Details of the Target

General Information of Target

Target ID LDTP01317
Target Name Ribonuclease P protein subunit p20 (POP7)
Gene Name POP7
Gene ID 10248
Synonyms
RPP20; Ribonuclease P protein subunit p20; RNaseP protein p20; Ribonucleases P/MRP protein subunit POP7 homolog; hPOP7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGA
RGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREP
LTRIRNNSAIHIRVFRVTPK
Target Bioclass
Enzyme
Family
Histone-like Alba family
Subcellular location
Nucleus, nucleolus
Function
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Uniprot ID
O75817
Ensemble ID
ENST00000303151.5
HGNC ID
HGNC:19949

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y20(19.40); Y38(26.11)  LDD3495  [1]
DBIA
 Probe Info  		C66(1.31)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
HHS-465
 Probe Info  		K24(0.00); Y20(0.00)  LDD2240  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C66(1.43)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C66(1.51)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C66(0.95)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C66(0.95)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C66(0.94)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C66(0.91)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C66(0.92)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C66(0.93)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C66(0.98)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C66(0.87)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C66(0.90)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C66(0.92)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C66(1.86)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C66(0.98)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C66(1.06)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C66(0.98)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C66(0.80)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C66(1.07)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C66(1.46)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C66(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C66(0.92)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C66(1.51)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C66(0.90)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C66(1.23)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C66(1.16)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C66(1.07)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C66(1.07)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C66(0.93)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C66(0.62)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C66(0.87)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C66(1.12)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C66(0.72)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C66(0.98)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C66(0.83)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C66(0.99)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C66(0.95)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C66(0.99)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C66(0.94)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C66(0.85)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C66(0.87)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C66(0.84)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C66(0.87)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C66(1.07)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C66(0.87)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C66(1.38)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C66(0.93)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C66(0.91)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C66(0.83)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C66(1.13)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C66(1.13)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C66(1.24)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C66(1.17)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C66(1.09)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C66(1.24)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C66(1.19)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C66(1.06)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C66(0.90)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C66(0.96)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C66(1.07)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C66(1.45)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C66(1.18)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C66(1.17)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C66(1.40)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C66(1.11)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C66(0.85)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C66(1.13)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C66(1.03)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C66(1.32)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C66(0.84)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C66(1.00)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C66(0.80)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C66(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C66(0.82)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C66(1.25)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C66(0.98)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C66(2.19)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C66(1.21)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C66(1.54)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C66(1.91)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C66(1.45)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C66(1.26)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C66(1.74)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C66(1.46)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C66(1.46)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C66(1.09)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C66(0.95)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C66(1.06)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C66(1.04)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C66(0.97)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C66(2.07)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C66(1.09)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C66(0.97)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C66(1.03)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C66(1.04)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C66(0.96)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C66(1.03)  LDD1546  [8]
 LDCM0308  AC46 HCT 116 C66(0.99)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C66(1.08)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C66(0.98)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C66(1.04)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C66(2.13)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C66(1.26)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C66(0.99)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C66(0.81)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C66(0.86)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C66(0.88)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C66(1.00)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C66(0.73)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C66(1.08)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C66(0.97)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C66(0.98)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C66(0.93)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C66(0.86)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C66(0.84)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C66(0.98)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C66(0.93)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C66(0.91)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C66(0.79)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C66(0.89)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C66(0.84)  LDD0929  [2]
 LDCM0334  AC7 HCT 116 C66(1.00)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C66(0.70)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C66(1.03)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C66(0.94)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C66(1.15)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C66(1.05)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C66(1.03)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C66(0.87)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C66(1.19)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C66(1.14)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C66(0.97)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C66(1.07)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C66(0.76)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C66(1.18)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C66(0.77)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C66(0.95)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C66(1.18)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C66(0.83)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C66(0.82)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C66(1.24)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C66(1.30)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C66(0.86)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C66(1.31)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C66(3.99)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C66(0.96)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C66(0.89)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C66(0.97)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C66(1.15)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C66(1.36)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C66(1.18)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C66(0.92)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C66(0.84)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C66(1.04)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C66(0.86)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C66(0.84)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C66(1.03)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C66(1.35)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C66(0.84)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C66(1.11)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C66(1.37)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C66(1.23)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C66(1.07)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C66(0.94)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C66(1.46)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C66(0.94)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C66(1.08)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C66(0.93)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C66(1.02)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C66(0.97)  LDD1595  [8]
 LDCM0392  CL121 HCT 116 C66(0.78)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C66(0.97)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C66(1.00)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C66(0.90)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C66(0.99)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C66(1.02)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C66(1.20)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C66(1.24)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C66(0.95)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C66(1.07)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C66(0.90)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C66(0.94)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C66(0.92)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C66(0.98)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C66(1.11)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C66(1.08)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C66(1.02)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C66(0.96)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C66(1.05)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C66(1.08)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C66(0.98)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C66(1.05)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C66(1.01)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C66(1.01)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C66(0.94)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C66(0.96)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C66(0.97)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C66(1.13)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C66(0.93)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C66(0.84)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C66(1.01)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C66(1.09)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C66(0.96)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C66(1.02)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C66(1.11)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C66(0.94)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C66(1.04)  LDD1633  [8]
 LDCM0430  CL40 HCT 116 C66(1.07)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C66(0.97)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C66(1.03)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C66(1.15)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C66(0.92)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C66(1.06)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C66(0.98)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C66(1.02)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C66(0.93)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C66(0.99)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C66(1.04)  LDD1644  [8]
 LDCM0441  CL50 HCT 116 C66(0.91)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C66(1.04)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C66(1.07)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C66(1.09)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C66(0.95)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C66(0.78)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C66(0.96)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C66(1.12)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C66(1.02)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C66(1.02)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C66(1.03)  LDD1654  [8]
 LDCM0452  CL60 HCT 116 C66(0.88)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C66(0.76)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C66(0.91)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C66(1.03)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C66(0.88)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C66(0.84)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C66(0.83)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C66(0.94)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C66(1.03)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C66(1.02)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C66(0.93)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C66(1.04)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C66(1.10)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C66(1.00)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C66(1.07)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C66(1.11)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C66(1.19)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C66(1.11)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C66(1.22)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C66(1.27)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C66(0.84)  LDD1676  [8]
 LDCM0474  CL80 HCT 116 C66(1.18)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C66(1.41)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C66(1.50)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C66(1.25)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C66(1.30)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C66(0.98)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C66(1.26)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C66(1.17)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C66(1.21)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C66(1.22)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C66(1.09)  LDD1687  [8]
 LDCM0485  CL90 HCT 116 C66(1.16)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C66(1.35)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C66(0.90)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C66(0.82)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C66(0.87)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C66(1.05)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C66(1.75)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C66(1.68)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C66(2.47)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C66(1.97)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C66(0.97)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C66(0.86)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C66(0.96)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C66(0.98)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C66(1.01)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C66(1.42)  LDD3310  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C66(0.81)  LDD2206  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C66(0.88)  LDD2207  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Ribonuclease P protein subunit p25-like protein (RPP25L) Histone-like Alba family Q8N5L8
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EKC/KEOPS complex subunit LAGE3 (LAGE3) CTAG/PCC1 family Q14657
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Guanine nucleotide exchange factor C9orf72 (C9orf72) . Q96LT7

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.