1.16); C41(1.16)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C13(0.97); C34(1.25); C41(1.25)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C13(0.98); C34(1.15); C41(1.15)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C34(1.34); C41(1.34); C13(1.39)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C34(2.18); C41(2.18); C13(2.72)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C13(0.79); C34(1.07); C41(1.07)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C34(1.04); C41(1.04); C13(1.09)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C13(0.88); C34(0.95); C41(0.95)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C34(0.87); C41(0.87); C13(1.20)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C13(0.86); C34(1.10); C41(1.10)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C13(0.90); C34(0.99); C41(0.99)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C13(0.98); C34(0.99); C41(0.99)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C13(1.04); C34(1.20); C41(1.20)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C13(0.96); C34(1.02); C41(1.02)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C13(1.10); C34(1.15); C41(1.15)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C13(0.86); C34(1.01); C41(1.01)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C34(0.98); C41(0.98); C13(1.16)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C34(1.07); C41(1.07); C13(1.72)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C34(1.18); C41(1.18); C13(1.49)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C34(0.86); C41(0.86); C13(0.97)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C34(1.15); C41(1.15); C13(1.80)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C13(0.99); C34(1.09); C41(1.09)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C34(1.22); C41(1.22); C13(1.90)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C34(1.62); C41(1.62); C13(1.98)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C34(1.41); C41(1.41); C13(1.41)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C34(1.90); C41(1.90); C13(2.56)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C13(1.17); C34(1.28); C41(1.28)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C34(1.38); C41(1.38); C13(1.97)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C34(1.06); C41(1.06); C13(1.84)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C34(1.24); C41(1.24); C13(1.80)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C34(0.83); C41(0.83); C13(1.17)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C34(1.17); C41(1.17); C13(1.44)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C34(1.11); C41(1.11); C13(1.31)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C34(2.38); C41(2.38); C13(2.56)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C34(1.32); C41(1.32); C13(1.45)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C34(1.06); C41(1.06); C13(1.37)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C34(1.11); C41(1.11); C13(1.62)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C34(1.14); C41(1.14); C13(1.18)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C34(1.10); C41(1.10); C13(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C34(1.15); C41(1.15); C13(1.49)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C34(1.05); C41(1.05); C13(1.13)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C34(1.06); C41(1.06); C13(1.18)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C13(1.25); C34(1.48); C41(1.48)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C34(1.28); C41(1.28); C13(1.36)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C34(1.07); C41(1.07); C13(1.35)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C34(1.04); C41(1.04); C13(1.93)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C34(1.04); C41(1.04); C13(1.31)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C34(1.15); C41(1.15); C13(1.42)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C34(1.21); C41(1.21); C13(1.69)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C34(1.51); C41(1.51); C13(2.90)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C34(1.00); C41(1.00); C13(1.17)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C13(0.94); C34(0.94); C41(0.94)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C34(0.93); C41(0.93); C13(0.99)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C34(0.90); C41(0.90); C13(2.08)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C13(1.63); C34(1.05); C41(1.05)  LDD2171  [3]
 LDCM0630  CCW28-3 231MFP C117(0.51)  LDD2214  [1]
 LDCM0632  CL-Sc Hep-G2 C13(20.00)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C13(0.83); C34(0.90); C41(0.90)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C34(1.21); C41(1.21); C13(1.40)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C34(1.15); C41(1.15); C13(1.28)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C34(0.82); C41(0.82); C13(1.08)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C34(0.79); C41(0.79); C13(0.83)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C34(0.73); C41(0.73); C13(0.82)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C34(0.87); C41(0.87); C13(0.99)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C34(0.96); C41(0.96); C13(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C13(0.73); C34(1.12); C41(1.12)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C13(0.66); C34(1.16); C41(1.16)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C13(0.57); C34(1.18); C41(1.18)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C13(0.78); C34(0.99); C41(0.99)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C34(1.21); C41(1.21); C13(1.54)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C13(0.35); C34(1.01); C41(1.01)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C13(0.87); C34(1.08); C41(1.08)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C34(0.96); C41(0.96); C13(1.21)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C34(1.04); C41(1.04); C13(2.29)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C34(0.96); C41(0.96); C13(2.19)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C34(1.11); C41(1.11); C13(1.82)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C34(1.07); C41(1.07); C13(1.44)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C34(1.28); C41(1.28); C13(1.96)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C13(0.93); C34(0.95); C41(0.95)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C34(0.99); C41(0.99); C13(1.19)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C34(1.35); C41(1.35); C13(1.43)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C13(0.83); C34(1.05); C41(1.05)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C13(0.68); C34(0.68); C41(0.68)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C13(0.88); C34(1.18); C41(1.18)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C13(1.28); C34(1.48); C41(1.48)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C34(1.35); C41(1.35); C13(2.02)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C13(0.97); C34(1.06); C41(1.06)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C13(0.68); C34(1.01); C41(1.01)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C13(0.80); C34(0.98); C41(0.98)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C13(0.86); C34(0.94); C41(0.94)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C34(1.11); C41(1.11); C13(1.13)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C13(0.87); C34(1.05); C41(1.05)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C34(0.99); C41(0.99); C13(1.15)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C34(0.79); C41(0.79); C13(1.15)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C13(0.83); C34(0.92); C41(0.92)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C34(0.93); C41(0.93); C13(1.46)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C34(0.95); C41(0.95); C13(1.26)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C13(0.90); C34(1.01); C41(1.01)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C34(1.08); C41(1.08); C13(1.37)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C34(1.08); C41(1.08); C13(1.69)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C34(1.47); C41(1.47); C13(2.66)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C34(0.93); C41(0.93); C13(1.54)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C34(1.10); C41(1.10); C13(1.81)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C13(1.54); C34(1.01); C41(1.01)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C13(1.45); C34(1.12); C41(1.12)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C13(1.19); C34(1.00); C41(1.00)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C13(1.45); C34(0.97); C41(0.97)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C13(1.58); C34(0.95); C41(0.95)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C13(0.95); C34(1.00); C41(1.00)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C13(1.20); C34(0.98); C41(0.98)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C117(0.78); C13(0.96); C34(0.91); C41(0.91)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C117(0.79); C13(1.11); C34(1.05); C41(1.05)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C117(0.93); C13(1.38); C34(1.14); C41(1.14)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C117(1.13); C13(1.44); C34(1.05); C41(1.05)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C117(0.95); C13(2.42); C34(1.15); C41(1.15)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C117(0.93); C13(1.56); C34(1.08); C41(1.08)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C117(0.93); C13(1.59); C34(1.11); C41(1.11)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C117(0.89); C13(0.99); C34(1.08); C41(1.08)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C13(0.88); C34(1.03); C41(1.03)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C117(0.91); C13(1.26); C34(0.95); C41(0.95)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C117(0.98); C13(1.01); C34(1.14); C41(1.14)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C117(0.81); C13(2.05); C34(1.34); C41(1.34)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C117(0.95); C13(1.56); C34(1.10); C41(1.10)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C117(0.87); C13(1.28); C34(0.92); C41(0.92)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C117(0.92); C13(1.73); C34(0.98); C41(0.98)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C117(0.78); C13(0.76); C34(1.01); C41(1.01)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C117(0.75); C13(0.71); C34(0.89); C41(0.89)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C117(0.72); C13(0.77); C34(0.91); C41(0.91)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C117(0.97); C13(0.74); C34(0.87); C41(0.87)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C13(1.04); C34(1.02); C41(1.02)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C117(0.75); C13(0.81); C34(1.00); C41(1.00)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C117(0.87); C13(0.76); C34(1.14); C41(1.14)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C117(0.97); C13(0.75); C34(1.01); C41(1.01)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C117(0.73); C13(0.79); C34(1.09); C41(1.09)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C117(0.77); C13(0.86); C34(0.98); C41(0.98)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C117(0.81); C13(0.83); C34(0.99); C41(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C117(0.79); C13(0.90); C34(1.02); C41(1.02)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C117(0.93); C13(0.61); C34(0.97); C41(0.97)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C117(0.76); C13(0.82); C34(1.01); C41(1.01)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C117(0.81); C13(0.76); C34(0.99); C41(0.99)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C13(1.17); C34(0.98); C41(0.98)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C117(0.67); C13(0.71); C34(0.90); C41(0.90)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C13(1.35); C34(1.15); C41(1.15)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C13(1.15); C34(1.07); C41(1.07)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C13(1.48); C34(1.18); C41(1.18)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C13(1.52); C34(1.17); C41(1.17)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C13(1.35); C34(1.08); C41(1.08)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C13(2.02); C34(1.16); C41(1.16)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C13(1.47); C34(1.01); C41(1.01)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C13(1.57); C34(1.00); C41(1.00)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C13(1.21); C34(0.97); C41(0.97)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C13(1.22); C34(1.09); C41(1.09)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C13(1.42); C34(1.12); C41(1.12)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C13(1.65); C34(1.09); C41(1.09)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C13(1.74); C34(1.08); C41(1.08)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C13(1.55); C34(1.09); C41(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C13(1.35); C34(1.20); C41(1.20)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C13(0.92); C34(1.02); C41(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C13(1.06); C34(1.25); C41(1.25)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C13(1.47); C34(1.27); C41(1.27)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C13(1.52); C34(1.31); C41(1.31)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C13(1.74); C34(1.72); C41(1.72)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C13(1.03); C34(1.18); C41(1.18)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C13(1.26); C34(1.26); C41(1.26)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C13(1.92); C34(1.44); C41(1.44)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C13(1.25); C34(1.14); C41(1.14)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C13(1.74); C34(1.54); C41(1.54)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C13(1.37); C34(1.15); C41(1.15)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C13(0.91); C34(1.15); C41(1.15)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C13(1.06); C34(1.15); C41(1.15)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C13(1.42); C34(1.17); C41(1.17)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C13(2.49); C34(1.85); C41(1.85)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C13(1.16); C34(1.13); C41(1.13)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C13(1.01); C34(1.07); C41(1.07)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C13(1.04); C34(1.04); C41(1.04)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C13(1.08); C34(1.00); C41(1.00)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C13(1.01); C34(0.92); C41(0.92)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C13(1.09); C34(1.03); C41(1.03)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C13(1.26); C34(1.07); C41(1.07)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C13(0.96); C34(1.08); C41(1.08)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C13(1.01); C34(1.02); C41(1.02)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C13(1.43); C34(1.15); C41(1.15)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C13(1.44); C34(1.29); C41(1.29)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C13(1.38); C34(1.02); C41(1.02)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C117(0.85); C13(1.72); C34(1.55); C41(1.55)  LDD0744  [3]
 LDCM0022  KB02 A-375 C13(2.09)  LDD2255  [5]
 LDCM0023  KB03 MDA-MB-231 C13(0.93)  LDD1701  [2]
 LDCM0024  KB05 OZ C13(1.59)  LDD3389  [5]
 LDCM0021  THZ1 HCT 116 C13(1.63); C34(1.05); C41(1.05)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Cyclin-dependent kinase 1 (CDK1) CMGC Ser/Thr protein kinase family P06493
Cyclin-dependent kinase 14 (CDK14) CMGC Ser/Thr protein kinase family O94921
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 5 (CDK5) CMGC Ser/Thr protein kinase family Q00535
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
E3 ubiquitin-protein ligase makorin-1 (MKRN1) . Q9UHC7
S-phase kinase-associated protein 2 (SKP2) . Q13309
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G1/S-specific cyclin-D1 (CCND1) Cyclin family P24385
Cellular tumor antigen p53 (TP53) P53 family P04637
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Signal transducer and activator of transcription 5B (STAT5B) Transcription factor STAT family P51692
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cell division control protein 45 homolog (CDC45) CDC45 family O75419
Cell division control protein 6 homolog (CDC6) CDC6/cdc18 family Q99741
Cyclin-A1 (CCNA1) Cyclin family P78396
Cyclin-A2 (CCNA2) Cyclin family P20248
G1/S-specific cyclin-D2 (CCND2) Cyclin family P30279
G1/S-specific cyclin-D3 (CCND3) Cyclin family P30281
G1/S-specific cyclin-E1 (CCNE1) Cyclin family P24864
G1/S-specific cyclin-E2 (CCNE2) Cyclin family O96020
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Proliferating cell nuclear antigen (PCNA) PCNA family P12004
SOSS complex subunit B1 (NABP2) SOSS-B family Q9BQ15
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Gelsolin (GSN) Villin/gelsolin family P06396
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
LRP2-binding protein (LRP2BP) . Q9P2M1
Signal-induced proliferation-associated protein 1 (SIPA1) . Q96FS4
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arsenic Trioxide Small molecular drug DB01169
Valproic Acid Small molecular drug DB00313

References

1 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840