Details of the Target

General Information of Target

Target ID LDTP00605
Target Name Apoptosis regulatory protein Siva (SIVA1)
Gene Name SIVA1
Gene ID 10572
Synonyms
SIVA; Apoptosis regulatory protein Siva; CD27-binding protein; CD27BP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDE
GCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRA
VDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Uniprot ID
O15304
Ensemble ID
ENST00000329967.11
HGNC ID
HGNC:17712

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.A120T DBIA    Probe Info 
NUGC3 SNV: p.V65I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C135(2.43); C138(2.43); C127(2.19); C130(2.19)  LDD0080  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C62(0.00); C6(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
TFBX
 Probe Info  		C117(0.00); C6(0.00); C114(0.00)  LDD0027  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C135(1.22); C138(1.22)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C114(0.94); C117(0.94); C135(0.96); C138(0.96)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C114(0.73); C117(0.73); C135(1.02); C138(1.02)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C114(0.88); C117(0.88); C135(1.13); C138(1.13)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C114(0.83); C117(0.83); C135(0.95); C138(0.95)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C114(0.97); C117(0.97); C135(1.25); C138(1.25)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C114(0.95); C117(0.95); C135(1.09); C138(1.09)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C114(1.01); C117(1.01); C135(1.18); C138(1.18)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C114(1.05); C117(1.05); C135(1.75); C138(1.75)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C114(0.97); C117(0.97); C135(1.07); C138(1.07)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C114(0.87); C117(0.87); C135(1.11); C138(1.11)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C114(0.81); C117(0.81); C135(0.85); C138(0.85)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C114(0.99); C117(0.99); C135(0.75); C138(0.75)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C114(0.98); C117(0.98); C135(1.23); C138(1.23)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C114(0.99); C117(0.99); C135(1.73); C138(1.73)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C114(0.97); C117(0.97); C135(1.31); C138(1.31)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C114(0.61); C117(0.61)  LDD0547  [1]
 LDCM0237  AC12 HCT 116 C114(0.90); C117(0.90); C135(0.99); C138(0.99)  LDD0554  [1]
 LDCM0246  AC128 HCT 116 C114(0.78); C117(0.78); C135(0.30); C138(0.30)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C114(1.18); C117(1.18); C135(0.28); C138(0.28)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C114(0.69); C117(0.69); C135(0.26); C138(0.26)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C114(1.93); C117(1.93); C135(0.40); C138(0.40)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C114(0.57); C117(0.57); C135(0.34); C138(0.34)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C114(0.50); C117(0.50); C135(0.30); C138(0.30)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C114(0.70); C117(0.70); C135(0.41); C138(0.41)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C114(0.54); C117(0.54); C135(0.44); C138(0.44)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C114(0.54); C117(0.54); C135(0.45); C138(0.45)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C114(0.60); C117(0.60); C135(0.45); C138(0.45)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C114(0.61); C117(0.61); C135(0.53); C138(0.53)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C114(0.63); C117(0.63); C135(0.50); C138(0.50)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C114(1.48); C117(1.48); C135(0.74); C138(0.74)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C114(0.60); C117(0.60); C135(0.43); C138(0.43)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C114(0.63); C117(0.63); C135(0.47); C138(0.47)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C114(0.59); C117(0.59); C135(0.40); C138(0.40)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C114(0.78); C117(0.78)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C114(1.36); C117(1.36)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C114(1.03); C117(1.03)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C114(0.92); C117(0.92)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C114(1.37); C117(1.37)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C114(1.49); C117(1.49)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C114(1.31); C117(1.31)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C114(0.91); C117(0.91); C135(1.13); C138(1.13)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C114(0.88); C117(0.88)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C114(1.10); C117(1.10)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C114(1.20); C117(1.20)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C114(1.44); C117(1.44)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C114(1.02); C117(1.02)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C114(1.09); C117(1.09)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C114(1.15); C117(1.15)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C114(1.05); C117(1.05)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C130(1.48); C135(1.12); C138(1.12)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C130(1.58); C135(1.29); C138(1.29)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C130(1.19); C135(1.03); C138(1.03)  LDD0876  [1]
 LDCM0279  AC2 HCT 116 C135(1.39); C138(1.39)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C130(1.21); C135(1.09); C138(1.09)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C130(1.21); C135(1.20); C138(1.20)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C130(1.29); C135(1.14); C138(1.14)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C130(1.52); C135(1.10); C138(1.10)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C130(1.39); C135(1.08); C138(1.08)  LDD0882  [1]
 LDCM0285  AC25 HCT 116 C135(1.61); C138(1.61)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C135(1.15); C138(1.15)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C135(1.14); C138(1.14)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C135(1.02); C138(1.02)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C135(0.85); C138(0.85)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C135(1.38); C138(1.38)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C135(1.18); C138(1.18)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C135(1.25); C138(1.25)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C135(1.23); C138(1.23)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C135(1.28); C138(1.28)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C135(1.15); C138(1.15)  LDD0612  [1]
 LDCM0296  AC35 HEK-293T C114(1.35); C117(1.35); C135(1.18); C138(1.18)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C114(1.05); C117(1.05); C135(1.51); C138(1.51)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C114(1.29); C117(1.29); C135(0.96); C138(0.96)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C114(1.43); C117(1.43); C135(1.35); C138(1.35)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C114(1.45); C117(1.45); C135(1.34); C138(1.34)  LDD0898  [1]
 LDCM0301  AC4 HCT 116 C135(1.66); C138(1.66)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C114(1.14); C117(1.14); C135(1.41); C138(1.41)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C114(0.96); C117(0.96); C135(1.11); C138(1.11)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C114(1.11); C117(1.11); C135(1.15); C138(1.15)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C114(1.71); C117(1.71); C135(1.64); C138(1.64)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C114(1.15); C117(1.15); C135(1.28); C138(1.28)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C114(1.30); C117(1.30); C135(1.27); C138(1.27)  LDD0905  [1]
 LDCM0308  AC46 HCT 116 C114(1.45); C117(1.45)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C114(0.81); C117(0.81)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C114(0.81); C117(0.81)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C114(0.97); C117(0.97)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C135(1.32); C138(1.32)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C114(1.27); C117(1.27)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C114(1.63); C117(1.63)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C114(0.97); C117(0.97)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C114(1.04); C117(1.04)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C114(1.25); C117(1.25)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C114(1.24); C117(1.24)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C114(1.47); C117(1.47)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C135(0.96); C138(0.96)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C135(1.41); C138(1.41)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C135(1.22); C138(1.22)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C135(0.79); C138(0.79); C114(1.02); C117(1.02)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C135(0.87); C138(0.87)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C135(1.17); C138(1.17)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C135(0.81); C138(0.81)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C135(1.15); C138(1.15)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C135(0.97); C138(0.97)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C135(0.86); C138(0.86)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C135(0.84); C138(0.84)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C135(0.76); C138(0.76)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C114(0.64); C117(0.64); C135(1.67); C138(1.67)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C135(0.71); C138(0.71); C114(1.01); C117(1.01)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C135(0.84); C138(0.84); C114(0.98); C117(0.98)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C114(0.72); C117(0.72); C135(1.08); C138(1.08)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C114(0.49); C117(0.49); C135(1.60); C138(1.60)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C114(1.09); C117(1.09); C135(3.51); C138(3.51)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C114(0.86); C117(0.86); C135(2.72); C138(2.72)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C114(0.64); C117(0.64); C135(2.42); C138(2.42)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C114(0.92); C117(0.92); C135(1.21); C138(1.21)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C114(0.81); C117(0.81); C135(1.04); C138(1.04)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C114(0.76); C117(0.76); C135(2.10); C138(2.10)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C135(0.70); C138(0.70); C114(0.76); C117(0.76)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C114(0.60); C117(0.60); C135(0.68); C138(0.68)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C114(0.85); C117(0.85); C135(1.02); C138(1.02)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C114(0.73); C117(0.73); C135(0.99); C138(0.99)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C114(0.65); C117(0.65); C135(0.90); C138(0.90)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C114(0.74); C117(0.74); C135(1.16); C138(1.16)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C114(0.85); C117(0.85)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C114(0.96); C117(0.96)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C114(0.64); C117(0.64)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C114(0.89); C117(0.89)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C114(0.98); C117(0.98)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C114(1.25); C117(1.25)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C114(1.39); C117(1.39)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C114(0.96); C117(0.96)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C114(1.07); C117(1.07)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C114(1.09); C117(1.09)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C114(0.96); C117(0.96)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C114(0.91); C117(0.91)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C114(1.08); C117(1.08)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C114(1.25); C117(1.25)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C114(1.23); C117(1.23)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C114(0.94); C117(0.94); C135(1.11); C138(1.11)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C114(0.80); C117(0.80); C135(0.89); C138(0.89)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C114(1.02); C117(1.02); C135(1.03); C138(1.03)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C135(0.99); C138(0.99); C114(1.09); C117(1.09)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C114(0.96); C117(0.96); C135(1.05); C138(1.05)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C127(1.40); C130(1.40); C114(1.35); C117(1.35)  LDD2171  [1]
 LDCM0632  CL-Sc Hep-G2 C6(1.37)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C135(1.11); C138(1.11)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C135(1.87); C138(1.87)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C135(1.28); C138(1.28)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C135(0.75); C138(0.75); C114(2.54); C117(2.54)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C135(0.65); C138(0.65); C114(2.36); C117(2.36)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C135(0.79); C138(0.79); C114(1.60); C117(1.60)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C135(0.77); C138(0.77); C114(1.61); C117(1.61)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C130(1.42); C135(0.90); C138(0.90)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C130(1.33); C135(0.94); C138(0.94)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C130(1.39); C135(1.06); C138(1.06)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C130(1.22); C135(1.08); C138(1.08)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C130(1.40); C135(1.28); C138(1.28)  LDD0976  [1]
 LDCM0379  CL11 HCT 116 C135(1.72); C138(1.72)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C130(1.56); C135(1.50); C138(1.50)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C130(1.23); C135(1.26); C138(1.26)  LDD0979  [1]
 LDCM0382  CL112 HCT 116 C135(0.74); C138(0.74)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C135(1.10); C138(1.10)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C135(0.74); C138(0.74)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C135(0.73); C138(0.73)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C135(1.25); C138(1.25)  LDD0703  [1]
 LDCM0387  CL117 HEK-293T C114(1.12); C117(1.12); C135(1.20); C138(1.20)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C114(0.89); C117(0.89); C135(1.31); C138(1.31)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C114(1.42); C117(1.42); C135(1.19); C138(1.19)  LDD0987  [1]
 LDCM0390  CL12 HCT 116 C135(2.20); C138(2.20)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C114(0.92); C117(0.92); C135(1.37); C138(1.37)  LDD0989  [1]
 LDCM0392  CL121 HCT 116 C114(1.63); C117(1.63)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C114(0.46); C117(0.46)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C114(1.03); C117(1.03)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C114(1.01); C117(1.01)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C135(0.86); C138(0.86)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C135(0.87); C138(0.87)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C135(1.68); C138(1.68)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C135(1.09); C138(1.09)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C135(1.52); C138(1.52)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C135(1.36); C138(1.36)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C135(1.11); C138(1.11)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C135(1.43); C138(1.43)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C135(0.86); C138(0.86)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C135(1.09); C138(1.09)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C135(1.31); C138(1.31)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C135(0.91); C138(0.91)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C135(1.36); C138(1.36)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C135(1.34); C138(1.34)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C135(1.12); C138(1.12)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C135(1.12); C138(1.12)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C135(1.37); C138(1.37)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C135(1.20); C138(1.20)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C135(1.24); C138(1.24)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C135(1.55); C138(1.55)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C135(1.31); C138(1.31)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C135(1.73); C138(1.73)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C135(1.52); C138(1.52)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C135(1.44); C138(1.44)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C114(0.98); C117(0.98); C130(0.96)  LDD1018  [1]
 LDCM0421  CL32 HCT 116 C135(1.14); C138(1.14)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C135(1.18); C138(1.18)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C135(1.36); C138(1.36)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C135(1.65); C138(1.65)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C135(1.00); C138(1.00)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C135(1.55); C138(1.55)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C135(1.87); C138(1.87)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C135(0.90); C138(0.90)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C135(1.40); C138(1.40)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C135(1.10); C138(1.10)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C135(1.27); C138(1.27)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C135(1.29); C138(1.29)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C135(1.52); C138(1.52)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C135(1.50); C138(1.50)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C114(0.88); C117(0.88); C135(0.72); C138(0.72)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C114(0.86); C117(0.86); C135(0.96); C138(0.96)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C114(0.78); C117(0.78); C135(1.35); C138(1.35)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C114(0.82); C117(0.82); C135(1.50); C138(1.50)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C135(1.31); C138(1.31)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C114(1.09); C117(1.09); C135(0.99); C138(0.99)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C114(0.90); C117(0.90); C135(0.92); C138(0.92)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C114(1.18); C117(1.18); C135(0.73); C138(0.73)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C114(0.87); C117(0.87); C135(1.06); C138(1.06)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C114(1.41); C117(1.41); C135(0.71); C138(0.71)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C114(1.30); C117(1.30); C135(1.04); C138(1.04)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C114(1.10); C117(1.10); C135(1.14); C138(1.14)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C114(0.86); C117(0.86); C135(1.29); C138(1.29)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C114(1.00); C117(1.00); C135(1.65); C138(1.65)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C114(1.12); C117(1.12); C135(1.32); C138(1.32)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C135(1.32); C138(1.32)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C114(1.28); C117(1.28); C135(1.06); C138(1.06)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C114(0.82); C117(0.82); C135(1.11); C138(1.11)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C114(1.02); C117(1.02); C135(1.05); C138(1.05)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C114(0.81); C117(0.81); C135(1.17); C138(1.17)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C114(0.85); C117(0.85); C135(1.14); C138(1.14)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C114(0.75); C117(0.75); C135(1.08); C138(1.08)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C114(1.04); C117(1.04); C135(1.09); C138(1.09)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C114(0.84); C117(0.84); C135(0.98); C138(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C114(1.08); C117(1.08); C135(0.86); C138(0.86)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C114(1.01); C117(1.01); C135(1.15); C138(1.15)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C135(1.83); C138(1.83)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C114(1.06); C117(1.06); C135(0.86); C138(0.86)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C114(0.86); C117(0.86); C135(0.92); C138(0.92)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C114(0.79); C117(0.79); C135(1.02); C138(1.02)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C114(1.06); C117(1.06); C135(0.96); C138(0.96)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C114(0.79); C117(0.79); C135(0.97); C138(0.97)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C114(0.84); C117(0.84); C135(0.93); C138(0.93)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C114(0.71); C117(0.71); C135(0.89); C138(0.89)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C114(0.73); C117(0.73); C135(0.93); C138(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C114(0.71); C117(0.71); C135(0.97); C138(0.97)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C135(0.85); C138(0.85)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C114(0.78); C117(0.78); C135(1.01); C138(1.01)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C114(0.73); C117(0.73); C135(0.82); C138(0.82)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C114(0.72); C117(0.72); C135(0.95); C138(0.95)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C114(0.89); C117(0.89); C135(0.95); C138(0.95)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C114(0.95); C117(0.95); C135(0.99); C138(0.99)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C114(1.06); C117(1.06); C135(1.18); C138(1.18)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C114(0.83); C117(0.83); C135(0.95); C138(0.95)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C114(0.72); C117(0.72); C135(0.82); C138(0.82)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C114(0.81); C117(0.81); C135(0.89); C138(0.89)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C114(0.81); C117(0.81); C135(1.05); C138(1.05)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C135(1.13); C138(1.13)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C114(0.62); C117(0.62); C135(0.86); C138(0.86)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C135(0.84); C138(0.84)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C135(0.88); C138(0.88)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C135(1.27); C138(1.27)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C135(1.36); C138(1.36)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C135(1.52); C138(1.52)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C135(1.17); C138(1.17)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C135(1.41); C138(1.41)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C135(1.11); C138(1.11)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C135(0.97); C138(0.97)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C62(0.80)  LDD1698  [9]
 LDCM0625  F8 Ramos C6(0.76)  LDD2187  [10]
 LDCM0575  Fragment13 Ramos C6(2.52)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C6(1.60)  LDD2193  [10]
 LDCM0580  Fragment21 Ramos C6(1.33)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C6(0.67)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C6(0.78)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C6(1.11)  LDD2198  [10]
 LDCM0589  Fragment31 Ramos C6(0.84)  LDD2200  [10]
 LDCM0468  Fragment33 HCT 116 C114(0.90); C117(0.90); C135(1.01); C138(1.01)  LDD0785  [1]
 LDCM0596  Fragment38 Ramos C6(0.51)  LDD2203  [10]
 LDCM0427  Fragment51 HCT 116 C135(1.48); C138(1.48)  LDD0744  [1]
 LDCM0614  Fragment56 Ramos C6(0.53)  LDD2205  [10]
 LDCM0022  KB02 HCT 116 C135(2.43); C138(2.43); C127(2.19); C130(2.19)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C135(1.51); C138(1.51); C127(2.12); C130(2.12)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C135(2.01); C138(2.01); C127(1.46); C130(1.46)  LDD0082  [1]
 LDCM0627  NUDT7-COV-1 HEK-293T C6(0.11)  LDD2206  [11]
 LDCM0021  THZ1 HCT 116 C127(1.40); C130(1.40); C114(1.35); C117(1.35)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis regulator Bcl-2 (BCL2) Bcl-2 family P10415
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Peroxisomal membrane protein 2 (PXMP2) Peroxisomal membrane protein PXMP2/4 family Q9NR77
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD27 antigen (CD27) . P26842
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
UPF0561 protein C2orf68 (C2orf68) UPF0561 family Q2NKX9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.