Details of the Target

General Information of Target

Target ID LDTP00476
Target Name Regulator of G-protein signaling 12 (RGS12)
Gene Name RGS12
Gene ID 6002
Synonyms
Regulator of G-protein signaling 12; RGS12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRA
GDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWL
KPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFD
VGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIEL
PSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLA
FSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFG
FECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSS
NSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPGGSAWDGVGGRGAQPWGAPWTGPFCPDP
EGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPV
HVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKR
EWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITR
SLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLL
QDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATT
PVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRA
LPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSW
SRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKA
TKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSS
ILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSG
EKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEE
RTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSN
RADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQ
WEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQ
SQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRD
LPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAKPKTS
AHHATFV
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus; Nucleus matrix
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.; [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.
TTD ID
T06146
Uniprot ID
O14924
DrugMap ID
TTP9AV7
Ensemble ID
ENST00000336727.8
HGNC ID
HGNC:9994
ChEMBL ID
CHEMBL1293276

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L929M .
HCT116 SNV: p.N752D DBIA    Probe Info 
HCT15 SNV: p.A404T .
Ishikawa (Heraklio) 02 ER SNV: p.P867S .
KNS42 SNV: p.K523N .
LNCaP clone FGC Insertion: p.G1291PfsTer51
SNV: p.R1206H		 .
MCC13 SNV: p.P1106S .
NCIH2291 SNV: p.E152K .
RKO SNV: p.A465D .
SUPT1 SNV: p.R734K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C683(1.18); C701(1.18)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C683(0.76); C701(0.76)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C683(0.73); C701(0.73)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C683(0.80); C701(0.80)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C683(0.78); C701(0.78)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C683(0.74); C701(0.74)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C683(0.81); C701(0.81)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C683(0.82); C701(0.82)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C683(0.76); C701(0.76)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C683(0.88); C701(0.88)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C683(0.86); C701(0.91)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C683(0.79); C701(0.90)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C683(0.64); C701(0.68)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C683(0.66); C701(0.66)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C683(0.86); C701(0.72)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C683(0.81); C701(0.82)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C683(0.84); C701(0.70)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C683(1.00); C701(1.00)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C683(1.86); C701(1.86)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C683(1.25); C701(1.25)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C683(1.59); C701(1.59)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C683(1.41); C701(1.41)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C683(1.38); C701(1.38)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C683(1.58); C701(1.58)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C683(0.71); C701(0.71)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C683(1.51); C701(1.51)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C683(1.02); C701(1.02)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C683(1.38); C701(1.38)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C683(1.39); C701(1.39)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C683(1.54); C701(1.54)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C683(1.48); C701(1.48)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C683(1.65); C701(1.65)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C683(2.67); C701(2.67)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C701(1.33)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C701(0.87)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C701(1.22)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C701(1.36)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C701(0.80)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C701(0.96)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C701(1.53)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C701(1.28)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C701(0.96)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C701(1.37)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C701(1.50)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C701(1.28)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C683(0.65); C701(0.65)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C701(1.07)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C701(1.12)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C701(1.06)  LDD0860  [1]
 LDCM0263  AC143 HCT 116 C683(0.83); C701(0.83)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C701(0.88); C683(1.44)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C701(0.65); C683(1.28)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C701(0.60); C683(1.31)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C683(1.01); C701(1.59)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C701(0.65); C683(1.31)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C701(0.69); C683(1.15)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C683(0.65); C701(0.65)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C683(0.93); C701(1.08)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C701(0.89); C683(1.04)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C701(0.82); C683(1.19)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C701(0.65); C683(1.37)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C683(1.12); C701(0.79)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C683(1.23); C701(0.75)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C683(1.70); C701(1.00)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C683(1.13); C701(0.83)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C683(0.91); C701(0.91)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C683(0.60); C701(0.60)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C683(1.02); C701(1.02)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C683(0.88); C701(0.88)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C683(1.04); C701(1.04)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C683(0.98); C701(0.98)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C683(1.56); C701(1.56)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C683(0.85); C701(0.85)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C683(1.13); C701(1.13)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C683(0.63); C701(0.63)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C683(0.63); C701(0.63)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C683(0.51); C701(0.51)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C683(0.52); C701(0.52)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C683(0.54); C701(0.54)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C683(0.95); C701(0.95)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C683(0.52); C701(0.52)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C683(0.61); C701(0.61)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C683(0.42); C701(0.42)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C683(0.44); C701(0.44)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C683(0.45); C701(0.45)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C683(1.33); C701(1.33)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C683(1.27); C701(1.27)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C683(1.04); C701(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C683(0.93); C701(0.93)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C683(0.96); C701(0.96)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C683(0.71); C701(0.71)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C683(0.87); C701(0.87)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C683(0.96); C701(0.96)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C683(1.10); C701(1.10)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C683(0.98); C701(0.98)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C683(0.82); C701(0.82)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C683(0.99); C701(0.99)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C683(1.28); C701(1.28)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C683(1.23); C701(1.23)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C683(1.16); C701(1.16)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C683(1.27); C701(1.27)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C683(0.66); C701(0.66)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C683(1.13); C701(1.13)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C683(1.43); C701(1.43)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C683(0.80); C701(0.80)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C683(1.25); C701(1.25)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C683(1.18); C701(1.18)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C683(0.97); C701(0.97)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C683(1.09); C701(1.09)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C683(0.56); C701(0.56)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C683(0.73); C701(0.73)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C683(0.60); C701(0.60)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C683(0.64); C701(0.64)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C683(0.67); C701(0.67)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C683(0.98); C701(0.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C683(0.65); C701(0.65)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C683(0.58); C701(0.58)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C683(0.71); C701(0.71)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C683(0.38); C701(0.38)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C683(0.37); C701(0.37)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C683(0.40); C701(0.40)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C683(0.98); C701(0.98)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C683(1.07); C701(1.07)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C683(0.74); C701(0.74)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C683(0.84); C701(0.84)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C683(0.76); C701(0.76)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C683(1.37); C701(1.37)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C683(1.75); C701(1.75)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C683(1.66); C701(1.66)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C683(1.58); C701(1.58)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C683(1.26); C701(1.26)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C683(1.11); C701(1.11)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C683(1.14); C701(1.14)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C683(1.06); C701(1.06)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C683(0.67); C701(0.67)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C683(1.20); C701(1.20)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C683(1.20); C701(1.20)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C683(2.40); C701(2.40)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C683(1.62); C701(1.62)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C683(1.47); C701(1.47)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C683(1.14); C701(1.14)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C683(1.15); C701(1.15)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C683(1.51); C701(1.51)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C683(1.05); C701(1.05)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C683(1.40); C701(1.40)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C683(1.10); C701(1.10)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C683(1.48); C701(1.48)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C683(1.52); C701(1.52)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C683(1.29); C701(1.29)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C683(1.36); C701(1.36)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C683(1.31); C701(1.31)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C683(1.41); C701(1.41)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C683(1.45); C701(1.45)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C683(1.05); C701(1.05)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C683(0.75); C701(0.75)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C683(0.78); C701(0.78)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C683(0.69); C701(0.69)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C683(0.60); C701(0.60)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C683(1.18); C701(1.18)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C683(1.42); C701(1.42)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C683(1.26); C701(1.26)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C683(0.84); C701(0.84)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C683(0.65); C701(0.65)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C683(0.84); C701(0.84)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C683(0.94); C701(0.94)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C683(0.92); C701(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C683(0.76); C701(0.76)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C683(0.76); C701(0.76)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C683(0.60); C701(0.60)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C683(0.76); C701(0.76)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C683(0.66); C701(0.66)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C683(1.02); C701(1.02)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C683(0.99); C701(0.99)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C683(0.89); C701(0.89)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C683(0.88); C701(0.88)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C683(0.48); C701(0.48)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C683(0.90); C701(0.90)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C683(0.57); C701(0.57)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C683(0.48); C701(0.48)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C683(1.32); C701(1.32)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C683(0.87); C701(0.87)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C683(0.93); C701(0.93)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C683(1.01); C701(1.01)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C683(0.83); C701(0.83)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C683(2.21); C701(2.21)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C683(1.12); C701(1.12)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C683(1.49); C701(1.49)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C683(0.91); C701(0.91)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C683(0.88); C701(0.88)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C683(0.91); C701(0.91)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C683(0.63); C701(0.63)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C683(0.68); C701(0.68)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C683(0.95); C701(0.95)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C683(1.60); C701(1.60)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C683(1.93); C701(1.93)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C683(0.88); C701(0.88)  LDD0720  [1]
 LDCM0404  CL17 HEK-293T C701(1.02)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C701(1.34)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C701(1.17)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C683(1.04); C701(1.04)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C701(1.18)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C701(1.12)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C701(1.47)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C701(1.27)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C701(1.27)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C701(1.09)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C701(1.13)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C701(1.12)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C701(1.37)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C701(1.41)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C683(1.60); C701(1.60)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C701(1.54)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C683(0.62); C701(0.62)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C683(1.19); C701(1.19)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C683(1.26); C701(1.26)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C683(0.81); C701(0.81)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C683(0.87); C701(0.87)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C683(0.66); C701(0.66)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C683(0.84); C701(0.84)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C683(0.70); C701(0.70)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C683(1.58); C701(1.58)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C683(0.90); C701(0.90)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C683(0.79); C701(0.79)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C683(0.79); C701(0.79)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C683(0.90); C701(0.90)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C683(0.68); C701(0.68)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C683(0.82); C701(0.82)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C683(0.99); C701(0.99)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C683(1.13); C701(1.13)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C683(0.90); C701(0.90)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C683(1.04); C701(1.04)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C683(1.06); C701(1.06)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C683(0.86); C701(0.86)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C683(1.10); C701(1.10)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C683(0.73); C701(0.73)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C683(1.23); C701(1.23)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C683(1.03); C701(1.03)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C683(0.71); C701(0.71)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C683(0.80); C701(0.80)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C683(0.90); C701(0.90)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C683(0.82); C701(0.82)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C683(0.82); C701(0.82)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C683(1.51); C701(1.51)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C683(0.93); C701(0.93)  LDD1331  [1]
 LDCM0453  CL61 HCT 116 C683(0.89); C701(0.89)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C683(0.96); C701(0.96)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C683(0.72); C701(0.72)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C683(0.78); C701(0.78)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C683(0.86); C701(0.86)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C683(0.78); C701(0.78)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C683(0.56); C701(0.56)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C683(0.69); C701(0.69)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C683(1.15); C701(1.15)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C683(1.13); C701(1.13)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C683(0.86); C701(0.86)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C683(0.92); C701(0.92)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C683(0.82); C701(0.82)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C683(0.63); C701(0.63)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C683(0.77); C701(0.77)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C683(0.99); C701(0.99)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C683(0.97); C701(0.97)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C683(0.93); C701(0.93)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C683(0.82); C701(0.82)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C683(2.17); C701(2.17)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C683(2.21); C701(2.21)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C683(0.89); C701(0.89)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C683(0.87); C701(0.87)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C683(0.68); C701(0.68)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C683(1.01); C701(1.01)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C683(0.58); C701(0.58)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C683(0.75); C701(0.75)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C683(0.85); C701(0.85)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C683(0.64); C701(0.64)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C683(0.92); C701(0.92)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C683(1.02); C701(1.02)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C683(1.34); C701(1.34)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C683(1.11); C701(1.11)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C683(0.85); C701(0.85)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C683(0.81); C701(0.81)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C683(1.01); C701(1.01)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C683(1.14); C701(1.14)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C683(0.88); C701(0.88)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C683(0.69); C701(0.69)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C683(0.80); C701(0.80)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C683(0.74); C701(0.74)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C531(0.98)  LDD1698  [2]
 LDCM0468  Fragment33 HCT 116 C683(0.83); C701(0.83)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C683(0.83); C701(0.83)  LDD0744  [1]
 LDCM0022  KB02 MGG123 C531(2.62)  LDD2469  [3]
 LDCM0023  KB03 MGG123 C531(2.58)  LDD2886  [3]
 LDCM0024  KB05 MGG123 C531(2.55)  LDD3303  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840