Details of the Target

General Information of Target

Target ID LDTP02044
Target Name Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Gene Name ERBB2
Gene ID 2064
Synonyms
HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Subcellular location
Cytoplasm; Cell membrane
Function
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
TTD ID
T14597
Uniprot ID
P04626
DrugMap ID
TT6EO5L
Ensemble ID
ENST00000269571.10
HGNC ID
HGNC:3430
ChEMBL ID
CHEMBL1824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L720P DBIA    Probe Info 
COLO792 SNV: p.C7R DBIA    Probe Info 
EFO27 SNV: p.V842I DBIA    Probe Info 
FTC133 SNV: p.A830V DBIA    Probe Info 
HEC1 SNV: p.T798I; p.V842I DBIA    Probe Info 
HEC1B SNV: p.T798I; p.V842I .
J82 SNV: p.R678Q .
JURKAT SNV: p.S335I .
LN229 SNV: p.L755S .
MDAMB468 Deletion: p.V153SfsTer2 DBIA    Probe Info 
MOLT4 Deletion: p.A1232LfsTer70 .
NCIH1793 SNV: p.V541M .
NCIN87 SNV: p.L436V DBIA    Probe Info 
OVCAR8 SNV: p.G776V .
RL952 SNV: p.G518V DBIA    Probe Info 
SKNSH SNV: p.P18T .
SW480 SNV: p.E1229Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K200(6.23)  LDD3494  [1]
m-APA
 Probe Info  		10.94  LDD0403  [2]
AHL-Pu-1
 Probe Info  		C1032(2.82)  LDD0168  [3]
DBIA
 Probe Info  		C947(0.92)  LDD0531  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_5
 Probe Info  		C367(0.00); C342(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1032(2.82)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1032(4.16)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C947(0.92)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C947(0.96)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C958(0.60); C965(0.60)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C958(0.77); C965(0.77)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C958(0.87); C965(0.87)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C958(0.81); C965(0.81)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C958(0.64); C965(0.64)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C958(1.11); C965(1.11)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C958(0.96); C965(0.96)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C958(0.79); C965(0.49)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C958(0.94); C965(1.06)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C958(0.56); C965(1.51)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C947(1.05)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C958(0.78); C965(1.10)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C958(0.62); C965(0.85)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C958(0.85); C965(0.62)  LDD0546  [4]
 LDCM0230  AC113 PaTu 8988t C947(0.84)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C947(0.85)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C947(0.75)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C947(0.72)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C947(0.85)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C947(1.14)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C947(0.94)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C947(1.02)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C947(0.86)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C947(0.91)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C947(0.93)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C947(0.91)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C947(0.94)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C947(1.01)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C947(0.81)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C947(0.74)  LDD1124  [4]
 LDCM0246  AC128 HCT 116 C958(0.80); C965(0.80)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C958(0.97); C965(0.97)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C958(1.01); C965(1.01)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C958(0.82); C965(0.82)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C958(0.92); C965(0.92)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C958(0.88); C965(0.88)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C958(0.97); C965(0.97)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C958(0.83); C965(0.83)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C958(0.82); C965(0.82)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C958(1.01); C965(1.01)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C958(0.92); C965(0.92)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C958(1.18); C965(1.18)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C947(0.98)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C958(1.01); C965(1.01)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C958(0.91); C965(0.91)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C958(0.77); C965(0.77)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C947(0.93)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C947(0.74)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C947(0.97)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C947(1.30)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C947(1.21)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C947(0.96)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C947(0.82)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C947(0.97)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C947(1.05)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C947(1.15)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C947(0.81)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C947(1.36)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C947(1.03)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C947(0.99)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C947(0.86)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C947(1.03)  LDD2169  [4]
 LDCM0276  AC17 HCT 116 C958(1.02); C965(1.10); C642(1.52)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C965(0.95); C958(0.96); C642(1.50)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C965(0.84); C958(0.92); C642(1.34)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C947(0.81)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C965(1.04); C958(1.14); C642(1.60)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C958(0.72); C965(0.85); C642(1.72)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C965(0.91); C958(1.01); C642(1.58)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C958(0.95); C965(0.96); C642(1.80)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C958(0.91); C965(0.93); C642(1.28)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C965(0.88); C958(0.95); C642(1.11)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C642(0.94); C958(1.13); C965(1.21)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C642(0.88); C965(1.08); C958(1.15)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C642(1.03); C958(1.09); C965(1.29)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C642(1.19); C958(1.26); C965(1.41)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C947(0.77)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C965(1.09); C958(1.13); C642(1.36)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C642(1.04); C958(1.10); C965(1.11)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C642(0.97); C958(1.18); C965(1.39)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C642(0.96); C958(1.09); C965(1.13)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C642(0.91); C965(1.02); C958(1.10)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C958(0.75); C965(0.75); C642(0.99)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C958(0.88); C965(0.88); C642(0.96)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C642(1.13); C958(1.23); C965(1.23)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C642(1.04); C958(1.13); C965(1.13)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C958(0.95); C965(0.95); C642(1.31)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C947(0.87)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C958(1.06); C965(1.06); C642(1.22)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C958(1.04); C965(1.04); C642(1.33)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C642(1.00); C958(1.07); C965(1.07)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C958(0.92); C965(0.92); C642(1.01)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C642(1.05); C958(1.22); C965(1.22)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C642(1.15); C958(1.19); C965(1.19)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C642(0.80); C958(1.61); C965(1.61)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C958(0.99); C965(0.99); C642(1.26)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C642(1.43); C958(1.60); C965(1.60)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C958(1.24); C965(1.24); C642(1.34)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C947(0.80)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C642(1.19); C958(1.42); C965(1.42)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C642(1.05); C958(1.43); C965(1.43)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C642(0.96); C958(1.26); C965(1.26)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C642(1.14); C958(1.25); C965(1.25)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C642(0.89); C958(1.22); C965(1.22)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C642(1.06); C958(1.26); C965(1.26)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C642(0.89); C958(1.32); C965(1.32)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C958(1.39); C965(1.39)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C958(0.90); C965(0.90)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C958(1.32); C965(1.32)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C947(0.97)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C958(0.98); C965(0.98)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C958(1.60); C965(1.60)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C958(2.06); C965(2.06)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C958(0.92); C965(0.92)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C958(1.32); C965(1.32)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C958(1.69); C965(1.69)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C958(1.57); C965(1.57)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C958(2.12); C965(2.12)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C958(0.79); C965(0.79)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C958(0.95); C965(0.95)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C947(0.92)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C958(1.05); C965(1.05)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C958(0.76); C965(0.76)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C958(0.95); C965(0.95)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C958(1.49); C965(1.49)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C958(1.18); C965(1.18)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C958(2.54); C965(2.54)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C958(1.23); C965(1.23)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C958(1.16); C965(1.16)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C958(0.71); C965(0.71)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C958(0.70); C965(0.70)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C947(1.01)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C958(0.87); C965(0.87)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C958(1.06); C965(1.06)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C958(1.55); C965(1.55)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C947(0.85)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C947(0.89)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C947(0.87)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C947(0.95)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C947(0.86)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C947(0.91)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C947(0.96)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C947(0.75)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C947(0.81)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C947(1.00)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C947(0.88)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C947(1.02)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C947(0.88)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C947(0.81)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C947(0.86)  LDD1243  [4]
 LDCM0365  AC98 HCT 116 C958(1.29); C965(1.29)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C958(0.63); C965(0.63)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C947(0.92)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C947(0.91)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C947(1.01)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 10.94  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C642(1.05)  LDD2171  [4]
 LDCM0367  CL1 HCT 116 C958(0.92); C965(0.92); C947(0.96)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C947(0.85); C958(1.58); C965(1.58)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C947(0.77)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C947(0.89)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C947(0.84)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C947(0.82)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C947(0.89)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C965(1.14); C958(1.24); C642(1.44)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C965(1.08); C958(1.16); C642(1.96)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C965(1.22); C642(1.41); C958(1.54)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C965(1.22); C958(1.23); C642(1.53)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C958(0.97); C965(1.05); C642(1.33)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C947(0.96); C958(1.83); C965(1.83)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C965(1.04); C958(1.09); C642(1.82)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C965(0.88); C958(0.90); C642(1.60)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C958(0.90); C642(0.92); C965(0.97)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C642(1.00); C965(1.10); C958(1.10)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C965(0.98); C958(0.98); C642(1.21)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C958(1.05); C965(1.08); C642(1.17)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C642(0.95); C965(1.04); C958(1.05)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C642(1.30); C958(1.53); C965(1.53)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C642(1.05); C958(1.12); C965(1.12)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C958(1.17); C965(1.17); C642(1.28)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C947(0.97); C958(1.04); C965(1.04)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C958(1.13); C965(1.13); C642(1.24)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C642(0.98); C958(1.04); C965(1.04)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C642(0.94); C958(1.15); C965(1.15)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C958(1.11); C965(1.11); C642(1.14)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C642(1.06); C958(1.51); C965(1.51)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C958(0.95); C965(0.95)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C958(1.26); C965(1.26)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C958(1.27); C965(1.27)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C958(1.38); C965(1.38)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C958(0.99); C965(0.99); C947(1.11)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C947(0.84); C958(1.33); C965(1.33)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C947(0.89); C958(1.18); C965(1.18)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C965(1.14)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C965(1.29)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C965(0.99)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C965(1.16)  LDD1004  [4]
 LDCM0407  CL2 HCT 116 C947(0.87); C958(1.19); C965(1.19)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C965(1.01)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C965(1.14)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C965(0.89)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C965(0.67)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C965(0.99)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C965(0.87)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C965(0.84)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C965(1.31)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C965(0.85)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C965(0.71)  LDD1015  [4]
 LDCM0418  CL3 HCT 116 C947(0.87); C958(1.01); C965(1.01)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C965(1.05)  LDD1017  [4]
 LDCM0420  CL31 HCT 116 C947(1.10); C958(1.26); C965(1.26)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C947(1.36); C958(1.25); C965(1.25)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C947(1.07); C958(1.64); C965(1.64)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C947(1.35); C958(1.46); C965(1.46)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C947(2.00); C958(1.29); C965(1.29)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C947(1.37); C958(1.39); C965(1.39)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C947(1.55); C958(1.42); C965(1.42)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C947(1.39); C958(1.41); C965(1.41)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C947(0.84); C958(1.05); C965(1.05)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C947(1.15); C958(1.61); C965(1.61)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C947(1.32); C958(1.27); C965(1.27)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C947(1.61); C958(1.82); C965(1.82)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C947(1.58); C958(1.25); C965(1.25)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C947(1.60); C958(1.07); C965(1.07)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C947(1.56); C958(1.45); C965(1.45)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C965(1.39)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C965(1.15)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C965(1.10)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C965(1.15)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C947(0.89); C958(1.38); C965(1.38)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C965(1.11)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C965(1.23)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C965(1.24)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C965(0.89)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C965(1.10)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C965(0.90)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C965(0.99)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C965(1.14)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C965(1.22)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C965(1.09)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C947(0.81); C958(1.35); C965(1.35)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C965(1.17)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C947(0.85); C958(1.06); C965(0.98)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C947(0.92); C958(1.05); C965(1.03)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C947(0.90); C958(0.99); C965(1.27)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C947(1.02); C958(1.23); C965(1.10)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C947(0.81); C958(1.24); C965(0.83)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C947(0.86); C958(1.25); C965(1.06)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C947(0.94); C958(1.22); C965(0.90)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C947(0.90); C958(1.34); C965(0.90)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C947(0.82); C958(1.14); C965(0.98)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C947(0.98); C958(1.16); C965(1.16)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C947(0.88); C958(1.53); C965(0.79)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C947(0.92); C958(1.25); C965(0.86)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C947(1.03); C958(0.95); C965(0.88)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C947(1.40); C958(1.14); C965(0.90)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C947(0.92); C958(1.01); C965(0.91)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C958(0.80)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C958(0.87)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C958(0.96)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C958(0.97)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C947(0.99); C958(1.09); C965(1.09)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C958(0.98)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C958(1.04)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C958(1.02)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C958(0.95)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C958(1.11)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C958(1.01)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C958(0.94)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C958(1.03)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C958(1.09)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C958(0.83)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C947(1.14); C958(1.13); C965(1.13)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C958(0.76)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C947(0.77)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C947(0.74)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C947(0.87)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C947(0.80)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C947(0.75)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C947(0.77)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C947(0.79)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C947(0.75)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C947(0.75)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C947(0.93)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C947(0.88); C958(1.03); C965(1.04)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C947(1.49); C958(1.53); C965(1.53)  LDD0744  [4]
 LDCM0022  KB02 22RV1 C642(2.31); C947(1.63)  LDD2243  [8]
 LDCM0023  KB03 22RV1 C642(4.45); C947(2.74)  LDD2660  [8]
 LDCM0024  KB05 COLO792 C596(2.88); C642(2.80); C947(2.14); C342(1.91)  LDD3310  [8]
 LDCM0021  THZ1 HCT 116 C642(1.05)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Cullin-5 (CUL5) Cullin family Q93034
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Prostatic acid phosphatase (ACP3) Histidine acid phosphatase family P15309
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) PI3/PI4-kinase family O00750
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Protein-tyrosine kinase 6 (PTK6) Tyr protein kinase family Q13882
Megakaryocyte-associated tyrosine-protein kinase (MATK) Tyr protein kinase family P42679
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Receptor tyrosine-protein kinase erbB-4 (ERBB4) Tyr protein kinase family Q15303
Tyrosine-protein kinase JAK1 (JAK1) Tyr protein kinase family P23458
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fgr (FGR) Tyr protein kinase family P09769
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein kinase ITK/TSK (ITK) Tyr protein kinase family Q08881
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Protein-tyrosine phosphatase family Q06124
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) Protein-tyrosine phosphatase family Q05209
Tyrosine-protein phosphatase non-receptor type 18 (PTPN18) Protein-tyrosine phosphatase family Q99952
Receptor-type tyrosine-protein phosphatase C (PTPRC) Protein-tyrosine phosphatase family P08575
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) Protein-tyrosine phosphatase family Q15262
Receptor-type tyrosine-protein phosphatase beta (PTPRB) Protein-tyrosine phosphatase family P23467
Receptor-type tyrosine-protein phosphatase eta (PTPRJ) Protein-tyrosine phosphatase family Q12913
Receptor-type tyrosine-protein phosphatase O (PTPRO) Protein-tyrosine phosphatase family Q16827
Receptor-type tyrosine-protein phosphatase R (PTPRR) Protein-tyrosine phosphatase family Q15256
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Tensin-3 (TNS3) PTEN phosphatase protein family Q68CZ2
E3 SUMO-protein ligase RanBP2 (RANBP2) RanBP2 E3 ligase family P49792
DNA-directed RNA polymerase I subunit RPA1 (POLR1A) RNA polymerase beta' chain family O95602
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) . P16885
Calcyclin-binding protein (CACYBP) . Q9HB71
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Exportin-1 (XPO1) Exportin family O14980
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
Guanine nucleotide exchange factor VAV2 (VAV2) . P52735
Talin-1 (TLN1) . Q9Y490
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) . Q96JA1
Other
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crk-like protein (CRKL) CRK family P46109
Docking protein 1 (DOK1) DOK family Q99704
Docking protein 4 (DOK4) DOK family, Type B subfamily Q8TEW6
Ephrin-B1 (EFNB1) Ephrin family P98172
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Growth factor receptor-bound protein 7 (GRB7) GRB7/10/14 family Q14451
Endoplasmin (HSP90B1) Heat shock protein 90 family P14625
Core histone macro-H2A.1 (MACROH2A1) Histone H2A family O75367
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) JIP scaffold family Q9UQF2
C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) JIP scaffold family Q13387
Protein MEMO1 (MEMO1) MEMO1 family Q9Y316
ERBB receptor feedback inhibitor 1 (ERRFI1) MIG6 family Q9UJM3
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) RECK family O95980
Suppressor of cytokine signaling 1 (SOCS1) SOCS1 family O15524
Transcription elongation factor SPT6 (SUPT6H) SPT6 family Q7KZ85
Amyloid beta precursor protein binding family B member 1 (APBB1) . O00213
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) . Q92625
Breast cancer anti-estrogen resistance protein 3 (BCAR3) . O75815
Cytokine-dependent hematopoietic cell linker (CLNK) . Q7Z7G1
Cytokine-inducible SH2-containing protein (CISH) . Q9NSE2
Cytoplasmic protein NCK2 (NCK2) . O43639
Early endosome antigen 1 (EEA1) . Q15075
Insulin receptor substrate 1 (IRS1) . P35568
Ras GTPase-activating protein 1 (RASA1) . P20936
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
SH2 domain-containing protein 2A (SH2D2A) . Q9NP31
SHC-transforming protein 1 (SHC1) . P29353
SHC-transforming protein 2 (SHC2) . P98077
SHC-transforming protein 3 (SHC3) . Q92529
Src-like-adapter 2 (SLA2) . Q9H6Q3
Stress-induced-phosphoprotein 1 (STIP1) . P31948

The Drug(s) Related To This Target

Approved
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Margetuximab Antibody DB14967
Trastuzumab Antibody DB00072
Trastuzumab Emtansine Antibody drug conjugate DB05773
Pertuzumab Monoclonal antibody DB06366
Afatinib Small molecular drug DB08916
Brigatinib Small molecular drug DB12267
Fostamatinib Small molecular drug DB12010
Lapatinib Small molecular drug DB01259
Tucatinib . DB11652
Zanubrutinib . DB15035
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hki-272 Small molecular drug D0Q9CY
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-690514 Small molecular drug D0R6UV
Investigative
Click To Hide/Show 30 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 12882 Antisense drug D0S3AR
Isis 12883 Antisense drug D06VFH
Isis 12884 Antisense drug D09HJE
Isis 9002 Antisense drug D06JEJ
Isis 9003 Antisense drug D0EE7R
Isis 9005 Antisense drug D0C0EE
(1-benzyl-1h-indol-5-yl)-quinazolin-4-yl-amine Small molecular drug D02ARA
3,4-di-(4-methoxyphenyl)-1h-pyrrole-2,5-dione Small molecular drug D00NYT
3,4-diphenyl-1h-pyrrole-2,5-dione Small molecular drug D0C3WY
3-(4-methoxyphenyl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D0EK0G
3-(Indole-3-yl)-4-phenyl-1h-pyrrole-2,5-dione Small molecular drug D06AOY
4-(3-phenoxylphenyl)-5-cyano-2h-1,2,3-triazole Small molecular drug D09RFE
4-(4-bromophenyl)-5-cyano-2h-1,2,3-triazole Small molecular drug D0H2DD
4-(4-chlorophenyl)-5-cyano-2h-1,2,3-triazole Small molecular drug D0C2SF
4-(4-isopropylphenyl)-5-cyano-2h-1,2,3-triazole Small molecular drug D0B7ZB
4-(Bis(2-chloroethyl)Amino)-n-p-tolylbenzamide Small molecular drug D01OKF
4557w Small molecular drug D0X4OU
Ag-213 Small molecular drug D0Q3GG
Bms-536924 Small molecular drug D0M4SY
Cl-387785 Small molecular drug D00TZD
Hds-029 Small molecular drug D05FFT
N-(4-m-tolylamino-quinazolin-6-yl)-acrylamide Small molecular drug D01WYI
Pd-168393 Small molecular drug D01VFR
Pmid24915291c38 Small molecular drug D06BJG
Tesevatinib Small molecular drug DB11973
Varlitinib Small molecular drug DB05944
Av-412 . DB06021
Geldanamycin-estradiol Hybrid . D0H6OS
Ign311 . DB04988
Pnt-500 . D0AA2X

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840