Details of the Target

General Information of Target

Target ID LDTP00735
Target Name AP-5 complex subunit zeta-1 (AP5Z1)
Gene Name AP5Z1
Gene ID 9907
Synonyms
KIAA0415; SPG48; AP-5 complex subunit zeta-1; Adaptor-related protein complex 5 zeta subunit; Zeta5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSAGAESLLHQAREIQDEELKKFCSRICKLLQAEDLGPDTLDSLQRLFLIISATKYSRR
LEKTCVDLLQATLGLPACPEQLQVLCAAILREMSPSDSLSLAWDHTQNSRQLSLVASVLL
AQGDRNEEVRAVGQGVLRALESRQPEGPSLRHLLPVMAKVVVLSPGTLQEDQATLLSKRL
VDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNV
QAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEY
CQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGD
PASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHL
FSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVL
DLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLL
QPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGV
HSVLSSQFLALCTLKPSLVVELARDLLEFLGSVNGLCSRASLVTSVVWAIGEYLSVTYDR
RCTVEQINKFFEALEALLFEVTQCRPSAALPRCPPQVVTVLMTTLTKLASRSQDLIPRAS
LLLSKMRTLAHSPATSSTHSEEGAEAIRTRATELLTLLKMPSVAQFVLTPSTEVCSPRYH
RDANTALPLALRTVSRLVEREAGLMPG
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According toit is a putative helicase required for efficient homologous recombination DNA double-strand break repair.
Uniprot ID
O43299
Ensemble ID
ENST00000648925.1
HGNC ID
HGNC:22197

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A116T; p.T644A; p.A764T .
HT SNV: p.K615N .
Ishikawa (Heraklio) 02 ER SNV: p.T273A .
NALM6 SNV: p.M405L .
NCIH1155 SNV: p.V129A .
NCIH1793 SNV: p.G316R; p.R748L .
SNU1 SNV: p.Y186F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K725(9.52)  LDD0277  [1]
BTD
 Probe Info  		C505(1.01)  LDD2137  [2]
AHL-Pu-1
 Probe Info  		C693(3.76)  LDD0170  [3]
DBIA
 Probe Info  		C775(1.15); C546(0.92)  LDD0078  [4]
CY4
 Probe Info  		N.A.  LDD0247  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		C637(0.00); C301(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
AOyne
 Probe Info  		14.90  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C693(3.76)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C693(3.17)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C546(0.86)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C546(1.03)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C546(0.84)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C546(0.94)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C546(0.85)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C546(0.89)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C546(0.83)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C546(0.82)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C546(0.84)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C546(0.65)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C546(0.95)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C546(1.02)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C546(1.39)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C546(0.94)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C546(1.02)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C546(0.75)  LDD0546  [4]
 LDCM0230  AC113 HEK-293T C546(1.03)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C546(0.98)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C546(0.96)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C546(1.09)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C546(1.10)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C546(1.23)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C546(1.12)  LDD0834  [4]
 LDCM0237  AC12 HCT 116 C546(0.93)  LDD0554  [4]
 LDCM0238  AC120 HEK-293T C546(1.03)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C546(1.07)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C546(1.05)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C546(1.06)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C546(1.14)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C546(1.49)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C546(1.06)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C546(0.96)  LDD0843  [4]
 LDCM0246  AC128 HCT 116 C546(1.16)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C546(1.17)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C546(1.22)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C546(0.99)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C546(0.97)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C546(1.28)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C546(1.05)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C546(1.13)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C546(1.52)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C546(1.09)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C546(1.31)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C546(1.06)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C546(1.15)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C546(1.09)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C546(1.19)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C546(1.03)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C637(1.02); C301(1.28); C546(0.76); C662(0.89)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C637(1.16); C301(0.89); C546(0.64); C662(0.97)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C637(0.99); C301(1.00); C546(0.63); C662(1.03)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C637(0.97); C301(0.95); C546(0.43); C662(0.71)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C637(1.05); C301(1.19); C546(0.60); C662(0.79)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C637(1.32); C301(0.95); C546(0.71); C662(1.01)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C637(1.49); C301(0.90); C546(0.63); C662(1.28)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C546(1.03)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C637(1.26); C301(0.97); C546(0.67); C662(1.02)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C637(1.55); C301(0.92); C546(0.77); C662(1.15)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C637(1.25); C301(0.84); C546(0.47); C662(0.97)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C637(1.37); C301(0.98); C546(0.66); C662(1.02)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C637(1.60); C301(0.92); C546(0.65); C662(0.93)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C637(1.35); C301(0.91); C546(0.69); C662(1.15)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C637(1.31); C301(0.99); C546(0.56); C662(1.14)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C637(1.16); C301(1.08); C546(0.79); C662(0.98)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C546(1.43)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C546(1.33)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C546(1.39)  LDD0876  [4]
 LDCM0279  AC2 HCT 116 C546(0.86)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C546(1.38)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C546(1.67)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C546(1.10)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C546(1.14)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C546(1.17)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C546(0.92)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C546(0.79)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C546(1.07)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C546(2.03)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C546(1.08)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C546(0.96)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C546(1.03)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C546(1.01)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C546(0.92)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C546(1.28)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C546(1.24)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C546(1.38)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C546(1.19)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C546(1.04)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C546(1.00)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C546(1.07)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C546(1.12)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C546(1.25)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C546(1.16)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C546(1.29)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C546(1.20)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C546(1.07)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C546(1.10)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C546(0.88)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C546(0.98)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C546(0.82)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C546(0.89)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C546(1.12)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C546(0.91)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C546(0.90)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C546(0.92)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C546(1.24)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C546(1.15)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C546(0.84)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C546(1.12)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C546(0.86)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C546(0.76)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C546(0.90)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C546(0.93)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C546(0.81)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C546(0.75)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C546(1.00)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C546(0.79)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C546(0.91)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C546(0.82)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C546(0.77)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C546(0.80)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C546(0.90)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C546(0.98)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C546(0.99)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C546(0.90)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C546(1.03)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C546(1.14)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C546(1.37)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C546(1.29)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C546(1.19)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C546(1.04)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C546(1.09)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C546(0.86)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C546(1.02)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C546(0.80)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C546(1.04)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C546(0.88)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C546(1.45)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C546(1.02)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C546(0.78)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C546(0.80)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C546(1.07)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C546(0.83)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C546(0.84)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C546(0.99)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C546(0.85)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C546(1.16)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C546(1.05)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C546(0.92)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C546(0.91)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C546(0.77)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C546(0.92)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C546(1.14)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C546(0.86)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C546(0.83)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C546(0.95)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C546(0.84)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C546(0.99)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C775(1.15); C546(0.92)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C546(1.16)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C546(1.06)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C546(1.06)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C546(1.06)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C546(1.21)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C546(0.99)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C546(1.19)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C546(1.05)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C546(1.07)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C546(1.20)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C546(1.09)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C546(1.27)  LDD0976  [4]
 LDCM0379  CL11 HCT 116 C546(1.04)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C546(1.25)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C546(1.20)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C546(0.93)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C546(1.04)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C546(0.93)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C546(1.13)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C546(1.02)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C546(1.31)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C546(1.07)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C546(0.94)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C546(1.08)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C546(0.99)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C546(0.92)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C546(1.06)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C546(1.05)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C546(0.96)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C546(1.07)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C546(0.86)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C546(0.86)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C546(0.86)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C546(0.97)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C546(1.02)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C546(1.00)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C546(0.94)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C546(0.89)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C546(0.85)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C546(1.24)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C546(0.99)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C546(0.96)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C546(1.29)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C546(1.21)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C546(0.78)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C546(0.89)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C546(0.86)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C546(1.08)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C546(1.05)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C546(1.00)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C546(0.77)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C546(0.98)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C546(0.81)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C546(0.91)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C546(0.96)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C546(1.10)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C546(0.99)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C546(1.04)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C546(0.97)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C546(1.19)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C546(1.10)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C546(1.06)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C546(1.10)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C546(1.16)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C546(1.28)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C546(1.23)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C546(0.96)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C546(1.01)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C546(1.04)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C546(1.06)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C546(1.02)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C546(1.07)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C546(0.96)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C546(1.01)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C546(1.31)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C546(1.19)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C546(1.04)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C546(1.03)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C546(1.18)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C546(1.13)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C546(1.14)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C546(1.20)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C546(1.06)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C546(0.92)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C546(1.06)  LDD0769  [4]
 LDCM0453  CL61 PaTu 8988t C637(1.07); C301(1.30); C546(1.10); C662(0.89)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C637(1.00); C301(0.79); C546(0.87); C662(0.78)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C637(0.95); C301(0.92); C546(0.96); C662(1.09)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C637(1.42); C301(0.79); C546(0.95); C662(0.89)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C637(1.09); C301(1.08); C546(1.10); C662(1.09)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C637(1.22); C301(0.99); C546(0.90); C662(1.13)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C637(1.22); C301(1.29); C546(1.04); C662(1.05)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C637(2.07); C301(1.22); C546(1.05); C662(1.36)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C637(2.81); C301(0.92); C546(0.97); C662(1.18)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C546(1.02)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C637(1.20); C301(1.13); C546(0.92); C662(1.14)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C637(0.91); C301(0.82); C546(1.02); C662(1.05)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C637(0.78); C301(0.77); C546(1.01); C662(1.10)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C637(1.52); C301(0.81); C546(1.00); C662(0.94)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C637(0.82); C301(0.92); C546(0.86); C662(0.95)  LDD1346  [4]
 LDCM0469  CL76 HCT 116 C546(1.11)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C546(1.22)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C546(1.15)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C546(1.22)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C546(1.38)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C546(1.18)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C546(1.13)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C546(1.06)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C546(0.99)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C546(1.00)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C546(1.15)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C546(1.04)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C546(1.27)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C546(1.29)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C546(1.19)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C546(1.06)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C546(1.07)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C546(1.09)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C546(0.95)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C546(1.01)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C546(1.11)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C546(1.03)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C546(0.91)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C546(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C546(0.99)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C546(1.01)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C775(1.10); C505(1.18); C693(0.76)  LDD1698  [12]
 LDCM0468  Fragment33 PaTu 8988t C637(1.29); C301(0.98); C546(0.98); C662(0.99)  LDD1347  [4]
 LDCM0427  Fragment51 HCT 116 C546(0.93)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C662(0.87); C775(1.06); C693(1.15)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C662(0.94); C775(0.96); C693(1.01)  LDD1497  [12]
 LDCM0024  KB05 G361 C693(3.96)  LDD3311  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C505(1.01)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore complex protein Nup93 (NUP93) Nucleoporin interacting component (NIC) family Q8N1F7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840