Details of the Target

General Information of Target

Target ID LDTP02847
Target Name Epithelial cell adhesion molecule (EPCAM)
Gene Name EPCAM
Gene ID 4072
Synonyms
GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD antigen CD326
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICS
KLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVN
TAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKF
ITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQL
DLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKA
EIKEMGEMHRELNA
Target Type
Clinical trial
Target Bioclass
Other
Family
EPCAM family
Subcellular location
Lateral cell membrane
Function
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
TTD ID
T47863
Uniprot ID
P16422
DrugMap ID
TTZ8WH4
Ensemble ID
ENST00000263735.9
HGNC ID
HGNC:11529
ChEMBL ID
CHEMBL3580493

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K296(0.28)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K160(2.33); K155(2.33); K129(6.18); K168(6.35)  LDD3494  [2]
DBIA
 Probe Info  		C135(0.97); C38(1.28); C46(1.54); C48(1.57)  LDD0531  [3]
IA-alkyne
 Probe Info  		C38(0.00); C99(0.00); C135(0.00)  LDD0162  [4]
ATP probe
 Probe Info  		K149(0.00); K61(0.00); K65(0.00)  LDD0035  [5]
NAIA_5
 Probe Info  		C99(0.00); C135(0.00); C38(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C135(0.97); C38(1.28); C46(1.54); C48(1.57)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C135(1.22); C38(1.33); C46(1.18); C48(1.20)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C135(0.75); C38(0.91); C46(0.82); C48(0.82)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C135(0.81); C38(0.78); C46(0.86); C48(0.87)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C135(0.76); C38(0.96); C46(0.85); C48(0.89)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C135(0.53); C38(0.83); C46(0.80); C48(0.83)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C135(1.11); C38(0.96); C46(0.82); C48(0.86)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C135(0.61); C38(1.18); C46(0.86); C48(0.86)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C135(0.59); C38(0.95); C46(0.76); C48(0.79)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C135(0.75); C38(0.85); C46(0.81); C48(0.90)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C135(0.65); C38(0.86); C46(0.81); C48(0.82)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C135(0.77); C38(1.08); C46(0.84); C48(0.85)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C135(1.15); C38(1.42); C46(1.19); C48(1.15)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C135(0.65); C38(1.03); C46(0.78); C48(0.81)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C135(0.62); C38(0.83); C46(0.79); C48(0.85)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C135(0.69); C38(0.89); C46(0.90); C48(0.92)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C135(1.08); C38(1.11); C46(1.15); C48(1.19)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C135(1.01); C38(1.18); C46(1.11); C48(1.14)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C135(0.94); C38(1.29); C46(1.20); C48(1.10)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C135(1.11); C38(1.09); C46(1.12); C48(1.09)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C135(0.99); C38(1.29); C46(1.18); C48(1.14)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C135(1.01); C38(1.15); C46(1.16); C48(1.14)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C135(1.15); C38(1.22); C46(1.13); C48(1.11)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C135(0.97); C38(1.39); C46(1.14); C48(1.02)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C135(1.53); C38(1.25); C46(1.20); C48(1.19)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C135(0.85); C38(1.19); C46(1.10); C48(1.09)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C135(1.22); C38(1.10); C46(1.18); C48(1.14)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C135(0.91); C38(1.38); C46(1.11); C48(1.08)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C135(1.12); C38(1.20); C46(1.08); C48(1.09)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C135(0.81); C38(1.21); C46(1.13); C48(1.10)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C135(1.04); C38(1.21); C46(1.23); C48(1.16)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C135(1.01); C38(1.28); C46(1.23); C48(1.16)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C135(1.13); C38(1.33); C46(1.00); C48(1.02)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C135(1.10); C38(1.06); C46(0.82); C48(0.86)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C135(1.01); C38(1.06); C46(0.88); C48(0.93)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C135(0.99); C38(1.15); C46(0.94); C48(0.97)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C135(1.15); C38(1.01); C46(0.93); C48(0.96)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C135(1.12); C38(1.08); C46(0.92); C48(0.97)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C135(1.04); C38(1.29); C46(0.97); C48(0.99)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C135(1.30); C38(1.06); C46(1.11); C48(1.10)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C135(0.82); C38(1.11); C46(1.01); C48(1.02)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C135(1.09); C38(1.19); C46(1.03); C48(1.12)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C135(0.80); C38(1.19); C46(0.92); C48(0.96)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C135(0.73); C38(1.27); C46(0.91); C48(0.97)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C135(1.26); C38(1.09); C46(1.06); C48(1.09)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C135(0.78); C38(1.17); C46(0.95); C48(0.98)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C135(0.73); C38(1.09); C46(0.93); C48(0.99)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C135(0.68); C38(1.29); C46(0.89); C48(0.99)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C135(0.99); C38(1.01); C46(0.93); C48(1.10)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C135(0.87); C59(1.04); C46(1.05); C38(1.05)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C46(0.94); C59(0.99); C38(1.06); C135(1.07)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C46(1.00); C48(1.07); C59(1.09); C135(1.15)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C135(0.82); C59(0.94); C38(0.96); C46(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C135(0.87); C46(0.99); C38(1.01); C59(1.07)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C38(1.00); C46(1.01); C135(1.12); C48(1.15)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C135(1.00); C59(1.04); C48(1.08); C46(1.08)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C38(0.98); C46(0.99); C59(1.08); C135(1.14)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C46(0.93); C59(0.98); C38(1.03); C48(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C38(0.95); C135(1.01); C46(1.08); C59(1.15)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C38(0.97); C46(1.00); C135(1.04); C59(1.12)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C135(1.04); C38(1.09); C46(0.98); C48(1.31)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C135(1.15); C38(1.02); C46(0.96); C48(1.09)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C135(1.15); C38(0.88); C46(0.81); C48(0.88)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C135(1.27); C38(1.06); C46(0.81); C48(1.03)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C135(0.99); C38(1.06); C46(1.10); C48(1.29)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C135(1.11); C38(1.23); C59(1.30); C46(1.36)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C135(0.93); C46(1.09); C38(1.10); C59(1.34)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C135(1.06); C38(1.14); C46(1.33); C59(1.33)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C135(1.01); C46(1.06); C38(1.06); C48(1.13)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C135(1.00); C38(1.05); C59(1.10); C46(1.15)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C59(1.00); C46(1.04); C48(1.06); C135(1.06)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C46(0.99); C59(1.01); C135(1.01); C38(1.03)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C46(1.03); C38(1.12); C48(1.13); C59(1.21)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C38(0.86); C48(1.07); C59(1.08); C46(1.15)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C38(0.90); C48(1.02); C59(1.11); C135(1.16)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C135(1.14); C48(1.19); C59(1.22); C46(1.28)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C38(0.90); C48(1.19); C135(1.20); C59(1.24)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C135(1.06); C48(1.14); C38(1.24); C59(1.25)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C38(1.00); C135(1.08); C59(1.20); C46(1.21)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C135(1.00); C48(1.32); C46(1.43); C59(1.45)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C135(1.01); C38(1.12); C48(1.26); C59(1.37)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C135(0.89); C38(1.24); C48(1.32); C59(1.41)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C135(1.09); C48(1.25); C59(1.28); C46(1.30)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C38(0.85); C135(0.90); C48(1.18); C59(1.28)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C38(0.88); C135(0.97); C46(1.19); C48(1.19)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C38(0.95); C135(1.02); C48(1.06); C46(1.15)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C135(1.10); C38(1.10); C46(1.15); C59(1.26)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C46(1.08); C38(1.08); C59(1.11); C48(1.13)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C135(0.65); C48(1.19); C46(1.20); C59(1.25)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C135(0.88); C38(1.13); C59(1.31); C48(1.31)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C38(0.95); C135(1.13); C46(1.18); C59(1.21)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C135(0.99); C46(1.28); C48(1.33); C59(1.35)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C135(1.12); C46(1.21); C59(1.22); C48(1.27)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C135(0.76); C38(1.12); C59(1.12); C46(1.17)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C135(0.98); C46(1.23); C48(1.25); C59(1.27)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C38(1.00); C135(1.06); C46(1.19); C48(1.24)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C135(0.84); C59(0.97); C38(0.99); C48(1.01)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C59(0.93); C38(1.01); C46(1.05); C48(1.12)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C59(0.89); C38(1.01); C46(1.15); C48(1.20)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C135(0.79); C59(1.06); C38(1.15); C48(1.21)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C38(1.08); C135(1.28); C48(1.49); C59(1.51)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C135(0.81); C59(1.16); C48(1.18); C38(1.21)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C48(1.04); C46(1.09); C135(1.11); C59(1.19)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C135(0.98); C48(1.09); C59(1.13); C46(1.17)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C135(0.84); C48(1.00); C59(1.03); C38(1.14)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C135(0.79); C59(1.04); C38(1.13); C48(1.19)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C135(0.94); C48(1.13); C59(1.17); C46(1.19)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C135(0.75); C59(0.85); C38(1.06); C48(1.26)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C135(0.91); C38(1.11); C59(1.46); C48(1.51)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C135(0.90); C38(1.06); C59(1.21); C46(1.33)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C135(0.89); C38(1.14); C46(1.27); C48(1.30)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C135(0.79); C38(1.04); C59(1.12); C48(1.16)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C135(1.03); C59(1.15); C46(1.16); C38(1.22)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C46(1.02); C59(1.10); C48(1.12); C38(1.14)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C135(0.73); C38(1.19); C59(1.24); C46(1.25)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C135(1.04); C38(1.11); C59(1.14); C46(1.14)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C135(0.66); C38(1.07); C46(1.14); C59(1.23)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C135(1.14); C38(1.23); C59(1.46); C46(1.60)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C135(1.17); C38(1.22); C59(1.55); C46(1.71)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C135(0.74); C38(1.21); C59(1.25); C46(1.31)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C59(0.84); C48(0.95); C46(0.97); C135(1.02)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C59(0.75); C46(0.85); C48(0.85); C38(0.95)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C48(1.04); C59(1.06); C38(1.07); C46(1.16)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C135(0.86); C59(0.86); C46(0.92); C38(0.99)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C59(0.80); C48(0.95); C38(1.00); C46(1.00)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C135(0.86); C46(0.88); C59(0.90); C48(0.93)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C135(0.77); C46(0.78); C48(0.80); C59(0.80)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C59(0.67); C46(0.76); C48(0.82); C135(0.92)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C46(0.76); C135(0.78); C59(0.80); C48(0.85)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C59(0.73); C46(0.76); C48(0.78); C38(0.81)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C59(0.74); C46(0.78); C48(0.80); C135(0.92)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C59(0.78); C48(0.89); C46(0.96); C38(0.98)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C59(0.81); C135(0.87); C46(0.89); C48(0.91)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C59(1.07); C48(1.13); C38(1.13); C46(1.18)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C59(0.75); C48(0.79); C46(0.79); C38(0.89)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C46(0.92); C48(0.92); C59(0.93); C38(0.95)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C46(0.53); C135(0.56); C59(0.56); C48(0.60)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C135(0.82); C59(1.07); C46(1.07); C48(1.11)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C135(0.79); C48(0.98); C46(1.00); C59(1.00)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C135(1.02); C48(1.16); C59(1.17); C46(1.17)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C135(0.87); C48(0.99); C59(1.06); C46(1.08)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C46(1.01); C48(1.04); C59(1.04); C135(1.06)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C135(0.88); C48(1.04); C46(1.08); C38(1.09)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C135(0.82); C48(1.05); C46(1.07); C38(1.14)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C38(1.06); C135(1.11); C46(1.12); C48(1.13)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C135(0.66); C46(1.02); C59(1.07); C48(1.10)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C135(0.65); C59(1.15); C46(1.15); C48(1.16)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C135(0.78); C48(1.04); C46(1.11); C59(1.11)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C135(1.01); C48(1.16); C46(1.22); C38(1.22)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C46(1.05); C48(1.08); C59(1.11); C38(1.21)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C135(0.85); C48(1.10); C38(1.11); C46(1.12)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C135(0.74); C48(1.14); C46(1.15); C59(1.16)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C135(0.40); C46(0.67); C59(0.71); C48(0.73)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C135(0.73); C59(0.79); C46(0.81); C48(0.82)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C135(1.44); C38(1.14); C46(1.08); C48(1.04)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C38(1.05); C46(1.10); C59(1.13); C48(1.19)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C135(0.81); C38(1.20); C59(1.30); C46(1.37)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C38(1.28); C135(1.07); C46(1.16); C48(1.16)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C135(0.92); C48(1.05); C46(1.12); C38(1.14)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C135(0.76); C48(1.20); C38(1.29); C59(1.36)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C135(0.97); C38(1.10); C59(1.40); C48(1.48)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C135(0.74); C38(1.17); C59(1.43); C48(1.50)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C135(0.79); C59(1.03); C48(1.07); C38(1.14)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C38(1.24); C48(1.32); C59(1.41); C46(1.46)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C38(1.17); C59(1.22); C48(1.24); C46(1.39)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C135(0.79); C46(1.18); C38(1.38); C59(1.65)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C135(0.87); C38(1.29); C59(1.39); C46(1.43)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C135(1.03); C59(1.07); C38(1.23); C46(1.30)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C135(0.83); C38(1.33); C46(1.35); C59(1.63)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C135(0.80); C46(1.08); C38(1.18); C59(1.56)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C135(1.13); C59(1.24); C48(1.28); C46(1.30)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C135(0.85); C46(1.04); C38(1.22); C59(2.41)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C135(0.79); C46(1.05); C38(1.15); C59(1.37)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C38(1.03); C135(1.06); C46(1.41); C48(1.43)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C135(0.87); C38(1.00); C48(1.20); C59(1.29)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C38(0.91); C135(0.98); C48(1.21); C46(1.22)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C38(1.03); C135(1.04); C46(1.44); C59(1.58)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C48(1.03); C38(1.07); C135(1.09); C59(1.13)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C135(0.79); C38(0.97); C46(1.46); C48(1.47)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C135(0.91); C38(1.22); C46(1.31); C59(1.40)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C135(1.05); C48(1.15); C46(1.16); C59(1.20)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C135(1.02); C48(1.33); C46(1.37); C59(1.40)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C135(0.77); C38(0.90); C46(1.23); C59(1.31)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C59(1.01); C38(1.20); C135(1.34); C46(2.04)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C135(0.96); C48(1.13); C46(1.17); C59(1.19)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C38(0.81); C59(0.95); C135(0.96); C48(1.03)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C135(0.81); C59(1.02); C48(1.11); C38(1.16)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C38(1.26); C135(1.37); C48(1.67); C59(1.83)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C38(1.06); C135(1.36); C48(2.27); C59(2.30)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C38(1.22); C135(1.26); C48(1.63); C59(1.65)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C135(0.78); C38(1.10); C59(1.52); C48(1.57)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C135(0.90); C46(1.21); C48(1.26); C59(1.26)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C48(1.05); C59(1.25); C46(1.28); C135(1.36)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C135(0.53); C38(0.76); C46(1.80); C59(1.85)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C135(1.18); C38(1.23); C48(1.26); C46(1.52)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C135(0.68); C48(1.09); C46(1.18); C38(1.21)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C135(0.98); C48(1.25); C46(1.29); C59(1.39)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C135(0.93); C38(1.16); C48(1.20); C46(1.29)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C48(1.29); C38(1.32); C59(1.36); C46(1.40)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C135(0.64); C48(1.29); C38(1.32); C46(1.34)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C135(0.59); C48(1.22); C38(1.22); C46(1.25)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C135(0.48); C48(1.56); C38(1.58); C46(1.62)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C135(0.72); C48(1.27); C38(1.29); C46(1.35)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C135(0.62); C38(1.18); C46(1.28); C48(1.30)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C135(0.70); C38(1.42); C46(1.43); C48(1.39)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C135(0.60); C38(1.51); C46(1.34); C48(1.30)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C135(0.86); C38(1.24); C46(1.53); C48(1.37)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C135(0.77); C38(1.23); C46(1.49); C48(1.29)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C135(0.72); C38(1.41); C46(1.31); C48(1.23)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C135(1.60); C38(1.03); C46(1.28); C48(1.17)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C135(1.30); C38(1.30); C46(1.23); C48(1.20)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C135(1.01); C38(1.07); C46(0.94); C48(1.21)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C135(1.01); C38(1.21); C46(0.90); C48(1.13)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C135(0.79); C38(1.11); C46(0.98); C48(1.12)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C135(0.57); C38(1.27); C46(0.91); C48(1.28)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C135(0.78); C38(1.42); C46(1.09); C48(1.26)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C135(0.77); C38(1.35); C46(0.93); C48(1.22)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C135(0.79); C38(1.17); C46(0.94); C48(1.26)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C135(0.68); C38(1.06); C46(1.01); C48(1.18)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C135(1.26); C38(1.17); C46(1.26); C48(1.22)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C135(0.68); C38(1.17); C46(0.79); C48(1.11)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C135(0.84); C38(1.23); C46(0.90); C48(1.11)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C135(0.65); C38(1.43); C46(0.98); C48(1.41)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C135(0.76); C38(1.36); C46(0.95); C48(1.26)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C135(0.70); C38(1.34); C46(0.91); C48(1.15)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C135(0.75); C38(1.29); C46(0.90); C48(1.18)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C135(1.30); C38(1.06); C46(1.31); C48(1.05)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C135(1.08); C38(1.13); C46(1.34); C48(1.15)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C135(1.17); C38(1.29); C46(1.10); C48(1.05)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C135(1.06); C38(1.40); C46(1.23); C48(1.15)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C135(0.98); C38(1.19); C46(1.11); C48(1.11)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C135(1.34); C38(0.98); C46(1.20); C48(1.06)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C135(1.15); C38(1.01); C46(1.09); C48(1.02)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C135(1.41); C38(1.08); C46(1.06); C48(1.04)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C135(1.06); C38(1.15); C46(1.23); C48(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C135(1.19); C38(1.10); C46(1.23); C48(1.12)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C135(1.33); C38(1.25); C46(1.08); C48(1.01)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C135(0.93); C38(1.23); C46(1.34); C48(1.18)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C135(1.17); C38(1.14); C46(1.26); C48(1.02)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C135(1.14); C38(1.13); C46(1.04); C48(0.98)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C135(1.18); C38(1.18); C46(1.43); C48(1.18)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C135(1.70); C38(1.28); C46(1.29); C48(1.17)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C135(1.12); C38(1.37); C46(1.38); C48(1.38)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C135(1.08); C38(1.34); C46(1.30); C48(1.31)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C135(0.94); C38(1.34); C46(1.49); C48(1.45)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C135(0.82); C38(1.22); C46(1.45); C48(1.39)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C135(0.81); C38(1.24); C46(1.82); C48(1.70)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C135(0.88); C38(1.06); C46(1.43); C48(1.36)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C135(0.90); C38(1.18); C46(1.86); C48(1.61)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C135(0.79); C38(1.19); C46(1.41); C48(1.47)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C135(1.14); C38(1.20); C46(1.59); C48(1.40)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C135(0.87); C38(1.28); C46(1.55); C48(1.40)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C135(1.27); C38(1.26); C46(1.47); C48(1.28)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C135(0.97); C38(1.22); C46(1.32); C48(1.35)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C135(0.91); C38(1.23); C46(1.58); C48(1.60)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C135(1.15); C38(1.31); C46(1.20); C48(1.14)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C135(0.91); C38(0.97); C46(1.28); C48(1.27)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C135(0.84); C38(1.19); C46(1.42); C48(1.43)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C135(1.49); C38(1.20); C46(1.26); C48(1.22)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C135(0.92); C38(1.17); C46(1.71); C48(1.75)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C135(1.39); C38(1.42); C46(1.50); C48(1.53)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C135(1.19); C38(1.46); C46(1.74); C48(1.75)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C135(0.54); C38(1.07); C46(1.11); C48(1.12)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C135(1.81); C38(1.37); C46(1.31); C48(1.30)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C135(1.33); C38(1.58); C46(1.37); C48(1.48)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C135(1.23); C38(1.47); C46(1.79); C48(1.73)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C135(0.92); C38(1.16); C46(1.67); C48(1.63)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C135(0.83); C38(1.06); C46(1.92); C48(1.97)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C135(1.29); C38(1.07); C46(1.51); C48(1.50)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C135(1.27); C38(1.23); C46(1.36); C48(1.37)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C135(1.25); C38(1.35); C46(1.93); C48(2.06)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C135(0.94); C38(1.17); C46(1.63); C48(1.72)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C135(1.01); C38(1.51); C46(2.20); C48(2.10)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C135(1.11); C38(1.36); C46(1.27); C48(1.18)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C135(1.04); C38(1.01); C46(1.36); C48(1.32)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C135(1.02); C38(1.14); C46(1.67); C48(1.60)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C135(0.89); C38(1.18); C46(1.52); C48(1.57)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C135(0.93); C38(1.15); C46(1.49); C48(1.46)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C135(1.04); C38(1.06); C46(1.34); C48(1.24)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C135(0.86); C38(1.14); C46(1.28); C48(1.28)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C135(0.84); C38(1.12); C46(1.20); C48(1.22)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C135(0.78); C38(1.15); C46(1.93); C48(1.78)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C135(0.96); C38(1.04); C46(1.88); C48(1.81)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C135(1.07); C38(1.07); C46(1.80); C48(2.12)  LDD0811  [3]
 LDCM0468  Fragment33 HCT 116 C135(0.91); C38(1.20); C46(1.57); C48(1.52)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C135(0.62); C38(1.52); C46(0.89); C48(1.43)  LDD0744  [3]
 LDCM0022  KB02 A2780 C99(2.42); C135(2.31)  LDD2254  [7]
 LDCM0023  KB03 A2780 C99(1.60); C38(3.17)  LDD2671  [7]
 LDCM0024  KB05 COLO792 C38(2.31)  LDD3310  [7]
 LDCM0021  THZ1 HCT 116 C38(1.28); C135(1.07); C46(1.16); C48(1.16)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Cadherin-1 (CDH1) . P12830
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 5 activator 1 (CDK5R1) Cyclin-dependent kinase 5 activator family Q15078

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Catumaxomab . DB06607
Hypromellose . DB11075
Technetium Tc-99m Nofetumomab Merpentan . DB09336
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vb4-845 Antibody D0Q3IS
Vicineum Recombinant protein DRP4Q9
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Car-t Cells Targeting Epcam CAR T Cell Therapy D08QYW
Phase 1
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A-337 Antibody D7FPZ4
Citatuzumab Bogatox Antibody D0C6ID
Ing-1 Antibody D05DOY
Mt-110 Antibody D00YOV
Car-t Cells Recognizing Epcam CAR T Cell Therapy D04RNG
Car-t Cells Targeting Epcam CAR T Cell Therapy D01TNK
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epcam-targeted Car-t Cells CAR T Cell Therapy D0T8DD
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Oportuzumab Monatox . DB05319
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ign-101 Vaccine D0J9KC

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840