Details of the Target

General Information of Target

Target ID LDTP18504
Target Name Thymocyte nuclear protein 1 (THYN1)
Gene Name THYN1
Gene ID 29087
Synonyms
THY28; Thymocyte nuclear protein 1; Thymocyte protein Thy28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDISEGNKTLVTEFVLTGLTDRPWLHVLFFVVFLVVYLITMVGNLGLIVLIWNDPHLHMP
MYLFLGGLAFSDACTSTSITPRMLVNFLDKTAMISLAECITQFYFFASSATTECFLLVMM
AYDRYVAICNPLLYPVMMSNKLSAQLLSISYVIGFLHPLVHVSLLLRLTFCRFNIIHYFY
CEILQLFKISCNGPSINALMIFIFGAFIQIPTLMTIIISYTRVLFDILKKKSEKGRSKAF
STCGAHLLSVSLYYGTLIFMYVRPASGLAEDQDKVYSLFYTIIIPLLNPFIYSLRNKKVM
HALRRVIRK
Target Bioclass
Other
Subcellular location
Nucleus
Function Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Uniprot ID
Q9P016
Ensemble ID
ENST00000341541.8
HGNC ID
HGNC:29560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.C49Y DBIA    Probe Info 
IM95 SNV: p.R66L DBIA    Probe Info 
KMCH1 SNV: p.P174T DBIA    Probe Info 
MFE296 Deletion: p.N194IfsTer15 DBIA    Probe Info 
REH SNV: p.T199S DBIA    Probe Info 
RKO Deletion: p.N194IfsTer15 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y181(6.78)  LDD0260  [2]
STPyne
 Probe Info  		K179(9.26); K186(10.00)  LDD0277  [3]
BTD
 Probe Info  		C89(0.88)  LDD2137  [4]
DBIA
 Probe Info  		C89(1.48)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C118(0.00); C89(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPIAA_L
 Probe Info  		C89(0.00); C118(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C118(0.00); C89(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
Phosphinate-6
 Probe Info  		C49(0.00); C118(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		13.80  LDD0443  [14]
NAIA_5
 Probe Info  		C118(0.00); C49(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Photonaproxen
 Probe Info  		N.A.  LDD0157  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C89(1.66)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C89(1.04)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C89(0.65)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C89(0.73)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C89(0.79)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C89(0.57)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C89(0.98)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C89(0.68)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C89(0.55)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C89(0.67)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C89(0.70)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C89(0.86)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C89(1.12)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C89(0.65)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C89(0.67)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C89(0.63)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C89(1.23)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C89(0.96)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C89(1.21)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C89(1.02)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C89(1.08)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C89(1.08)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C89(0.99)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C89(1.18)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C89(0.90)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C89(0.93)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C89(0.93)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C89(1.07)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C89(0.98)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C89(0.85)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C89(0.92)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C89(0.93)  LDD0562  [5]
 LDCM0246  AC128 HEK-293T C89(0.94)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C89(1.03)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C89(0.90)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C89(1.04)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C89(0.89)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C89(0.99)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C89(1.00)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C89(0.79)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C89(0.77)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C89(1.00)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C89(0.96)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C89(0.85)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C89(1.27)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C89(0.96)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C89(1.08)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C89(0.96)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C89(0.71)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C89(1.23)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C89(1.07)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C89(1.10)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C89(1.01)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C89(1.02)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C89(1.07)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C89(0.98)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C89(0.96)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C89(0.98)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C89(0.94)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C89(1.08)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C89(1.01)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C89(0.98)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C89(1.20)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C89(1.04)  LDD2165  [5]
 LDCM0276  AC17 PaTu 8988t C89(0.77)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C89(0.44)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C89(0.69)  LDD1157  [5]
 LDCM0279  AC2 HCT 116 C89(1.19)  LDD0596  [5]
 LDCM0280  AC20 PaTu 8988t C89(0.56)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C89(0.30)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C89(0.28)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C89(0.35)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C89(0.64)  LDD1163  [5]
 LDCM0285  AC25 HCT 116 C89(0.83)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C89(0.65)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C89(0.83)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C89(0.61)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C89(0.41)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C89(1.35)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C89(0.43)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C89(0.62)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C89(0.44)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C89(0.87)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C89(0.75)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C89(1.64)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C89(1.13)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C89(1.79)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C89(1.27)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C89(1.39)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C89(1.84)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C89(0.95)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C89(1.35)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C89(1.14)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C89(0.95)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C89(1.60)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C89(1.24)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C89(0.91); C118(1.22)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C89(0.95); C118(1.09)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C89(1.14); C118(1.06)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C118(1.03)  LDD1550  [16]
 LDCM0312  AC5 HCT 116 C89(1.55)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C89(1.00); C118(1.36)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C89(1.12); C118(1.10)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C89(1.02); C118(0.97)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C89(1.12); C118(1.12)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C89(0.93); C118(1.23)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C89(1.13); C118(1.11)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C89(1.13); C118(1.12)  LDD1558  [16]
 LDCM0320  AC57 HCT 116 C89(0.56)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C89(0.58)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C89(0.42)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C89(0.99)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C89(0.67)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C89(0.73)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C89(0.34)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C89(0.86)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C89(0.32)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C89(0.49)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C89(0.70)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C89(0.15)  LDD0648  [5]
 LDCM0332  AC68 PaTu 8988t C89(1.43)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C89(1.27)  LDD1212  [5]
 LDCM0334  AC7 HCT 116 C89(0.89)  LDD0651  [5]
 LDCM0335  AC70 PaTu 8988t C89(1.00)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C89(1.38)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C89(1.41)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C89(1.15)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C89(1.55)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C89(0.92)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C89(1.26)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C89(1.41)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C89(2.25)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C89(1.12)  LDD1223  [5]
 LDCM0345  AC8 HCT 116 C89(0.87)  LDD0662  [5]
 LDCM0346  AC80 PaTu 8988t C89(1.19)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C89(1.26)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C89(1.23)  LDD1227  [5]
 LDCM0349  AC83 HCT 116 C89(0.83)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C89(0.71)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C89(0.90)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C89(0.77)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C89(0.51)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C89(0.51)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C89(0.59)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C89(0.55)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C89(1.13)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C89(0.96)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C89(0.59)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C89(1.40)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C89(0.55)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C89(1.38)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C89(0.58)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C89(0.61)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C89(0.69)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C89(1.33)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C89(1.21)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C89(0.91)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 14.02  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H146(0.00); C89(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C89(0.79)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C89(0.41)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C89(1.38)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C89(0.90)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C89(0.99)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C89(1.24)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C89(1.14)  LDD0690  [5]
 LDCM0374  CL105 PaTu 8988t C89(1.04)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C89(1.26)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C89(0.51)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C89(1.18)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C89(0.97)  LDD1257  [5]
 LDCM0379  CL11 HCT 116 C89(0.22)  LDD0696  [5]
 LDCM0380  CL110 PaTu 8988t C89(0.65)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C89(0.27)  LDD1260  [5]
 LDCM0382  CL112 HCT 116 C89(0.71)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C89(0.45)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C89(0.41)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C89(0.53)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C89(0.88)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C89(0.61)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C89(1.11)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C89(1.28)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C89(0.21)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C89(1.15)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C89(0.93)  LDD1596  [16]
 LDCM0394  CL123 HEK-293T C118(1.12)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C118(1.14)  LDD1599  [16]
 LDCM0396  CL125 HCT 116 C89(0.84)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C89(0.86)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C89(1.39)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C89(0.55)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C89(0.55)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C89(0.66)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C89(0.44)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C89(0.98)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C89(1.03)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C89(0.97)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C89(1.02)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C89(1.05)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C89(0.95)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C89(1.07)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C89(0.88)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C89(1.01)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C89(1.09)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C89(0.99)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C89(0.71)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C89(0.93)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C89(0.98)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C89(1.04)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C89(0.78)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C89(0.83)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C89(0.57)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C89(0.50)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C89(0.85)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C89(0.18)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C89(0.21)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C89(0.35)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C89(0.17)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C89(0.30)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C89(0.88)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C89(0.35)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C89(0.38)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C89(0.13)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C89(0.15)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C89(0.37)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C89(0.22)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C89(1.25)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C89(1.36)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C89(1.16)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C89(1.28)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C89(1.06)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C89(1.35)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C89(1.34)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C89(1.01)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C89(1.16)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C89(1.15)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C89(1.15)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C89(1.20)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C89(1.52)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C89(1.14)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C89(1.17)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C89(0.57)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C89(1.30)  LDD0769  [5]
 LDCM0453  CL61 PaTu 8988t C89(0.97)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C89(0.81)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C89(0.76)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C89(0.71)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C89(0.87)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C89(0.67)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C89(0.83)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C89(0.78)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C89(0.54)  LDD1340  [5]
 LDCM0462  CL7 HCT 116 C89(0.40)  LDD0779  [5]
 LDCM0463  CL70 PaTu 8988t C89(0.87)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C89(0.83)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C89(0.95)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C89(0.52)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C89(0.92)  LDD1346  [5]
 LDCM0469  CL76 HEK-293T C89(1.08)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C89(0.88)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C89(1.28)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C89(0.82)  LDD1070  [5]
 LDCM0473  CL8 HCT 116 C89(0.20)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C89(0.98)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C89(1.53)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C89(0.86)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C89(1.24)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C89(1.03)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C89(0.78)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C89(0.93)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C89(0.91)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C89(0.60)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C89(0.94)  LDD1081  [5]
 LDCM0484  CL9 HCT 116 C89(0.61)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C89(0.79)  LDD1083  [5]
 LDCM0486  CL91 HCT 116 C89(0.72)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C89(0.78)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C89(1.10)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C89(1.36)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C89(0.85)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C89(0.86)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C89(0.86)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C89(1.48)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C89(1.37)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C118(1.18)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C118(1.16)  LDD1702  [4]
 LDCM0625  F8 Ramos C118(2.58)  LDD2187  [17]
 LDCM0573  Fragment11 Ramos C118(20.00)  LDD2190  [17]
 LDCM0576  Fragment14 Ramos C118(0.95)  LDD2193  [17]
 LDCM0586  Fragment28 Ramos C118(1.14)  LDD2198  [17]
 LDCM0468  Fragment33 PaTu 8988t C89(0.67)  LDD1347  [5]
 LDCM0566  Fragment4 Ramos C118(0.89)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C89(0.11)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C118(1.23)  LDD2186  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C89(1.48)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C89(1.21)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C89(1.38)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C89(0.88)  LDD2137  [4]

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578