Details of the Target

General Information of Target

Target ID LDTP02229
Target Name Cytochrome b-c1 complex subunit 6, mitochondrial (UQCRH)
Gene Name UQCRH
Gene ID 7388
Synonyms
Cytochrome b-c1 complex subunit 6, mitochondrial; Complex III subunit 6; Complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSR
SHTEEDCTEELFDFLHARDHCVAHKLFNNLK
Target Bioclass
Enzyme
Family
UQCRH/QCR6 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Uniprot ID
P07919
Ensemble ID
ENST00000311672.10
HGNC ID
HGNC:12590

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K42(2.96); K85(6.50)  LDD0277  [1]
BTD
 Probe Info  		C81(0.81)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C81(2.55)  LDD0170  [3]
DBIA
 Probe Info  		C81(0.73)  LDD0531  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		K42(0.00); K85(0.00)  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C53(0.00); C67(0.00); C37(0.00); C81(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C67(0.00); C53(0.00)  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C53(0.00); C67(0.00); C37(0.00); C81(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		C67(0.00); C81(0.00); C53(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		C53(0.00); C43(0.00); C81(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C67(0.00); H62(0.00); C53(0.00); H76(0.00)  LDD0217  [14]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C53(0.00); C67(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C81(0.77); C43(0.55); C53(0.87); C37(0.71)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C81(0.57); C43(0.58); C53(1.02); C37(0.81)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C81(0.85)  LDD2095  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C37(0.59)  LDD2117  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C81(0.65); C43(0.66); C53(0.52)  LDD2103  [2]
 LDCM0025  4SU-RNA DM93 C81(2.55)  LDD0170  [3]
 LDCM0214  AC1 HCT 116 C81(0.73)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C37(0.96); C53(1.03); C81(0.95)  LDD1508  [17]
 LDCM0216  AC100 HEK-293T C81(0.79)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C81(0.93)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C81(0.79)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C81(1.08)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C81(0.93)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C81(1.28)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C81(0.82)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C81(0.81)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C81(0.80)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C81(0.74)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C37(1.14); C81(1.20); C67(0.95)  LDD1509  [17]
 LDCM0227  AC110 HEK-293T C81(0.74)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C81(0.82)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C81(0.87)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C81(1.00)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C81(1.15)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C81(1.23)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C81(1.23)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C81(1.14)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C81(0.96)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C81(1.24)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C37(1.73); C53(1.73); C81(1.69); C67(1.10)  LDD1510  [17]
 LDCM0238  AC120 HCT 116 C81(1.23)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C81(1.01)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C81(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C81(0.94)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C81(1.09)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C81(1.10)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C81(1.51)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C81(1.28)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C81(1.13)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C81(1.30)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C81(1.68)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C81(1.30)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C81(1.35)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C81(1.35)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C81(1.14)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C81(1.12)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C81(1.23)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C81(1.04)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C81(0.96)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C81(1.21)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C37(1.43); C53(1.40); C81(1.45)  LDD1512  [17]
 LDCM0260  AC140 HEK-293T C81(1.04)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C81(0.95)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C81(1.21)  LDD0860  [4]
 LDCM0263  AC143 HCT 116 C81(1.00)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C81(1.33)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C81(1.01)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C81(1.18)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C81(1.10)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C81(0.94)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C81(1.13)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C37(1.87); C53(2.11); C81(1.73)  LDD1513  [17]
 LDCM0271  AC150 HCT 116 C81(1.11)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C81(1.23)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C81(1.27)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C81(1.43)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C81(1.34)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C81(1.58)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C81(1.46)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C81(1.33)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C37(2.53); C53(2.28); C81(3.56)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C37(1.16); C53(1.09); C81(1.19)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C37(1.34); C81(1.42); C67(0.95)  LDD1517  [17]
 LDCM0279  AC2 HCT 116 C81(1.02)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C37(2.30); C53(2.21); C81(2.29); C67(1.09)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C37(1.71); C53(1.42); C81(1.60)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C37(1.81); C53(1.87); C81(1.87)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C37(2.59); C53(2.59); C81(2.14)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C37(1.81); C53(1.38); C81(2.00)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C37(1.43); C53(1.45); C81(1.43)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C37(0.70); C53(0.76); C81(0.66)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C37(0.77); C81(0.80); C67(0.95)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C37(1.38); C53(1.28); C81(1.23); C67(1.05)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C37(0.94); C53(0.98); C81(0.97)  LDD1528  [17]
 LDCM0290  AC3 HCT 116 C81(0.88)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C37(0.87); C53(0.89); C81(0.90)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C37(1.12); C53(1.15); C81(1.09)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C37(1.56); C53(1.25); C81(1.51)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C37(3.03); C53(2.82); C81(3.07)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C37(1.41); C53(1.61); C81(1.56)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C37(1.75); C81(1.79); C67(1.02)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C37(2.41); C53(2.49); C81(2.45); C67(1.14)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C37(1.39); C53(1.17); C81(1.40)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C37(1.80); C53(1.86); C81(1.99)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C37(2.71); C53(2.27); C81(2.00)  LDD1539  [17]
 LDCM0301  AC4 HCT 116 C81(0.81)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C37(1.66); C53(1.14); C81(1.65)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C37(3.17); C53(2.49); C81(2.63)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C37(1.01); C53(1.05); C81(1.08)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C37(1.89); C81(1.86); C67(0.99)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C37(2.33); C53(2.25); C81(2.38); C67(1.15)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C37(1.65); C53(1.53); C81(1.52)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C37(1.66); C53(1.75); C81(1.59)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C37(2.14); C53(2.22); C81(1.87)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C37(2.17); C53(1.47); C81(1.93)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C37(2.00); C53(2.01); C81(1.80)  LDD1550  [17]
 LDCM0312  AC5 HCT 116 C81(0.95)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C37(1.04); C53(1.14); C81(1.01)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C37(1.39); C81(1.44); C67(1.15)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C37(2.33); C53(2.09); C81(2.26); C67(1.20)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C37(2.07); C53(1.71); C81(1.83)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C37(2.06); C53(1.85); C81(1.93)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C37(2.73); C53(2.69); C81(2.58)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C37(1.82); C53(1.45); C81(1.79)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C37(1.80); C53(1.50); C81(1.78)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C37(1.18); C53(1.21); C81(1.23)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C37(1.22); C81(1.31); C67(1.00)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C37(0.79); C53(0.80); C81(0.78)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C37(1.84); C53(1.62); C81(1.77); C67(1.11)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C37(1.27); C53(1.16); C81(1.26)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C37(1.73); C53(1.61); C81(1.55)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C37(2.05); C53(2.04); C81(1.66)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C37(1.09); C53(0.99); C81(1.11)  LDD1567  [17]
 LDCM0332  AC68 HCT 116 C81(0.84)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C81(1.10)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C37(0.76); C53(0.78); C81(0.80)  LDD1568  [17]
 LDCM0335  AC70 HCT 116 C81(4.00)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C81(0.83)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C81(1.29)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C81(0.85)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C81(0.91)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C81(0.88)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C81(1.17)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C81(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C81(1.03)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C81(0.97)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C37(0.53); C53(0.54); C81(0.54)  LDD1569  [17]
 LDCM0346  AC80 HCT 116 C81(1.20)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C81(0.86)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C81(0.56)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C81(1.14)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C81(1.15)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C81(1.18)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C81(1.12)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C81(1.07)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C81(1.01)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C81(1.11)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C81(1.08)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C81(1.08)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C81(1.16)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C81(0.96)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C81(1.21)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C81(1.09)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C81(1.18)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C81(1.19)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C81(0.82)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C81(0.88)  LDD0964  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C81(0.99); C43(0.90); C53(1.05); C37(0.94)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C37(1.83); C53(1.40); C81(1.68)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C37(1.94); C53(1.68); C81(1.67)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C37(1.24); C53(1.03); C81(1.23)  LDD1514  [17]
 LDCM0108  Chloroacetamide HeLa C67(0.00); C53(0.00); H76(0.00); H62(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C81(0.87); C67(0.76)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C37(1.00); C53(0.74); C81(0.98)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C37(0.56); C53(0.57); C81(0.57)  LDD1572  [17]
 LDCM0369  CL100 HCT 116 C81(0.71)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C37(1.29); C53(1.12); C81(1.34)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C37(0.81); C53(0.85); C81(0.84)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C37(1.54); C53(1.58); C81(1.92)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C37(0.96); C53(0.93); C81(0.91)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C37(1.88); C53(1.34); C81(1.74)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C37(1.23); C53(1.18); C81(1.33)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C37(1.45); C53(1.84); C81(1.66)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C37(1.57); C53(1.08); C81(1.42)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C37(1.04); C53(0.86); C81(0.99)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C37(1.19); C53(1.23); C81(1.23)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C37(0.72); C53(0.89); C81(0.88)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C37(1.07); C53(0.96); C81(1.05)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C37(0.85); C53(0.89); C81(0.83)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C37(2.02); C53(1.46); C81(1.86)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C37(0.82); C53(1.08); C81(1.04)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C37(1.09); C53(1.31); C81(1.32)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C37(1.70); C53(1.18); C81(1.74)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C37(1.97); C53(1.32); C81(1.97)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C37(1.03); C53(1.15); C81(1.20)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C37(1.07); C53(1.20); C81(1.18)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C37(1.46); C53(1.40); C81(1.45)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C37(1.45); C53(1.12); C81(1.41)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C37(2.05); C53(1.40); C81(1.96)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C37(1.24); C53(1.56); C81(1.58)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C37(1.26); C53(1.40); C81(1.43)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C37(1.39); C53(0.88); C81(1.20)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C37(1.20); C53(0.91); C81(1.18)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C37(1.22); C53(1.34); C81(1.34)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C37(1.15); C53(1.12); C81(1.29)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C37(1.29); C53(0.98); C81(1.20)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C37(1.67); C53(1.23); C81(1.59)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C37(0.97); C53(1.22); C81(1.18)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C37(1.50); C53(1.82); C81(2.16)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C37(1.15); C53(0.94); C81(1.22)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C37(2.01); C53(1.96); C81(2.33)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C37(1.11); C53(1.17); C81(1.05)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C37(1.28); C81(1.55); C67(1.12)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C37(0.97); C53(0.97); C81(1.05)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C37(1.97); C53(1.85); C81(2.07); C67(1.12)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C37(1.89); C53(1.47); C81(1.78)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C37(1.27); C53(1.41); C81(1.33)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C37(2.20); C53(2.39); C81(1.79)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C37(1.58); C53(1.29); C81(1.47)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C37(2.00); C53(1.82); C81(1.98)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C37(1.65); C53(1.65); C81(2.17)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C37(1.50); C53(1.70); C81(1.87)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C37(1.59); C53(1.37); C81(1.41)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C37(2.09); C53(1.81); C81(2.86)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C37(0.64); C53(0.61); C81(0.65)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C37(1.29); C53(1.39); C81(1.24)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C37(1.19); C81(1.13); C67(1.07)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C37(1.92); C53(1.86); C81(2.02); C67(1.22)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C37(1.61); C53(1.51); C81(1.47)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C37(1.66); C53(1.75); C81(1.97)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C37(2.19); C53(3.10); C81(1.77)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C37(1.79); C53(1.19); C81(1.79)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C37(2.22); C53(1.49); C81(2.25)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C37(1.77); C53(2.01); C81(2.35)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C37(0.80); C53(0.86); C81(0.80)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C37(2.38); C53(1.35); C81(2.05)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C37(2.07); C53(1.68); C81(1.79)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C37(1.33); C53(1.20); C81(1.22)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C37(1.22); C81(1.30); C67(0.98)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C37(1.75); C53(1.71); C81(1.65); C67(1.07)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C37(1.86); C53(1.87); C81(1.74)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C37(1.49); C53(1.60); C81(1.54)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C37(1.92); C53(2.06); C81(1.56)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C37(2.56); C53(1.51); C81(2.42)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C37(1.36); C53(1.06); C81(1.39)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C37(1.22); C53(1.44); C81(1.11)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C37(1.52); C53(1.26); C81(1.82)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C37(1.17); C53(0.99); C81(1.10)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C37(1.82); C53(1.51); C81(1.87)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C37(1.05); C53(1.11); C81(1.04)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C37(1.23); C81(1.41); C67(1.00)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C37(1.95); C53(2.08); C81(2.08); C67(1.12)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C37(1.50); C53(1.48); C81(1.56)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C37(1.39); C53(1.66); C81(1.52)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C37(2.18); C53(2.22); C81(2.12)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C37(0.70); C53(0.78); C81(0.69)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C37(2.70); C53(1.72); C81(2.50)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C37(2.04); C53(1.45); C81(2.11)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C37(1.36); C53(1.49); C81(1.77)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C37(1.59); C53(1.69); C81(2.01)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C37(1.54); C53(0.97); C81(1.44)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C37(2.90); C53(2.92); C81(2.60)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C37(1.47); C53(1.46); C81(1.48)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C37(1.20); C81(1.12); C67(0.99)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C37(2.41); C53(2.37); C81(2.22); C67(1.11)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C37(2.08); C53(1.57); C81(2.10)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C37(0.74); C81(0.94); C67(1.13)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C37(2.01); C53(1.89); C81(1.98)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C37(1.91); C53(2.05); C81(1.62)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C37(3.18); C53(1.87); C81(3.15)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C37(1.04); C53(0.88); C81(1.03)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C37(0.94); C53(0.94); C81(0.99)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C37(1.17); C53(0.95); C81(1.12)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C37(1.09); C53(1.05); C81(1.14)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C37(0.86); C53(0.86); C81(0.78)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C37(0.66); C81(0.78); C67(1.06)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C37(0.54); C53(0.52); C81(0.61); C67(0.97)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C37(0.76); C53(0.84); C81(0.78); C67(1.09)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C37(2.17); C53(1.82); C81(1.99)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C37(0.76); C53(0.93); C81(0.82)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C37(0.97); C53(1.06); C81(1.01)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C37(1.10); C53(1.02); C81(1.12)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C37(1.95); C53(1.34); C81(1.90)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C37(1.34); C53(1.38); C81(1.61)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C37(1.29); C53(1.26); C81(1.53)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C37(1.59); C53(1.17); C81(1.47)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C37(2.51); C53(1.92); C81(2.21)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C37(0.76); C53(0.78); C81(0.82)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C37(1.14); C53(1.12); C81(1.24)  LDD1688  [17]
 LDCM0486  CL91 HCT 116 C81(0.71)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C81(0.72)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C81(0.59)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C81(0.68)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C81(0.92)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C81(0.72)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C81(0.73)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C81(0.66)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C81(0.63)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C37(1.75); C53(2.07); C81(2.33)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C81(3.81)  LDD1702  [2]
 LDCM0625  F8 Ramos C37(1.31)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C37(0.85)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C37(5.66); C53(0.53)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C37(0.61); C53(0.36)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C37(1.01)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C37(0.48); C53(1.10)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C37(0.41); C53(0.23)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C37(0.78)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C37(1.07)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C37(1.11)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C37(0.72); C53(0.64)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C37(1.11)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C37(0.57)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C37(0.77)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C37(0.97); C53(0.97); C81(1.09)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C37(0.82); C53(0.50)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C37(0.88)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C37(1.65); C53(1.09); C81(1.89)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C37(1.17)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C37(1.35)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C37(0.85)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C37(0.46); C53(0.35)  LDD2188  [18]
 LDCM0107  IAA HeLa H62(0.00); C67(0.00); C53(0.00); H76(0.00)  LDD0221  [14]
 LDCM0022  KB02 Ramos C37(1.05)  LDD2182  [18]
 LDCM0023  KB03 Ramos C37(0.48)  LDD2183  [18]
 LDCM0024  KB05 COLO792 C53(1.27)  LDD3310  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C43(0.82)  LDD2102  [2]
 LDCM0109  NEM HeLa H62(0.00); C67(0.00); C53(0.00); H76(0.00)  LDD0223  [14]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C43(1.35); C53(1.34)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C81(0.85); C43(0.76); C53(0.77)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C81(0.94)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C81(0.89); C43(1.18); C53(0.75)  LDD2094  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C81(0.81); C43(0.98); C53(1.02); C37(0.97)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C81(0.28); C43(0.85); C53(0.98)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C81(0.91); C37(0.96)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C81(0.31); C43(0.40); C53(0.69)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C81(2.49); C43(0.98); C53(1.01)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C81(0.39); C43(0.45); C53(0.92)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C81(1.23); C43(1.31)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C81(0.34); C53(0.57)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C81(1.22); C37(1.00)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C81(0.73); C43(0.52); C53(0.56)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C37(1.29)  LDD2109  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C43(0.91)  LDD2110  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C81(0.68)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C43(0.56); C53(0.71); C37(0.48)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C81(0.79); C43(0.70); C37(0.45)  LDD2115  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C81(2.97)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C81(1.04)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C37(0.74)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C81(1.00); C37(0.67)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C81(0.80); C43(0.56)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C81(0.94)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C81(0.81); C43(0.75); C53(0.56); C37(0.60)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C81(0.76); C43(0.81)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C81(1.53)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C81(1.50); C43(0.87); C37(0.87)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C81(1.16); C43(1.31)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C81(0.81)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C81(0.63); C43(0.99); C37(0.90)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C81(0.54); C43(0.53); C53(0.79); C37(1.12)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C81(1.00)  LDD2143  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C81(2.25); C43(1.18); C53(5.47); C37(1.25)  LDD2145  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C81(0.77)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C81(0.77); C43(0.82); C37(0.43)  LDD2148  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C43(1.38); C53(1.33)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 8A (ARL8A) Arf family Q96BM9
Transmembrane gamma-carboxyglutamic acid protein 1 (PRRG1) . O14668
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NEDD4 family-interacting protein 1 (NDFIP1) . Q9BT67
NEDD4 family-interacting protein 2 (NDFIP2) . Q9NV92
RING finger protein 24 (RNF24) . Q9Y225

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-nonyl-4-quinolinol 1-oxide Small molecular drug DB08453
6-hydroxy-5-undecyl-47-benzothiazoledione Small molecular drug DB04799
Ubiquinone Q2 Small molecular drug DB08690
(5s)-3-anilino-5-(24-difluorophenyl)-5-methyl-13-oxazolidine-24-dione . DB07763
(S)-famoxadone . DB07778
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141
Azoxystrobin . DB07401
Methyl (2z)-3-methoxy-2-{2-[(E)-2-phenylvinyl]Phenyl}Acrylate . DB08330

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840