Details of the Target

General Information of Target

Target ID LDTP00091
Target Name RCC1 domain-containing protein 1 (RCCD1)
Gene Name RCCD1
Gene ID 91433
Synonyms
RCC1 domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL
ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE
GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF
SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG
QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS
DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT
CGPWNTYVYAVEKGKS
Target Bioclass
Other
Subcellular location
Chromosome
Function
Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.
Uniprot ID
A6NED2
Ensemble ID
ENST00000394258.7
HGNC ID
HGNC:30457

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C139(1.08)  LDD2102  [1]
NAIA_5
 Probe Info  		C139(20.00)  LDD2227  [2]
DBIA
 Probe Info  		C42(1.54)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		C42(0.00); C139(0.00)  LDD0005  [5]
TFBX
 Probe Info  		C42(0.00); C139(0.00)  LDD0148  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C42(0.69)  LDD2117  [1]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C139(0.91)  LDD2103  [1]
 LDCM0214  AC1 HCT 116 C139(0.95)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C139(1.11)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C139(1.17)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C139(0.82)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C139(0.85)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C139(0.90)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C139(0.97)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C139(0.91)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C139(1.00)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C139(1.09)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C139(1.19)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C139(0.94)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C139(1.20)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C139(1.12)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C139(1.22)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C139(1.14)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C139(0.72)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C139(1.33)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C139(1.30)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C139(1.04)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C139(1.13)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C139(0.76)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C139(0.84)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C139(0.88)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C139(0.83)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C139(0.84)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C139(0.83)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C139(0.75)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C139(0.81)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C139(0.79)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C139(0.81)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C139(1.00)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C139(0.82)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C139(0.90)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C139(1.00)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C139(0.96)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C139(1.12)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C139(1.23)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C139(1.04)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C139(0.96)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C139(1.09)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C139(1.21)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C139(1.18)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C139(1.43)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C139(0.93)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C139(2.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C139(1.60)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C139(1.12)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C139(1.55)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C139(1.29)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C139(0.96)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C139(1.10)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C139(3.42)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C139(2.57)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C139(1.44)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C139(1.01)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C139(1.06)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C139(1.07)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C139(0.96); C361(1.00)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C139(1.02); C361(1.34); C42(0.92)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C139(1.01); C361(0.85)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C139(0.89)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C139(1.05)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C139(1.08)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C139(1.10)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C139(1.08)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C139(1.03)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C139(1.00); C361(1.15)  LDD1546  [9]
 LDCM0308  AC46 HCT 116 C139(1.13)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C139(0.88)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C139(0.84)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C139(0.95)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C139(0.88)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C139(0.95)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C139(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C139(0.89)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C139(1.26)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C139(0.91)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C139(1.29)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C139(1.23)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C139(1.07)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C139(1.02)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C139(0.98)  LDD1561  [9]
 LDCM0323  AC6 HCT 116 C139(1.03)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C139(1.10)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C139(1.01); C361(0.86)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C139(1.03); C361(1.17); C42(0.94)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C139(1.05); C361(0.86)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C139(0.98)  LDD1567  [9]
 LDCM0334  AC7 HCT 116 C139(1.02)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C139(0.95)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C139(1.24)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C139(1.33)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C139(1.26)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C139(1.26)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C139(1.25)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C139(1.22)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C139(1.21)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C139(1.24)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C139(1.12)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C139(1.38)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C139(1.22)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C139(1.15)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C139(1.29)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C139(1.35)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C139(1.43)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C139(0.84)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C139(1.11)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C139(0.88)  LDD0592  [3]
 LDCM0630  CCW28-3 231MFP C139(1.15)  LDD2214  [10]
 LDCM0632  CL-Sc Hep-G2 C139(20.00)  LDD2227  [2]
 LDCM0367  CL1 HEK-293T C139(3.08)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C139(4.42); C361(1.05); C42(0.82)  LDD1572  [9]
 LDCM0369  CL100 HCT 116 C139(1.17)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C139(1.21)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C139(2.73)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C139(0.92)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C139(1.03)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C139(2.10)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C139(1.47)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C139(1.23)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C139(1.53)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C139(2.04)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C139(2.53); C361(1.06)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C139(2.04)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C139(2.30)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C139(1.98)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C139(1.76)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C139(3.14)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C139(2.20)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C139(1.39)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C139(1.29)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C139(1.27)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C139(1.17)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C139(1.25)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C139(1.07)  LDD1595  [9]
 LDCM0392  CL121 HCT 116 C139(1.93)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C139(1.85)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C139(3.88)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C139(2.54)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C139(1.09)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C139(2.53)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C139(1.55)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C139(1.02)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C139(1.64)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C139(3.09)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C139(1.60)  LDD1606  [9]
 LDCM0403  CL16 HCT 116 C139(0.73)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C139(2.30)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C139(1.10)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C139(1.20)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C139(3.29)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C139(1.00)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C139(2.24); C361(0.95)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C139(3.24); C361(1.12); C42(0.84)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C139(0.95); C361(1.29)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C139(0.97)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C139(2.21)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C139(1.08)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C139(1.27)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C139(2.17)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C139(1.05)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C139(1.18)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C139(1.03)  LDD1623  [9]
 LDCM0420  CL31 HCT 116 C139(5.79)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C139(3.86)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C139(5.70)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C139(1.73)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C139(1.20)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C139(2.06)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C139(1.17)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C139(1.90)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C139(1.72)  LDD1633  [9]
 LDCM0430  CL40 HCT 116 C139(6.83)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C139(1.56)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C139(3.22)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C139(1.95)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C139(4.13)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C139(3.62)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C139(4.00)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C139(2.12)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C139(3.18)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C139(1.17)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C139(1.18)  LDD1644  [9]
 LDCM0441  CL50 HCT 116 C139(1.07)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C139(1.56)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C139(3.22)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C139(1.30)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C139(1.42)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C139(2.43)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C139(1.20)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C139(3.24)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C139(3.53)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C139(0.82)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C139(1.48)  LDD1654  [9]
 LDCM0452  CL60 HCT 116 C139(1.50)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C139(0.94)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C139(2.09)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C139(1.34)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C139(1.98)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C139(1.69)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C139(3.51)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C139(1.04)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C139(4.37)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C139(2.92); C361(0.98)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C139(1.23)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C139(1.03); C361(1.01); C42(0.85)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C139(1.23); C361(1.07)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C139(1.04)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C139(1.29)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C139(1.15)  LDD1670  [9]
 LDCM0469  CL76 HCT 116 C139(1.46)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C139(0.99)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C139(1.69)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C139(0.94)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C139(4.85)  LDD1676  [9]
 LDCM0474  CL80 HCT 116 C139(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C139(0.98)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C139(0.95)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C139(1.34)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C139(1.39)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C139(0.92)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C139(1.10)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C139(1.34)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C139(0.82)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C139(0.75)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C139(1.72); C361(1.22)  LDD1687  [9]
 LDCM0485  CL90 HCT 116 C139(2.63)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C139(1.54)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C139(2.72)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C139(1.72)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C139(2.21)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C139(5.28)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C139(1.52)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C139(2.01)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C139(2.87)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C139(2.11)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C139(3.60)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C139(3.95)  LDD1702  [1]
 LDCM0625  F8 Ramos C42(1.13); C361(0.57); C139(0.73)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C42(2.55)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C42(0.10); C361(1.64); C139(0.25)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C42(0.98)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C42(0.86); C139(0.84)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C42(0.61); C361(1.07); C139(1.20)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C42(1.03)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C42(1.05)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C42(0.99); C139(0.92)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C42(0.88); C139(1.43)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C42(0.99); C361(0.64)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C42(0.54)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C42(0.84); C139(0.89)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C42(1.08)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C139(2.91)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C42(0.94); C139(1.77)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C42(0.97); C361(0.52)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C139(10.45)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C42(0.95)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C139(0.51)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C42(1.25)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C42(1.86)  LDD2188  [11]
 LDCM0022  KB02 HCT 116 C42(1.54)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C42(1.27)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C42(1.36)  LDD0082  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C139(1.08)  LDD2102  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C139(0.45); C42(1.05)  LDD2109  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C139(1.40)  LDD2111  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C139(0.26)  LDD2123  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C139(0.74)  LDD2127  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C139(0.42); C42(1.02)  LDD2137  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional peptidase and arginyl-hydroxylase JMJD5 (KDM8) . Q8N371

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578