Details of the Target

General Information of Target

Target ID LDTP01552
Target Name Cyclin-D1-binding protein 1 (CCNDBP1)
Gene Name CCNDBP1
Gene ID 23582
Synonyms
DIP1; GCIP; HHM; Cyclin-D1-binding protein 1; Grap2 and cyclin-D-interacting protein; Human homolog of Maid
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAA
VTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRG
ATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKN
VDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQEL
IIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMC
HLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL
Target Bioclass
Other
Family
CCNDBP1 family
Subcellular location
Cytoplasm
Function
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
Uniprot ID
O95273
Ensemble ID
ENST00000300213.9
HGNC ID
HGNC:1587

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.V73F .
LNCaP clone FGC SNV: p.V135I .
LS180 SNV: p.A67D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C89(0.63)  LDD2098  [1]
IPM
 Probe Info  		C89(1.10)  LDD1702  [1]
DBIA
 Probe Info  		C89(0.86)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C89(0.86)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C89(0.93)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C89(0.87)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C89(0.85)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C89(0.78)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C89(0.83)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C89(0.84)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C89(0.74)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C89(0.84)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C89(0.74)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C89(0.81)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C89(0.86)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C89(0.95)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C89(0.83)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C89(0.75)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C89(0.76)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C89(1.13)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C89(0.89)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C89(0.88)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C89(0.94)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C89(1.06)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C89(1.13)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C89(1.04)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C89(0.92)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C89(0.96)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C89(1.59)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C89(1.03)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C89(0.95)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C89(1.13)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C89(0.98)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C89(0.94)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C89(1.06)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C89(0.92)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C89(0.95)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C89(0.86)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C89(1.19)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C89(0.93)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C89(0.97)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C89(0.99)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C89(0.95)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C89(1.05)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C89(0.94)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C89(1.02)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C89(0.97)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C89(0.80)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C89(0.87)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C89(1.05)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C89(0.96)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C89(0.97)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C89(1.40)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C89(0.88)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C89(1.01)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C89(1.06)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C89(1.17)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C89(1.64)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C89(0.83)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C89(1.23)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C89(1.00)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C89(1.32)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C89(1.15)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C89(1.04)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C89(1.10)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C89(1.15)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C89(1.44)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C89(0.98)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C89(0.93)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C89(0.93)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C89(0.89)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C89(0.94)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C89(0.87)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C89(0.85)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C89(0.85)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C89(0.89)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C89(1.10)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C89(1.03)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C89(0.92)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C89(0.90)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C89(0.88)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C89(0.98)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C89(0.88)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C89(0.86)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C89(0.88)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C89(0.81)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C89(0.84)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C89(1.05)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C89(0.89)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C89(0.79)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C89(0.86)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C89(0.93)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C89(0.98)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C89(0.66)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C89(0.77)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C89(0.78)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C89(0.69)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C89(0.71)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C89(0.72)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C89(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C89(1.07)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C89(1.11)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C89(1.07)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C89(1.03)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C89(1.13)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C89(0.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C89(0.96)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C89(1.00)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C89(1.11)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C89(1.02)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C89(1.07)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C89(1.05)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C89(0.88)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C89(0.75)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C89(0.96)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C89(0.74)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C89(0.97)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C89(0.73)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C89(0.76)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C89(0.78)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C89(0.81)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C89(0.76)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C89(0.76)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C89(0.83)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C89(0.70)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C89(0.96)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C89(0.84)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C89(0.84)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C89(0.78)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C89(0.77)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C89(0.82)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C89(0.88)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C89(0.73)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C89(0.82)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C89(0.80)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C89(0.72)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C89(1.01)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C89(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C89(0.76)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C89(0.69)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C89(0.90)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C89(0.84)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C89(0.85)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C89(0.92)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C89(1.05)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C89(1.01)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C89(0.84)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C89(0.87)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C89(0.77)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C89(0.85)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C89(0.82)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C89(0.87)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C89(0.87)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C89(0.87)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C89(0.79)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C89(0.95)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C89(0.91)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C89(0.91)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C89(0.86)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C89(0.88)  LDD0592  [2]
 LDCM0630  CCW28-3 231MFP C300(1.16)  LDD2214  [5]
 LDCM0367  CL1 HCT 116 C89(0.94)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C89(0.78)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C89(0.97)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C89(1.00)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C89(0.84)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C89(1.02)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C89(0.90)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C89(0.94)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C89(0.98)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C89(0.96)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C89(1.04)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C89(0.87)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C89(0.70)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C89(0.88)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C89(0.91)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C89(1.01)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C89(0.77)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C89(0.77)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C89(0.72)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C89(0.79)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C89(0.76)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C89(0.84)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C89(0.86)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C89(0.80)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C89(0.73)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C89(0.91)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C89(0.90)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C89(0.85)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C89(0.94)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C89(0.98)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C89(0.91)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C89(0.82)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C89(0.97)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C89(0.71)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C89(0.75)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C89(0.74)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C89(1.12)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C89(1.00)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C89(1.03)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C89(1.16)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C89(0.86)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C89(1.07)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C89(1.19)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C89(1.21)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C89(0.98)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C89(1.04)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C89(1.03)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C89(1.24)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C89(1.10)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C89(1.03)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C89(1.02)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C89(0.86)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C89(1.18)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C89(1.13)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C89(1.00)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C89(0.91)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C89(1.01)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C89(0.94)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C89(0.96)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C89(0.89)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C89(1.01)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C89(0.86)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C89(0.84)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C89(0.86)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C89(0.81)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C89(0.93)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C89(0.94)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C89(0.96)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C89(0.97)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C89(1.13)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C89(0.78)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C89(1.30)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C89(0.82)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C89(2.66)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C89(0.88)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C89(0.70)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C89(1.01)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C89(1.28)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C89(1.09)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C89(1.16)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C89(0.87)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C89(1.20)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C89(1.18)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C89(0.91)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C89(1.59)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C89(0.87)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C89(1.02)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C89(0.84)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C89(0.98)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C89(1.03)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C89(1.00)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C89(0.82)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C89(0.88)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C89(0.82)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C89(0.89)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C89(0.95)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C89(0.93)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C89(0.87)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C89(0.92)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C89(0.87)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C89(0.78)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C89(0.70)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C89(0.75)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C89(0.92)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C89(0.83)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C89(0.78)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C89(0.91)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C89(1.06)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C89(0.97)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C89(1.10)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C89(0.83)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C89(0.93)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C89(0.90)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C89(0.92)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C89(1.14)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C89(0.76)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C89(0.93)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C89(0.91)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C89(1.00)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C89(1.05)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C89(0.94)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C89(0.94)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C89(0.99)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C89(0.92)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C89(1.01)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C89(0.99)  LDD0811  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C89(1.10)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C89(0.89)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C89(0.99)  LDD0744  [2]
 LDCM0022  KB02 T cell-activated C300(16.09)  LDD1708  [6]
 LDCM0023  KB03 A2058 C89(4.32)  LDD2670  [7]
 LDCM0024  KB05 COLO792 C89(4.28)  LDD3310  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C89(0.63)  LDD2098  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C89(0.87)  LDD2114  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paraplegin (SPG7) AAA ATPase family; Peptidase M41 family Q9UQ90
Cullin-5 (CUL5) Cullin family Q93034
Glutathione S-transferase kappa 1 (GSTK1) Kappa family Q9Y2Q3
AMP deaminase 2 (AMPD2) Adenosine and AMP deaminases family Q01433
COP9 signalosome complex subunit 5 (COPS5) Peptidase M67A family Q92905
Proteasome subunit beta type-10 (PSMB10) Peptidase T1B family P40306
E3 SUMO-protein ligase PIAS2 (PIAS2) PIAS family O75928
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) STE Ser/Thr protein kinase family P36507
Serine/threonine-protein kinase 25 (STK25) STE Ser/Thr protein kinase family O00506
GTP-binding protein RAD (RRAD) RGK family P55042
Interferon-inducible GTPase 5 (IRGC) IRG family Q6NXR0
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Monocarboxylate transporter 13 (SLC16A13) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY0
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Potassium-transporting ATPase subunit beta (ATP4B) X(+)/potassium ATPases subunit beta family P51164
Transcription factor
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
High mobility group protein B1 (HMGB1) HMGB family P09429
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 136 (ZNF136) Krueppel C2H2-type zinc-finger protein family P52737
Zinc finger protein 155 (ZNF155) Krueppel C2H2-type zinc-finger protein family Q12901
Zinc finger protein 169 (ZNF169) Krueppel C2H2-type zinc-finger protein family Q14929
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Zinc finger protein 223 (ZNF223) Krueppel C2H2-type zinc-finger protein family Q9UK11
Zinc finger protein 230 (ZNF230) Krueppel C2H2-type zinc-finger protein family Q9UIE0
Zinc finger protein 334 (ZNF334) Krueppel C2H2-type zinc-finger protein family Q9HCZ1
Zinc finger protein 394 (ZNF394) Krueppel C2H2-type zinc-finger protein family Q53GI3
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 439 (ZNF439) Krueppel C2H2-type zinc-finger protein family Q8NDP4
Zinc finger protein 480 (ZNF480) Krueppel C2H2-type zinc-finger protein family Q8WV37
Zinc finger protein 490 (ZNF490) Krueppel C2H2-type zinc-finger protein family Q9ULM2
Zinc finger protein 552 (ZNF552) Krueppel C2H2-type zinc-finger protein family Q9H707
Zinc finger protein 555 (ZNF555) Krueppel C2H2-type zinc-finger protein family Q8NEP9
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 578 (ZNF578) Krueppel C2H2-type zinc-finger protein family Q96N58
Zinc finger protein 627 (ZNF627) Krueppel C2H2-type zinc-finger protein family Q7L945
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 707 (ZNF707) Krueppel C2H2-type zinc-finger protein family Q96C28
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Zinc finger protein 786 (ZNF786) Krueppel C2H2-type zinc-finger protein family Q8N393
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
THAP domain-containing protein 10 (THAP10) . Q9P2Z0
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger and SCAN domain-containing protein 26 (ZSCAN26) . Q16670
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Zinc finger protein 581 (ZNF581) . Q9P0T4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-10 (FZD10) G-protein coupled receptor Fz/Smo family Q9ULW2
Other
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin P2 protein (PMP2) Fatty-acid binding protein (FABP) family P02689
Retinol-binding protein 5 (RBP5) Fatty-acid binding protein (FABP) family P82980
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
Large ribosomal subunit protein eL28 (RPL28) Eukaryotic ribosomal protein eL28 family P46779
Ribosomal protein eL39-like 2 (RPL39L) Eukaryotic ribosomal protein eL39 family Q96EH5
Small ribosomal subunit protein eS28 (RPS28) Eukaryotic ribosomal protein eS28 family P62857
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM74A4/A6 (FAM74A4; FAM74A6) FAM74 family Q5TZK3
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Hemoglobin subunit zeta (HBZ) Globin family P02008
Hyccin (HYCC1) Hyccin family Q9BYI3
Nuclear apoptosis-inducing factor 1 (NAIF1) NAIF1 family Q69YI7
Nanos homolog 2 (NANOS2) Nanos family P60321
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Pre-mRNA-splicing factor SYF2 (SYF2) SYF2 family O95926
Transcription elongation factor A protein-like 1 (TCEAL1) TFS-II family Q15170
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Trafficking protein particle complex subunit 5 (TRAPPC5) TRAPP small subunits family Q8IUR0
Large ribosomal subunit protein uL10 (RPLP0) Universal ribosomal protein uL10 family P05388
Large ribosomal subunit protein uL15m (MRPL15) Universal ribosomal protein uL15 family Q9P015
Ribosomal protein uL30-like (RPL7L1) Universal ribosomal protein uL30 family Q6DKI1
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) Universal ribosomal protein uS4 family Q9NV31
UPF0193 protein EVG1 (C22orf23) UPF0193 (EVG1) family Q9BZE7
Putative UPF0633 protein LOC554249 UPF0633 family Q5XG85
Protein Wnt-11 (WNT11) Wnt family O96014
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Protein lin-37 homolog (LIN37) . Q96GY3
Protein PIMREG (PIMREG) . Q9BSJ6
Rho GTPase-activating protein 22 (ARHGAP22) . Q7Z5H3
Tetratricopeptide repeat protein 23 (TTC23) . Q5W5X9
TYMS opposite strand protein (TYMSOS) . Q8TAI1
U3 small nucleolar RNA-associated protein NOL7 (NOL7) . Q9UMY1
Uncharacterized protein C6orf226 (C6orf226) . Q5I0X4

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840