Details of the Target

General Information of Target

Target ID LDTP02647
Target Name 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)
Gene Name ALAS1
Gene ID 211
Synonyms
ALAS3; ALASH; 5-aminolevulinate synthase, non-specific, mitochondrial; ALAS-H; EC 2.3.1.37; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKE
TPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGS
SVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPE
RVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLI
TKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADL
HGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHND
VSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYG
ARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPM
LLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKN
TEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLE
LKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA
Target Type
Successful
Target Bioclass
Enzyme
Family
Class-II pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Mitochondrion inner membrane
Function Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
TTD ID
T86041
Uniprot ID
P13196
DrugMap ID
TTG1FXO
Ensemble ID
ENST00000310271.6
HGNC ID
HGNC:396

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.Y199H DBIA    Probe Info 
HCT15 SNV: p.V266A .
HEC1B SNV: p.D252N .
HT115 SNV: p.F629C .
MCAS SNV: p.Y29C .
MFE319 SNV: p.A305T .
MOLT4 SNV: p.Q77E; p.R347Ter .
RKO SNV: p.L492P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [2]
STPyne
 Probe Info  		K353(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C124(2.74); C249(14.23)  LDD0080  [4]
IA-alkyne
 Probe Info  		C544(0.00); C263(0.00); C330(0.00)  LDD0162  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		C124(0.00); C108(0.00)  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C124(0.00); C108(0.00)  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C108(1.17); C124(0.54); C249(1.27)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C108(1.32); C249(1.15)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C124(0.96)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C124(1.03)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C124(0.93)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C124(1.35)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C124(0.97)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C124(1.11)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C124(1.21)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C124(1.17)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C124(1.00)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C124(0.90)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C108(1.16); C249(1.11)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C124(1.11)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C124(1.03)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C124(1.09)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C108(0.94); C124(1.11)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C108(1.14); C124(1.03)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C108(1.51); C124(1.33)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C108(1.30); C124(1.33)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C108(1.04); C124(1.27)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C108(1.67); C124(1.32)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C108(1.48); C124(1.16)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C108(1.27); C249(1.02)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C108(1.06); C124(1.07)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C108(1.19); C124(1.14)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C108(1.43); C124(1.30)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C108(1.83); C124(0.82)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C108(1.39); C124(1.10)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C108(1.97); C124(1.05)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C108(1.31); C124(1.18)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C108(1.31); C124(1.22)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C108(1.10); C124(0.95)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C108(1.36); C124(0.91)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C108(1.49); C124(1.02)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C108(0.99); C124(1.06)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C108(1.24); C124(1.03)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C108(1.31); C124(1.03)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C108(1.47); C124(0.96)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C108(1.73); C124(1.20)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C108(1.55); C124(0.99)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C108(0.79); C124(1.00)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C108(0.98); C124(0.95)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C108(1.62); C124(1.06)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C108(0.94); C249(1.27)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C108(1.10); C124(1.19)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C108(1.46); C124(1.18)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C108(1.22); C124(0.86)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C108(1.36); C124(1.35); C249(1.14)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C124(0.87); C249(0.99); C108(1.28)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C124(0.99); C249(0.99); C108(1.26)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C249(0.91); C124(0.99); C108(1.39)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C249(0.99); C108(1.19); C124(1.32)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C249(0.77); C124(0.87); C108(1.57)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C249(0.81); C124(0.98); C108(1.87)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C108(1.16); C249(1.30)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C249(0.98); C124(1.06); C108(1.31)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C249(0.89); C124(0.99); C108(1.26)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C124(0.82); C249(1.06); C108(1.54)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C124(0.73); C249(0.88); C108(1.74)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C108(1.50); C124(0.91); C249(0.97)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C108(1.80); C124(0.90); C249(1.00)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C108(1.53); C124(0.94); C249(1.00)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C108(1.57); C124(0.91); C249(0.91)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C249(0.90); C108(0.90); C124(0.92)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C124(0.57); C108(0.83); C249(0.91)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C124(0.61); C108(0.82); C249(0.94)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C124(0.56); C249(0.97); C108(1.24)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C108(0.95); C124(0.98); C249(1.03)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C124(0.67); C108(0.77); C249(0.88)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C249(0.80); C124(0.84); C108(0.95)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C124(0.58); C108(0.70); C249(0.84)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C108(0.92); C249(1.02); C124(1.08)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C108(1.61)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C108(1.51)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C108(1.66)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C108(1.56)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C108(1.53)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C124(0.52); C249(0.84); C108(1.09)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C108(1.58)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C108(1.43)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C108(1.49)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C108(1.58)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C108(1.64)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C263(0.98)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C263(1.06); C108(1.21)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C263(1.18); C124(0.84)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C263(1.04); C108(0.92); C525(1.00)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C263(1.08); C525(1.09)  LDD1539  [12]
 LDCM0301  AC4 HCT 116 C124(0.44); C249(1.08); C108(1.12)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C263(1.05)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C263(1.15); C108(1.15)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C263(0.99); C449(0.68); C124(1.14)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C263(1.23)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C263(1.06); C108(1.13)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C263(1.03); C124(1.08)  LDD1546  [12]
 LDCM0308  AC46 PaTu 8988t C544(0.91); C449(0.97)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C544(0.81); C449(0.94)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C544(0.71); C449(1.16)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C544(0.75); C449(0.88)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C124(0.44); C249(0.98); C108(1.04)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C544(1.00); C449(0.84)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C544(0.23); C449(0.46)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C544(1.53); C449(1.21)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C544(0.58); C449(0.85)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C544(0.62); C449(0.82)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C544(0.87); C449(1.03)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C544(0.66); C449(0.90)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C263(1.10); C108(1.29)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C263(1.00); C449(0.79); C124(0.99)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C263(1.15)  LDD1561  [12]
 LDCM0323  AC6 HCT 116 C108(0.96); C249(1.14)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C263(1.03); C108(1.14)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C263(1.15); C124(1.10)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C263(0.91); C108(0.89); C525(1.23)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C263(1.10); C525(0.97)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C263(1.20)  LDD1567  [12]
 LDCM0332  AC68 HCT 116 C108(1.04)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C108(1.28)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C249(1.01); C108(1.01)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C108(1.13)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C108(0.82)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C108(1.14)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C108(1.65)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C108(1.64)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C108(1.81)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C108(1.22)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C108(1.31)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C108(1.56)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C108(1.22)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C249(1.12); C108(1.23)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C108(1.21)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C108(0.85)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C108(1.57)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C124(1.15); C108(1.52)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C124(0.88); C108(1.24)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C124(0.85); C108(1.54)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C124(0.90); C108(1.18)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C124(0.91); C108(1.19)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C108(0.90); C124(1.06)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C124(0.98); C108(1.36)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C124(1.27); C108(2.10)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C124(0.75); C108(1.33)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C124(0.82); C108(1.91)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C124(0.89); C108(1.18)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C124(0.60); C108(0.78)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C124(1.00); C108(1.70)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C124(0.60); C108(0.80)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C124(0.93); C108(1.40)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C124(1.49)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C124(0.99)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C108(1.30); C249(1.13)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C249(1.03); C108(1.43)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C108(0.98); C249(1.29)  LDD0592  [4]
 LDCM0367  CL1 HCT 116 C249(0.91); C124(1.03)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C124(0.76); C249(1.39)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C124(0.54); C249(1.03); C108(1.19)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C108(0.84); C249(1.08)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C249(1.16); C108(1.27)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C249(0.95); C108(1.07)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C249(0.95); C108(1.11)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C124(0.65); C108(0.84); C249(1.13)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C124(0.28); C108(0.67); C249(1.09)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C124(0.56); C108(0.88); C249(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C124(0.55); C108(0.78); C249(0.98)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C124(0.67); C249(0.86); C108(0.91)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C124(0.79); C249(0.87)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C124(0.55); C108(0.82); C249(0.82)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C124(0.58); C249(0.81); C108(0.99)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C108(1.28)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C108(1.44)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C108(1.77)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C108(1.54)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C108(1.70)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C263(1.05); C108(1.09)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C263(1.08); C108(1.16)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C263(1.10); C449(0.92); C108(1.22)  LDD1593  [12]
 LDCM0390  CL12 HCT 116 C249(1.06); C124(1.14)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C263(1.09); C108(1.05)  LDD1595  [12]
 LDCM0392  CL121 PaTu 8988t C544(0.81); C449(1.30)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C544(0.91); C449(0.74)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C544(0.70); C449(0.72)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C544(1.06); C449(0.89)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C263(0.97); C108(1.00)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C263(1.01); C108(1.03)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C263(1.01); C449(0.92); C108(1.16)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C263(0.95); C108(0.93)  LDD1603  [12]
 LDCM0400  CL13 HCT 116 C249(1.05); C124(1.12)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C124(0.88); C249(1.08)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C124(0.92); C249(1.13)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C108(1.18); C249(1.23)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C249(0.88); C124(0.94); C108(3.49)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C124(0.75); C249(1.47); C108(1.82)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C124(0.84); C249(1.00); C108(1.33)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C249(0.94); C124(1.30)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C124(0.97); C249(0.99); C108(2.52)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C124(0.58); C108(1.42); C249(1.73)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C124(0.35); C108(1.34); C249(1.61)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C124(0.51); C108(1.33); C249(1.83)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C124(0.43); C108(1.32); C249(1.86)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C108(1.34); C124(0.29); C249(0.92)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C108(1.59); C124(0.45); C249(1.83)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C108(1.08); C124(0.42); C249(1.46)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C108(1.39); C124(0.36); C249(1.18)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C108(1.49); C124(0.59); C249(1.40)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C124(0.55); C249(0.85)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C108(1.19); C124(0.35); C249(2.56)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C108(1.11); C124(0.52); C249(0.72)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C108(1.18); C124(0.66); C249(0.72)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C108(2.40); C124(0.97); C249(0.88)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C108(1.20); C124(0.96); C249(0.70)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C108(1.31); C124(1.20); C249(0.96)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C108(1.08); C124(1.02); C249(0.82)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C108(1.17); C124(0.98); C249(0.68)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C108(0.89); C124(0.56); C249(0.83)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C124(1.30); C249(0.89)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C108(1.30); C124(0.93); C249(1.02)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C108(0.95); C124(0.60); C249(1.01)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C108(1.09); C124(0.69); C249(0.90)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C108(0.94); C124(0.54); C249(0.94)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C108(1.16); C124(0.60); C249(0.95)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C108(1.26); C124(0.62); C249(0.91)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C108(1.45); C249(0.98)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C108(0.93); C249(0.90)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C108(1.06); C249(0.94)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C108(0.96); C249(1.12)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C124(0.75); C249(1.03)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C108(1.08); C249(1.00)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C108(1.01); C249(0.86)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C108(1.22); C249(0.94)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C108(1.15); C249(1.12)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C108(1.13); C249(0.84)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C108(1.04); C249(0.84)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C108(0.85); C249(1.02)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C108(0.89); C249(0.96)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C108(1.63); C249(0.89)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C108(0.95); C249(1.01)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C124(0.95); C249(0.89)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C108(1.06); C249(1.05)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C108(1.60); C124(0.85); C249(1.48)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C108(1.51); C124(1.12); C249(0.77)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C108(1.55); C124(1.20); C249(1.01)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C108(1.45); C124(0.94); C249(1.19)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C108(1.01); C124(1.12); C249(1.15)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C108(1.28); C124(0.88); C249(0.79)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C108(0.88); C124(0.65); C249(1.25)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C108(0.97); C124(0.90); C249(0.81)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C108(1.61); C124(0.83); C249(0.97)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C124(0.94); C249(0.90)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C108(1.09); C124(1.15); C249(1.21)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C108(1.49); C124(1.15); C249(1.07)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C108(1.65); C124(0.87); C249(1.07)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C108(1.27); C124(1.23); C249(0.87)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C108(1.21); C124(0.84); C249(0.98)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C108(0.86)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C108(0.92)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C108(1.27)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C108(0.94)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C124(0.76); C249(2.89)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C108(0.92)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C108(0.84)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C108(0.81)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C108(0.73)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C108(0.90)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C108(0.90)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C108(0.88)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C108(0.79)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C108(0.83)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C108(0.90)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C124(0.93); C249(1.33)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C108(0.83)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C108(0.87); C124(0.67); C249(0.73)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C108(1.00); C124(0.76); C249(0.71)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C108(1.05); C124(0.39); C249(0.91)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C108(1.09); C124(0.69); C249(0.74)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C108(1.25); C124(0.96); C249(0.69)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C108(0.96); C124(0.55); C249(0.86)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C108(1.21); C124(0.58); C249(0.88)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C108(1.24); C124(0.69); C249(0.74)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C108(1.22); C124(0.44); C249(0.63)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C263(1.09); C449(1.05); C108(1.27)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C108(2.21)  LDD1702  [13]
 LDCM0468  Fragment33 HCT 116 C108(1.44); C124(0.75); C249(1.13)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C108(1.20); C124(1.02); C249(0.89)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C124(2.74); C249(14.23)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C124(1.73); C249(1.74)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C124(2.40); C249(1.59)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Glutaredoxin domain-containing cysteine-rich protein 1 (GRXCR1) GRXCR1 family A8MXD5
Ubiquitin carboxyl-terminal hydrolase 20 (USP20) Peptidase C19 family Q9Y2K6
Dual specificity protein phosphatase 19 (DUSP19) Protein-tyrosine phosphatase family Q8WTR2
E3 ubiquitin-protein ligase RNF168 (RNF168) RNF168 family Q8IYW5
E1A-binding protein p400 (EP400) SNF2/RAD54 helicase family Q96L91
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) TRAFAC class YlqF/YawG GTPase family Q9NVN8
Ceramide kinase (CERK) . Q8TCT0
F-box/LRR-repeat protein 8 (FBXL8) . Q96CD0
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sorting nexin-20 (SNX20) Sorting nexin family Q7Z614
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 175 (ZNF175) Krueppel C2H2-type zinc-finger protein family Q9Y473
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell CLL/lymphoma 7 protein family member A (BCL7A) BCL7 family Q4VC05
Adenylyl cyclase-associated protein 2 (CAP2) CAP family P40123
Parafibromin (CDC73) CDC73 family Q6P1J9
Retrotransposon Gag-like protein 8B (RTL8B) FAM127 family Q17RB0
Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) HSBP1 family C9JCN9
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Mitochondrial fission regulator 2 (MTFR2) MTFR1 family Q6P444
Protein MTSS 2 (MTSS2) MTSS family Q765P7
Periplakin (PPL) Plakin or cytolinker family O60437
U2 small nuclear ribonucleoprotein B'' (SNRPB2) RRM U1 A/B'' family P08579
Tektin-4 (TEKT4) Tektin family Q8WW24
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Thymosin beta-10 (TMSB10) Thymosin beta family P63313
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
Kelch-like protein 35 (KLHL35) . Q6PF15
Leucine-rich repeat-containing protein 45 (LRRC45) . Q96CN5
Polymerase delta-interacting protein 2 (POLDIP2) . Q9Y2S7
Protein cordon-bleu (COBL) . O75128
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9
Uncharacterized protein C2orf42 (C2orf42) . Q9NWW7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Givosiran Small interfering RNA DF36DY
Glycine Small molecular drug DB00145
Pyridoxal Phosphate Small molecular drug DB00114

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761