Details of the Target

General Information of Target

Target ID LDTP03094
Target Name Ras GTPase-activating protein 1 (RASA1)
Gene Name RASA1
Gene ID 5921
Synonyms
GAP; RASA; Ras GTPase-activating protein 1; GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
HVLKKLLAITELLQQKQNQYTKTNDVR
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.
TTD ID
T21580
Uniprot ID
P20936
DrugMap ID
TTPNZ1F
Ensemble ID
ENST00000274376.11
HGNC ID
HGNC:9871

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 Insertion: p.M780KfsTer5 DBIA    Probe Info 
COLO320 SNV: p.I253T DBIA    Probe Info 
HCT15 SNV: p.R711Ter DBIA    Probe Info 
IGROV1 Deletion: p.N838MfsTer4 DBIA    Probe Info 
IM95 Deletion: p.N838MfsTer4 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.Q542RfsTer2 DBIA    Probe Info 
KYSE30 SNV: p.V309I DBIA    Probe Info 
LS180 Deletion: p.N474TfsTer9 DBIA    Probe Info 
MCC13 SNV: p.P145S DBIA    Probe Info 
P31FUJ SNV: p.D455H DBIA    Probe Info 
PF382 SNV: p.N660S DBIA    Probe Info 
SW620 SNV: p.A6D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.94  LDD0402  [1]
STPyne
 Probe Info  		K1025(7.49); K815(7.96)  LDD0277  [2]
BTD
 Probe Info  		C576(0.89)  LDD2123  [3]
DBIA
 Probe Info  		C906(17.33)  LDD0209  [4]
HHS-475
 Probe Info  		Y426(0.72)  LDD0264  [5]
IPM
 Probe Info  		C576(1.72)  LDD1702  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
ATP probe
 Probe Info  		K661(0.00); K663(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1002(0.00); C261(0.00); C402(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C1002(0.00); C261(0.00); C616(0.00); C576(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C261(0.00); C906(0.00); C1002(0.00); C616(0.00)  LDD0037  [8]
NAIA_5
 Probe Info  		N.A.  LDD2225  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C576(0.97); C771(0.95); C876(1.42)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C576(0.71); C771(0.90); C876(1.30)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C876(0.82); C906(0.47)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C876(0.77); C906(0.52)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C876(0.79); C906(0.55)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C876(0.69); C906(0.44)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C876(0.83); C906(0.46)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C876(0.69); C906(0.59)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C876(0.66); C906(0.48)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C876(0.70); C906(0.52)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C876(0.81); C906(0.99)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C876(0.93); C906(0.88)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C576(0.60); C771(0.87); C876(1.48)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C876(0.84); C906(0.62)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C876(0.76); C906(0.83)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C876(0.72); C906(0.54)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C576(0.99); C876(1.01)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C576(0.89); C876(0.91)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C576(0.99); C876(0.94)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C576(0.96); C876(0.90)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C576(0.91); C876(0.86)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C576(0.85); C876(0.99)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C576(0.90); C876(0.91)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C576(0.72); C771(0.88); C876(1.43)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C576(1.18); C876(0.84)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C576(1.14); C876(1.04)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C576(0.82); C876(0.80)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C576(1.13); C876(1.04)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C576(1.01); C876(0.95)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C576(1.05); C876(0.79)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C576(1.11); C876(0.89)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C576(0.92); C876(0.93)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C236(0.99); C876(0.73)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C236(1.13); C876(1.12)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C236(1.17); C876(1.28)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C236(1.46); C876(0.74)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C236(0.93); C876(1.64)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C236(1.05); C876(1.12)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C236(0.94); C876(0.94)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C236(1.24); C876(1.51)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C236(0.76); C876(1.34)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C236(1.17); C876(1.26)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C236(1.26); C876(1.14)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C236(1.01); C876(1.38)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C576(0.86); C771(0.97); C876(1.25)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C236(0.94); C876(1.51)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C236(0.93); C876(1.36)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C236(1.08); C876(1.67)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C236(0.82)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C236(0.66)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C236(0.91)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C236(0.77)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C236(0.76)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C236(0.70)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C236(0.64)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C771(0.78); C576(0.98); C876(1.07)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C236(0.74)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C236(0.82)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C236(0.69)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C236(0.75)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C236(0.79)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C236(0.70)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C236(0.84)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C236(0.87)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C576(0.91); C402(0.96)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C402(0.88); C576(1.06)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C402(0.92); C576(1.00)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C576(0.95); C771(1.07); C876(1.12)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C402(0.87); C576(1.23)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C402(0.87); C576(1.08)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C576(1.01); C402(1.03)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C402(0.85); C576(1.03)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C402(0.92); C576(1.26)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C402(0.76); C771(0.94); C876(1.10)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C402(0.74); C771(0.85); C876(0.92)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C876(0.95); C402(0.95); C771(0.99)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C402(0.82); C771(0.88); C876(0.98)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C402(0.69); C876(0.81); C771(0.96)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C576(0.92); C771(1.08); C876(1.41)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C402(0.75); C876(0.84); C771(1.05)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C402(0.75); C876(0.91); C771(0.93)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C402(0.79); C876(0.83); C771(0.88)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C771(0.84); C402(0.87); C876(1.02)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C876(0.90); C402(0.94); C771(0.96)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C771(0.81); C906(1.06); C876(1.11); C576(1.19)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C876(0.83); C771(0.98); C906(1.23); C236(1.51)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C771(0.77); C576(0.82); C906(1.01); C236(1.06)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C876(0.89); C771(1.06); C906(1.16); C576(1.27)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C236(0.98); C876(1.01); C576(1.02); C771(1.14)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C771(0.92); C576(1.03); C876(1.35)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C876(1.13); C771(1.17); C906(1.18); C236(1.26)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C876(1.00); C576(1.07); C236(1.11); C906(1.16)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C876(0.88); C771(0.95); C906(1.08); C576(1.12)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C876(0.79); C771(1.06); C906(1.14); C236(1.20)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C906(1.02); C576(1.09); C771(1.11); C876(1.15)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C236(0.92); C906(1.03); C771(1.10); C876(1.40)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C876(0.77); C236(1.00); C402(1.10); C576(1.16)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C876(0.81); C236(0.85); C906(1.02); C576(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C876(0.75); C236(0.82); C402(1.04); C576(1.06)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C876(0.60); C576(0.68); C236(0.86); C402(0.99)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C576(0.97); C771(0.98); C876(1.57)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C876(0.65); C236(0.72); C576(0.81); C402(1.05)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C876(0.66); C236(0.94); C576(1.05); C402(1.05)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C876(0.72); C402(0.97); C236(1.02); C906(1.12)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C876(0.82); C236(0.93); C402(0.95); C576(0.97)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C876(0.79); C236(0.80); C906(1.04); C576(1.09)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C576(0.77); C236(0.83); C876(1.02); C906(1.15)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C876(0.70); C236(0.88); C576(0.92); C402(1.07)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C906(0.90); C576(1.10)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C906(0.85); C576(1.35)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C906(0.90); C576(1.14)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C576(0.81); C771(0.85); C876(1.07)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C906(0.85); C576(1.01)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C906(1.02); C576(1.04)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C906(0.89); C576(0.95)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C906(0.81); C576(0.93)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C906(0.85); C576(0.92)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C576(1.04); C906(1.14)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C576(1.12); C906(1.14)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C906(0.96); C576(1.07)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C576(1.08)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C576(1.20)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C576(0.77); C771(0.89); C876(1.11)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C576(0.84)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C576(1.03)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C576(0.98)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C576(1.05)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C576(1.15)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C576(1.06)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C576(0.99)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C576(1.06)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C576(1.04)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C576(1.03)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C771(0.74); C576(0.80); C876(1.16)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C576(1.07)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C576(1.01)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C576(1.08)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C576(0.96); C876(1.28)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C576(1.03); C876(1.08)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C576(0.80); C876(1.39)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C576(0.83); C876(1.33)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C576(0.95); C876(1.24)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C576(1.00); C876(1.19)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C576(0.92); C876(1.45)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C576(0.80); C876(1.11)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C576(0.77); C876(1.40)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C576(0.79); C876(1.39)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C576(0.80); C876(0.98)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C576(0.80); C876(1.68)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C576(0.85); C876(1.15)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C576(0.68); C876(1.17)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C576(0.76); C876(1.20)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C906(0.60); C876(0.70)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C906(0.79); C876(0.81)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C576(0.69); C771(0.87); C876(1.27)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C576(0.80); C771(0.83); C876(1.36)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C771(0.87); C576(0.95); C876(1.08)  LDD0592  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C34(0.64)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C576(0.95); C771(1.12)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C576(0.57); C771(0.94)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C576(0.96); C771(0.97); C876(1.34)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C771(0.84); C576(0.88); C876(1.19)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C576(0.67); C771(0.88); C876(1.25)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C576(0.66); C771(0.83); C876(1.32)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C576(0.85); C771(0.90); C876(1.27)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C402(0.89); C576(1.07)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C402(0.85); C576(1.09)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C576(0.95); C402(0.97)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C576(1.00); C402(1.02)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C402(0.81); C576(0.95)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C576(0.59); C771(1.15)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C402(1.05); C576(1.06)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C402(0.86); C576(0.98)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C402(0.86); C771(0.91); C876(1.00)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C402(0.75); C771(0.81); C876(0.81)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C876(0.84); C402(0.97); C771(1.01)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C771(0.78); C402(0.84); C876(0.87)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C402(0.96); C771(1.00); C876(1.01)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C876(0.89); C236(1.04); C906(1.16); C771(1.23)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C876(0.81); C236(0.99); C906(1.01); C771(1.08)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C876(0.82); C771(0.83); C906(1.01); C236(1.13)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C576(0.63); C771(1.01)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C876(0.86); C576(0.90); C236(0.94); C771(1.01)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C236(0.67); C876(0.90); C906(0.97); C576(1.03)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C876(0.75); C236(0.82); C906(1.00); C576(1.08)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C576(0.80); C402(0.80); C236(0.82); C876(0.91)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C876(0.81); C236(0.83); C576(0.86); C402(0.94)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C576(0.97); C906(1.12)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C906(0.71); C576(1.11)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C906(1.07); C576(1.09)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C906(0.88); C576(1.14)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C576(1.02); C771(1.04)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C576(0.89); C771(0.99)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C771(0.90); C576(1.26)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C876(0.67); C771(0.79)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C576(0.80); C771(0.83); C876(0.89)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C576(0.85); C771(0.85); C876(0.85)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C771(0.83); C876(0.90); C576(0.92)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C576(1.03); C771(1.23)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C771(0.73); C876(0.80); C576(0.82)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C576(0.79); C771(0.87); C876(0.87)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C771(1.15); C876(1.18); C576(1.46)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C771(0.80); C876(0.89); C576(1.14)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C576(0.99); C771(0.87); C876(0.88)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C576(1.03); C771(0.85); C876(0.85)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C576(0.90); C771(0.77); C876(0.75)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C576(0.96); C771(0.88); C876(0.86)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C576(0.83); C771(0.82); C876(0.75)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C576(1.05); C771(0.90); C876(0.90)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C576(0.84); C771(0.91)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C576(0.99); C771(0.92); C876(0.86)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C576(0.90); C876(1.00)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C876(0.97)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C876(0.88)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C876(0.92)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C876(0.86)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C876(0.81)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C876(0.87)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C876(0.93)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C576(1.08); C771(1.14)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C876(1.02)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C876(0.96)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C876(0.87)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C876(0.96)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C876(0.95)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C876(1.24)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C576(1.15)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C576(1.19)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C576(1.35)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C576(1.19)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C576(1.13); C771(0.97)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C576(0.96)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C576(1.24)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C576(0.93)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C576(0.89)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C576(1.10)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C576(0.81)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C576(1.17)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C576(0.77)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C576(1.31)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C576(0.99)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C576(0.84); C771(0.93)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C576(1.16)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C402(1.11); C576(0.96); C906(0.91)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C402(1.07); C576(0.93); C906(0.72)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C402(1.11); C576(1.04); C906(0.74)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C402(1.10); C576(0.89); C906(0.80)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C402(1.10); C576(1.00); C906(0.93)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C402(1.12); C576(0.97); C906(0.77)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C402(1.32); C576(1.16); C906(0.80)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C402(0.96); C576(1.82); C906(0.78)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C402(1.13); C576(0.96); C906(0.91)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C576(0.73); C771(1.09)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C402(1.28); C576(0.93); C906(0.87)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C402(1.04); C576(1.05); C906(0.74)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C402(1.33); C576(1.10); C906(0.93)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C402(1.16); C576(1.09); C906(0.76)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C402(1.19); C576(1.27); C906(0.71)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C576(1.24); C771(0.95)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C576(1.56); C771(1.01)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C576(1.13); C771(0.82)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C576(1.07); C771(0.87)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C576(0.97); C771(0.90)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C576(1.02); C771(0.76)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C576(0.99); C771(0.77)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C576(1.09); C771(0.94)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C576(1.04); C771(0.96)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C576(0.98); C771(1.05)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C576(1.15); C771(0.95)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C576(1.25); C771(1.02)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C576(1.19); C771(1.05)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C576(1.54); C771(1.04)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C576(1.07); C771(1.19)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C576(0.97); C771(0.98)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C576(1.46); C771(0.94)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C576(1.05); C771(1.05); C876(1.07)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C576(1.00); C771(0.98); C876(0.86)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C576(1.00); C771(1.00); C876(1.03)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C576(1.08); C771(0.97); C876(1.29)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C576(1.06); C771(0.95); C876(0.95)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C576(1.00); C771(0.91); C876(1.00)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C576(1.01); C771(0.90); C876(1.08)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C576(0.96); C771(0.97); C876(1.14)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C576(0.98); C771(0.97); C876(1.34)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C828(1.26); C402(0.81); C876(1.17); C1002(1.01)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C576(1.72)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C402(1.28); C576(1.05); C906(0.86)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C876(1.07)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y426(0.72)  LDD0264  [5]
 LDCM0119  HHS-0401 DM93 Y426(1.66)  LDD0267  [5]
 LDCM0022  KB02 HEK-293T C576(1.00); C402(1.10); C876(0.93); C906(0.94)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C906(17.33)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C835(1.90); C402(1.58); C69(2.26); C906(3.07)  LDD3310  [14]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C576(0.89)  LDD2123  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 1 (ABI1) ABI family Q8IZP0
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Calpain small subunit 1 (CAPNS1) . P04632
Rho GTPase-activating protein 7 (DLC1) . Q96QB1
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840