Details of the Target

General Information of Target

Target ID LDTP01491
Target Name Ribonuclease P protein subunit p14 (RPP14)
Gene Name RPP14
Gene ID 11102
Synonyms
Ribonuclease P protein subunit p14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALP
LDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRE
LVLD
Target Bioclass
Enzyme
Family
Eukaryotic/archaeal RNase P protein component 2 family
Subcellular location
Nucleus, nucleolus
Function Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Uniprot ID
O95059
Ensemble ID
ENST00000295959.10
HGNC ID
HGNC:30327

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K49(4.97)  LDD2217  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C31(1.31)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C25(1.29); C31(1.29)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C31(0.85)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C31(1.13)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C31(1.40)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C31(1.11)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C31(1.04)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C31(1.34)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C31(1.00)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C31(1.27)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C31(1.06)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C31(0.77)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C31(0.89)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C31(0.94)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C31(0.81)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C31(1.41)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C31(1.13)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C31(0.73)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C31(1.29)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C31(1.38)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C31(1.26)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C31(1.30)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C31(1.06)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C31(1.45)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C31(0.88)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C31(1.49)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C31(1.01)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C31(1.35)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C31(1.11)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C31(1.46)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C31(1.25)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C31(1.53)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C31(0.98)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C31(0.81)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C31(1.51)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C31(1.53)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C31(1.10)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C31(1.14)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C31(1.47)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C31(1.68)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C31(1.09)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C31(1.26)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C31(1.42)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C31(1.42)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C31(1.51)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C31(1.03)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C31(1.47)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C31(1.63)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C31(1.96)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C31(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C31(1.06)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C31(1.03)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C31(1.21)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C31(1.18)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C31(2.41)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C31(1.63)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C31(1.33)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C31(1.14)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C31(0.89)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C31(1.01)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C31(1.94)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C31(1.02)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C31(1.25)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C31(0.95)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C31(1.16)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C31(0.84)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C31(1.01)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C31(0.96)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C25(1.21); C31(1.21)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C31(1.16)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C31(0.88)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C31(1.10)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C31(0.95)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C31(1.17)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C31(0.99); C25(1.13)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C25(0.88); C31(0.96)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C25(1.01); C31(1.08)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C31(1.02); C25(1.05)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C25(1.17); C31(1.29)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C25(1.13); C31(1.13)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C25(1.18); C31(1.22)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C31(1.11); C25(1.17)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C25(1.06); C31(1.13)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C31(1.01); C25(1.05)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C31(1.14); C25(1.22)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C31(0.93)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C31(0.92)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C31(0.91)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C31(0.86)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C78(1.26); C31(0.94)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C25(1.17); C31(1.17)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C31(0.92)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C31(0.97)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C31(0.96)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C31(0.87)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C31(0.93)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C31(1.00)  LDD1546  [6]
 LDCM0308  AC46 HCT 116 C31(1.26)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C31(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C31(1.27)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C31(1.42)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C25(1.17); C31(1.17)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C31(1.54)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C31(1.46)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C31(1.29)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C31(1.14)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C31(1.29)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C31(0.93)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C31(1.36)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C31(1.10)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C31(1.17)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C31(1.95)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C31(1.40)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C31(0.97)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C31(1.05)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C31(1.49)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C31(2.05)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C31(1.16)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C31(1.48)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C31(1.09)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C31(1.63)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C31(0.79)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C31(0.74)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C31(1.15)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C31(1.02)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C31(0.82)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C31(0.63)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C31(0.60)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C31(1.02)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C31(1.82)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C31(0.64)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C31(1.07)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C31(1.23)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C31(0.89)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C31(1.83)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C31(1.01)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C31(1.15)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C31(1.39)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C31(0.95)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C31(1.27)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C31(1.33)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C31(1.18)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C31(1.21)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C31(1.12)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C31(1.44)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C31(1.60)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C31(1.17)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C31(1.25)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C31(1.12)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C31(1.26)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C31(1.37)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C31(1.41)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C31(1.94)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C31(0.97)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C31(1.13)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C31(1.17)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C31(1.07)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C31(1.33)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C31(1.31)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C31(0.76); C25(0.86)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C25(0.86); C31(0.91)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C25(1.00); C31(1.00)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C31(1.42)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C31(1.26)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C31(1.29)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C31(1.30)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C31(0.78)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C31(0.72)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C31(0.86)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C31(0.84)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C31(0.93)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C31(0.96); C25(1.04)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C31(0.88)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C31(0.94)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C25(0.89); C31(1.00)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C25(0.84); C31(0.96)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C25(0.89); C31(1.08)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C25(0.98); C31(1.07)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C31(1.00); C25(1.06)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C78(1.12); C31(0.87)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C78(0.97); C31(0.94)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C78(0.90); C31(0.85)  LDD1593  [6]
 LDCM0390  CL12 HCT 116 C25(0.76); C31(0.87)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C31(0.90)  LDD1595  [6]
 LDCM0392  CL121 HCT 116 C31(1.05)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C31(1.18)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C31(1.20)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C31(1.20)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C31(1.51)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C31(0.79)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C31(1.14)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C31(1.14)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C31(0.94); C25(1.00)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C31(0.81); C25(0.94)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C25(0.62); C31(0.73)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C31(0.98)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C31(0.92)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C31(0.97)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C31(1.02)  LDD1610  [6]
 LDCM0407  CL2 HCT 116 C31(0.80); C25(1.07)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C31(1.06)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C31(0.83)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C31(0.93)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C78(1.43); C31(1.16)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C31(1.03)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C78(1.01); C31(0.94)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C78(1.03); C31(0.91)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C78(1.15); C31(0.96)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C31(1.02)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C31(0.96)  LDD1621  [6]
 LDCM0418  CL3 HCT 116 C25(1.10); C31(0.82)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C31(0.95)  LDD1623  [6]
 LDCM0420  CL31 HCT 116 C31(0.87)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C31(0.86)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C31(0.85)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C31(1.56)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C31(1.03)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C31(0.93)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C31(1.00)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C31(0.92)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C25(1.13); C31(0.97)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C31(0.91)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C31(0.99)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C31(0.96)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C31(0.98)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C31(0.86)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C31(0.86)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C31(0.77)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C31(0.91)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C31(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C31(0.88)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C25(0.99); C31(0.89)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C31(0.82)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C31(0.85)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C31(0.95)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C31(0.88)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C31(0.76)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C31(0.79)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C31(0.99)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C31(0.86)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C31(1.00)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C31(0.82)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C25(0.92); C31(0.80)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C31(0.92)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C25(1.01); C31(1.01)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C25(0.86); C31(0.86)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C25(1.09); C31(1.09)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C25(1.21); C31(1.21)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C25(0.97); C31(0.97)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C25(1.16); C31(1.16)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C25(1.15); C31(1.15)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C25(1.09); C31(1.09)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C25(0.88); C31(0.88)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C25(0.98); C31(0.90)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C25(1.00); C31(1.00)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C25(0.85); C31(0.85)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C25(0.92); C31(0.92)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C25(1.07); C31(1.07)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C25(1.08); C31(1.08)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C25(1.09); C31(1.05)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C25(1.46); C31(1.17)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C25(0.96); C31(0.99)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C25(1.68); C31(1.50)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C25(0.67); C31(0.72)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C25(1.98); C31(1.52)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C25(1.27); C31(1.21)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C25(1.49); C31(1.28)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C25(1.52); C31(1.16)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C25(0.97); C31(0.92)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C25(1.35); C31(1.31)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C25(1.19); C31(1.10)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C25(1.79); C31(1.35)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C25(1.21); C31(1.02)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C25(0.88); C31(0.92)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C25(1.03); C31(1.05)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C25(1.00); C31(1.04)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C25(1.08); C31(1.08)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C25(0.85); C31(0.85)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C25(0.87); C31(0.87)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C25(1.08); C31(1.08)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C25(1.08); C31(1.08)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C25(1.34); C31(1.34)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C25(1.25); C31(1.25)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C25(1.18); C31(1.18)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C25(1.13); C31(1.13)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C78(1.08); C31(0.88)  LDD1698  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C78(1.05)  LDD1702  [7]
 LDCM0625  F8 Ramos C78(0.61)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C78(0.97)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C78(0.13)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C78(1.05)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C78(0.83)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C78(0.30)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C78(0.58)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C78(1.05)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C78(1.26)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C78(0.76)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C78(0.53)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C78(0.88)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C78(0.82)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C78(1.00)  LDD2201  [8]
 LDCM0468  Fragment33 HCT 116 C25(1.10); C31(1.10)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C78(0.74)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C78(0.46)  LDD2184  [8]
 LDCM0427  Fragment51 HCT 116 C31(1.22)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C78(0.94)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C78(0.83)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C78(0.64)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C78(0.96)  LDD2188  [8]
 LDCM0022  KB02 HCT 116 C31(1.32); C25(1.20)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C31(1.16); C25(1.13)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C31(1.36); C25(1.09)  LDD0082  [3]
 LDCM0131  RA190 MM1.R C31(1.08)  LDD0304  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p29 (POP4) Eukaryotic/archaeal RNase P protein component 1 family O95707
Ribonuclease P protein subunit p30 (RPP30) Eukaryotic/archaeal RNase P protein component 3 family P78346
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gem-associated protein 2 (GEMIN2) Gemin-2 family O14893

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.