Details of the Target

General Information of Target

Target ID LDTP01614
Target Name Claudin-7 (CLDN7)
Gene Name CLDN7
Gene ID 1366
Synonyms
CEPTRL2; CPETRL2; Claudin-7; CLDN-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV
Target Bioclass
Transporter and channel
Family
Claudin family
Subcellular location
Cell membrane
Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Uniprot ID
O95471
Ensemble ID
ENST00000360325.11
HGNC ID
HGNC:2049

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.W30Ter .
HT115 SNV: p.I125L .
KELLY SNV: p.A2D .
MOLT4 SNV: p.R117H .
NALM6 SNV: p.R106C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C54(0.64); C64(0.64)  LDD0531  [1]
IA-alkyne
 Probe Info  		C54(0.00); C107(0.00)  LDD0162  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C54(0.64); C64(0.64)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C54(0.81); C64(1.03)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C54(0.76); C64(0.76)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C54(0.76); C64(0.76)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C54(1.09); C64(1.09)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C54(0.78); C64(0.78)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C54(0.78); C64(0.78)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C54(0.84); C64(0.84)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C54(0.70); C64(0.70)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C54(0.63); C64(0.82)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C54(0.76); C64(0.73)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C54(0.98); C64(0.89)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C54(0.60); C64(0.86)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C54(0.79); C64(0.85)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C54(0.75); C64(0.76)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C54(0.85); C64(0.87)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C54(0.94); C64(0.94)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C54(0.79); C64(0.79)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C54(0.82); C64(0.82)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C54(0.81); C64(0.81)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C54(0.99); C64(0.99)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C54(0.95); C64(0.95)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C54(1.06); C64(1.06)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C54(0.72); C64(0.87)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C54(0.94); C64(0.94)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C54(1.03); C64(1.03)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C54(1.04); C64(1.04)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C54(1.01); C64(1.01)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C54(1.15); C64(1.15)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C54(0.93); C64(0.93)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C54(0.82); C64(0.82)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C54(0.81); C64(0.81)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C54(0.90); C64(0.90)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C54(1.08); C64(1.08)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C54(0.89); C64(0.89)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C54(1.04); C64(1.04)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C54(1.13); C64(1.13)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C54(0.96); C64(0.96)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C54(0.92); C64(0.92)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C54(0.94); C64(0.94)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C54(0.95); C64(0.95)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C54(1.02); C64(1.02)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C54(0.97); C64(0.97)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C54(0.98); C64(0.98)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C54(0.66); C64(0.85)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C54(0.88); C64(0.88)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C54(0.96); C64(0.96)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C54(1.08); C64(1.08)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C54(0.79); C64(0.74)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C64(0.55); C54(0.58)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C64(0.74); C54(0.74)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C64(0.55); C54(0.56)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C64(0.53); C54(0.53)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C54(0.40); C64(0.45)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C54(0.47); C64(0.52)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C54(0.62); C64(0.93)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C54(0.83); C64(0.87)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C54(0.68); C64(0.70)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C64(0.53); C54(0.54)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C54(0.35); C64(0.39)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C54(0.54); C64(0.57)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C54(0.61); C64(0.61)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C54(0.91); C64(0.82)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C54(0.81); C64(0.80)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C64(1.03); C54(1.33)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C54(0.98); C64(1.04)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C54(0.94); C64(0.97)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C54(0.73); C64(0.73)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C64(1.10); C54(1.24)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C64(0.99); C54(1.08)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C64(1.09); C54(1.14)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C64(1.05); C54(1.11)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C64(1.25); C54(1.37)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C64(0.77)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C64(0.71)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C64(0.68)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C64(0.78)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C64(0.90)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C54(0.77); C64(0.77)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C64(0.75)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C64(0.91)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C64(0.61)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C64(0.65)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C64(0.66)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C54(0.80); C64(0.93)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C54(0.95); C64(1.07)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C54(0.89); C64(0.91)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C64(1.06); C54(1.07)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C54(0.71); C64(0.92)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C54(0.57); C64(0.57)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C54(0.73); C64(0.85)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C54(1.00); C64(1.04)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C54(0.95); C64(0.99)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C54(0.84); C64(0.85)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C64(0.91); C54(1.02)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C54(0.73); C64(0.87)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C54(0.81); C64(0.88)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C54(0.86); C64(0.92)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C54(0.70); C64(0.73)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C54(0.64); C64(0.74)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C54(0.66); C64(0.66)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C54(0.63); C64(0.68)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C64(0.98); C54(1.11)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C64(0.91); C54(0.93)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C64(0.83); C54(0.89)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C54(0.78); C64(0.87)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C54(0.61); C64(0.66)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C54(0.45); C64(0.56)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C64(0.58); C54(0.70)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C64(0.49); C54(0.54)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C64(0.59); C54(0.67)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C54(0.64); C64(0.83)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C64(0.58); C54(0.63)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C64(0.65); C54(0.67)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C64(0.52); C54(0.65)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C64(0.60); C54(0.73)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C64(0.53); C54(0.59)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C64(0.64); C54(0.74)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C64(0.67); C54(0.77)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C64(0.37); C54(0.47)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C54(0.82); C64(0.82)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C54(0.69); C64(0.69)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C54(0.67); C64(0.98)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C54(0.62); C64(0.62)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C54(0.90); C64(0.90)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C54(0.89); C64(0.89)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C54(0.49); C64(0.49)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C54(0.57); C64(0.57)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C54(0.47); C64(0.47)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C54(0.73); C64(0.73)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C54(0.64); C64(0.64)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C54(0.81); C64(0.81)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C54(0.98); C64(0.98)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C54(0.69); C64(0.99)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C54(0.73); C64(0.73)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C54(1.14); C64(1.14)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C54(0.31); C64(0.31)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C54(0.58); C64(0.58)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C54(0.59); C64(0.59)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C54(0.73); C64(0.73)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C54(0.91); C64(0.91)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C54(0.90); C64(0.90)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C54(0.93); C64(0.93)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C54(0.74); C64(0.74)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C54(1.39); C64(1.39)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C54(0.62); C64(0.62)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C54(0.74); C64(0.74)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C54(0.82); C64(0.82)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C54(0.75); C64(0.75)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C54(0.83); C64(0.83)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C54(0.71); C64(0.71)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C54(0.73); C64(0.73)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C54(0.37); C64(0.37)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C54(0.65); C64(0.65)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C54(0.72); C64(1.02)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C54(0.68); C64(0.96)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C54(0.49); C64(0.87)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C64(1.37); C54(1.70)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C64(0.64); C54(0.81)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C54(0.63); C64(0.63)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C54(0.70); C64(0.89)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C54(0.69); C64(0.87)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C54(0.70); C64(1.04)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C54(0.78); C64(1.07)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C64(1.20); C54(1.49)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C54(0.81); C64(0.82)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C64(1.05); C54(1.16)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C54(0.83); C64(1.01)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C64(1.04); C54(1.14)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C54(0.86); C64(0.94)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C64(0.86); C54(1.04)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C64(1.00); C54(1.07)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C64(0.82)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C64(0.65)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C64(0.73)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C64(0.76)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C64(0.81)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C54(0.64); C64(0.78)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C64(1.04); C54(1.17)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C54(0.77); C64(0.89)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C54(0.78); C64(0.84)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C64(1.03); C54(1.05)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C64(0.90); C54(1.23)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C54(0.72); C64(0.79)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C54(0.83); C64(0.86)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C54(0.69); C64(0.74)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C64(0.81); C54(0.89)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C64(0.63); C54(0.74)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C64(0.77); C54(0.86)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C64(0.65); C54(0.70)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C54(0.74); C64(0.77)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C64(1.04); C54(1.17)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C64(0.91); C54(0.91)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C54(0.89); C64(0.93)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C54(0.71); C64(0.79)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C54(0.75); C64(0.88)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C54(0.68); C64(0.77)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C64(1.13); C54(1.37)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C54(0.69); C64(0.76)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C54(0.60); C64(0.72)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C54(0.53); C64(0.62)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C54(0.80); C64(0.93)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C54(0.66); C64(0.83)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C54(0.70); C64(0.74)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C54(0.69); C64(0.74)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C54(0.80); C64(0.91)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C54(0.74); C64(0.83)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C54(0.67); C64(0.77)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C54(1.33); C64(1.14)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C54(0.74); C64(0.82)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C54(0.85); C64(0.89)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C54(0.78); C64(0.70)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C54(0.84); C64(0.84)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C54(0.57); C64(0.46)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C54(0.76); C64(0.69)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C54(0.72); C64(0.70)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C54(0.68); C64(0.61)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C54(0.69); C64(0.65)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C54(1.30); C64(1.08)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C54(0.76); C64(0.69)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C54(0.72); C64(0.64)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C54(0.60); C64(0.46)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C54(0.67); C64(0.62)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C54(0.67); C64(0.64)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C54(0.61); C64(0.56)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C54(1.27); C64(0.95)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C54(1.23); C64(1.01)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C54(1.26); C64(0.93)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C54(1.04); C64(0.92)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C54(0.98); C64(0.96)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C54(1.11); C64(0.88)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C54(0.96); C64(1.05)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C54(0.93); C64(0.80)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C54(1.08); C64(0.87)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C54(1.03); C64(0.92)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C54(0.97); C64(0.86)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C54(0.89); C64(0.98)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C54(0.98); C64(0.80)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C54(1.13); C64(1.18)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C54(1.00); C64(0.87)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C54(0.86); C64(0.82)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C54(1.03); C64(0.74)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C54(0.81); C64(0.81)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C54(0.71); C64(0.74)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C54(0.71); C64(0.68)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C54(0.69); C64(0.65)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C54(0.74); C64(0.74)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C54(0.54); C64(0.48)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C54(0.62); C64(0.58)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C54(0.70); C64(0.62)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C54(0.89); C64(0.93)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C54(0.88); C64(0.85)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C54(0.63); C64(0.65)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C54(0.66); C64(0.66)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C54(0.94); C64(0.92)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C54(0.77); C64(0.72)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C54(0.63); C64(0.57)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C54(0.78); C64(0.78)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C54(0.82); C64(0.82)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C54(0.75); C64(0.75)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C54(0.65); C64(0.65)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C54(0.75); C64(0.81)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C54(0.63); C64(0.63)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C54(0.69); C64(0.69)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C54(0.50); C64(0.50)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C54(0.54); C64(0.54)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C54(0.47); C64(0.47)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C54(0.75); C64(0.75)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C54(0.96); C64(0.96)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C54(0.75); C64(0.75)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C54(0.58); C64(0.58)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C54(0.41); C64(0.41)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C54(1.12); C64(0.97)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C54(1.18); C64(1.18)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C54(0.93); C64(0.93)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C54(1.05); C64(1.05)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C54(0.87); C64(0.87)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C54(0.80); C64(0.80)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C54(0.80); C64(0.80)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C54(0.82); C64(0.82)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C54(0.82); C64(0.82)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C54(0.72); C64(0.72)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C54(0.79); C64(0.79)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C54(0.75); C64(0.76)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C54(0.57); C64(0.52)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) Complex I NDUFB11 subunit family Q9NX14
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
Transmembrane reductase CYB561D2 (CYB561D2) . O14569
Transporter and channel
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Protein cornichon homolog 1 (CNIH1) Cornichon family O95406
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Integral membrane protein 2A (ITM2A) ITM2 family O43736
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Myelin and lymphocyte protein (MAL) MAL family P21145
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Magnesium transporter NIPA4 (NIPAL4) NIPA family Q0D2K0
Cardiac phospholamban (PLN) Phospholamban family P26678
Secretory carrier-associated membrane protein 4 (SCAMP4) SCAMP family Q969E2
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Protein unc-93 homolog B1 (UNC93B1) Unc-93 family Q9H1C4
Uroplakin-2 (UPK2) Uroplakin-2 family O00526
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) . Q9NWW5
Transmembrane protein 100 (TMEM100) . Q9NV29
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C motif chemokine 9 (CXCL9) Intercrine alpha (chemokine CxC) family Q07325
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Apolipoprotein D (APOD) Lipocalin family P05090
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
MAL-like protein (MALL) MAL family Q13021
Nesprin-4 (SYNE4) Nesprin family Q8N205
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Protein reprimo (RPRM) Reprimo family Q9NS64
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Asialoglycoprotein receptor 1 (ASGR1) . P07306
B-cell differentiation antigen CD72 (CD72) . P21854
Epididymal secretory protein E3-beta (EDDM3B) . P56851
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Leucine-rich single-pass membrane protein 2 (LSMEM2) . Q8N112
Olfactomedin-4 (OLFM4) . Q6UX06
Scavenger receptor class F member 1 (SCARF1) . Q14162
Serine-rich and transmembrane domain-containing protein 1 (SERTM1) . A2A2V5
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane protein 140 (TMEM140) . Q9NV12

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264