Details of the Target

General Information of Target

Target ID LDTP00757
Target Name U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3)
Gene Name PRPF3
Gene ID 9129
Synonyms
HPRP3; PRP3; U4/U6 small nuclear ribonucleoprotein Prp3; Pre-mRNA-splicing factor 3; hPrp3; U4/U6 snRNP 90 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTL
RFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVE
EEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPER
LPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGI
APPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEK
PSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAAR
KTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEH
PAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISN
LMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQG
VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLH
RIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFGEMKFKQCPTENMAREH
FKKHGAEHYWDLALSESVLESTD
Target Bioclass
Other
Subcellular location
Nucleus
Function Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Uniprot ID
O43395
Ensemble ID
ENST00000324862.7
HGNC ID
HGNC:17348

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.K446E DBIA    Probe Info 
HCT116 SNV: p.T29M DBIA    Probe Info 
HSC4 SNV: p.E621K DBIA    Probe Info 
KASUMI2 SNV: p.R115H DBIA    Probe Info 
MEWO SNV: p.R549Ter DBIA    Probe Info 
NCIH1944 SNV: p.E7K DBIA    Probe Info 
ONS76 SNV: p.P255T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y439(13.81); Y546(11.25); Y411(7.62); Y393(5.39)  LDD0257  [1]
ONAyne
 Probe Info  		K495(5.88)  LDD0274  [2]
STPyne
 Probe Info  		K202(7.61); K205(9.38); K40(6.07); K46(2.30)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C651(0.56)  LDD2089  [4]
DBIA
 Probe Info  		C630(0.92)  LDD0533  [5]
ATP probe
 Probe Info  		K589(0.00); K65(0.00); K17(0.00); K20(0.00)  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
CY-1
 Probe Info  		E7(0.00); K5(0.00); R6(0.00)  LDD0246  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C630(0.00); C651(0.00); C37(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C630(0.00); C651(0.00); C37(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
1c-yne
 Probe Info  		K509(0.00); K350(0.00); K202(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C37(0.00); H499(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		13.10  LDD0443  [17]
NAIA_5
 Probe Info  		C630(0.00); C651(0.00); C37(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C651(1.08)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C651(0.97)  LDD2117  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C651(0.50)  LDD2132  [4]
 LDCM0214  AC1 HEK-293T C651(0.98); C37(0.95); C630(0.75)  LDD1507  [18]
 LDCM0215  AC10 PaTu 8988t C651(1.23); C630(0.61)  LDD1094  [5]
 LDCM0216  AC100 HCT 116 C630(0.92)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C630(0.65)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C630(0.57)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C630(0.36)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C630(0.47)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C630(0.45)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C630(0.44)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C630(0.30)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C630(0.76)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C630(0.78)  LDD0542  [5]
 LDCM0226  AC11 PaTu 8988t C651(0.56); C630(0.72)  LDD1105  [5]
 LDCM0227  AC110 HCT 116 C630(0.75)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C630(0.66)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C630(0.47)  LDD0546  [5]
 LDCM0237  AC12 PaTu 8988t C651(1.17); C630(0.60)  LDD1116  [5]
 LDCM0246  AC128 PaTu 8988t C630(0.87)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C630(0.64)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C630(0.83)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C630(0.78)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C630(0.87)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C630(0.37)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C630(0.48)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C630(0.42)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C630(0.44)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C630(0.34)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C630(0.76)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C630(0.67)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C651(0.78); C630(0.89)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C630(0.74)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C630(0.78)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C630(0.66)  LDD1141  [5]
 LDCM0263  AC143 HCT 116 C651(1.95); C630(0.89)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C630(0.55); C651(1.22)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C630(0.76); C651(3.56)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C630(0.78); C651(1.32)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C630(0.50); C651(0.96)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C630(0.23); C651(0.74)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C630(0.49); C651(1.06)  LDD0586  [5]
 LDCM0270  AC15 PaTu 8988t C651(1.12); C630(0.77)  LDD1149  [5]
 LDCM0271  AC150 HCT 116 C651(1.16); C630(1.23)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C630(0.86); C651(2.95)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C630(0.40); C651(1.22)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C630(0.22); C651(0.56)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C651(0.82); C630(0.58)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C651(1.77); C630(0.64)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C651(1.35); C630(0.87)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C651(1.16); C630(0.78)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C630(0.84)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C630(0.63)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C630(0.78)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C651(1.01); C37(0.98); C630(1.01)  LDD1518  [18]
 LDCM0280  AC20 HCT 116 C630(0.90)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C630(0.78)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C630(0.82)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C630(0.76)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C630(0.90)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C651(1.27); C37(0.98); C630(0.68)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C651(0.99); C37(1.00); C630(0.91)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C651(1.02); C37(0.87); C630(1.04)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C651(1.13); C37(0.99); C630(1.11)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C651(1.11); C37(0.96); C630(1.10)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C651(1.03); C37(0.92); C630(1.11)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C651(1.18); C37(1.05); C630(1.02)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C651(1.03); C37(0.96); C630(1.04)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C651(1.07); C37(0.97); C630(0.92)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C651(1.20); C37(0.90); C630(0.84)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C651(1.00); C37(0.92); C630(1.03)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C651(0.96); C37(0.94); C630(1.09)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C651(0.89); C37(0.94); C630(0.99)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C651(1.21); C37(0.94); C630(1.14)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C651(1.17); C37(0.91); C630(1.21)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C651(1.06); C37(1.00); C630(1.17)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C651(1.00); C37(0.87); C630(1.03)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C651(1.03); C37(1.05); C630(0.86)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C651(0.90); C37(0.92); C630(0.78)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C651(1.01); C37(0.90); C630(0.92)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C651(1.05); C37(0.94); C630(1.07)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C651(0.84); C37(0.98); C630(1.00)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C651(1.12); C37(0.98); C630(1.09)  LDD1546  [18]
 LDCM0308  AC46 HCT 116 C630(1.05)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C630(1.01)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C630(1.60)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C630(0.39)  LDD0628  [5]
 LDCM0312  AC5 HEK-293T C651(1.08); C37(0.92); C630(1.23)  LDD1551  [18]
 LDCM0313  AC50 HCT 116 C630(0.51)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C630(1.52)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C630(0.99)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C630(0.64)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C630(0.64)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C630(0.44)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C630(0.34)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C630(0.57)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C630(0.54)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C630(0.35)  LDD0639  [5]
 LDCM0323  AC6 PaTu 8988t C651(1.41); C630(1.02)  LDD1202  [5]
 LDCM0324  AC60 HCT 116 C630(0.76)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C630(1.00)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C630(0.30)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C630(0.65)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C630(0.34)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C630(0.39)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C630(0.51)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C630(0.13)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C630(0.77)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C630(0.71)  LDD0650  [5]
 LDCM0334  AC7 PaTu 8988t C651(1.25); C630(0.89)  LDD1213  [5]
 LDCM0335  AC70 HCT 116 C630(0.32)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C630(1.07)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C630(0.68)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C630(0.25)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C630(0.27)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C630(0.25)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C630(0.46)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C630(0.41)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C630(1.33)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C630(0.85)  LDD0661  [5]
 LDCM0345  AC8 PaTu 8988t C651(1.09); C630(0.93)  LDD1224  [5]
 LDCM0346  AC80 HCT 116 C630(0.57)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C630(1.28)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C630(0.25)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C630(0.24); C651(0.43)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C630(0.30); C651(0.81)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C630(0.75); C651(2.09)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C630(0.56); C651(1.09)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C630(0.93); C651(20.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C630(0.59); C651(1.62)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C630(0.43); C651(1.00)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C630(1.02); C651(2.28)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C630(0.21); C651(0.66)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C630(0.27); C651(0.63)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C630(0.53); C651(1.45)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C630(0.73); C651(1.94)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C630(1.11); C651(2.08)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C630(0.54); C651(1.16)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C630(0.38); C651(1.01)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C630(0.13)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C630(0.76)  LDD0683  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C651(0.48); C630(1.07)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C651(1.44); C630(0.42)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C651(1.00); C630(0.59)  LDD1154  [5]
 LDCM0108  Chloroacetamide HeLa C37(0.00); H499(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C37(1.37); C37(0.77)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C630(1.25)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C630(0.52)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C651(1.00); C37(0.97)  LDD1573  [18]
 LDCM0370  CL101 PaTu 8988t C651(1.53); C630(0.84)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C651(20.00); C630(0.67)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C651(0.38); C630(0.65)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C651(0.77); C630(0.80)  LDD1252  [5]
 LDCM0374  CL105 HCT 116 C630(0.60)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C630(0.60)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C630(0.52)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C630(0.42)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C630(0.76)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C630(0.48)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C630(0.60)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C630(0.75)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C651(1.01); C37(0.87)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C651(1.13); C37(0.97)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C651(0.96); C37(0.97); C630(0.95)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C651(1.13); C37(0.99); C630(1.01)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C651(1.02); C37(0.99)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C651(1.12); C37(0.97)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C651(1.02); C37(1.07); C630(0.98)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C651(1.10); C37(1.01); C630(1.14)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C630(0.38)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C651(1.06); C37(1.00)  LDD1595  [18]
 LDCM0392  CL121 HCT 116 C630(0.84)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C630(1.01)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C630(0.58)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C630(0.47)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C630(1.04)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C630(0.86)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C630(0.82)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C630(0.44)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C630(0.78)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C630(0.93)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C630(0.95)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C630(0.72); C651(0.81)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C630(0.75); C651(1.08)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C630(1.03); C651(20.00)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C630(0.85); C651(1.58)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C630(1.30)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C630(0.49); C651(0.83)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C630(0.50); C651(0.57)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C630(0.32); C651(0.33)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C630(0.76); C651(1.09)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C651(0.61); C630(0.49)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C651(0.83); C630(0.52)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C651(1.75); C630(0.69)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C651(0.81); C630(0.82)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C651(0.96); C630(0.67)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C651(0.74); C630(0.77)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C630(1.02)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C651(0.83); C630(0.79)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C651(1.20); C630(0.88)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C651(1.05); C630(1.15)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C651(1.06); C630(0.96)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C651(0.61); C630(0.53)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C651(0.64); C630(0.48)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C651(0.55); C630(0.57)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C651(0.51); C630(0.46)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C651(0.69); C630(0.51)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C630(1.06)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C651(0.71); C630(0.58)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C651(0.84); C630(0.66)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C651(0.49); C630(0.31)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C651(0.69); C630(0.39)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C651(0.78); C630(0.80)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C651(0.97); C630(0.67)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C651(1.03); C37(1.06); C630(1.22)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C651(0.94); C37(1.07); C630(0.95)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C651(1.00); C37(1.01); C630(0.95)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C651(1.15); C37(0.93)  LDD1643  [18]
 LDCM0440  CL5 HCT 116 C630(1.01)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C651(1.06); C37(1.02); C630(0.86)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C651(0.94); C37(0.91)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C651(1.02); C37(0.87); C630(0.66)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C651(0.98); C37(0.84); C630(0.85)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C651(1.15); C37(1.05); C630(1.00)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C651(1.26); C37(0.93); C630(0.93)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C651(1.03); C37(0.89); C630(0.95)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C651(1.09); C37(0.96); C630(1.18)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C651(1.04); C37(1.08); C630(1.09)  LDD1653  [18]
 LDCM0451  CL6 HCT 116 C630(1.18)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C651(0.96); C37(1.04); C630(0.93)  LDD1655  [18]
 LDCM0453  CL61 HCT 116 C630(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C630(0.98)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C630(0.93)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C630(0.71)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C630(0.99)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C630(0.48)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C630(0.69)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C630(0.94)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C630(1.27)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C630(0.59)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C630(1.03)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C630(0.75)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C630(0.98)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C630(0.78)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C630(0.77)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C630(0.92)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C630(0.76)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C630(0.73)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C630(0.42)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C630(0.38)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C630(1.45)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C630(0.72)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C630(0.37)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C630(0.42)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C630(0.31)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C630(0.61)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C630(0.55)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C630(0.63)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C630(0.48)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C630(0.30)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C630(0.77)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C630(0.64)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C651(1.11); C37(1.07); C630(0.95)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C651(0.86); C37(0.89); C630(0.81)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C651(1.07); C37(0.98); C630(0.92)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C651(1.14); C37(0.88); C630(1.31)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C651(0.89); C37(0.84); C630(0.77)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C651(1.06); C37(0.86); C630(0.92)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C651(1.07); C37(0.83)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C651(1.01); C37(1.03); C630(1.07)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C651(1.10); C37(0.96); C630(1.08)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C651(1.14); C37(0.95); C630(0.92)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C37(2.31); C630(1.33); C651(0.78)  LDD1702  [4]
 LDCM0625  F8 Ramos C37(0.44)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C37(1.03)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C37(6.92)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C37(1.19)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C37(1.52)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C37(1.08)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C37(1.52)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C37(1.81)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C37(1.17)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C37(2.06)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C37(0.58)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C37(1.73)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C37(1.95)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C37(1.20)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C630(0.75)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C37(1.57)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C37(0.31)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C651(0.53); C630(0.37)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C37(1.62)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C37(1.59)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C37(0.36)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C37(1.29)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C651(0.98); C37(0.99)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C651(1.08); C37(0.93)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C651(1.51)  LDD3310  [20]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C651(1.19)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C651(0.56)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C651(0.76)  LDD2090  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C651(0.84)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C651(0.75)  LDD2107  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C651(1.48)  LDD2116  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C651(0.37)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C651(1.29)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C651(1.15)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C651(0.88)  LDD2128  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C651(1.12)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C651(0.98)  LDD2137  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C651(0.39)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) Proteasome subunit S3 family O43242
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZFPM2 (ZFPM2) FOG (Friend of GATA) family Q8WW38
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
SH3KBP1-binding protein 1 (SHKBP1) KCTD3 family Q8TBC3
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
NF-kappa-B-activating protein (NKAP) NKAP family Q8N5F7
Oxysterol-binding protein-related protein 3 (OSBPL3) OSBP family Q9H4L5
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
Survival of motor neuron-related-splicing factor 30 (SMNDC1) SMN family O75940
U4/U6.U5 tri-snRNP-associated protein 1 (SART1) SNU66/SART1 family O43290
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Alpha-taxilin (TXLNA) Taxilin family P40222
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Heat shock factor 2-binding protein (HSF2BP) . O75031
Pre-mRNA-processing factor 6 (PRPF6) . O94906
RING finger protein 151 (RNF151) . Q2KHN1
Splicing factor 3B subunit 2 (SF3B2) . Q13435
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840