Details of the Target

General Information of Target

Target ID LDTP02686
Target Name Tissue factor (F3)
Gene Name F3
Gene ID 2152
Synonyms
Tissue factor; TF; Coagulation factor III; Thromboplastin; CD antigen CD142
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Tissue factor family
Subcellular location
Secreted; Membrane
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
TTD ID
T72702
Uniprot ID
P13726
DrugMap ID
TT38MDJ
Ensemble ID
ENST00000334047.12
HGNC ID
HGNC:3541
ChEMBL ID
CHEMBL4081

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.R106W DBIA    Probe Info 
HT115 SNV: p.F132C .
HT1197 SNV: p.D161H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K279(0.30)  LDD0274  [1]
STPyne
 Probe Info  		K100(5.90); K279(0.42); K78(7.43)  LDD0277  [1]
BTD
 Probe Info  		C241(1.04)  LDD1700  [2]
DBIA
 Probe Info  		C81(0.98); C89(0.98)  LDD0078  [3]
IA-alkyne
 Probe Info  		C81(0.00); C218(0.00); C241(0.00)  LDD0162  [4]
PF-06672131
 Probe Info  		N.A.  LDD0152  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C241(0.69)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C241(0.61)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C241(0.70)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C241(0.99)  LDD2117  [2]
 LDCM0215  AC10 HCT 116 C81(1.08); C89(0.91)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C81(0.82); C89(0.82)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C81(0.77); C89(0.77)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C81(0.58); C89(0.58)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C81(0.66); C89(0.66)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C81(0.60); C89(0.60)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C81(0.61); C89(0.61)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C81(0.54); C89(0.54)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C81(0.50); C89(0.77)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C81(0.47); C89(0.40)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C81(0.59); C89(0.35)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C81(1.05); C89(0.89)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C81(0.58); C89(0.38)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C81(0.59); C89(0.52)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C81(0.49); C89(0.55)  LDD0546  [3]
 LDCM0237  AC12 HCT 116 C81(1.07); C89(1.16)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C81(1.21); C89(1.17)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C81(0.89)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C81(1.02)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C81(0.83)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C81(0.91)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C81(0.91)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C81(1.16)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C81(1.29)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C89(0.84); C81(1.01)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C81(1.06)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C81(0.91)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C81(1.02)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C81(1.08)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C81(0.90)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C81(1.00)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C81(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C81(0.99)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C81(1.07); C89(1.08)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C89(0.90); C81(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C81(0.99); C89(1.01)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C89(0.96); C81(0.99)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C89(0.95); C81(0.95)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C81(0.99); C89(1.01)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C89(1.00); C81(1.01)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C81(1.17); C89(1.24)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C81(0.98); C89(0.98)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C81(0.83); C89(0.83)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C81(1.00); C89(1.00)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C81(0.93); C89(0.93)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C81(1.13); C89(1.13)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C81(1.03); C89(1.03)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C81(1.04); C89(1.04)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C81(0.80); C89(0.80)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C81(0.98); C89(0.98)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C81(0.75); C89(0.75)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C81(1.00); C89(1.00)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C81(1.00); C89(1.00)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C81(1.07); C89(1.07)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C81(1.09); C89(1.09)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C81(0.85); C89(0.85)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C81(0.86); C89(0.86)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C81(0.99); C89(0.99)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C81(0.93); C89(0.93)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C81(0.96); C89(0.96)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C81(0.83); C89(0.83)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C81(0.78); C89(0.78)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C81(0.99); C89(0.99)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C81(0.86); C89(0.86)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C81(1.85); C89(1.85)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C81(0.55); C89(0.55)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C81(0.63); C89(0.63)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C81(1.28); C89(1.28)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C81(0.82); C89(0.82)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C81(0.92); C89(0.92)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C81(0.77); C89(0.77)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C81(0.67); C89(0.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C81(0.38); C89(0.38)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C89(0.82); C81(1.05)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C89(0.86); C81(1.27)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C89(0.53); C81(0.84)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C89(0.96); C81(1.05)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C89(0.77); C81(1.02)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C89(1.07); C81(1.15)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C89(0.57); C81(0.92)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C89(0.75); C81(0.91)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C89(0.57); C81(0.93)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C89(1.08); C81(1.42)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C89(1.03); C81(1.53)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C89(0.44); C81(0.84)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C89(1.11); C81(1.20)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C89(0.90); C81(1.00)  LDD0662  [3]
 LDCM0365  AC98 HCT 116 C81(0.10); C89(0.10)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C81(0.71); C89(0.71)  LDD0683  [3]
 LDCM0545  Acetamide MDA-MB-231 C241(0.25)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C241(0.70)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C81(1.09); C89(1.08)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C89(1.02); C81(1.13)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C89(0.65); C81(0.91)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C81(0.98); C89(0.98)  LDD0078  [3]
 LDCM0367  CL1 HCT 116 C81(1.37); C89(1.73)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C89(0.95); C81(1.09)  LDD0685  [3]
 LDCM0370  CL101 HCT 116 C89(1.21); C81(1.27)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C89(1.22); C81(1.39)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C81(1.42); C89(1.66)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C81(1.12); C89(1.22)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C89(0.90); C81(0.98)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C89(0.94); C81(1.06)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C89(0.71); C81(0.78)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C89(0.71); C81(0.86)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C89(1.09); C81(1.13)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C89(0.82); C81(0.93)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C89(0.98); C81(1.03)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C89(0.98); C81(1.02)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C81(1.15); C89(1.15)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C81(0.83); C89(0.83)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C81(1.15); C89(1.15)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C81(1.05); C89(1.05)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C81(1.03); C89(1.03)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C81(0.48); C89(0.48)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C81(0.89); C89(0.89)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C81(0.81); C89(0.81)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C89(0.70); C81(1.00)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C81(0.90); C89(0.90)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C81(3.27); C89(3.27)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C81(1.03); C89(1.03)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C81(0.89); C89(0.89)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C81(0.80); C89(0.80)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C89(1.00); C81(1.05)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C89(0.89); C81(0.96)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C89(0.89); C81(0.96)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C89(0.51); C81(0.82)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C89(1.16); C81(1.26)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C81(1.34); C89(1.42)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C81(1.39); C89(1.51)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C89(1.00); C81(1.09)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C89(1.12); C81(1.24)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C89(1.48); C81(1.50)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C89(0.99); C81(1.19)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C81(1.31); C89(1.47)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C89(0.65); C81(0.96)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C89(0.75); C81(1.04)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C89(0.33); C81(0.71)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C89(0.80); C81(1.04)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C89(0.53); C81(0.84)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C81(1.04); C89(0.60)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C81(0.98); C89(0.77)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C81(1.09); C89(0.88)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C81(1.08); C89(0.88)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C81(0.98); C89(0.70)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C81(1.20); C89(1.29)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C81(1.06); C89(0.86)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C81(0.99); C89(0.95)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C81(1.15); C89(1.18)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C81(1.13); C89(0.97)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C81(1.04); C89(0.87)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C81(0.80); C89(0.66)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C81(0.97); C89(0.76)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C81(0.91); C89(0.69)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C81(0.95); C89(0.72)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C81(1.30); C89(1.54)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C81(0.83); C89(0.68)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C81(1.10); C89(0.83)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C81(0.64); C89(0.33)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C81(0.81); C89(0.55)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C81(0.98); C89(0.87)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C81(1.10); C89(0.81)  LDD0752  [3]
 LDCM0440  CL5 HCT 116 C81(1.06); C89(1.13)  LDD0757  [3]
 LDCM0451  CL6 HCT 116 C81(1.45); C89(1.57)  LDD0768  [3]
 LDCM0453  CL61 HCT 116 C81(1.11); C89(0.98)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C81(1.04); C89(0.87)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C81(1.02); C89(0.83)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C81(0.98); C89(0.72)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C81(1.06); C89(1.03)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C81(0.83); C89(0.56)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C81(0.78); C89(0.61)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C81(0.93); C89(0.99)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C81(1.26); C89(1.49)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C81(1.18); C89(1.00)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C81(0.94); C89(0.91)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C81(0.86); C89(0.69)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C81(1.03); C89(0.96)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C81(0.87); C89(0.79)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C81(0.87); C89(0.75)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C81(1.00)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C81(0.89)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C81(0.92)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C81(1.15)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C81(0.90); C89(0.73)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C81(1.07)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C81(1.09)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C81(1.08)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C81(1.19)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C81(1.01)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C81(1.04)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C81(1.05)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C81(1.05)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C81(0.92)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C81(0.79)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C81(0.99); C89(1.06)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C81(1.00)  LDD0802  [3]
 LDCM0468  Fragment33 HCT 116 C81(1.02); C89(0.73)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C81(0.80); C89(0.52)  LDD0744  [3]
 LDCM0022  KB02 A431 C241(2.34)  LDD2258  [6]
 LDCM0023  KB03 A431 C241(2.64)  LDD2675  [6]
 LDCM0024  KB05 HMCB C241(3.10)  LDD3312  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C241(0.58)  LDD2089  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C241(0.92)  LDD2097  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C241(1.07)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C241(0.34)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C241(0.78)  LDD2101  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C241(0.26)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C241(0.97)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C241(1.08)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C241(1.22)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C241(0.47)  LDD2115  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C241(1.60)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C241(1.04)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C241(0.83)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C241(1.08)  LDD2127  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C241(0.63)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C241(0.46)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C241(0.93)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C241(1.23)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C241(1.00)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C241(1.04)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C241(1.07)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C241(0.75)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C241(2.32)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C241(0.93)  LDD2145  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C241(0.52)  LDD2148  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C241(0.54)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coagulation factor VII (F7) Peptidase S1 family P08709
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteinase-activated receptor 2 (F2RL1) G-protein coupled receptor 1 family P55085
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hippocalcin-like protein 4 (HPCAL4) Recoverin family Q9UM19

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coagulation Factor Viia Recombinant Human BiotechDrug DB00036
Coagulation Factor Vii Human . DB13150
Tisotumab Vedotin . DB16732
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alt-836 . D04DKL
Tt-173 . D0E2LH
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Morab-066 Antibody D0H8PX
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-pro-phe-arg Chloromethyl Ketone Small molecular drug D0M4VZ
2-(4-hydroxy-5-phenyl-1h-pyrazol-3-yl)-1h-benzoimidazole-5-carboxamidine . DB07207
Rnapc2 . DB06552
[2'-hydroxy-3'-(1h-pyrrolo[32-c]Pyridin-2-yl)-biphenyl-3-ylmethyl]-urea . DB07247
[5-(5-amino-1h-pyrrolo[32-b]Pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]Acetic Acid . DB08232

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840