Details of the Target

General Information of Target

Target ID LDTP00884
Target Name Zinc finger and BTB domain-containing protein 14 (ZBTB14)
Gene Name ZBTB14
Gene ID 7541
Synonyms
ZFP161; ZNF478; Zinc finger and BTB domain-containing protein 14; Zinc finger protein 161 homolog; Zfp-161; Zinc finger protein 478; Zinc finger protein 5 homolog; ZF5; Zfp-5; hZF5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTY
FKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFL
DKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDDSPSDDTVEG
TPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALT
FNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHT
ADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERP
FACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTP
SAIQSETEQLQAAAMAAEAEQQLETIACS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
Uniprot ID
O43829
Ensemble ID
ENST00000357006.8
HGNC ID
HGNC:12860
ChEMBL ID
CHEMBL5069377

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C215(1.09)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C215(1.09)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C215(1.24)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C215(1.76)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C215(1.51)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C215(1.17)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C215(1.57)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C215(1.25)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C215(1.52)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C215(1.93)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C215(1.49)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C215(1.73)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C215(1.23)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C215(1.23)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C215(1.58)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C215(1.73)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C215(1.54)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C215(0.97)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C215(0.89)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C215(0.97)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C215(1.05)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C215(1.09)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C215(0.97)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C215(1.14)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C215(1.03)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C215(0.96)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C215(0.93)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C215(0.96)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C215(0.74)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C215(0.96)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C215(0.92)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C215(0.89)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C215(0.93)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C215(0.70)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C215(0.81)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C215(1.01)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C215(0.83)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C215(1.08)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C215(1.09)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C215(1.04)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C215(0.93)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C215(1.00)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C215(1.02)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C215(1.07)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C215(1.24)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C215(1.11)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C215(1.29)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C215(1.21)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C215(1.06)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C215(1.04)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C215(0.92)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C215(0.96)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C215(0.91)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C215(0.90)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C215(1.01)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C215(1.09)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C215(1.18)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C215(0.98)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C215(0.87)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C215(0.91)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C215(1.14)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C215(0.82)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C215(1.05)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C215(0.93)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C215(0.93)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C215(1.00)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C215(1.43)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C215(1.02)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C215(1.10)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C215(1.01)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C215(1.19)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C215(1.01)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C215(1.04)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C215(0.95)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C215(0.88)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C215(1.15)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C215(1.54)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C215(1.33)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C215(1.15)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C215(1.07)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C215(1.26)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C215(1.26)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C215(1.37)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C215(1.38)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C215(1.39)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C215(0.97)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C215(1.11)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C215(1.07)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C215(1.09)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C215(1.07)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C215(1.12)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C215(0.99)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C215(1.09)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C215(0.95)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C215(1.36)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C215(1.01)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C215(0.96)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C215(1.30)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C215(1.06)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C215(1.09)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C215(1.21)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C215(1.10)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C215(1.09)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C215(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C215(1.05)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C215(1.09)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C215(1.04)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C215(1.12)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C215(1.15)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C215(0.91)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C215(0.93)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C215(1.01)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C215(1.13)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C215(1.06)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C215(1.11)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C215(1.03)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C215(1.07)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C215(1.05)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C215(1.14)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C215(1.04)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C215(1.12)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C215(1.02)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C215(0.92)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C215(1.00)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C215(1.09)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C215(0.86)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C215(1.19)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C215(1.21)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C215(0.94)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C215(1.23)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C215(0.95)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C215(1.03)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C215(1.02)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C215(1.15)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C215(1.14)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C215(1.07)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C215(0.97)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C215(1.01)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C215(1.21)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C215(1.07)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C215(1.35)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C215(1.07)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C215(1.03)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C215(1.01)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C215(1.07)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C215(1.16)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C215(1.15)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C215(1.25)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C215(1.09)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C215(1.47)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C215(1.11)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C215(1.37)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C215(1.37)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C215(1.85)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C215(1.64)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C215(1.05)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C215(1.15)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C215(1.61)  LDD0592  [1]
 LDCM0632  CL-Sc Hep-G2 C124(1.55)  LDD2227  [3]
 LDCM0367  CL1 HCT 116 C215(0.87)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C215(1.23)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C215(1.11)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C215(1.21)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C215(1.01)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C215(1.01)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C215(1.02)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C215(1.16)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C215(1.40)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C215(1.20)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C215(1.24)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C215(1.21)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C215(1.35)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C215(1.42)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C215(1.14)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C215(1.06)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C215(1.29)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C215(1.23)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C215(1.32)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C215(1.28)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C215(1.05)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C215(1.03)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C215(1.12)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C215(1.56)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C215(1.12)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C215(1.19)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C215(1.10)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C215(1.07)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C215(1.20)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C215(1.16)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C215(1.02)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C215(1.10)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C215(0.96)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C215(1.25)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C215(1.06)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C215(1.14)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C215(1.10)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C215(1.10)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C215(1.17)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C215(1.23)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C215(0.93)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C215(1.28)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C215(1.45)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C215(1.67)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C215(1.13)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C215(1.28)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C215(1.32)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C215(1.10)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C215(1.24)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C215(1.26)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C215(1.42)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C215(0.95)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C215(1.06)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C215(1.01)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C215(1.09)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C215(1.10)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C215(1.37)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C215(1.30)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C215(1.15)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C215(1.36)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C215(1.25)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C215(1.01)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C215(1.26)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C215(1.16)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C215(1.55)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C215(1.45)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C215(1.26)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C215(1.38)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C215(1.09)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C215(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C215(0.92)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C215(0.98)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C215(1.05)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C215(1.02)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C215(1.20)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C215(1.22)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C215(0.84)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C215(0.88)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C215(0.98)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C215(0.96)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C215(0.90)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C215(0.89)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C215(0.88)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C215(1.28)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C215(0.98)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C215(1.05)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C215(1.10)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C215(1.10)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C215(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C215(1.03)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C215(1.40)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C215(1.20)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C215(1.13)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C215(1.04)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C215(1.29)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C215(1.16)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C215(1.14)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C215(1.10)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C215(1.15)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C215(1.14)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C215(1.11)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C215(1.01)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C215(1.12)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C215(1.39)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C215(1.30)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C215(1.03)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C215(1.23)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C215(1.52)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C215(1.38)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C215(1.65)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C215(1.15)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C215(1.02)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C215(1.29)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C215(1.41)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C215(1.74)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C215(1.15)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C215(0.85)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C215(1.25)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C215(1.08)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C215(0.93)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C215(1.06)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C215(1.17)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C215(1.13)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C215(1.10)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C215(1.18)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C215(1.18)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C215(1.16); C36(0.99)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C215(1.12)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C215(1.49)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C215(1.01); C36(1.04)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C215(1.11); C36(0.89)  LDD1497  [6]
 LDCM0024  KB05 NCI-N87 C215(1.81)  LDD3364  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
N-alpha-acetyltransferase 11 (NAA11) Acetyltransferase family Q9BSU3
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Caspase-6 (CASP6) Peptidase C14A family P55212
Calpain-6 (CAPN6) Peptidase C2 family Q9Y6Q1
Cyclin-dependent kinase 16 (CDK16) CMGC Ser/Thr protein kinase family Q00536
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
Cytochrome c (CYCS) Cytochrome c family P99999
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Optineurin (OPTN) . Q96CV9
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Small ribosomal subunit protein eS25 (RPS25) Eukaryotic ribosomal protein eS25 family P62851
Small ribosomal subunit protein eS7 (RPS7) Eukaryotic ribosomal protein eS7 family P62081
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Integrator complex subunit 3 (INTS3) Integrator subunit 3 family Q68E01
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
MAD2L1-binding protein (MAD2L1BP) MAD2L1BP family Q15013
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
U2 small nuclear ribonucleoprotein B'' (SNRPB2) RRM U1 A/B'' family P08579
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Large ribosomal subunit protein uL11m (MRPL11) Universal ribosomal protein uL11 family Q9Y3B7
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
UPF0561 protein C2orf68 (C2orf68) UPF0561 family Q2NKX9
Gelsolin (GSN) Villin/gelsolin family P06396
Protein Wnt-9a (WNT9A) Wnt family O14904
Chromobox protein homolog 8 (CBX8) . Q9HC52
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) . Q8N8B7
Ubiquilin-1 (UBQLN1) . Q9UMX0
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840