Details of the Target

General Information of Target

Target ID LDTP02704
Target Name CD59 glycoprotein (CD59)
Gene Name CD59
Gene ID 966
Synonyms
MIC11; MIN1; MIN2; MIN3; MSK21; CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD antigen CD59
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQV
YNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLENGGTSLSEKTVLLLVTPFL
AAAWSLHP
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
TTD ID
T78552
Uniprot ID
P13987
DrugMap ID
TTBGTEJ
Ensemble ID
ENST00000351554.8
HGNC ID
HGNC:1689

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		11.61  LDD0318  [1]
STPyne
 Probe Info  		K63(9.57); K90(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y61(36.40)  LDD3495  [3]
BTD
 Probe Info  		C70(1.33)  LDD2089  [4]
IPM
 Probe Info  		C70(1.33)  LDD1702  [4]
DBIA
 Probe Info  		C89(2.16)  LDD0080  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C88(0.00); C70(0.00)  LDD0162  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
Acrolein
 Probe Info  		H69(0.00); C28(0.00); C70(0.00); C88(0.00)  LDD0217  [10]
Cinnamaldehyde
 Probe Info  		C28(0.00); C38(0.00)  LDD0220  [10]
Crotonaldehyde
 Probe Info  		C28(0.00); C70(0.00); H69(0.00); C88(0.00)  LDD0219  [10]
Methacrolein
 Probe Info  		C28(0.00); C70(0.00); H69(0.00); C31(0.00)  LDD0218  [10]
NAIA_5
 Probe Info  		C64(0.00); C89(0.00); C88(0.00); C70(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C70(0.67)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C70(0.52)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C70(1.00)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C70(1.21)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C70(1.04)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C70(1.07)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C70(0.94)  LDD2132  [4]
 LDCM0214  AC1 HCT 116 C70(1.07)  LDD0531  [5]
 LDCM0215  AC10 PaTu 8988t C88(1.19); C89(1.27); C70(0.94)  LDD1094  [5]
 LDCM0216  AC100 HCT 116 C70(0.90)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C70(1.16)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C70(0.86)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C70(1.02)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C70(0.86)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C70(1.01)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C70(0.78)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C70(0.85)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C70(0.87)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C70(0.78)  LDD0542  [5]
 LDCM0226  AC11 PaTu 8988t C88(1.21); C89(1.19); C70(1.07)  LDD1105  [5]
 LDCM0227  AC110 HCT 116 C70(0.82)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C70(0.95)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C70(0.99)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C89(0.90)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C89(0.98)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C89(0.88)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C89(0.92)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C89(0.81)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C89(0.72)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C89(0.96)  LDD0553  [5]
 LDCM0237  AC12 PaTu 8988t C88(1.19); C89(1.15); C70(1.02)  LDD1116  [5]
 LDCM0238  AC120 HCT 116 C89(0.93)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C89(0.72)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C89(1.02)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C89(0.87)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C89(0.87)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C89(0.90)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C89(0.85)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C89(0.88)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C88(0.71)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C88(0.78)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C88(0.78)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C88(0.94)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C88(0.89)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C88(0.89)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C88(0.82)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C88(0.84)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C88(0.73)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C88(0.71)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C88(0.74)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C88(0.74)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C88(1.54); C89(1.13); C70(1.16)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C88(0.82)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C88(0.85)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C88(0.78)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C70(1.08)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C70(0.75)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C70(1.11)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C70(0.76)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C70(1.07)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C70(1.21)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C70(1.05)  LDD1148  [5]
 LDCM0270  AC15 PaTu 8988t C88(1.50); C89(1.15); C70(1.07)  LDD1149  [5]
 LDCM0271  AC150 PaTu 8988t C70(0.97)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C70(1.06)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C70(1.10)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C70(1.17)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C70(1.13)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C70(0.84)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C70(1.14)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C70(0.77)  LDD2169  [5]
 LDCM0276  AC17 PaTu 8988t C88(0.66); C89(0.95); C70(0.81)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C88(0.54); C89(1.19); C70(1.14)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C88(0.49); C89(0.88); C70(0.89)  LDD1157  [5]
 LDCM0279  AC2 HCT 116 C70(1.00)  LDD0596  [5]
 LDCM0280  AC20 PaTu 8988t C88(0.65); C89(1.07); C70(1.15)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C88(0.58); C89(1.17); C70(0.87)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C88(0.68); C89(1.23); C70(1.15)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C88(0.67); C89(1.13); C70(1.11)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C88(0.78); C89(1.12); C70(1.17)  LDD1163  [5]
 LDCM0285  AC25 HCT 116 C70(1.14)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C70(1.14)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C70(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C70(1.28)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C70(1.13)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C70(0.91)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C70(1.34)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C70(1.18)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C70(1.47)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C70(1.35)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C70(1.28)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C70(0.92)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C70(1.09)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C70(1.02)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C70(0.95)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C70(1.01)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C70(1.04)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C70(1.12)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C70(1.07)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C70(1.14)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C70(1.12)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C70(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C70(1.19)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C70(0.97)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C70(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C70(1.21)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C70(1.25)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C70(0.89)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C70(1.07)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C70(0.99)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C70(1.11)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C70(1.11)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C70(1.35)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C70(1.26)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C70(0.90)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C70(1.56)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C70(1.62)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C70(1.56)  LDD0639  [5]
 LDCM0323  AC6 PaTu 8988t C88(1.77); C89(1.37); C70(1.12)  LDD1202  [5]
 LDCM0324  AC60 HCT 116 C70(1.59)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C70(1.41)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C70(1.58)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C70(1.46)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C70(1.81)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C70(2.00)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C70(1.74)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C70(1.46)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C89(1.04); C70(1.14)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C89(0.95); C70(1.46)  LDD0650  [5]
 LDCM0334  AC7 PaTu 8988t C88(1.31); C89(1.14); C70(0.83)  LDD1213  [5]
 LDCM0335  AC70 HCT 116 C89(1.14); C70(1.47)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C70(1.25); C89(1.94)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C70(1.03); C89(1.11)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C89(0.93); C70(1.04)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C89(1.05); C70(1.29)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C89(0.81); C70(0.86)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C89(0.98); C70(1.29)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C89(0.88); C70(1.62)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C70(1.18); C89(1.24)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C70(1.14); C89(1.17)  LDD0661  [5]
 LDCM0345  AC8 PaTu 8988t C88(1.22); C89(1.08); C70(0.77)  LDD1224  [5]
 LDCM0346  AC80 HCT 116 C89(0.99); C70(1.21)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C89(0.78); C70(1.01)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C70(0.26); C89(0.32)  LDD0665  [5]
 LDCM0349  AC83 PaTu 8988t C88(1.01); C89(1.11); C70(0.92)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C88(1.09); C89(1.25); C70(1.10)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C88(1.01); C89(1.19); C70(1.18)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C88(0.87); C89(0.91); C70(1.20)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C88(0.99); C89(1.12); C70(1.28)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C88(1.09); C89(1.17); C70(1.10)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C88(0.97); C89(0.94); C70(0.86)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C88(1.08); C89(0.89); C70(1.13)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C88(0.92); C89(0.95); C70(1.02)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C88(0.96); C89(0.97); C70(0.93)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C88(1.12); C89(1.33); C70(1.21)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C88(0.96); C89(1.05); C70(0.88)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C88(1.05); C89(1.29); C70(1.04)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C88(1.00); C89(1.01); C70(0.90)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C88(1.13); C89(1.09); C70(0.89)  LDD1243  [5]
 LDCM0365  AC98 HCT 116 C70(0.96)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C70(0.92)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C70(0.89)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C70(1.16)  LDD2113  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C88(1.13); C89(1.16); C70(1.32)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C88(1.08); C89(1.28); C70(1.21)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C88(1.68); C89(1.38); C70(1.04)  LDD1154  [5]
 LDCM0020  ARS-1620 HCC44 C70(1.00)  LDD2171  [5]
 LDCM0498  BS-3668 MDA-MB-231 C70(1.30)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C70(0.00); H69(0.00); C28(0.00); C88(0.00)  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C70(0.92)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C70(1.10)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C70(0.98)  LDD0686  [5]
 LDCM0370  CL101 PaTu 8988t C88(1.84); C89(1.26); C70(1.08)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C88(1.17); C89(1.08); C70(0.84)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C88(0.70); C89(1.03); C70(0.90)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C88(0.90); C89(1.18); C70(1.06)  LDD1252  [5]
 LDCM0374  CL105 PaTu 8988t C88(0.66); C89(1.02); C70(1.03)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C88(0.71); C89(1.02); C70(0.98)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C88(0.60); C89(1.00); C70(1.07)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C88(0.82); C89(0.94); C70(1.08)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C88(0.43); C89(0.99); C70(1.02)  LDD1257  [5]
 LDCM0379  CL11 HCT 116 C70(1.51)  LDD0696  [5]
 LDCM0380  CL110 PaTu 8988t C88(0.46); C89(0.96); C70(0.99)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C88(0.45); C89(1.18); C70(1.24)  LDD1260  [5]
 LDCM0382  CL112 HCT 116 C70(1.03)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C70(1.26)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C70(1.02)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C70(1.36)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C70(1.36)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C70(1.10)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C70(1.11)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C70(0.95)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C70(1.64)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C70(1.21)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C70(1.59)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C70(1.16)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C70(1.19)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C70(1.27)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C70(1.40)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C70(1.38)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C70(1.37)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C70(1.72)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C70(1.04)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C70(0.96)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C70(0.39)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C89(2.67)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C89(2.40)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C89(1.95)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C89(1.85)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C70(1.38)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C89(1.95)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C89(1.82)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C89(1.78)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C89(1.59)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C89(1.97)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C89(2.25)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C89(1.58)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C89(2.35)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C89(2.20)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C89(1.62)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C70(1.16)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C89(1.65)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C88(0.96); C89(1.18); C70(1.09)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C88(0.83); C89(1.08); C70(1.35)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C88(0.85); C89(1.16); C70(0.62)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C88(1.12); C89(1.33); C70(1.37)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C88(1.18); C89(1.15); C70(1.64)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C88(1.07); C89(1.42); C70(0.19)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C88(0.88); C89(1.26); C70(1.23)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C88(0.73); C89(0.85); C70(0.86)  LDD1307  [5]
 LDCM0429  CL4 HCT 116 C70(1.07)  LDD0746  [5]
 LDCM0430  CL40 PaTu 8988t C88(1.32); C89(1.59); C70(1.27)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C88(1.03); C89(1.25); C70(1.04)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C88(1.11); C89(1.37); C70(1.35)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C88(0.49); C89(1.13); C70(1.31)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C88(1.02); C89(1.36); C70(1.46)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C88(1.24); C89(1.28); C70(1.13)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C89(1.26)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C89(1.34)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C89(1.29)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C89(1.31)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C70(1.05)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C89(1.54)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C89(1.32)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C89(1.38)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C89(1.66)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C89(1.42)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C89(1.35)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C89(0.51)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C89(1.92)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C89(1.34)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C89(1.75)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C70(1.10)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C89(1.80)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C89(0.84); C70(1.00)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C89(1.10); C70(0.97)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C89(1.22); C70(1.03)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C89(1.14); C70(1.09)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C89(1.12); C70(0.97)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C89(1.29); C70(1.09)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C89(1.33); C70(1.20)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C89(1.22); C70(1.36)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C89(1.45); C70(1.31)  LDD1340  [5]
 LDCM0462  CL7 HCT 116 C70(2.12)  LDD0779  [5]
 LDCM0463  CL70 PaTu 8988t C89(0.96); C70(1.45)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C89(1.10); C70(0.90)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C89(1.15); C70(0.85)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C89(1.52); C70(1.23)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C89(1.20); C70(1.17)  LDD1346  [5]
 LDCM0469  CL76 HCT 116 C70(1.12); C89(1.30)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C70(0.89); C89(1.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C70(0.96); C89(1.54)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C70(1.44); C89(1.81)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C70(1.87)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C70(0.92); C89(1.38)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C70(1.20); C89(1.44)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C70(1.53); C89(1.72)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C70(1.46); C89(1.71)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C70(1.48); C89(1.50)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C70(1.16); C89(1.33)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C70(1.05); C89(1.44)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C70(1.52); C89(2.07)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C70(1.64); C89(1.93)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C70(1.34); C89(1.09)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C70(1.27)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C70(0.87); C89(1.13)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C70(0.99)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C70(0.86)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C70(1.11)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C70(1.09)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C70(0.92)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C70(0.85)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C70(0.86)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C70(0.94)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C70(0.96)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C70(0.93)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C70(1.33)  LDD1702  [4]
 LDCM0468  Fragment33 PaTu 8988t C89(1.45); C70(1.12)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C88(1.15); C89(1.97); C70(1.47)  LDD1306  [5]
 LDCM0107  IAA HeLa H69(0.00); C28(0.00); C70(0.00); C88(0.00)  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C89(2.16)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C89(2.02)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C89(2.08)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C70(1.24)  LDD2121  [4]
 LDCM0109  NEM HeLa H69(0.00); C70(0.00); C28(0.00); C88(0.00)  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C70(1.33)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C70(0.93)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C70(1.27)  LDD2093  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C70(0.82)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C70(1.37)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C70(0.35)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C70(0.91)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C70(0.27)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C70(2.24)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C70(0.36)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C70(1.01)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C70(0.66)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C70(0.56)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C70(0.97)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C70(0.55)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C70(0.95)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C70(0.53)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C70(0.62)  LDD2123  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C70(0.57)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C70(0.89)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C70(1.04)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C70(0.65)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C70(1.01)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C70(0.66)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C70(1.17)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C70(0.55)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C70(1.13)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C70(1.01)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C70(1.00)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C70(0.57)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C70(1.28)  LDD2150  [4]
 LDCM0021  THZ1 HCT 116 C70(1.00)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane emp24 domain-containing protein 2 (TMED2) EMP24/GP25L family Q15363
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hmr59 Gene therapy DEI4U0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402