Details of the Target

General Information of Target

Target ID LDTP00845
Target Name Probable 18S rRNA (guanine-N(7))-methyltransferase (BUD23)
Gene Name BUD23
Gene ID 114049
Synonyms
MERM1; WBSCR22; Probable 18S rRNA; guanine-N(7))-methyltransferase; EC 2.1.1.-; Bud site selection protein 23 homolog; Metastasis-related methyltransferase 1; Williams-Beuren syndrome chromosomal region 22 protein; rRNA methyltransferase and ribosome maturation factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDI
GCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCI
SISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATK
AGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMS
RRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, BUD23/WBSCR22 family
Subcellular location
Nucleus
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.
Uniprot ID
O43709
Ensemble ID
ENST00000265758.7
HGNC ID
HGNC:16405

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.N52H .
LU65 SNV: p.W251L .
RVH421 SNV: p.G118D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y272(10.99)  LDD0257  [1]
Probe 1
 Probe Info  		Y191(22.19)  LDD3495  [2]
DBIA
 Probe Info  		C203(44.63)  LDD0209  [3]
HHS-482
 Probe Info  		Y164(1.18)  LDD0285  [4]
HHS-475
 Probe Info  		Y164(1.32)  LDD0264  [5]
HHS-465
 Probe Info  		Y164(5.41)  LDD2237  [6]
ATP probe
 Probe Info  		K196(0.00); K198(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.02  LDD1733  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C203(0.92); C129(0.98)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C203(1.12); C129(0.98)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C129(0.87)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C129(0.99)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C203(1.05); C129(1.00)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C203(1.08)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C203(0.84); C129(0.95)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C203(1.02); C129(0.92)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C129(0.77)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C203(1.00); C129(0.95)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C129(1.00)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C203(0.96); C129(1.02)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C203(1.33); C129(0.90)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C203(0.93)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C203(0.96); C129(0.89)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C203(1.20); C129(0.87)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C203(1.06); C129(1.16)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C129(0.93)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C129(0.95)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C203(1.06); C129(1.04)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C129(0.84)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C203(1.25); C129(0.87)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C203(0.79)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C203(0.96); C129(0.93)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C203(0.84); C129(1.03)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C203(1.04); C129(0.98)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C129(0.92)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C129(0.98)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C203(1.04); C129(1.00)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C203(0.99); C129(1.04)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C203(1.24)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C129(0.98)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C203(0.93); C129(0.95)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C203(0.90); C129(1.08)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C203(1.12); C129(1.13)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C129(0.93)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C129(0.98)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C203(0.96); C129(1.06)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C203(0.98); C129(0.96)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C203(1.21)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C203(1.05); C129(0.94)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C203(1.30); C129(0.96)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C203(0.98); C129(0.98)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C203(1.17); C129(0.96)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C129(0.96)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C129(0.86)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C203(1.11); C129(0.95)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C203(1.02); C129(0.86)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C203(1.02)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C203(1.12); C129(0.95)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C203(1.05); C129(1.02)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C203(1.00); C129(1.12)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C129(1.00)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C203(0.94); C129(0.99)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C129(0.95)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C203(1.09); C129(1.05)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C203(0.98); C129(0.92)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C203(1.02)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C203(1.07); C129(0.97)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C203(0.98)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C203(0.99); C129(1.03)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C203(0.99); C129(0.94)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C203(1.12); C129(0.90)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C203(1.03); C129(1.03)  LDD1514  [14]
 LDCM0367  CL1 HEK-293T C203(1.10); C129(0.95)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C203(1.02); C129(1.50)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C129(1.04)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C203(0.83); C129(0.99)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C129(0.99)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C203(1.09); C129(0.86)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C129(1.29)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C203(1.05); C129(0.89)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C129(0.93)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C203(1.10); C129(0.99)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C129(0.91)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C203(1.79); C129(0.80)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C203(0.79)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C129(0.96)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C203(1.47); C129(0.82)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C129(1.08)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C203(1.14); C129(1.06)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C129(0.98)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C203(1.05); C129(0.86)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C129(0.99)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C203(0.93); C129(0.94)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C129(1.00)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C203(1.28); C129(0.86)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C203(0.98); C129(1.47)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C129(1.27)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C203(0.91); C129(0.85)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C129(0.96)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C203(0.98); C129(0.77)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C129(0.98)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C203(1.12); C129(1.02)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C129(0.93)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C203(0.93); C129(0.89)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C129(0.99)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C203(1.60); C129(0.96)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C129(1.07)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C203(1.56); C129(0.95)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C129(1.49)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C203(1.05); C129(1.04)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C203(1.18); C129(1.33)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C129(1.18)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C129(1.32)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C129(1.21)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C203(0.74); C129(1.28)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C203(1.10); C129(1.56)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C203(1.02)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C203(1.09); C129(1.46)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C203(0.94); C129(0.90)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C129(0.98)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C203(0.89); C129(1.09)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C129(1.00)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C203(1.21); C129(1.13)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C203(1.14); C129(1.20)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C203(1.18); C129(1.27)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C129(1.02)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C129(1.21)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C203(0.92); C129(1.36)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C203(1.00); C129(1.27)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C203(0.96)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C203(1.03); C129(1.19)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C203(1.51); C129(0.87)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C203(0.85); C129(0.97)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C129(1.75)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C129(1.23)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C203(0.94); C129(0.97)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C203(1.22); C129(0.92)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C129(1.12)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C129(1.10)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C203(1.00); C129(1.36)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C203(0.95); C129(1.47)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C203(1.08)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C203(0.97); C129(1.18)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C203(1.10); C129(0.92)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C203(1.15); C129(1.10)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C129(1.03)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C129(1.52)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C203(0.83); C129(0.99)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C203(1.01); C129(1.07)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C129(1.25)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C129(1.04)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C203(0.98); C129(1.21)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C203(1.21); C129(1.35)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C203(1.14)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C203(0.97); C129(1.16)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C203(1.14); C129(1.25)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C203(1.29); C129(0.92)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C129(1.01)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C203(1.64); C129(1.06)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C129(0.93)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C203(1.03); C129(0.92)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C203(1.14); C129(1.19)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C129(1.12)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C129(1.03)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C203(1.17); C129(1.23)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C129(1.17)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C203(0.86); C129(1.32)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C203(1.11)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C203(1.15); C129(1.11)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C203(0.99); C129(0.92)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C129(1.01)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C129(1.02)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C203(0.91); C129(1.01)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C203(0.91); C129(1.27)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C129(1.00)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C129(1.04)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C129(1.09)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C203(1.08); C129(1.27)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C203(1.16); C129(1.22)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C203(0.96)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C203(1.10); C129(1.14)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C203(1.19); C129(0.99)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C129(1.09)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C203(1.08); C129(0.91)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C129(0.89)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C203(1.24); C129(0.86)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C203(0.88); C129(1.58)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C203(0.82); C129(0.96)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C129(0.95)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C129(1.14)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C203(0.90); C129(1.23)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C203(1.02); C129(1.36)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C203(0.83)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C203(0.97); C129(1.20)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C203(1.05); C129(1.03)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C129(1.03)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C203(1.05); C129(0.83)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C203(1.69); C129(0.99)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C203(0.76); C129(0.91)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C129(0.89)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y164(1.32)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y164(1.77)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y164(1.07)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y164(2.27)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y164(0.93)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y164(1.18)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y164(1.29)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y164(1.56)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y164(2.86)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y164(1.97)  LDD0289  [4]
 LDCM0129  JWB202 DM93 Y164(1.67)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y164(1.09)  LDD0292  [4]
 LDCM0022  KB02 HEK-293T C203(1.11)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C203(44.63)  LDD0209  [3]
 LDCM0024  KB05 NCI-H1650 C203(1.48)  LDD3345  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) TRM112 family Q9UI30

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840